Computer-Aided Construction and Evaluation of Poly-L-Lysine/Hyodeoxycholic Acid Nanoparticles for Hemorrhage and Infection Therapy by Qin Qin, Wenxing Wu, Ling Che, Xing Zhou, Diedie Wu, Xiaohui Li, Yumin Yang, Jie Lou

“…Theoretical simulations and experimental studies were combined to optimize their structure and functionality. In vitro platelet aggregation, antibacterial assays, cytotoxicity tests, and hemolysis evaluations were performed. …”
Get full text

Gaining Insight into Operative Performance: Analysis of an Automated 360-Degree Feedback Tool Among Perioperative Staff by Stefanie J. Soelling, MD, MPH, Robert D. Sinyard, MD, Lauren Spigel, MPH, Max Riley, MD, Paul Gregory, PhD, Nick Perdomo, MS, Yves Sonnay, MScPH, Steven Yule, PhD, Steven J. Fishman, MD, Douglas S. Smink, MD, MPH, FACS

“…Aggregated survey responses were provided to surgeons and surgical leadership. We performed semi-structured interviews with 10 surgeons and 5 surgical leaders. …”
Get full text

Esophageal Endoscopic Submucosal Dissection Assisted by an Overtube with a Traction Forceps: An Animal Study by Ken Ohata, Kuangi Fu, Eiji Sakai, Kouichi Nonaka, Tomoaki Tashima, Yohei Minato, Akiko Ohno, Takafumi Ito, Yosuke Tsuji, Hideyuki Chiba, Makoto Yamawaki, Hideyuki Hemmi, Teruo Nakaya, Junichi Fukushima, Nobuyuki Matsuhashi

“…After circumferential mucosal incision for the target lesion, structured as the isolated pig esophagus 3 cm long, either C-ESD or OTF-ESD was randomly selected for submucosal dissection. …”
Get full text

Effects of GABA Supplementation on Intestinal SIgA Secretion and Gut Microbiota in the Healthy and ETEC-Infected Weanling Piglets by Yuanyuan Zhao, Jing Wang, Hao Wang, Yonggang Huang, Ming Qi, Simeng Liao, Peng Bin, Yulong Yin

“…In conclusion, GABA supplementation can enhance intestinal mucosal immunity by promoting jejunal SIgA secretion, which might be related with the T-cell-dependent pathway and altered gut microbiota structure and metabolism.…”
Get full text

Late-onset first epileptic seizure and cerebral small vessel disease: role of juxtacortical white matter lesions by Adrian Nasca, Adrian Nasca, Leo Sokolovič, Leo Sokolovič, Oliver Koprda, Patrick Haage, Patrick Haage, Thorsten Schmidt, Juraj Kukolja, Juraj Kukolja

“…We aimed to further investigate the impact of white matter lesion (WML) burden and distribution pattern on LOFES.MethodsWe retrospectively compared structural MRI of LOFES patients (n = 39) aged 60 years or older to controls with a transient ischemic attack (TIA, n = 38) and to patient controls (n = 35). …”
Get full text

Assessment of Knowledge, Attitude, and Associated Factors of Mpox Among Healthcare Professionals at Debre Tabor Comprehensive Specialized Hospital, Northwest Ethiopia, 2024: A Cros... by Teklehaimanot Kiros, Mulat Erkihun, Mitikie Wondmagegn, Andargachew Almaw, Ayenew Assefa, Ayenew Berhan, Dessie Tegegne, Alemie Fentie, Tegenaw Tiruneh, Birhanemaskal Malkamu, Mahider Shimelis, Eninur Dejen, Birhanu Getie, Shewaneh Damtie, Yenealem Solomon, Bekele Sharew

“…A pretested, and well‐structured, questionnaire was used to assess the sociodemographic characteristics, knowledge, and attitudes of HCPs. …”
Get full text

Association of Self-DNA Mediated TLR9-Related Gene, DNA Methyltransferase, and Cytokeratin Protein Expression Alterations in HT29-Cells to DNA Fragment Length and Methylation Statu... by István Fűri, Ferenc Sipos, Sándor Spisák, Gergő Kiszner, Barnabás Wichmann, Andrea Schöller, Zsolt Tulassay, Györgyi Műzes, Béla Molnár

