Lipid nanoparticles deliver DNA-encoded biologics and induce potent protective immunity by Dafei Chai, Junhao Wang, Jing Ming Lim, Xiaohui Xie, Xinfang Yu, Dan Zhao, Perry Ayn Mayson Maza, Yifei Wang, Dana Cyril-Remirez, Ken H. Young, Yong Li

“…The LNP formulation used in Moderna’s Spikevax mRNA vaccine (LNP-M) demonstrated a stable nanoparticle structure, high expression efficiency, and low toxicity. …”
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Intense Pulsed Light Therapy with Optimal Pulse Technology as an Adjunct Therapy for Moderate to Severe Blepharitis-Associated Keratoconjunctivitis by Fang Ruan, Yunxiao Zang, Ruti Sella, Hongshuang Lu, Shang Li, Ke Yang, Tao Jin, Natalie A. Afshari, Zhiqiang Pan, Ying Jie

“…Safety outcome measures included visual acuity, intraocular pressure, eye structure damage, and facial skin appearance at each visit. …”
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Supra-Acetabular Brown Tumor due to Primary Hyperparathyroidism Associated with Chronic Renal Failure by Rosaria M. Ruggeri, Emanuele Calamoneri, Antonia Russo, Alessandro Sindoni, Baldassarre Mondello, Maurizio Monaco, Michele A. Rosa, Sergio Baldari, Salvatore Benvenga, Alfredo Campennì, Francesco Trimarchi

“…X-rays and CT scan detected an osteolytic and expansive lesion of the right supra-acetabular region with structural reabsorption of the right iliac wing. 99mTc-MDP whole-body bone scan showed an abnormal uptake in the right iliac region. …”
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Cryptic species and hybridisation in corals: challenges and opportunities for conservation and restoration by Riginos, Cynthia, Popovic, Iva, Meziere, Zoe, Garcia, Vhon, Byrne, Ilha, Howitt, Samantha M., Ishida, Hisatake, Bairos-Novak, Kevin, Humanes, Adriana, Scharfenstein, Hugo, Richards, Thomas, Briggs, Ethan, Clark, Vanessa, Lei, Chuan, Khan, Mariam, Prata, Katharine E.

“…Here, we investigate the prevalence of cryptic coral groups and assess evidence for their permeability to gene flow (hybridisation) via a structured literature review of genomic studies. Using reproducible criteria to detect distinct genetic groups that are sympatric, we find that 68% of nominal species represented in population genomic studies show evidence for comprising partially reproductively isolated groups and that these distinct groups are often linked by gene flow. …”
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The Influences of Key Strata Compound Breakage on the Overlying Strata Movement and Strata Pressure Behavior in Fully Mechanized Caving Mining of Shallow and Extremely Thick Seams:... by Junmeng Li, Yanli Huang, Jixiong Zhang, Meng Li, Ming Qiao, Fengwan Wang

“…The research results showed that during the fully mechanized caving mining in shallow and extremely thick seams, the inferior key strata affected by mining movement behaved in the mode of sliding instability and could not form the stable structure of the voussoir beam after breaking and caving. …”
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Knowledge, willingness to provide service and preparedness for monkeypox infection among medical practitioners working in Bangladesh: a multicentred cross-sectional study by Mohammad Jahid Hasan, Salwa Islam, Mir Susmita Zaman, Jannatul Fardous, Shehab Uddin Al Abid, Tamanna Tabassum, Monirul Hasan, Mohiuddin Sharif

“…Knowledge about monkeypox was assessed by 20 questions, collected through a self-answered paper-based structured questionnaire. Good knowledge was defined by 70% of correct responses among the asked questions. …”
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Therapeutic reduction of neurocan in murine intracerebral hemorrhage lesions promotes oligodendrogenesis and functional recovery by Hongmin Li, Samira Ghorbani, Olayinka Oladosu, Ping Zhang, Frank Visser, Jeff Dunn, Yunyan Zhang, Chang-Chun Ling, V. Wee Yong, Mengzhou Xue

“…Brain cryosections were also stained for microglia/macrophage phenotype, oligodendrocyte lineage cells and neuroblasts by immunofluorescence microscopy. Tissue structural changes were assessed using brain magnetic resonance imaging (MRI). …”
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Sustainable closed-loop supply chain network design: heuristic hybrid approach with considering inflation and carbon emission policies by Saeid Kalantari, Hamed Kazemipoor, Farzad Movahedi Sobhani, Seyyed Mohammad Hadji Molana

“…Purpose: Establishing the structure and expansion of sustainable closed-loop supply chains is critical to meeting environmental, economic, and social standards to strengthen their position in competitive markets. …”
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Optical genome mapping: Unraveling complex variations and enabling precise diagnosis in dystrophinopathy by Jiahui Mai, Jing Duan, Xiaoyu Chen, Liqin Liu, Dachao Liang, Tao Fu, Gang Lu, Wai Yee Chan, Xufeng Luo, Feiqiu Wen, Jianxiang Liao, Zhuo Li, Xinguo Lu

“…We used the optical genome mapping (OGM) technology to detect and analyze uncommon mutations or structural variations (SVs) within the DMD gene, thus contributing to more precise clinical diagnoses. …”
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Grazing mortality as a controlling factor in the uncultured non-cyanobacterial diazotroph (Gamma A) around the Kuroshio region by T. Sato, T. Sato, T. Yamaguchi, K. Hidataka, S. Sogawa, T. Setou, T. Kodama, T. Kodama, T. Shiozaki, K. Takahashi

