Therapeutic Role of Protein Tyrosine Phosphatase 1B in Parkinson’s Disease via Antineuroinflammation and Neuroprotection In Vitro and In Vivo by Chien-Wei Feng, Nan-Fu Chen, Te-Fu Chan, Wu-Fu Chen

“…Our study showed that suramin, an inhibitor of PTP1B, could improve neuronal damage. …”
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An Update on African Trypanocide Pharmaceutics and Resistance. by Keneth Iceland, Kasozi, MacLeod, Ewan Thomas, Ntulume, Ibrahim, Welburn, Susan Christina

“…Resistance to suramin is associated with pathogen altered transport proteins. …”
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Prevalence and Types of Coinfections in Sleeping Sickness Patients in Kenya (2000/2009) by J. M. Kagira, N. Maina, J. Njenga, S. M. Karanja, S. M. Karori, J. M. Ngotho

“…The HAT patients were treated with suramin (early stage, 9/31) and melarsoprol (late stage, 22/31). …”
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Development of a Functional Schwann Cell Phenotype from Autologous Porcine Bone Marrow Mononuclear Cells for Nerve Repair by Michael J. Rutten, Michael Ann Janes, Ivy R. Chang, Cynthia R. Gregory, Kenton W. Gregory

“…We found ATP dose-dependently increased intracellular calcium [Ca2+]i, with nucleotide potency being UTP=ATP>ADP>AMP>adenosine. Suramin blocked the ATP-induced [Ca2+]i but α, β,-methylene-ATP had little effect suggesting an ATP purinergic P2Y2 G-protein-coupled receptor is present. …”
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Immobilization of NTPDase-1 from Trypanosoma cruzi and Development of an Online Label-Free Assay by Felipe Antunes Calil, Juliana Maria Lima, Arthur Henrique Cavalcante de Oliveira, Christiane Mariotini-Moura, Juliana Lopes Rangel Fietto, Carmen Lucia Cardoso

“…Besides that, the ICER was stable for 32 days, enough time to investigate samples of possible inhibitors, including especially the compound Suramin, that inhibited 51% the enzyme activity at 100 µmol·L−1, which is in accordance with the data for the enzyme in solution.…”
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