Effects of non-pharmacological interventions on biochemical hyperandrogenism in women with polycystic ovary syndrome: a systematic review and network meta-analysis by Qi Jin, Ge Xu, Yuchen Ying, Lumin Liu, Huimin Zheng, Shifen Xu, Ping Yin, Yuelai Chen

“…No significant effects were observed on Free Androgen Index (FAI), Sex Hormone-Binding Globulin (SHBG), Dehydroepiandrosterone (DHEA), DHEA Sulfate (DHEAS), Free Testosterone (FT), or Dihydrotestosterone (DHT) levels (all p > 0.05). …”
Get full text

Distinct regulation of Tau Monomer and aggregate uptake and intracellular accumulation in human neurons by Amir T. Marvian, Tabea Strauss, Qilin Tang, Benjamin J. Tuck, Sophie Keeling, Daniel Rüdiger, Negar Mirzazadeh Dizaji, Hossein Mohammad-Beigi, Brigitte Nuscher, Pijush Chakraborty, Duncan S. Sutherland, William A. McEwan, Thomas Köglsperger, Stefan Zahler, Markus Zweckstetter, Stefan F. Lichtenthaler, Wolfgang Wurst, Sigrid Schwarz, Günter Höglinger

“…A competition assay revealed a distinction in the neuronal accumulation between physiological eTau Monomers and pathology-relevant aggregates, suggesting differential transport mechanisms. Blocking heparan sulfate proteoglycans (HSPGs) with heparin only inhibited the accumulation of eTau aggregates, whereas monomers’ uptake remained unaltered. …”
Get full text

AI-NAOS: an AI-based nonspherical aerosol optical scheme for the chemical weather model GRAPES_Meso5.1/CUACE by X. Wang, L. Bi, H. Wang, Y. Wang, W. Han, X. Shen, X. Zhang

“…Specifically, the AI-NAOS considers black carbon (BC) to be fractal aggregates and models soil dust (SD) as super-spheroids, encapsulated partially or completely with hygroscopic aerosols such as sulfate, nitrate, and aerosol water. To obtain AI-NAOS, a database of the optical properties for the models was constructed using the invariant imbedding T-matrix method (IITM), and deep neural networks (DNN) were trained based on this database. …”
Get full text

Real-world of Limosilactobacillus reuteri in mitigation of acute experimental colitis by Ningning Yue, Hailan Zhao, Peng Hu, Yuan Zhang, Chengmei Tian, Chen Kong, Zhiliang Mai, Longbin Huang, Qianjun Luo, Daoru Wei, Ruiyue Shi, Shaohui Tang, Yuqiang Nie, Yujie Liang, Jun Yao, Lisheng Wang, Defeng Li

“…Here, we report that Limosilactobacillus reuteri (L. reuteri), as a probiotic, secretes cytoplasmic membrane vesicles (CMVs) that communicate with host cells, alter host physiology, and alleviate dextran sulfate sodium (DSS)-induced colitis. First, L. reuteri-CMVs selectively promoted the proliferation of the beneficial bacterium Akkermansia muciniphila (AKK) by upregulating the expression of glycosidases (beta-N-acetylhexosaminidase and alpha-N-acetylglucosaminidase) involved in glycan degradation and metabolic pathways and restored the disrupted gut microbiota balance. …”
Get full text

Probiotic Bacillus pumilus LV149 enhances gut repair, modulates microbiota, and alters transcriptome in DSS-induced colitis mice by Xinyu Sun, Long Yun, Keming Xie, Renhui Liu, Xinyue Ren, Bokun Zeng, Xudong Cao, Zhi Li, Guihao Zhou, Bang Liu, Luo Peng, Lihong Yuan

“…This study evaluated the effects of different doses of Bacillus pumilus LV149, an aquatic-derived probiotic, on gut injury repair in male C57BL/6 mice with dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) and investigated the underlying mechanisms.MethodsUC was induced by allowing mice free access to a 3% DSS solution for 7 days, with concurrent daily oral gavage of either a low (LV149-L, 1 × 108 CFU/day/mouse) or high (LV149-H, 1 × 109 CFU/day/mouse) dose of LV149. …”
Get full text

High-Pressure Treatment in Combination with Reduced Sodium for Improving the Physicochemical Properties and Sensory Qualities of Pork Gels by Weitong Wang, Jingying Cai, Satomi Tsutsuura, Tadayuki Nishiumi

“…Protein analysis by sodium dodecyl sulfate–polyacrylamide gel electrophoresis showed a reduction in the <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi>α</mi></semantics></math></inline-formula>-actinin band with increased pressure, which suggested protein interactions were enhanced. …”
Get full text

&alpha;-Methyl-Tryptophan Inhibits SLC6A14 Expression and Exhibits Immunomodulatory Effects in Crohn&rsquo;s Disease by Su Y, Li J, Chen Y, Bao J, Lei Z, Ma M, Zhang W, Liu Q, Xu B, Hu T, Hu Y

