Evaluation of Siemens Healthineers’ StrokeSegApp for automated diffusion and perfusion lesion segmentation in patients with ischemic stroke by Lynnet-Samuel J. Teichmann, Ahmed A. Khalil, Kersten Villringer, Jochen B. Fiebach, Stefan Huwer, Eli Gibson, Ivana Galinovic

“…The mean volume deviation was 0.49 mL for diffusion lesions and −7.69 mL for perfusion lesions. Out of 56 subjects meeting DEFUSE 2/3 criteria in the cohort, it correctly identified mechanical thrombectomy candidates with a sensitivity of 82.1% (95% CI: 63.1–93.9%) and a specificity of 96.4% (95% CI: 81.7–99.9%).ConclusionThe Siemens Healthineers’ StrokeSegApp provides accurate automated segmentation of ischemic stroke lesions, comparable to human experts as well as similar commercial software, and shows potential as a reliable tool in clinical decision-making for stroke treatment.…”
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Feedback loop centered on MAF1 reduces blood–brain barrier damage in sepsis-associated encephalopathy by Xuebiao Wei, Wenqiang Jiang, Zhonghua Wang, Yichen Li, Yuanwen Jing, Yongli Han, Linqiang Huang, Shenglong Chen

“…Abstract Background A previous study found that MAF1 homolog, a negative regulator of RNA polymerase III (MAF1), protects the blood–brain barrier (BBB) in sepsis-associated encephalopathy (SAE); however, the related molecular mechanisms remain unclear. Subjects and methods In this study, a rat sepsis model was constructed using the cecum ligation and puncture (CLP) method. …”
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Automatic etiological classification of stroke thrombus digital photographs using a deep learning model by Álvaro Lucero-Garófano, Álvaro Lucero-Garófano, Alicia Aliena-Valero, Isabel Vielba-Gómez, Isabel Vielba-Gómez, Irene Escudero-Martínez, Irene Escudero-Martínez, Lluís Morales-Caba, Lluís Morales-Caba, Fernando Aparici-Robles, Fernando Aparici-Robles, Diana L. Tarruella Hernández, Diana L. Tarruella Hernández, Gerardo Fortea, Gerardo Fortea, José I. Tembl, José I. Tembl, Juan B. Salom, Juan B. Salom, José V. Manjón

“…We aimed to develop a Deep Learning (DL)-based model for automatic etiological classification of ischemic stroke using digital images of thrombi retrieved by mechanical thrombectomy.MethodsPatients with large vessel occlusion stroke subjected to mechanical thrombectomy between April 2016 and January 2023 at La Fe University and Polytechnic Hospital in Valencia were included. …”
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Effects of Apolipoprotein E Isoforms in Diabetic Nephropathy of Chinese Type 2 Diabetic Patients by YongWei Jiang, Liang Ma, ChengWu Han, Qian Liu, Xiao Cong, YaPing Xu, TingTing Zhao, Ping Li, YongTong Cao

“…ApoE genotype was determined by ApoE genotyping chip and the plasmatic biochemical characterization was performed on all subjects. There were differences (P<0.001) in HbA1c, creatinine, and urinary albumin between the two groups. …”
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Pharmacological Evaluation of Secondary Metabolites and Their Simultaneous Determination in the Arabian Medicinal Plant Plicosepalus curviflorus Using HPTLC Validated Method by Raha Orfali, Shagufta Perveen, Nasir Ali Siddiqui, Perwez Alam, Tawfeq Abdullah Alhowiriny, Areej Mohammad Al-Taweel, Sami Al-Yahya, Fuad Ameen, Najwa Majrashi, Khulud Alluhayb, Bandar Alghanem, Hayat Shaibah, Shabana Iqrar Khan

“…The PCME and the isolated compounds were subjected to pharmacological assays to estimate peroxisome proliferator-activated receptors PPARα and PPARγ agonistic, anti-inflammatory, cytotoxic, and antimicrobial activities. …”
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A New Device Improves Signs and Symptoms of TMD by Ruggero Cattaneo, Davide Pietropaoli, Barry C. Cooper, Dino Capparè, Eleonora Ortu, Annalisa Monaco

“…The study group received the ELIBA device (lingual elevator by Balercia) constructed under ULF-TENS (ultra-low-frequency transcoutaneous electrical nervous stimulation). Subjects were instructed to use ELIBA at least for 16 h/day. …”
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Portable devices for periodic monitoring of bioelectrical impedance along meridian pathways in healthy individuals by Yu-Chen Xu, Xiu-Yan Cao, Shuai Liu, Bo Liu, Hao Chen, Min Cheng, Wei-Hua Ye

