HER-SAFE study design: an open-label, randomised controlled trial to investigate the safety of withdrawal of pharmacological treatment for recovered HER2-targeted therapy-related cardiac dysfunction by Robin Chung, James C Moon, Alexander R Lyon, Charlotte H Manisty, Muhummad Sohaib Nazir, Malcolm Walker, Peter Kellman, Benjamin Dowsing, Daniel Chen, Jessica Artico, Mark Westwood, Hakim-Moulay Dehbi, Rebecca Roylance, Tom Crake, Peter Schmid, Arjun Ghosh, Maria Sol Andres, Joanna Pedra, Orla Worn

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Dual Clinical Practice (DCP) policy to improve the retention of human resources for health in Rwanda: a mid-term review using a cross-sectional and retrospective study design by Kizito Kayumba, Corneille Ntihabose, Sabine Musange Furere, Bernard Ngabo, Piero Irakiza, Felix K. Rubuga, Nathalie Umutoni, Ina Rukundo Kalisa, Pascal Birindabagabo, Emile Rwamasirabo, Emmanuel Kayibanda, Patience Mukundirukuri, Gashaija Absolomon, Sumana Dhanani, Jeanine Condo

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Trabeculectomy versus stepwise treatment for breaking the attack of acute primary angle closure in patients with long attack duration: study design and protocol for a multicentre randomised controlled trial (LAAAC) by Jing Jiang, Qing Zhang, Bo Qu, Chao Dai, Mingguang He, Ye Zhang, Ning-Li Wang, Shuning Li, Guangxian Tang, Su Jie Fan, Zhi Li, Chi Liu, Xinqi Chang, Yanyan Cheng

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Risk of adverse cardiovascular events based on common genetic variants in 8-year follow-up of the LIPIDOGEN2015 population using the polygenic risk score (PRS): study design and methodology by Maciej Banach, Martyna Fronczek, Tadeusz Osadnik, Agnieszka Gach, Dominik Strapagiel, Marcin Słomka, Mateusz Lejawa, Anna Goc, Ewa Boniewska-Bernacka, Anna Pańczyszyn, Gregory Y.H. Lip, Dimitri P. Mikhailidis, Peter P. Toth, Peter E. Penson, Jacek Jóźwiak

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Risk of aortic aneurysm and dissection following exposure to fluoroquinolones, common antibiotics, and febrile illness using a self-controlled case series study design: Retrospective analyses of three large healthcare databases in the US. by Ajit A Londhe, Chantal E Holy, James Weaver, Sergio Fonseca, Angelina Villasis, Daniel Fife

“…The objective of our study is to evaluate the potential association between FQ, other common antibiotics and febrile illness with risk of AAD using a self-controlled case series (SCCS) study design.<h4>Design</h4>Retrospective database analysis-SCCS.…”
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Effect of Laryngeal Mask Air Way Insertion versus Endotracheal Intubation over Hemodynamic Responses in Pediatrics Patient Who Underwent Ophthalmic Surgery at Menelik II Hospital, Addis Ababa: A Prospective Observational Study Design by Mohammed Suleiman Obsa, Azeb Lencha Sholla, Betelhem Girma Baraki, Getahun Dendir Welde, Temesgen Bati Gelgelu, Melese Meleku Kuruche

“…An institutional-based prospective observational study design was employed. A systematic random sampling technique was used to select study participants. …”
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The Relationship between Natriuretic Peptide Precursor a Gene T2238C Polymorphism and Hypertension: A Meta-Analysis by Wenquan Niu

“…Further meta-regression analysis exclusively indicated the significant influence of study design (P=.042) on heterogeneity. Taken together, these findings support the notion that carriers of 2238C allele were at moderate decreased risk of developing hypertension, whereas study design was identified as a potentially significant source of between-study heterogeneity.…”
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A Comparison of the Morbidities Associated with Different Early Treatments in Tubo-Ovarian Abscess Patients by Sumanta Saha, Sujata Saha

“…Less than three studies of a particular study design reported each of the remaining outcomes. …”
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On the pursuit of reproducibility: the importance of large sample sizes in psychoimmunology by Manivel Rengasamy, Daniel Moriarity, Rebecca Price

