The anticancer properties, cell-cycle cytotoxicity and apoptosis of cissus rotundifolia, trema orientalis, and buddleja polystachya with ocular applications by Ali Hendi Alghamdi, Aimun A.E. Ahmed, Mahadi bashir, Haidar abdalgadir, Asaad khalid, Ashraf N. Abdalla, Mohamed E. elzubier, Riyad almaimani, Bassem refaat, Khalid alzahrani, Saleh MS. alghamdi, Sheraz gul

“…The most promising extract was subjected to GC–MS analysis to determine the phytochemical composition. …”
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Pharmacological approaches in drug-resistant pediatric epilepsies caused by pathogenic variants in potassium channel genes by Ilaria Filareto, Ilaria Mosca, Elena Freri, Francesca Ragona, Laura Canafoglia, Roberta Solazzi, Barbara Castellotti, Giuliana Messina, Cinzia Gellera, Maria Virginia Soldovieri, Paolo Ambrosino, Maurizio Taglialatela, Jacopo C. DiFrancesco, Tiziana Granata

“…The application in vivo of fluoxetine to counteract GoF effects induced by Kv3.1 or KNa1.1 variants determined a significant reduction of both seizure frequency and behavior disturbances in patient #4 (Kv3.1 V425M), and in both subjects carrying KNa1.1 variants (#5, S937G and #6, R262Q). …”
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Chichimene field T2 sand: a successful application of cycles in a water injection project on heavy crude oil, enabled by a novel smart selective completion system adapted for water... by Pedro Luis Solorzano, Carlos Emilio Giosa, Carol Stephanny Rojas, Mónica Andrea Satizabal, Amelia Jhoanna Araque, Luisa Fernanda Falla, Walter Enrique Sanchez, Luis Oswaldo Castañeda, Mónica Alexandra Martínez, Diana Patricia Ahmedt

“…The target unit has been subjected to selective water injection since 2016, this process consisted of injection of a controlled amount of water within 3-4 zones in equilibrium with the extractive system on producers wells to find a better crude oil movement and a commercial recovery factor. …”
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Effectiveness of mDiabetes intervention in enhancing diabetes awareness and promoting healthy lifestyle changes among the general population in rural India by Padmaja Kumari Rani, Padmaja Kumari Rani, Padmaja Kumari Rani, Jachin David Williams, Nidhi Jaswal, Venkateswaralu Yandluri, Payal Sangani, Kavya Sanagavarapu, Ramya Natarajan, Sandhya Ramalingam, Nalini Saligram, Rohit C. Khanna, Rohit C. Khanna, Rohit C. Khanna, Rohit C. Khanna

“…Analysis compared data from 545 subjects who participated in all the three surveys.ResultsThe cohort comprised 45.5% males and 54.5% females, aged 19–85 years (mean: 55.42; SD 10.3). …”
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Hemodiafiltration with endogenous reinfusion for uremic toxin removal in patients undergoing maintenance hemodialysis: a pilot study by Renhua Lu, Yan Fang, Wangshu Wu, Xiaojun Zeng, Tingting Liu, Yue Qian, Yuanyuan Xie, Yijun Zhou, Leyi Gu

“…Objective To delineate the efficacy and safety profile of hemodiafiltration with endogenous reinfusion (HFR) for uremic toxin removal in patients undergoing maintenance hemodialysis (MHD).Methods Patients who have been on MHD for a period of at least 3 months were enrolled. Each subject underwent one HFR and one hemodiafiltration (HDF) treatment. …”
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Autologous osteoperiosteal transplantation achieves comparable repair effect and superior interface integration to autologous osteochondral transplantation in porcine osteochondral... by Shuai Yang, En Deng, Linxin Chen, Yanbin Pi, Anhong Wang, Linghui Dai, Hongjie Huang, Xiaoning Duan, Xin Fu, Jiying Zhang, Qinwei Guo, Weili Shi

“…At 2, 4, and 6 months post-surgery, the knees were subjected to macroscopic, radiographic, nanoindentation and histological evaluations. …”
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Associations of prognostic nutritional index with cardiovascular all-cause mortality among CVD patients with diabetes or prediabetes: evidence from the NHANES 2005–2018 by WenYi Xu, Li Zhang, Li Zhang, QianKun Yang, Ying Cao, Rui Rao, Li Lv, Qin Cen, Qiong Wei, LuLing Yang

