Performance of a hybrid capture-based target enrichment next-generation sequencing for the identification of respiratory pathogens and resistance-associated genes in patients with... by Wei-Yu Hsu, Ting-Wei Kao, Hsin-Ching Cho, Sheng-Yuan Ruan, Tai-Fen Lee, Yu-Tsung Huang, Jung-Yien Chien

“…The performance of RPIP in pathogen and AMR-associated gene detection was compared to that of conventional culture methods and the multiplex PCR-based FilmArray Pneumonia Panel (FilmArray-PN). A total of 83 subjects were enrolled. The most prevalent pathogens detected by RPIP were Rothia mucilaginosa, Stenotrophomonas maltophilia, Pseudomonas aeruginosa; herpes simplex virus-1, cytomegalovirus, and Epstein-Barr virus, and Pneumocystis jirovecii. …”
Get full text

Modeling Portfolio Optimization based on behavioral Preferences and Investor’s Memory by vahideh mousavi kakhki, Sanaz Khatabi

“…ObjectiveThe optimization of asset portfolios, taking into account market advancements, has emerged as a pivotal subject in financial economics. Constructing asset portfolios is acknowledged as a critical decision for investors. …”
Get full text

EyeLiner by Yoga Advaith Veturi, MSc, Steve McNamara, OD, Scott Kinder, MS, Christopher William Clark, MS, Upasana Thakuria, MS, Benjamin Bearce, MS, Niranjan Manoharan, MD, Naresh Mandava, MD, Malik Y. Kahook, MD, Praveer Singh, PhD, Jayashree Kalpathy-Cramer, PhD

“…This makes manual image evaluation variable and subjective, potentially impacting clinical decision-making. …”
Get full text

The History of Miss Jane Pittman by Christopher Mulvey

“…The significance for Gaines is that what happened a hundred years ago is part of his present-day lived life.The nineteenth-century novel was possessed by history, and white nineteenth-century novelists found their great subject in the war of European nations that was fought between 1799 and 1815. …”
Get full text

Assessment of hemodynamic disturbances and impaired ventricular filling in asymptomatic fontan patients: A 4D flow CMR study by Li-Wei Hu, Xiaodan Zhao, Shuang Leng, RongZhen Ouyang, Qian Wang, Ai-Min Sun, Yi-Man Liu, Wei Dong, Liang Zhong, Yu-Min Zhong

“…Methods: Twenty-five Fontan patients (mean age: 10 ± 3 years, male/female: 15/10) and fourteen control subjects (mean age: 10 ± 2 years, male/female: 8/6) were recruited retrospectively for the study. …”
Get full text

Evaluating small coronary stents with dual-source photon-counting computed tomography: effect of different scan modes on image quality and performance in a phantom by Thomas Stein, Constantin von zur Muhlen, Niklas Verloh, Till Schürmann, Tobias Krauss, Martin Soschynski, Dirk Westermann, Jana Taron, Elif Can, Christopher L. Schlett, Fabian Bamberg, Christopher Schuppert, Muhammad Taha Hagar

“…Image quality and diagnostic confidence were assessed using subjective measures, including a 4-point visual grading scale (4 = excellent; 1 = non-diagnostic) utilized by two independent radiologists, and objective measures, including the full width at half maximum (FWHM). …”
Get full text

Association of inflammation cytokines with cognitive function in first-episode major depressive disorder by Yan Qing Xi, Yan Qing Xi, Yan Qing Xi, Zong Qi Wang, Zong Qi Wang, Zong Qi Wang, Guo Juan Li, Guo Juan Li, Guo Juan Li, Zhuo Qun Hao, Zhuo Qun Hao, Zhuo Qun Hao, Jia Hui Nie, Jin Xiang Li, Yu Ting Tan, Xiao Dong Hu, Xiao Dong Hu, Gen Wei Wang, Sha Liu, Sha Liu, Yan Fang Wang, Yan Fang Wang, Yan Fang Wang

“…Post-treatment, patients’ BDNF, IL-6, and TNF-α levels remained higher than those of healthy subjects, and their IFN-α levels were still lower; their language and attention scores were also inferior. …”
Get full text

Machine learning based models for predicting presentation delay risk among gastric cancer patients by Huali Zhou, Huali Zhou, Qiong Gu, Rong Bao, Liping Qiu, Yuhan Zhang, Fang Wang, Wenlian Liu, Lingling Wu, Li Li, Yihua Ren, Lei Qiu, Qian Wang, Gaomin Zhang, Xiaoqing Qiao, Wenjie Yuan, Juan Ren, Min Luo, Rong Huang, Qing Yang, Qing Yang

“…Feature ranking results indicated that both of subjective and objective factors have significant impact on the occurrence of presentation delay in gastric cancer patients.ConclusionThis study demonstrated that the RF based model has favorable performance for the prediction of presentation delay in gastric cancer patients. …”
Get full text