“…DNMT3A expression could also be induced by type-1 DNA treatment. DNA structure may play a significant role in activation of the TLR9-dependent and even independent proinflammatory pathways. …”
Get full text

The Effect of the Glucosinolate Sinigrin on Alterations in Molecular Biomarkers of the Myocardium in Swiss Mice by Nikola Ferara, Vedran Balta, Domagoj Đikić, Dyana Odeh, Ana Mojsović-Ćuić, Lana Feher Turković, Dario Dilber, Anđelo Beletić, Irena Landeka Jurčević, Ivana Šola

“…The alterations in myocardial parameters were assessed by measuring metabolic, inflammatory, structural, and antioxidant markers. Our findings revealed that subchronic exposure to sinigrin in the myocardia of female mice resulted in a significant increase (<i>p</i> ≤ 0.05) in the levels of the myokine irisin, matrix metalloproteinases (MMP-2, MMP-9), catalase (CAT), and total glutathione (tGSH), alongside a marked decrease (<i>p</i> ≤ 0.05) in the levels of atrial natriuretic peptide (ANP), compared to the control group consisting of both female and male mice. …”
Get full text

Experiences of ‘traditional’ and ‘one-stop’ MRI-based prostate cancer diagnostic pathways in England: a qualitative study with patients and GPs by Fiona M Walter, Stephanie Archer, Willie Hamilton, Samuel William David Merriel, John McGrath, Alice S Forster, Hashim Uddin Ahmed, David Eldred-Evans

“…Objectives This study aimed to understand and explore patient and general practitioner (GP) experiences of ‘traditional’ and ‘one-stop’ prostate cancer diagnostic pathways in England.Design Qualitative study using semi-structured interviews, analysed using inductive thematic analysisSetting Patients were recruited from National Health Service (NHS) Trusts in London and in Devon; GPs were recruited via National Institute for Health Research (NIHR) Clinical Research Networks. …”
Get full text

Lipid nanoparticles deliver DNA-encoded biologics and induce potent protective immunity by Dafei Chai, Junhao Wang, Jing Ming Lim, Xiaohui Xie, Xinfang Yu, Dan Zhao, Perry Ayn Mayson Maza, Yifei Wang, Dana Cyril-Remirez, Ken H. Young, Yong Li

“…The LNP formulation used in Moderna’s Spikevax mRNA vaccine (LNP-M) demonstrated a stable nanoparticle structure, high expression efficiency, and low toxicity. …”
Get full text

Intense Pulsed Light Therapy with Optimal Pulse Technology as an Adjunct Therapy for Moderate to Severe Blepharitis-Associated Keratoconjunctivitis by Fang Ruan, Yunxiao Zang, Ruti Sella, Hongshuang Lu, Shang Li, Ke Yang, Tao Jin, Natalie A. Afshari, Zhiqiang Pan, Ying Jie

“…Safety outcome measures included visual acuity, intraocular pressure, eye structure damage, and facial skin appearance at each visit. …”
Get full text

Supra-Acetabular Brown Tumor due to Primary Hyperparathyroidism Associated with Chronic Renal Failure by Rosaria M. Ruggeri, Emanuele Calamoneri, Antonia Russo, Alessandro Sindoni, Baldassarre Mondello, Maurizio Monaco, Michele A. Rosa, Sergio Baldari, Salvatore Benvenga, Alfredo Campennì, Francesco Trimarchi

“…X-rays and CT scan detected an osteolytic and expansive lesion of the right supra-acetabular region with structural reabsorption of the right iliac wing. 99mTc-MDP whole-body bone scan showed an abnormal uptake in the right iliac region. …”
Get full text

Cryptic species and hybridisation in corals: challenges and opportunities for conservation and restoration by Riginos, Cynthia, Popovic, Iva, Meziere, Zoe, Garcia, Vhon, Byrne, Ilha, Howitt, Samantha M., Ishida, Hisatake, Bairos-Novak, Kevin, Humanes, Adriana, Scharfenstein, Hugo, Richards, Thomas, Briggs, Ethan, Clark, Vanessa, Lei, Chuan, Khan, Mariam, Prata, Katharine E.