“…The mouse model of CD was induced by dextran sodium sulfate (DSS). Infiltrating immune cells in mouse model were screened by flow cytometry.Results: We discovered that SLC6A14 is significantly overexpressed in CD samples, and its expression is positively correlated with the degree of infiltration by CD4+ and CD8+ T cells. …”
Get full text

Phase-dependent iron depletion differentially regulates the niche of intestinal stem cells in experimental colitis via ERK/STAT3 signaling pathway by Shubin Wang, Xiangjun Liu, Lu Xu, Jinyi Lang, Dengqun Liu, Dengqun Liu

“…In this study, we aimed to explore whether and how iron depletion would affect the occurrence and outcome of experimental colitis.MethodsIron depletion was realized by deferoxamine (DFO) at either the early stage or late stage of dextran sulfate sodium (DSS) induced experimental colitis in mice. …”
Get full text

Machine learning-based identification and validation of amino acid metabolism related genes as novel biomarkers in chronic kidney disease by Guoqing Zhang, Hongyan Luo, Xiaohua Lu, Yonghua Liu, Mei Wang, Bo Li, Haixia Lu, Yali Zheng

“…The expression of ALDH18A1, CENPF were increased while CSAD, CTH and CYP27B1 were decreased in HK-2 cells cultured with indole sulfate. Conclusions: Our study identified key genes involved in amino acid metabolism associated with immune cells infiltration and renal function in CKD, which may be potential biomarkers for the diagnosis and prognosis of CKD.…”
Get full text

The Effect of Wheat Residues and Vermicompost on the Quality Characteristics of Corn (Zea mays L.) Forage and Soil Fertility by Hasanali Pooresmaeil, Mehdi Dahmradeh, Ahmad Ghanbari

“…The highest amount of potassium (0.37 meq.lit-1), sulfate (11.29 meq.lit-1), and calcium (6.33 meq.lit-1) in corn were observed in the treatment of 10% vermicompost+ 90% wheat residues, 70% vermicompost + 30% wheat residues and the treatment of 30% wheat residues, respectively. …”
Get full text

Muscarinic acetylcholine type 1 receptor antagonism activates TRPM3 to augment mitochondrial function and drive axonal repair in adult sensory neurons by Sanjana Chauhan, Darrell R. Smith, Shiva Shariati-Ievari, Abhay Srivastava, Sanjiv Dhingra, Michel Aliani, Paul Fernyhough

“…Methods: Dorsal root ganglion (DRG) neurons from adult control or diabetic rats were cultured and treated with TRPM3 agonists (CIM0216, pregnenolone sulfate) and M1R antagonists pirenzepine (PZ) or muscarinic toxin 7 (MT7). …”
Get full text

Serum metabolome indicators of early childhood development in the Brazilian National Survey on Child Nutrition (ENANI-2019) by Marina Padilha, Victor Nahuel Keller, Paula Normando, Raquel M Schincaglia, Nathalia C Freitas-Costa, Samary SR Freire, Felipe M Delpino, Inês RR de Castro, Elisa MA Lacerda, Dayana R Farias, Zachary Kroezen, Meera Shanmuganathan, Philip Britz-Mckibbin, Gilberto Kac

“…Results: Twenty-eight top-ranked metabolites were included in linear regression models adjusted for the child’s nutritional status, diet quality, and infant age. Cresol sulfate (β=–0.07; adjusted-p &lt;0.001), hippuric acid (β=–0.06; adjusted-p &lt;0.001), phenylacetylglutamine (β=–0.06; adjusted-p &lt;0.001), and trimethylamine-N-oxide (β=–0.05; adjusted-p=0.002) showed inverse associations with DQ. …”
Get full text

Experimental study on acoustic emission characteristics and damage-failure process of seawater sea-sand ultra-high-performance concrete under uniaxial compression by Tianyu Li, Yangtao Li, Tao Li, Xiamin Hu, Yuanhao Li, Jie Liao, Lidan Mei, Yuying Hou, Bokai Yang, Jinlong Gu

“…SSUHPC and FRUHPC specimens have undergone five years of sulfate corrosion, and were subjected to uniaxial compression tests until failure occurs. …”
Get full text

Degassing at the Volcanic/Geothermal System of Kos (Greece): Geochemical Characterization of the Released Gases and CO2 Output Estimation by Kyriaki Daskalopoulou, Antonina Lisa Gagliano, Sergio Calabrese, Lorenza Li Vigni, Manfredi Longo, Konstantinos Kyriakopoulos, Giovannella Pecoraino, Walter D’Alessandro

“…These areas are mainly characterized by the lack of vegetation and after long dry periods by the presence of sulfate salt efflorescence. Carbon dioxide is the prevailing gas species (ranging from 88 to 99%), while minor amounts of N2 (up to 7.5%) and CH4 (up to 2.1%) are also present. …”
Get full text