“…This study aims to investigate the association of the novel immunonutritional indicator of prognostic nutritional index (PNI) with all-cause and CVD mortality in diabetic and prediabetic CVD patients.MethodThis is an open-cohort study involving 1,509 CVD patients with diabetes or prediabetes collected from The National Health and Nutrition Examination Survey (NHANES) and initially interviewed between 2005 and 2018. Subjects were followed up until on December 31, 2019. …”
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LLT1 overexpression renders allogeneic-NK resistance and facilitates the generation of enhanced universal CAR-T cells by Shuxian Zhu, Shiyu Zuo, Chuo Li, Xingjie You, Erlie Jiang, Xiaoming Feng, Yuechen Luo

“…Methods We generated CD38-targeting universal CAR-T cells by transducing T cells with lentiviruses encoding the CD38 CAR and LLT1 constructs. T cells were subjected to CD38, TCR, HLA-I, and HLA-II gene knockdown using CRISPR/Cas9, followed by lentiviral transduction. …”
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Impact of the initiation of isCGM soon after type 1 diabetes mellitus diagnosis in adults on glycemic indices and fear of hypoglycemia: a randomized controlled trial by Jerzy Hohendorff, Jerzy Hohendorff, Agata Grzelka-Wozniak, Marta Wrobel, Michal Kania, Michal Kania, Lidia Lapinska, Dominika Rokicka, Dorota Stoltny, Irina Kowalska, Krzysztof Strojek, Dorota Zozulinska-Ziolkiewicz, Maciej T. Malecki, Maciej T. Malecki

“…Data on glycemic indices and fear of hypoglycemia (FoH) in newly diagnosed T1DM patients are limited.AimTo assess the impact of initiating intermittently scanned CGM (isCGM) within 1–6 months of diagnosis on glycemic control and FoH in adults with T1DM.Subjects and methodsAfter wearing a blinded sensor for 14 days, participants were randomized (1:1) to either isCGM (intervention) or self-monitoring blood glucose (SMBG) with glucometers and blinded CGM (control). …”
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Quantifying the spatial patterns of retinal ganglion cell loss and progression in optic neuropathy by applying a deep learning variational autoencoder approach to optical coherence... by Jui-Kai Wang, Jui-Kai Wang, Brett A. Johnson, Zhi Chen, Zhi Chen, Honghai Zhang, Honghai Zhang, David Szanto, Brian Woods, Brian Woods, Michael Wall, Young H. Kwon, Young H. Kwon, Edward F. Linton, Edward F. Linton, Andrew Pouw, Mark J. Kupersmith, Mark J. Kupersmith, Mark J. Kupersmith, Mona K. Garvin, Mona K. Garvin, Mona K. Garvin, Mona K. Garvin, Randy H. Kardon, Randy H. Kardon

“…A total of 10,701 OCT macular scans from 822 subjects were included in this study.ResultsIncorporating bLVs improved reconstruction accuracy, with the image-based root-mean-square error (RMSE) between input and reconstructed GCL thickness maps decreasing from 5.55 ± 2.29 µm (two dLVs only) to 4.02 ± 1.61 µm (two dLVs and eight bLVs). …”
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Characteristics of base materials and acrylates used in removable prosthetics in dental practice (review) by Yu.I. Poliukhovych, A.Ye. Demkovych, Yu.I. Bondarenko, V.V. Shcherba, O.I. Lebid, K.M. Duda

“…Searches were conducted according to MeSH (Medical Subject Headings) using the following search terms: "removable prosthetics", "removable prostheses", "dental base materials", "acrylates", "materials science", "adaptation". …”
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Effects of lipopolysaccharide infusion on feed intake, apparent digestibility, rumen fermentation and microorganisms of young Holstein bulls fed diets with different ratios of lysi... by Huiyao Wang, Hongyun Liu, Shijia Pan, Zhicong Ma, Yanming Wang, Jianxin Liu, Chong Wang, Zhigao An

“…Five seven-month-old Holstein bulls with similar body weights (279 ± 42 kg) were selected and subjected to a 5 × 5 Latin square experiment. The control group (CON) was fed with basal diet and the ratio of Lys to Met in the diet was adjusted to 3.0: 1. …”
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Computational analysis of reproducibility and image quality of 2011 and 2017 models of Heidelberg Spectralis SD-OCT machines by Kyoung A Viola Lee, Corey Tesdahl, Keith Zimmerman, Kimberly Jun, Sabrina Khalil, Alexander Shahin, Abdullah Abou-Samra, Ramesh Ayyala, Radouil Tzekov

“…Design: Prospective cohort study evaluating TRT measurements across two visits. Subjects and participants: Fourteen healthy individuals (28 eyes, age range: 22-54 years) underwent TRT measurements using both Old and New OCT models, with each eye receiving three consecutive scans per visit. …”
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Time-restricted feeding improves metabolic syndrome by activating thermogenesis in brown adipose tissue and reducing inflammatory markers by Yueling Gong, Yueling Gong, Honghui Zhang, Jiang Feng, Li Ying, Mengmeng Ji, Shiyin Wei, Shiyin Wei, Qiming Ma