“…The collected BEI data were subjected to statistical analysis, and line charts were constructed to depict the temporal variation patterns. …”
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Oxytocin ameliorates lipopolysaccharide-induced acute orchitis model: interplay of oxidative stress and inflammatory pathways by Mohamed El-Sherbiny, Hany A. Elkattawy, Shimaa Hadhoud, Ahmed N. Nasr, Ateya M. Ibrahim, Ateya M. Ibrahim, Omar Z. Ameer, Noorhan Alsaleebi, Joud Asfari, Madaniah O. Zakari, Moaz A. Mojaddidi, Ehab K. Ali, Hailah M. Almohaimeed, Ahmed Abdeen, Sahar K. Ali, Mamdouh Eldesoqui, Mamdouh Eldesoqui

“…This work examines the impact of OXY on LPS-induced testicular damage, aiming to elucidate its therapeutic potential in addressing inflammatory disorders and broadening the comprehension of its functions beyond conventional neuroendocrine roles.MethodsEighteen male albino rats were divided into three groups; the control group received no treatment; the LPS group received 0.5 mL of saline solution containing 5 mg/kg LPS intraperitoneally (orchitis model); and the LPS + OXY group received LPS and OXY (0.1 mg/kg) intraperitoneally every 12 h for 72 h.Results and discussionAnimals subjected to LPS were found to have severe orchitis, as evidenced by increased oxidative stress and surging inflammatory mediators (TNF-α, IL-1β, and IL-6), with declined IL-10 levels. …”
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Evolving perspectives in dental marketing: A study of Jordanian dentists' attitudes towards advertising and practice promotion by Rami J. Anshasi, Nizar Alsubahi, Ahmad A. Alhusein, Abd Alwali Lutfi Khassawneh, Mahmaod Alrawad, Adi Alsyouf

“…Advertising for dental services in Jordan is subject to regulation. Dental professionals must obtain approval from their respective councils before initiating any advertising campaigns to ensure compliance with ethical and professional standards. …”
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Evaluating the Performance of Low-cost PM Sensors over Multiple COALESCE Network Sites by Vishal R. Dharaiya, Vasudev Malyan, Vikas Kumar, Manoranjan Sahu, Chandra Venkatraman, Pratim Biswas, Kajal Yadav, Diksha Haswani, Ramya Sunder Raman, Ruqia Bhat, Tanveer Ahmad Najar, Arshid Jehangir, Rohit P. Patil, G. Pandithurai, Sandeep Singh Duhan, Jitendra Singh Laura

“…These are attributed to the MERRA-2 modelling analysis that measures less PM2.5 concentration as compared to ground-based measurements, whereas low-cost sensor are ground-based measurements but needs corrections as it is subject to the calibration dependencies and biases.…”
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Acute oral toxicity study of novel polyherbal formulations by using wistar rats and Swiss albino mice as per OECD 425 TG by Ramkishan Jatoth, S.P Dhanabal, V. Senthil, T. Ganesh, Jubie Selvaraj, P.S. Venkatesan

“…At the end of the study, animals were euthanized by using the CO2 asphyxiation technique and subjected to gross pathological examinations. Results: According to the assessment of the experimental data, the single-dose acute toxicity study of Hydaljss08 and Immunoboost-Tab formulations in mice and rats was fine. …”
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Secretory mitophagy: an extracellular vesicle-mediated adaptive mechanism for cancer cell survival under oxidative stress by Purva V. Gade, Angela Victoria Rojas Rivera, Layla Hasanzadah, Sofie Strompf, Thomas Raymond Philipson, Matthew Gadziala, Atharva Tyagi, Arnav Bandam, Rithvik Gabbireddy, Fatah Kashanchi, Amanda Haymond, Lance A. Liotta, Marissa A. Howard

“…Specifically, we show that tumor cells subjected to oxidative stress by carbonyl cyanide-3-chlorophenylhdrazone (CCCP) eliminate damaged mitochondria segments by bypassing the lysosome to export them outside the cell via extracellular vesicles (EVs), a process termed “secretory mitophagy”. …”
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Differentiating the cognitive development of early-term births in infants and toddlers: a cross-sectional study in China by Jing Hua, Jie Sun, Zhijuan Cao, Xiaotian Dai, Senran Lin, Jialin Guo, Guixiong Gu, Wenchong Du