Effects of external ankle support on balance control outcomes following muscle fatigue in individuals with ankle instability: A systematic review and meta-analysis by Hanieh KHALILIYAN, Mahmood BAHRAMIZADEH, Amirhossein ZARE, Kavita BATRA, Gabriella NUCERA, Aldo SITIBONDO, Aanuoluwapo AFOLABI, Majid ANSARI, Olayinka ILESANMI, Lukasz SZARPAK, Alireza KHAGHANI, Shahla MOHAJERI, Farhad GHAFFARI, Arash SHARAFATVAZIRI

“…Results: Nine crossover studies involving 230 subjects were included. The narrative synthesis shows that external ankle supports improve the single leg hop test [Mean difference=7.84, P=0.01], center of pressure range and velocity, and ankle inversion. …”
Get full text

Evaluation of Bone Mineral Metabolism in Pre-Dialysis Chronic Kidney Disease: Quantitative Computed Tomography vs. Dual-Energy Absorptiometry and Correlation with Bone Turnover Mar... by Aydan Mutis Alan, Zehra Sezer, Ahmet Oz, Cebrail Karaca, Mevlüt Tamer Dinçer, Ahmet Murt, Fatma Beyza Sag, Selma Alagoz, Serdar Sahin, Mustafa Sait Gonen, Elif Güzel, Sinan Trabulus, Nurhan Seyahi

“…<i>Results</i>: Data from 38 participants (patient group: 18; control group: 20) who underwent QCT and/or DXA were evaluated. Thirty-three subjects were assessed using both QCT and DXA (patient group: 14; control group: 19). …”
Get full text

Glaucoma Detection and Feature Identification via GPT-4V Fundus Image Analysis by Jalil Jalili, PhD, Anuwat Jiravarnsirikul, MD, Christopher Bowd, PhD, Benton Chuter, MD, Akram Belghith, PhD, Michael H. Goldbaum, MD, Sally L. Baxter, MD, Robert N. Weinreb, MD, Linda M. Zangwill, PhD, Mark Christopher, PhD

“…Design: Evaluation of multimodal large language models for reviewing fundus images in glaucoma. Subjects: A total of 300 fundus images from 3 public datasets (ACRIMA, ORIGA, and RIM-One v3) that included 139 glaucomatous and 161 nonglaucomatous cases were analyzed. …”
Get full text

Risk of aortic aneurysm or dissection following use of fluoroquinolones: a retrospective multinational network cohort studyResearch in context by Jack L. Janetzki, Jung Ho Kim, Evan Minty, Jung Ah Lee, Daniel R. Morales, Rohan Khera, Chungsoo Kim, Thamir M. Alshammari, Scott L. DuVall, Michael E. Matheny, Thomas Falconer, Seonji Kim, Thanh-Phuc Phan, Phung-Anh Nguyen, Min-Huei Hsu, Jason C. Hsu, Rae Woong Park, Kenneth K.C. Man, Sarah Seager, Mui Van Zandt, James P. Gilbert, Patrick B. Ryan, Martijn J. Schuemie, Marc A. Suchard, George Hripcsak, Nicole Pratt, Seng Chan You

“…Cox proportional hazards models with 1:1 propensity score (PS) matching were used to estimate the risk, with results calibrated using negative control outcomes. Analyses were subjected to pre-defined study diagnostics, and only those passing all diagnostics were reported. …”
Get full text

<i>Cichorium intybus</i> L. Oligo-Polysaccharides (CIO) Exerts Antianxiety and Antidepressant Effects on Mice Experiencing Behavioral Despair and Chronic Unpredicted Mild Stress by Yanqin Luo, Xueyi Bei, Yiwen Zhang, Xinran Sun, Yongzhi Zhao, Fang Chen, Ruile Pan, Qi Chang, Qinghu He, Xinmin Liu, Ning Jiang

“…Except for the control group, the other groups were subjected to 6 weeks of CUMS. From the fifth week of stress, the corresponding drugs were administered by gavage until the end of the behavioral tests. …”
Get full text

Guideline: Neurorehabilitation in patients with disorder of consciousness. Recommendations from the Spanish Society of Neurorehabilitation by E. Noé, M.D. Navarro, B. Moliner, M. O’Valle, J. Olaya, A. Maza, R. Llorens, J. Ferri, R. Rodríguez, T. Pérez, M. Bernabéu, C. Colomer, A. Gómez, C. González, A. Juárez-Belaúnde, C. López, S. Laxe, R. Pelayo, M. Ríos, I. Quemada, Enrique Noé Sebastián, María Dolores Navarro Pérez, Belén Moliner Muñoz, Myrtha O’Valle Rodríguez, José Olaya Sanchez, Roberto Llorens Rodríguez, Anny Maza Pino, Joan Ferri Campos, Rubén Rodríguez Duarte, Teresa Pérez Nieves, Montserrat Bernabeu, Carolina Colomer Font, Antonio Gómez Blanco, Carlos González Alted, Alan Juárez Belaúnde, Cristina López Pascua, Sara Laxe García, Raúl Pelayo Vergara, Marcos Ríos Lago, Ignacio Quemada