“…Additionally, liver tissue was subjected to Oil Red O staining to assess lipid accumulation, and white and brown adipose tissues were stained with hematoxylin and eosin (HE) to evaluate adipocyte size. …”
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Pilot study of a comprehensive multidisciplinary inpatient-based approach to smoking cessation in patients with vascular disease by Tanner Kim, MD, Anand Brahmandam, MBBS, Dana Alameddine, MD, Rachel Forman, MD, Amin Hardik, MD, Lisa Fucito, PhD, Carlos Mena-Hurtado, MD, Raul Guzman, MD, Cassius Iyad Ochoa Chaar, MD, MS, MPH

“…Patients received brief counselling sessions regarding smoking cessation from specialties including vascular surgery, cardiology, neurology, and the smoking cessation program during the hospitalization using the gain-frame approach. Subjects completed surveys related to smoking habits and mental health, including the Fagerstrom test for nicotine dependence and Patient-Reported Outcomes Measurement Information System questionnaire, respectively. …”
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A staged integrated model informing the promotion of healthy dietary behaviors in adolescents: a prospective study by Qijiao Liu, Huanyu Xu, Zihao Yuan, Lan Yu, Ruizhe Shang, Wanjie Tang, Yuchen Li, Shiying Li, Qiaolan Liu

“…The pivotal constructs included outcome expectancies, perceived severity, subjective norms, action self-efficacy, behavioral intentions, action planning, and maintenance self-efficacy. …”
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Immune and genomic biomarkers of immunotherapy response in cancer of unknown primary by Madhu Singh, Linda Mileshkin, Penelope Schofield, Bo Gao, Gary Richardson, Andrew Pattison, Rodney J Hicks, Niko Thio, Mark Warren, Colin Wood, Stephen B Fox, Anna DeFazio, Andrew Fellowes, Christopher Steer, David Bowtell, Nicholas Wilcken, Tharani Sivakumaran, Atara Posner, Dariush Etemadmoghadam, Krista Fisher, Samantha Webb, Christos S Karapetis, Ian M Collins, Narayan Karanth, Owen W J Prall, Richard William Tothill

“…We therefore assessed immune and genomic biomarkers as well as predicted TOO in patients with CUP, including a subset treated with ICIs.Methods Patients with CUP were subject to gene-expression profiling (GEP) and DNA panel sequencing. …”
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The value of exosomes suppressor of cytokine signaling 1， speckled protein 140 and calcyclin binding protein expressions in peritoneal dialysis effluent in the diagnosis of periton... by Han Xiao-li, Wang Jia-wei, Wei Zhi-feng, Wang Lin-lin, Guo Bao-zhu, Cao Yan-chun, Jin Yu-jie, Liu Sheng-jun

“…ObjectiveTo investigate the value of suppressor of cytokine signaling 1 （SOCS1）， speckled protein 140 （SP140）， calcyclin binding protein （CacyBP） expressions in peritoneal dialysis effluent in the diagnosis of peritoneal fibrosis （PF）.MethodsA total of 90 patients with end-stage renal disease who underwent peritoneal dialysis in the First Affiliated Hospital of Hebei North University from November 1， 2021 to September 30， 2023 were selected as study subjects. They were divided into PF group （n=38） and control group （non-PF， n=52） according to peritoneal tissue biopsy. …”
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Liraglutide Decreases Liver Fat Content and Serum Fibroblast Growth Factor 21 Levels in Newly Diagnosed Overweight Patients with Type 2 Diabetes and Nonalcoholic Fatty Liver Diseas... by Xinyue Li, Xiaojuan Wu, Yumei Jia, Jing Fu, Lin Zhang, Tao Jiang, Jia Liu, Guang Wang

“…Twenty healthy age, sex, and body mass index (BMI) matched subjects were enrolled as the control group. Enzyme-linked immunosorbent assay was used to measure serum FGF21 levels. …”
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Alternative psychopharmacologic treatments for pediatric catatonia: a retrospective analysis by Joshua R. Smith, Joshua R. Smith, Isaac Baldwin, Tasia York, Carina Anderson, Trey McGonigle, Simon Vandekar, Lee Wachtel, James Luccarelli, James Luccarelli

“…. = 43.2, p < 0.001, 95% CI = (0.931,0.992)], indicating the average subject is expected to experience some improvement.DiscussionIn conclusion, all patients responded to these treatments with improvement in their catatonic symptoms. …”
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