“…In this study, we investigated the diazotroph community structure using <i>nifH</i> amplicon sequencing and quantified the growth and microzooplankton grazing mortality rate of Gamma A using a combination of dilution experiments and quantitative polymerase chain reaction (PCR) in well-lit waters at the northern edge of the Kuroshio Current off the southern coast of Japan. …”
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Early Transcriptional Changes Induced by Wnt/β-Catenin Signaling in Hippocampal Neurons by Eduardo Pérez-Palma, Víctor Andrade, Mario O. Caracci, Bernabé I. Bustos, Camilo Villaman, Matías A. Medina, Miguel E. Ávila, Giorgia D. Ugarte, Giancarlo V. De Ferrari

“…Our results indicate that Wnt/β-catenin mediated transcription controls multiple biological processes related to neuronal structure and activity that are affected in synaptic dysfunction disorders.…”
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Recognition and cleavage of human tRNA methyltransferase TRMT1 by the SARS-CoV-2 main protease by Angel D'Oliviera, Xuhang Dai, Saba Mottaghinia, Sophie Olson, Evan P Geissler, Lucie Etienne, Yingkai Zhang, Jeffrey S Mugridge

“…We also determined the structure of an Mpro-TRMT1 peptide complex that shows how TRMT1 engages the Mpro active site in an uncommon substrate binding conformation. …”
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PENIAPHOBIA AS A COMPONENT OF THE DESTRUCTIVE DIGITAL MEDIA DISCOURSE IN THE ASIA-PACIFIC REGION by Margarita D. Lagutkina, Zhang Yi, Chang Thi Thu Huong

“…The authors attribute peniaphobia to one of the universal social stigmas that affect the social structure and culture of the community, recognizing that media discourse is actively using open public Internet communication to control public consciousness gently. …”
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Energy Transition in Northern Netherlands: seeking a balance between top-down and bottom-up initiatives [version 2; peer review: 1 approved, 4 approved with reservations, 1 not app... by Cyril Tjahja, Bas Oldenbroek, Tineke van der Schoor, Ifigenia Psarra

“…Specifically, this qualitative (thematic analysis) research study investigates the mismatch in expectations between a number of local energy initiatives and the municipality of Groningen regarding their roles within the local energy transition context. To this end, semi-structured interviews have been conducted with members of the municipality of Groningen, Grunneger Power (a local energy intermediary), and four local energy initiatives. …”
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Research Review and Prospect of Litchi Fruit Cracking by Xiwen LI, Haoshuang SUN, Xuequn PANG, Zhaoqi ZHANG

“…In the future, researches should be strengthened on the relationship between the structure of the suture line and fruit cracking in litchi fruit, and the possible influence of seed type on the susceptibility to fruit cracking.…”
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Collagen deposition in lung parenchyma driven by depletion of interstitial Lyve-1+ macrophages prevents cigarette smoke-induced emphysema and loss of airway function by Yinebeb Mezgebu Dagnachew, Yinebeb Mezgebu Dagnachew, Yinebeb Mezgebu Dagnachew, Hwee Ying Lim, Hwee Ying Lim, Liao Wupeng, Liao Wupeng, Sheau Yng Lim, Sheau Yng Lim, Sheng Jie Natalie Lim, Sheng Jie Natalie Lim, Chung Hwee Thiam, Chung Hwee Thiam, Shu Wen Tan, Shu Wen Tan, Joan Lau Joo Eng, Joan Lau Joo Eng, Dan Mei, Syaza Hazwany Mohammad Azhar, Wei Siong Ong, Qi Hui Caris Tan, Wai-Shiu Fred Wong, Wai-Shiu Fred Wong, Wai-Shiu Fred Wong, Veronique Angeli, Veronique Angeli

“…IntroductionCollagen is essential for maintaining lung structure and function and its remodeling has been associated with respiratory diseases including chronic obstructive pulmonary disease (COPD). …”
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Recruiting hard-to-reach populations via respondent driven sampling for mobile phone surveys in Colombia: a qualitative study by Camila Solorzano-Barrera, Mariana Rodriguez-Patarroyo, Angélica Tórres-Quintero, Deivis Nicolas Guzman-Tordecilla, Aixa Natalia Franco-Rodriguez, Vidhi Maniar, Prakriti Shrestha, Andrés I. Vecino-Ortiz, George W. Pariyo, Dustin G. Gibson, Joseph Ali

“…We conducted a qualitative study that drew from surveys with open and closed-ended items, semi-structured interviews for feedback, and focus group discussions to explore perceptions of the strategy and barriers to its application amongst MPS participants. …”
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Atomistic Study on the Mechanical Properties of HOP–Graphene Under Variable Strain, Temperature, and Defect Conditions by Qing Peng, Jiale Li, Xintian Cai, Gen Chen, Zeyu Huang, Lihang Zheng, Hongyang Li, Xiao-Jia Chen, Zhongwei Hu

“…HOP–graphene is a graphene structural derivative consisting of 5-, 6-, and 8-membered carbon rings with distinctive electrical properties. …”
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What are the expectations and experiences of a GMH research programme delivered in Bosnia-Herzegovina, Colombia and Uganda? A prospective longitudinal qualitative study by Stefan Priebe, Vian Rajabzadeh, Victoria Jane Bird, Francois van Loggerenberg, Michael McGrath

“…More resources and longer time scales may be required to address sustainable structural capacity and long-standing local leadership sufficiently.…”
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Degradation Kinetics of Ascorbic Acid in Xanthan Gum Solution by Runqi JIA, Yujie TANG, Weiwei HE, Xiaoxiao SONG, Junyi YIN

“…Ascorbic acid (AA) reacts with polysaccharides, resulting in changes in the rheological and structural properties of the polysaccharides. However, the degradation characteristics of AA and its degradation kinetics during this reaction require further investigation. …”
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