Abnormalities in mitochondrial energy metabolism induced by cryopreservation negatively affect goat sperm motility by Shengqin Zang, Shuqi Zou, Xiangyi Chen, Bo Pan, Ao Ning, Jianpeng Qin, Yaozong Wei, Kunlin Du, Jiangfeng Ye, Qiuxia Liang, Yi Fang, Qiongla, Cirenlamu, Tianzeng Song, Tianzeng Song, Guangbin Zhou

“…Further investigations unveiled that energy-related differential metabolites (capric acid, creatine, and D-glucosamine-6-phosphate) and differential metabolites with antioxidant effects (saikosaponin A, probucol, and cholesterol sulfate) were significantly downregulated. In addition, the activity of key rate-limiting enzymes involved in very long-chain fatty acid biosynthesis and β-oxidation—specifically acetyl-CoA carboxylase, fatty acid synthase, and carnitine palmitoyltransferase I related to capric acid metabolism—was considerably reduced. …”
Get full text

Quinazolinone Derivative MR2938 Protects DSS-Induced Barrier Dysfunction in Mice Through Regulating Gut Microbiota by Ling Lv, Mireguli Maimaitiming, Jichen Yang, Shuli Xia, Xin Li, Pingyuan Wang, Zhiqing Liu, Chang-Yun Wang

“…Herein, we aimed to investigate the impact of MR2938 on the gut microbiota in dextran sodium sulfate (DSS)-induced colitis in mice and to elucidate the role of the gut microbiota in the therapeutic mechanism of MR2938 for alleviating colitis. …”
Get full text

Successful Management of Peri-Implantitis around Short and Ultrashort Single-Crown Implants: A Case Series with a 3-Year Follow-Up by Giorgio Lombardo, Mauro Marincola, Andrea Cicconetti, Miguel Angel Simancas-Pallares, Jacopo Pighi, Jeffrey Lehrberg, Annarita Signoriello, Giovanni Corrocher, Xiomara Serpa-Romero, Luis Armando Vila Sierra, Luisa Arevalo-Tovar, Pier Francesco Nocini

“…The study is a retrospective evaluation of patients suffering from peri-implantitis and those who underwent access flap surgery, concomitant chemical and mechanical decontamination of implant surface, and bone grafting using a self-hardening mixture of bone substitutes and biphasic calcium sulfate. No membranes were applied to cover the grafting material, and primary tension-free closure was achieved. …”
Get full text

Assessing the relationships of 1,400 blood metabolites with abdominal aortic aneurysm: a Mendelian randomization study by Qian Guo, Xinghua Xu, Xiaohui Li, Yang Mao, Shengqiang Li, Yuxin Yao, Xiang Li, Yaxing Li, Jiayue Feng, Yan Shu, Xingli Xu

“…The top five metabolites associated with an increased risk of AAA were Oleoyl-linoleoyl-glycerol (18:1/18:2) [2], Glycosyl-N-(2-hydroxynervonoyl)-sphingosine (d18:1/24:1(2OH)), Glycochenodeoxycholate 3-sulfate, X-21441 and X-24328. In contrast, the top five metabolites that were linked to a reduced risk of AAA included Uridine to pseudouridine ratio, Octadecanedioate, Phosphate to oleoyl-linoleoyl-glycerol (18:1 to 18:2) [2] ratio, 1-(1-enyl-palmitoyl)-GPE (p-16:0), and 1-stearoyl-GPG (18:0).ConclusionAmong the 1,400 blood metabolites, we identified 17 known metabolites, 7 unknown metabolites, and 5 metabolite ratios associated with AAA. …”
Get full text

Therapeutic Potential of <i>Cajanus cajan</i> (L.) <i>Millsp</i>. Leaf Extract in Modulating Gut Microbiota and Immune Response for the Treatment of Inflammatory Bowel Disease by Mingzhang Lin, Linghua Piao, Zhendong Zhao, Li Liao, Dayong Wang, Haiwen Zhang, Xiande Liu

“…The IBD model was developed in C57BL/6 mice by administering continuous 4% (<i>w</i>/<i>v</i>) dextran sodium sulfate (DSS) aqueous solution over a period of seven days. …”
Get full text

Effects of fine particulate matter and its chemical constituents on influenza-like illness in Guangzhou, China by Keyi Wu, Weidong Fan, Jing Wei, Jianyun Lu, Xiaowei Ma, Zelin Yuan, Zhiwei Huang, Qi Zhong, Yining Huang, Fei Zou, Xianbo Wu

“…Methods: Daily data on ILI cases, PM2.5 levels, and specific PM2.5 constituents (black carbon [BC], chlorine [Cl−], ammonia [NH4+], nitrate [NO3−], and sulfate [SO42−]) in Guangzhou, China, were collected for the period of 2014–2019. …”
Get full text