“…., number of covariates) and characteristics related to study design (e.g., relationships within subgroups of patients). …”
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Genome-Wide Association Studies of Hypertension: Light at the End of the Tunnel by Claire E. Hastie, Sandosh Padmanabhan, Anna F. Dominiczak

“…With careful study design and analysis success is possible, as demonstrated by the recent large-scale studies. …”
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Support Services Provided by a Child and Youth Care Centre (CYCC) to Adolescent Witnesses of Domestic Violence by Shahana Rasool, Suzanne Swart

“…Method: For this study, a qualitative holistic case study design was adopted. This single case study design was chosen as information was gathered from various sources in only one CYCC. …”
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Risk prediction models for falls in hospitalized older patients: a systematic review and meta-analysis by Anli Mao, Jie Su, Mingzhu Ren, Shuying Chen, Huafang Zhang

“…Extraction of data from included studies, including study design, data sources, sample size, predictors, model development and performance, etc. …”
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Analysis of cardiovascular surgery specialization theses and their publication rates by Omer Faruk Rahman, Mustafa Baris Kemahli, Fevzi Ayyildiz

“…For each specialization thesis, details such as the year, institution, city, study design, advisor&apos;s title, and author information were recorded. …”
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The Usefulness of the Pressure Algometer in the Diagnosis and Treatment of Orofacial Pain Patients: A Systematic Review by Agata Kamińska, Bartosz Dalewski, Ewa Sobolewska

“…Study Design. Data were obtained from PubMed, Dentistry and Oral Sciences Source, ProQuest, Scopus, Medline (EBSCO), and ScienceDirect databases. …”
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Medical and social domains of ageing research in Singapore (2008–2018): a scoping review by Chen Hee Tam, Elaine Qiao Ying Ho, Sumali Subhashini Hewage, Shilpa Tyagi, Gerald Choon Huat Koh

“…Data such as article title, authors, year of publication, name of journal, type of journal, study design and the kind of data used were charted from the included articles for evidence synthesis. …”
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The Comparative Mental Health Responses Between Post-Musculoskeletal Injury and Post-Concussive Injury Among Collegiate Athletes: A Systematic Review by Joseph Sabol, Cecelia Kane, Mark P Wilhelm, Jennifer C Reneker, Megan Burrowbridge Donaldson

“…Data extracted from the included articles included the study design, number of participants, type of injury, sex, age, sport participation, outcome measures, and time to return to play…”
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Risk Factors Associated with First Time and Recurrent Shoulder Instability: A Systematic Review by Alexis Wright, Brandon Ness, Angela Spontelli-Gisselman, Dora Gosselin, Joshua Cleland, Craig Wassinger

“…At least two reviewers independently extracted information and data regarding author, year, study population, study design, criterion standard, and strength of association statistics with risk factors…”
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Effects of Kettlebell Swing Style and Mass on Female Hip Joint Kinetics by Kasey M Murphy, Bryan L Riemann

“…It was hypothesized that velocity, power, and work would be greater for the OHS compared to the SHS, as well as for the heavier compared to the lighter KB’s. # Study Design Crossover study design. # Methods Fifteen physically active females performed 15 swings under four conditions, SHS/12kg, SHS/16kg, OHS/12kg, and OHS/16kg, while three-dimensional dominant limb foot, shank, thigh, pelvis, and KB kinematic and ground reaction force (GRF) data were collected…”
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Equity and gender mainstreaming in public policy: A scoping review protocol. by Michelle Amri, Jinny Yang, Geneviève Jessiman-Perreault, Amne Haikal, Kathryn Barrett, Jesse B Bump

“…<h4>Discussion</h4>This protocol was developed to improve rigour in the study design and to promote transparency by sharing our methods with the broader research community. …”
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Interventions to improve primary healthcare in rural settings: A scoping review. by Kris Aubrey-Basler, Krystal Bursey, Andrea Pike, Carla Penney, Bradley Furlong, Mark Howells, Harith Al-Obaid, James Rourke, Shabnam Asghari, Amanda Hall

“…<h4>Charting methods</h4>We extracted and charted data by broad category (quality, access and efficiency), study design, country of origin, publication year, aim, health condition and type of intervention studied. …”
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