“…A total of 1444 children from singleton pregnancies born at term gestation were included in the study.Measures The cognitive outcomes of the subjects were measured using the cognitive subtest of Bayley Scales of Infant and Toddler Development, Third Edition (BSID-III) across three cities in China. …”
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Deficiency of purinergic P2Y2 receptor impairs the recovery after renal ischemia-reperfusion injury and accelerates renal fibrosis and tubular senescence in mice by Kyuho Jeong, Jihyun Je, Theodomir Dusabimana, Jacques Karekezi, Tatang Aldi Nugroho, Edvard Ntambara Ndahigwa, Hyun Joon Kim, Seung Pil Yun, Hye Jung Kim, Hwajin Kim, Sang Won Park

“…To investigate the role of the purinergic P2Y2 receptor (P2Y2R) in these processes, we used P2Y2R knockout (KO) mice subjected to IR. KO mice showed severe kidney dysfunction and structural damage compared to WT mice. …”
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Establishing of a risk prediction model for metabolic dysfunction-associated steatotic liver disease: a retrospective cohort study by Nan Li, Chenbing Liu, Zhangfan Lu, Wenjian Wu, Feng Zhang, Lihong Qiu, Chao Shen, Di Sheng, Zhong Liu

“…Methods The study included 5107 subjects, divided into training and validation groups in a 7:3 ratio using a random number table method. …”
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Acupuncture Treatment in Elderly People with Sarcopenia: Effects on the Strength and Inflammatory Mediators by Gisele Soares Mendes Damasceno, Thaís Helena Machado Marçal Teixeira, Vinicius Carolino de Souza, Tiago Sousa Neiva, Karina Prudente Pereira, Maria de Fátima Teles Landim, Gislane Ferreira de Melo, Juliana de Faria Fracon e Romão, Otávio Tolêdo Nóbrega, Gustavo de Azevedo Carvalho

“…After verification of the physical examination, the subjects were divided into two groups (sarcopenic and nonsarcopenic). …”
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Muscular Performance and Blood Pressure After Different Pre-Strength Training Strategies in Recreationally Strength-Trained Women: Cross-Over Trial by Estêvão Rios Monteiro, Linda S. Pescatello, Luis Leitão, Marcelo José Colonna de Miranda, Paulo H. Marchetti, Michelle Ribeiro Novaes, Gleisson da Silva Araújo, Victor Gonçalves Corrêa Neto, Jefferson da Silva Novaes

“…Conclusions: The results of this investigation may help to influence decision-making by practitioners who desire to elicit a post-exercise hypotension response in both subjects with normal BP and hypertension.…”
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Optimization of Black Garlic Protein Extraction Process and Exploration of Its Properties and Functions with Enzymatic Hydrolysis Products by Jian Liu, Yuanyuan Wang, Bo Wang, Wei Zhang, Xiaoyu Ren, Youchuang Zhang, Lijun Jiang, Chunming Dong, Guihong Zhao

“…Subsequently, this study extracted black garlic protein under optimal conditions and subjected it to enzymatic hydrolysis using different enzymes (trypsin, pepsin, and their mixed enzymes). …”
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Impact of solid fuel use on asthma prognosis and consistent peak expiratory flow changes: Evidence from China by Yuexi Chen, Shuojia Xie, Xirong Chen, Xiaowen Zhong, Linhang Yang, Weitong Lin, Junfeng Huang, Ruchong Chen

“…The study applied logistic and linear regression for the cross-sectional data, Cox proportional hazards models and linear mixed effects methods were utilized to gauge the impact on mortality and PEF among subjects with asthma. Results: Among the 12025 individuals surveyed, use of solid fuels was significantly associated to increased asthma risk and a decrease in PEF among the Chinese population (P < 0.001), with consistent trends noted across categories of age, gender, and smoking habits. …”
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Usefulness of the Hybrid RFR-FFR Approach: Results of a Prospective and Multicenter Analysis of Diagnostic Agreement between RFR and FFR—The RECOPA (REsting Full-Cycle Ratio Compar... by Juan Casanova-Sandoval, Diego Fernández-Rodríguez, Imanol Otaegui, Teresa Gil Jiménez, Marcos Rodríguez-Esteban, Kristian Rivera, Francisco Torres-Saura, Víctor Jiménez Díaz, Raymundo Ocaranza-Sánchez, Vicente Peral Disdier, Guillermo Sánchez-Elvira, Fernando Worner

“…Materials and Methods. Patients subjected to invasive physiological study in 9 Spanish centers were prospectively recruited between April 2019 and March 2020. …”
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