Specimen oriented intraoperative margin assessment in oral cavity and oropharyngeal squamous cell carcinoma by P. Horwich, C. MacKay, M. Bullock, S. M. Taylor, R. Hart, J. Trites, L. Geldenhuys, B. Williams, M. H. Rigby

“…Abstract Objective Evaluate the oncologic outcomes and cost analysis of transitioning to a specimen oriented intraoperative margin assessment protocol from a tumour bed sampling protocol in oral cavity (OCSCC) and oropharyngeal squamous cell carcinoma (OPSCC). Study design Retrospective case series and subsequent prospective cohort study Setting Tertiary care academic teaching hospital Subjects and methods Retrospective case series of all institutional T1-T2 OCSCC or OPSCC treated with primary surgery between January 1st 2009 – December 31st 2014. …”
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Two-stage revision anterior cruciate ligament reconstruction reduces failure risk but leads to lesser clinical outcomes than single-stage revision after primary anterior cruciate l... by Anna M. Ifarraguerri, George D. Graham, Alexander B. White, Alexander N. Berk, Kennedy K. Gachigi, Patrick N. Siparsky, David P. Trofa, Dana P. Piasecki, James E. Fleischli, Bryan M. Saltzman

“…Patients with a two-stage revision ACLR had a significantly reduced risk of revision graft failure but higher rates of postoperative anterior knee pain, lower pain scores, and lesser knee functional scores than single-stage revision patients. Study design Retrospective cohort study; level of evidence, 3…”
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The Contribution of the Hotel Industry on Youth Empowerment in Mbarara City: A Case Study of Hotel Triangle Mbarara City. by Owomuhangi, Emmanuel

“…A qualitative descriptive study design was employed as it allowed for straightforward and comprehensive explorations of participants’ experiences without imposing theoretical frameworks or preconceived categories. …”
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Changes in alcohol consumption among Belgian adults participating in the internet-based one-month-abstinence campaign ‘Tournée Minérale’ by Annelies Thienpondt, Jelle Van Cauwenberg, Joris Van Damme, Gera E. Nagelhout, Benedicte Deforche

“…Future research with a stronger study design is needed to rule out possible bias (e.g., selection bias, seasonal effects or regression to the mean) and to examine mechanisms and longer term effects of TACs.…”
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Spot Versus 24-Hour Urine Osmolality Measurement in Autosomal Dominant Polycystic Kidney Disease: A Diagnostic Test Study by Ayub Akbari, Sriram Sriperumbuduri, Shreepryia Mangalgi, Vijay Joshi, Manish Sood, Amos Buh, Mohan Biyani, Christopher McCudden, Gregory L. Hundemer, Pierre Antoine Brown

“…The agreement between these 2 measurements remains unclear. Study Design: A retrospective cohort study. Setting & Study Population: Three hundred and forty-nine patients with ADPKD with 839 urine samples from a tertiary care center. …”
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START—the Swiss tele-assisted rehabilitation and training program to support transition from inpatient to outpatient care in the subacute phase after a stroke: feasibility, safety... by Szabina Gäumann, Carina Ziller, Carina Ziller, Nele Paulissen, Nele Paulissen, Frank Behrendt, Frank Behrendt, Zorica Suica, Zorica Suica, Björn Crüts, Luana Gammerschlag, Katrin Parmar, Katrin Parmar, Hans Ulrich Gerth, Hans Ulrich Gerth, Leo H. Bonati, Leo H. Bonati, Leo H. Bonati, Corina Schuster-Amft, Corina Schuster-Amft, Corina Schuster-Amft

“…Secondary outcomes will focus on motor function, mobility, quality of life, activity level, heart rate, blood pressure, and performance-based measures.DiscussionThe study's strengths include its foundation in previous usability analyses, which informed refinements to the START program. The study's design is based on the ISO 14155 standard, ensuring high standards for medical device research and supporting the future certification of the START program on the Blended Clinic platform. …”
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Perbandingan Efektivitas Daya Hambat Kotrimoksazol Generik dan Paten terhadap Pertumbuhan Bakteri Escherichia coli sebagai Penyebab Infeksi Saluran Kemih secara In Vitro by Puti Anggun Sari, Erly ., Dessy Arisanty

“…The aim of this study was to compare the effectiveness of generic and patents co-trimoxazole inhibition on the growth of the bacteria Escherichia coli as a cause of urinary tract infection in in vitro.This study is an analytical experimental with cross-sectional study design. This study used 19 isolated-bacterial from infected-urinary tract patients which were caused by Escherichia coli in Dr. …”
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The AEDUCATE Collaboration. Comprehensive antenatal education birth preparation programmes to reduce the rates of caesarean section in nulliparous women. Protocol for an individual... by Soo Downe, Lisa Askie, Sarah J Lord, Hannah G Dahlen, Kenneth William Finlayson, Anna Lene Seidler, Federico Girosi, Kylie Elizabeth Hunter, Kate M Levett, Mary-Ann Davey, Caroline A Smith, Julie Fleet, Mary Steen, Elizabeth Newnham, Anette Werner, Leslie Arnott, Kerry Sutcliffe