“…Here, we investigate the prevalence of cryptic coral groups and assess evidence for their permeability to gene flow (hybridisation) via a structured literature review of genomic studies. Using reproducible criteria to detect distinct genetic groups that are sympatric, we find that 68% of nominal species represented in population genomic studies show evidence for comprising partially reproductively isolated groups and that these distinct groups are often linked by gene flow. …”
Get full text

The Influences of Key Strata Compound Breakage on the Overlying Strata Movement and Strata Pressure Behavior in Fully Mechanized Caving Mining of Shallow and Extremely Thick Seams:... by Junmeng Li, Yanli Huang, Jixiong Zhang, Meng Li, Ming Qiao, Fengwan Wang

“…The research results showed that during the fully mechanized caving mining in shallow and extremely thick seams, the inferior key strata affected by mining movement behaved in the mode of sliding instability and could not form the stable structure of the voussoir beam after breaking and caving. …”
Get full text

Optical genome mapping: Unraveling complex variations and enabling precise diagnosis in dystrophinopathy by Jiahui Mai, Jing Duan, Xiaoyu Chen, Liqin Liu, Dachao Liang, Tao Fu, Gang Lu, Wai Yee Chan, Xufeng Luo, Feiqiu Wen, Jianxiang Liao, Zhuo Li, Xinguo Lu

“…We used the optical genome mapping (OGM) technology to detect and analyze uncommon mutations or structural variations (SVs) within the DMD gene, thus contributing to more precise clinical diagnoses. …”
Get full text

Grazing mortality as a controlling factor in the uncultured non-cyanobacterial diazotroph (Gamma A) around the Kuroshio region by T. Sato, T. Sato, T. Yamaguchi, K. Hidataka, S. Sogawa, T. Setou, T. Kodama, T. Kodama, T. Shiozaki, K. Takahashi

“…In this study, we investigated the diazotroph community structure using <i>nifH</i> amplicon sequencing and quantified the growth and microzooplankton grazing mortality rate of Gamma A using a combination of dilution experiments and quantitative polymerase chain reaction (PCR) in well-lit waters at the northern edge of the Kuroshio Current off the southern coast of Japan. …”
Get full text

Early Transcriptional Changes Induced by Wnt/β-Catenin Signaling in Hippocampal Neurons by Eduardo Pérez-Palma, Víctor Andrade, Mario O. Caracci, Bernabé I. Bustos, Camilo Villaman, Matías A. Medina, Miguel E. Ávila, Giorgia D. Ugarte, Giancarlo V. De Ferrari

“…Our results indicate that Wnt/β-catenin mediated transcription controls multiple biological processes related to neuronal structure and activity that are affected in synaptic dysfunction disorders.…”
Get full text

Research Review and Prospect of Litchi Fruit Cracking by Xiwen LI, Haoshuang SUN, Xuequn PANG, Zhaoqi ZHANG

“…In the future, researches should be strengthened on the relationship between the structure of the suture line and fruit cracking in litchi fruit, and the possible influence of seed type on the susceptibility to fruit cracking.…”
Get full text

Degradation Kinetics of Ascorbic Acid in Xanthan Gum Solution by Runqi JIA, Yujie TANG, Weiwei HE, Xiaoxiao SONG, Junyi YIN

“…Ascorbic acid (AA) reacts with polysaccharides, resulting in changes in the rheological and structural properties of the polysaccharides. However, the degradation characteristics of AA and its degradation kinetics during this reaction require further investigation. …”
Get full text

Investigation on Mechanical Properties and Reaction Characteristics of Al-PTFE Composites with Different Al Particle Size by Jia-xiang Wu, Xiang Fang, Zhen-ru Gao, Huai-xi Wang, Jun-yi Huang, Shuang-zhang Wu, Yu-chun Li

“…The microstructure of selected specimens was anatomized through adopting a scanning electron microscope (SEM) to correlate the mesoscale structural characteristics to their macroproperties. …”
Get full text