“…Following this review, forty recommendations were formulated and subjected to evaluation by an expert committee using a 9-point Likert scale: 1–3 (inappropriate recommendation), 4–6 (uncertain recommendation), and 7–9 (appropriate recommendation), following the methodology of the “Modified Nominal Group Technique.” …”
Get full text

Sex-specific associations between body composition and depression among U.S. adults: a cross-sectional study by Yijing Li, Juan Li, Tianning Sun, Zhigang He, Cheng Liu, Zhixiao Li, Yanqiong Wu, Hongbing Xiang

“…Four body composition profiles were identified in the subjects: low adiposity-low muscle (LA-LM), low adiposity-high muscle (LA-HM), high adiposity-low muscle (HA-LM) and high adiposity-high muscle (HA-HM). …”
Get full text

Dynamic conditioning of porcine kidney grafts with extracellular vesicles derived from urine progenitor cells: A proof‐of‐concept study by Perrine Burdeyron, Sébastien Giraud, Maryne Lepoittevin, Nina Jordan, Sonia Brishoual, Maïté Jacquard, Virginie Ameteau, Nadège Boildieu, Estelle Lemarie, Jonathan Daniel, Frédéric Martins, Nicolas Mélis, Marine Coué, Raphaël Thuillier, Henri Leuvenink, Luc Pellerin, Thierry Hauet, Clara Steichen

“…Then these were used in an ex vivo porcine kidney preservation model. Kidneys were subjected to warm ischemia (32 min) and then preserved by hypothermic machine perfusion (HMP) for 24 h before 5 h of normothermic machine perfusion (NMP). …”
Get full text

Deep-Reticular Pseudodrusen-Net: A 3-Dimensional Deep Network for Detection of Reticular Pseudodrusen on OCT Scans by Amr Elsawy, PhD, Tiarnan D.L. Keenan, PhD, MD, Alisa T. Thavikulwat, MD, Amy Lu, MD, Sunil Bellur, MD, Souvick Mukherjee, PhD, Elvira Agron, MS, Qingyu Chen, PhD, Emily Y. Chew, MD, Zhiyong Lu, PhD

“…Results: Deep-RPD-Net achieved the highest performance metrics, with accuracy and AUROC of 0.81 (95% confidence interval [CI]: 0.76–0.87) and 0.91 (95% CI: 0.86–0.95) on the AREDS2 dataset and 0.80 (95% CI: 0.75–0.84) and 0.86 (95% CI: 0.79–0.91) on the DAAMD dataset. On the subjective test, it achieved accuracy of 0.84 compared with 0.76 for the most accurate retina specialist on the AREDS2 dataset and 0.82 compared with 0.84 on the DAAMD dataset. …”
Get full text

Micro-nano aerated subsurface drip irrigation and biochar promote photosynthesis, dry matter accumulation and yield of cucumbers in greenhouse by Zan Ouyang, Jie Zhang, Xueli Liang, Hui Wang, Zhenfeng Yang, Rong Tang, Qihua Yu, Yong Zhang

“…Three levels concentrations of dissolved oxygen (DO) in MNBW: O1 (4–5 mg/L), O2 (9–10 mg/L), and O3 (14–15 mg/L), as well as three levels amount of biochar application (BA): B1 (20 t/hm2), B2 (40 t/hm2), and B3 (60 t/hm2), and one control group (CK, O: 4–5 mg/L, B: 0 t/hm2) were the subjects of this study, followed by a two-factor randomized block design. …”
Get full text

High-risk human papillomavirus: prevalence, association with clinical and morphological characteristics of invasive cervical cancer by L. S. Mkrtchian, V. I. Kiseleva, B. V. Boyko, L. I. Krikunova, V. A. Petrov, V. R. Gusarova, S. A. Ivanov, A. D. Kaprin, I. A. Zamulaeva

“…With regard to such molecular genetic parameters of HPV HR as viral load and HPV DNA integration, associative relationship with prognostic important clinical indicators of cervical tumor – the stage of the disease, the loco-regional prevalence of the tumor process, the histological type of tumor – remains the subject of discussion.Conclusion. Many publications report a correlative link between HPV status and high oncogenic risk HPV genotype with such an important factor affecting ICC treatment outcomes as the morphological form of the tumor. …”
Get full text

Macrophage Notch1 signaling modulates regulatory T cells via the TGFB axis in early MASLD by Mengya Zhang, Kun Li, Xiaoxing Huang, Dongqin Xu, Ruobin Zong, Qintong Hu, Xiaoyu Dong, Qinyong Zhang, Chaochen Jiang, Yue Ge, Changyong Li, Jie Ping

“…Methods: A mouse model subjected to a short-term high-fat diet (HFD) to mimic early steatosis, along with liver biopsy samples from patients with simple steatosis, and macrophage-specific Notch1-knockout mice (Notch1M-KO), were used to investigate the role of Tregs in early MASLD and the effect of hepatic macrophage Notch1 signaling on Treg frequency. …”
Get full text