“…The intervention could occur in a hospital-based or community setting.Comparator: standard care alone in hospital-based maternity units.Outcomes Primary: CS.Secondary: epidural analgesia, mode of birth, perineal trauma, postpartum haemorrhage, newborn resuscitation, psychosocial well-being.Subgroup analysis: parity, model of care, maternal risk status, maternal education, maternal socio-economic status, intervention components.Study design An individual participant data (IPD) prospective meta-analysis (PMA) of randomised controlled trials, including cluster design. …”
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Matrine Inhibits Breast Cancer Cell Proliferation and Epithelial-Mesenchymal Transition Through Regulating the LINC01116/miR-9-5p/ITGB1 Axis by Lili Ren, Ziru Fang, Jiaojiao Xu, Xiaoxiao Wu, Yongjun Zhang, Hu Cai, Zhicun Han

“…Aims: To explore MAT’s role in BC and its regulatory mechanisms, as well as to identify targets for the development of novel medicines and improvement of BC treatment modalities. Study Design: Experimental study. Methods: The UALCAN and Lnc2Cancer 3.0 databases were used to predict the expression of LINC01116 in BC. …”
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Financial Toxicity and Kidney Disease in Children and Adults: A Scoping Review by Siligato R, Gembillo G, De Giorgi A, Di Maria A, Scichilone LM, Capone M, Vinci FM, Nicoletti S, Bondanelli M, Malaventura C, Storari A, Santoro D, Dionisi S, Fabbian F

“…For each included study, we considered the study design, the population and main results from different populations with distinct renal conditions and the results were summarized in four tables.Results: Socioeconomic deprivation was the main cause of FT, and the majority of studies on the relationship between FT and chronic kidney disease (CKD) were conducted in the USA (4 studies evaluated the pediatric population and 6 studies included adults). …”
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Microbiota, parasitic infections and their relationship with nutritional status and neurocognitive functioning in children from Ecuador—Proyecto Guagua: research protocol for a cro... by Sandra Victoria Abril-Ulloa, Tannia Valeria Carpio-Arias, Renata Alejandra Alvarado-Barba, Cristina Gabriela Ríos-Romero, Pamela Vinueza-Veloz, Sueny Paloma Lima-dos-Santos, Sueny Paloma Lima-dos-Santos, Igor Eduardo Astudillo-Skliarova, Igor Eduardo Astudillo-Skliarova, Ruth Irene Arias-Gutiérrez, Manuel Pérez-Quintana, Henk-Jan Boele, Henk-Jan Boele, Henk-Jan Boele, María Fernanda Vinueza-Veloz

“…Following the pilot phase, an addendum and minor changes to the study design were approved in October 2022. Written consent was obtained from parents before enrolling their children in the study. …”
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Prevalence of vitamin D deficiency and its association with adverse obstetric outcomes among pregnant women in Uganda: a cross-sectional study by Cristina Reverzani, Daniel Zaake, Faridah Nansubuga, Herman Ssempewo, Leonard Manirakiza, Anthony Kayiira, Gilbert Tumwine

“…Objective There is a dearth of published data on the vitamin D status of the Ugandan population; the objective of the study was to determine the prevalence of vitamin D deficiency among pregnant women in Uganda and its associations with maternal characteristics and adverse foetal-maternal outcomes.Study design and setting We conducted a cross-sectional study on pregnant women admitted to a tertiary referral hospital in Kampala, Uganda for delivery during the study period from July to December 2023.Participants The study was conducted on 351 pregnant women aged ≥18 years who consented to participate in the study, who had a single intrauterine pregnancy and a gestational age greater than 26 weeks, and who delivered at St. …”
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Perspectives and Practices of Healthcare Leaders in Supporting Healthcare Worker Well-Being: A Reality Check by Reijmerink IM, van der Laan MJ, Scheele F, Wietasch JKG

“…The interviews focused on exploring three key topics: factors influencing HCW well-being, data sources utilized for information gathering, and strategies leaders employ to influence HCW well-being. Our study design was grounded in constructionist epistemology and adopted a phenomenological approach. …”
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Feasibility and usefulness of Gini coefficients of primary care visits as a measure of service inequality: preliminary findings from a cross-sectional study using region-wide elect... by Xin Yang, Jing Chai, Jing Cheng, DeBin Wang, XingRong Shen, Rong Liu, ManMan Lu, Jia Xu, Ningjing Yang, Guocheng Li

