Molecular basis for the enzymatic inactivity of class III glutaredoxin ROXY9 on standard glutathionylated substrates by Pascal Mrozek, Stephan Grunewald, Katrin Treffon, Gereon Poschmann, Fabian Rabe von Pappenheim, Kai Tittmann, Christiane Gatz

“…Glutathionylation of the active site cysteine, a prerequisite for enzymatic activity, occurs only under highly oxidizing conditions established by the GSH/glutathione disulfide (GSSG) redox couple, while class I GRXs are readily glutathionylated even at very negative GSH/GSSG redox potentials. Thus, structural alterations in the GSH binding site leading to an altered GSH binding mode likely explain the enzymatic inactivity of ROXY9. …”
Get full text

Dioscin from Polygonatum sibiricum induces apoptosis and autophagy in Ishikawa human endometrial cancer cell and in vivo by Xiaoli Li, Runhui Ma, Zhijing Ni, Wei Wang, Kiran Thakur, Jianguo Zhang, Zhaojun Wei

“…With an aim to comprehend the precise regulatory mechanism of dioscin against endometrial carcinoma (EC), we firstly extracted the components from Polygonatum sibiricum followed by identification and structural characterization. The anti-EC activity of dioscin was initially determined based on the inhibition of Ishikawa cell proliferation and tumor growth. …”
Get full text

Efficient Feature Selection and Classification of Protein Sequence Data in Bioinformatics by Muhammad Javed Iqbal, Ibrahima Faye, Brahim Belhaouari Samir, Abas Md Said

“…The classification of protein sequences into existing superfamilies is helpful in predicting the structure and function of large amount of newly discovered proteins. …”
Get full text

Effect of mesostructure on quasi-static and dynamic tensile strength of rock: insights from a breakable grain-based model by Cheng Pan, Xing Li, Guangming Zhao, Bing Cheng

“…The breakable GBM effectively captures the tensile failure process under high strain rates, revealing the role of grain structure heterogeneity in strain rate effects. Additionally, the study evaluates the applicability of different dynamic increase factor (DIF) models, confirming the effectiveness of the normalized DIF model for predicting the dynamic tensile strength of granite. …”
Get full text

Short-Term Creep Experiment of Cement Asphalt Mortar and Its Numerical Simulation by Hao Xu, Ping Wang, Hong-song Lin, Hua Yan

“…The study results can improve the structural design theory of slab track.…”
Get full text

Advance in Significant Wave Height Prediction: A Comprehensive Survey by Jinyuan Mo, Xianghan Wang, Shengjun Huang, Rui Wang

“…The study introduces an all-encompassing predictive framework for significant wave height, which not only integrates diverse established forecasting techniques but also paves the way for novel research trajectories and creative breakthroughs. The framework is structured into four principal layers, i.e., feature selection, basic prediction, data decomposition, and parameter optimization. …”
Get full text

Mapping the Evolution of Sustainable Capitalism: A Bibliometric Analysis of Scholarly Trends and Influential Works by Shridhi Jain, Shubham Singhania, Varda Sardana, Amiya Kumar Mohapatra

“…This study aims to delve into the theoretic evolution and academic structure of the relationship between sustainability and capitalism, by employing a bibliometric analysis. …”
Get full text

The Influence of Religiosity, Personal Attitude, Subjective Norms, and Education in Developing Entrepreneurial Intention by Mokhamad Arwani, Maskudi Maskudi, Ratih Pratiwi, Ahmad Malik

“…The data was processed using structural equation modeling. The result show that the religiosity factor can encourage subjective norms to increase entrepreneurial intention. …”
Get full text

Local Void Fractions and Bubble Velocity in Vertical Air-Water Two-Phase Flows Measured by Needle-Contact Capacitance Probe by Shanfang Huang, Xiangxiang Wu, Benyang Zong, Yugao Ma, Xiaoyu Guo, Dong Wang

“…Further experiments indicate that the time series of the output signals vary as the different flow regimes and are consistent with each flow structure.…”
Get full text

The Immune Response and Its Therapeutic Modulation in Bronchiectasis by Massoud Daheshia, James D. Prahl, Jacob J. Carmichael, John S. Parrish, Gilbert Seda

“…Furthermore, the potential link(s) between an ongoing immune response and structural alterations accompanying the disease and the success of therapies that can modulate the nature and extent of immune response in BC are elaborated upon.…”
Get full text

A two-level resolution neural network with enhanced interpretability for freeway traffic forecasting by Semin Kwak, Danya Li, Nikolas Geroliminis

“…The first block captures large-scale regional traffic patterns, while the second block, using a GCN, focuses on small-scale spatial correlations, informed by the regional predictions. This structure allows the model to intuitively integrate both local and distant traffic data, improving long-term forecasting. …”
Get full text

Development and Assessment of a Water-Based Drilling Fluid Tackifier with Salt and High-Temperature Resistance by Yue Gao, Xiaobo Wang, Yun Cheng, Xuan Qi, Hao Yan

“…The polymer system’s structure was characterized using FTIR and 1H NMR, while its thermal properties were analyzed through thermogravimetric analysis. …”
Get full text

Is there a connection between ESG scores and a company’s profitability? Empirical evidence on selected Stoxx Europe 600 firms by Hussam Musa, Peter Krištofik, Yaroslav Lysenko, Juraj Medzihorsky

“…However, this is not the case for leverage, as the importance of capital structure for profitability is confirmed. AcknowledgmentThis research has been supported by the Scientific Grant Agency of the Slovak Republic under project VEGA No. 1/0579/21.…”
Get full text

Change Detection and Feature Extraction of Debris-Flow Initiation by Rock-Slope Failure Using Point Cloud Processing by Xiaoying He, Zeqing Yu, John M. Kemeny, Ann Youberg, Yunkun Wang

“…Our understanding of debris-flow initiation by slope failure is restricted by the challenge of acquiring accurate geomorphic features of debris flows and the structural setting of the rock mass in the remote mountainous terrain. …”
Get full text

The Influence of Work-Life Balance on Project Performance of Medical and Paramedical Professionals at RSUD Dr. Gunawan Mangunkusumo with Co-Worker Relationship Quality as a Moderat... by Nada Ulayya Martaningtyas, M. Farid Wajdi

“…Partial Least Squares (PLS) was used to examine the quantitative data that was gathered from 147 respondents using structured questionnaires. WLB has a beneficial impact on project performance, according to the data (β=0.418, p < 0.001). …”
Get full text

The Modeling Process of the Materials Management System in a Manufacturing Company Based on the System Dynamics Method by Małgorzata Baran

“…The validation of the simulation model was conducted by using the following methods: assessing the correctness of the boundary of modeling, adequacy of the model structure and adopted values (constants) compared with available knowledge about the modelled system; test of the accuracy and consistency of the units of variables adopted in the model and test of the model behavior in extreme conditions. …”
Get full text

The Curriculum of Iran: Emphasizing Citizenship Education by Saeid Sharifi Rahnmo, Seyed Mohammad Masoumi, Majid Sharifi Rahnmo

“…The data collection tool was a semi-structured interview, and to determine its reliability and validity, four criteria were used: credibility, transferability, confirmability, and dependability. …”
Get full text

Abelian instantons and monopole scattering by Csaba Csáki, Rotem Ovadia, Ofri Telem, John Terning, Shimon Yankielowicz

“…This theory, whose non-topological sectors were studied by Rubakov and Callan, has a far richer structure than previously explored. We show how to calculate the topological instanton number, demonstrate the existence of ’t Hooft zero modes localized around such instantons, and show how instantons in the path integral provide the underlying mechanism for the Callan-Rubakov process: monopole-catalyzed baryon decay with a cross section that saturates the unitarity bound. …”
Get full text

Modification of metal-cutting plates from tungsten-free hard alloy grade KNT16 by continuous ion beams by A. M. Badamshin, S. N. Povoroznuyk, V. V. Akimov, E. A. Rogachev, A. A. Krutko

“…This work is devoted to the problem of developing technological operations aimed at improving the structure and properties and, as a result expanding the scope of metalcutting inserts from tungsten-free hard alloys. …”
Get full text

ENRICHMENT OF MASSIVE SULFIDES FROM THE SEMENOV HYDROTHERMAL CLUSTER (MID-ATLANTIC RIDGE) IN BARITE: A RESULT OF E-MORB INVOLVEMENT AND MAGMATIC CONTRIBUTION by I.Yu. Melekestseva, G.A. Tret’yakov, V.E. Beltenev

“…The results of modeling of the system with felsic rocks show that oceanic plagiogranites from OCC structure could be an additional supplier of Ba.…”
Get full text