“…Objective The aim of this study was to investigate inequalities in primary healthcare visits by using the Gini coefficients of primary healthcare visits (GPVs) as derived from large-scale and region-wide electronic records and to explore estimation and utility of GPV.Design The study used a cross-sectional study design. It first extracted a random sample of 7.09 million primary care records from 1 October 2019 to 31 December 2021. …”
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Evaluating the Acceptance and Usability of an Independent, Noncommercial Search Engine for Medical Information: Cross-Sectional Questionnaire Study and User Behavior Tracking Analy... by Lisa Specht, Raphael Scheible, Martin Boeker, Erik Farin-Glattacker, Nikolas Kampel, Marina Schmölz, Andrea Schöpf-Lazzarino, Stefan Schulz, Christian Schlett, Fabian Thomczyk, Sebastian Voigt-Radloff, Constanze Wegner, Katharina Wollmann, Andy Maun

“…MethodsFor the questionnaire study, a cross-sectional study design was used. In total, 802 participants were recruited through a web-based panel and were asked to interact with the new search engine before completing a web-based questionnaire. …”
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The Global RAdical Cystectomy Evaluation and Management (GRACEM) pathway: single‐centre prospective observational cohort study protocol by Bruno Bernardini, Federico Piccioni, Manuele Pastore, Paolo Casale, NicolòMaria Buffi, Giovanni Lughezzani, Massimo Lazzeri, Alberto Saita, Maria Vittoria Fantacci, Stefano Mancon, Filipo Dagnino, Roberto Contieri, Pietro Brin, Stefano Mancin, Andrea Gobbo, Maria Rosaria Martucci, Giovanna Cerina, Sara Ghirmai, Ezio Lanza, Giulia Goretti, Giorgio Ferruccio Guazzoni, Rodolfoi Hurle

“…New insights will be gained into how to optimize the physical and mental status and quality of life of patients before and after surgery, up to 1 year later. Study design The Global RAdical Cystectomy Evaluation and Management (GRACEM) study is a prospective, observational, single‐centre, 2‐year cohort study. …”
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Evaluation of parent and youth experiences in advisory groups as part of a mental healthcare clinical trial: protocol for a mixed-method study by Maria-Jose Santana, Gina Dimitropoulos, Suneeta Monga, Isabelle J Gagnon, Bruce Wright, Jananee Rasiah, Katrina Hurley, Antonia Stang, Amanda Newton, Stephen Freedman, Jennifer Thull-Freedman, Kassi Prisnie, Yazid N Al Hamarneh, Ellen Louise Lipman, Yaron Finkelstein, Robert Porter, Mohamed Eltorki, Lee Macdonald, Gareth Hopkin, Matthew Prebeg, Margaret Steele, Ahmed Mater, Laurence Katz, Brian Greenfield, Laurie Plotnick

“…The purpose of this study is to evaluate patient engagement processes and the activities of patient partners during and after a paediatric mental healthcare trial.Methods and analysis Using a mixed-methods study design, we will evaluate patient partners’ engagement activities across set time-points during the trial and after trial completion. …”
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Supervised Injecting Room Cohort Study (SIRX): study protocol by Lisa Maher, Thomas Kerr, Matthew Hickman, Alexander Thompson, Peter Higgs, Paul Dietze, Paul A Agius, Nick Scott, Daniel O’Keefe, Mark A Stoové, Jack Stone, Dylan Vella-Horne, Ashleigh C Stewart, Amanda Roxburgh, Sione Crawford, Josephine Norman, Zachary Lloyd, Nico Clark

“…The Supervised Injecting Room Cohort Study (SIRX) aims to provide evidence of the effects, including cost-effectiveness, of a SIF embedded within a community health service, the Melbourne Medically Supervised Injecting Room (MSIR), which has a range of integrated harm reduction, health and social support services on-site.Methods and analysis The SIRX study design involves two prospective cohort studies that collect behavioural data and retrospectively and prospectively linked administrative data for primary and tertiary health services, criminal justice records, and mortality. …”
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Faktor-Faktor yang Berhubungan dengan Status Gizi Anak Balita di Wilayah Kerja Puskesmas Nanggalo Padang by Rona Firmana Putri, Delmi Sulastri, Yuniar Lestari

“…This research is conduct to determine whether there is a relationship between the socio-economic conditions of families on the nutritional status of children under five.This research is a analytic survey using a cross sectional study design with the number of samples are 227 people consisting of children under five and the mothers in the working areas Puskesmas Nanggalo Padang. …”
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Technology acceptance and use among nursing staff in Latin American hospitals: A mixed methods study by Juan Manuel Aranda, María Elisa Moreno-Fergusson, William Javier Guerrero, Beatriz Sanchez Herrera, María Alejandra Galiano, Maryory Guevara, Ingrid Xiomara Bustos, Francisca Muñóz

“…Design: A mixed methods study design. Setting(s): Two Latin American university hospitals, one in Chile and the other in Colombia. …”
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