Genetic Deletion and Pharmacological Inhibition of PI3Kγ Reduces Neutrophilic Airway Inflammation and Lung Damage in Mice with Cystic Fibrosis-Like Lung Disease by Maria Galluzzo, Elisa Ciraolo, Monica Lucattelli, Eriola Hoxha, Martina Ulrich, Carlo Cosimo Campa, Giuseppe Lungarella, Gerd Doring, Zhe Zhou-Suckow, Marcus Mall, Emilio Hirsch, Virginia De Rose

“…PI3Kγ plays a pivotal role in leukocyte recruitment and activation; in the present study we determined the effects of genetic deletion and pharmacologic inhibition of PI3Kγ on airway inflammation and structural lung damage in a mouse model of CF lung disease. …”
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Enhanced precise therapy of ROS-sensitive dual-layer shell nanoparticles loading quercetin on DSS-induced ulcerative colitis mice by Yang Bai, Danling Jiang, Boda Wu, Jiao Peng, Ji Wang, Yuhui Chen, Xi Li

“…This was evidenced by a significant increase in body weight, a reduction in occult blood in the feces, and a recovery of the crypt structure. The stained results indicated that Que@Gel-DA NPs attenuate inflammation by promoting the polarization of M2 macrophages to reduce apoptosis and modulate immunity. …”
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Transcatheter Approach for Critical Pulmonary Stenosis or Pulmonary Atresia with Intact Ventricular Septum in Young Infants Using the Simmons Catheter by Jian Wang, Jing Sun, Jian Shen, Jianping Yang, Ling Yang, Pengjun Zhao, Sun Chen

“…Patients were divided into three groups according to the type of catheter used to enter through the RVOT. The unique structure of the Simmons catheter allowed it to be maneuvered directly into the RVOT within a few minutes. …”
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Mental health in people living with and beyond colorectal cancer: A patient‐oriented constructivist grounded theory by Vicki Cheng, Helen McTaggart‐Cowan, Jonathan M. Loree, Rachel A. Murphy, Mikaela Barnes, Haydn Bechthold, Norman Jansen, Mary A. De Vera

“…We collected data through semi‐structured individual interviews using a guide co‐constructed with patient research partners. …”
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High-entropy assisted capacitive energy storage in relaxor ferroelectrics by chemical short-range order by Tongxin Wei, Jinzhu Zou, Xuefan Zhou, Miao Song, Yan Zhang, Cewen Nan, Yuanhua Lin, Dou Zhang

“…Atomic-scale scanning transmission electron microscopy observations show that Nb exhibits a chemical short-range order structure, with Nb enriched regions displaying ultrasmall polar nanoregions and more flexible polarization configurations, which is conducive to achieving high maximum polarization and low residual polarization. …”
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Influence of Smartphone Usage on development of Sexuality among Late Adolescent Boys in Health Sciences Colleges of South India [version 2; peer review: 2 approved] by Sara J Ommen, Preeti M Galagali, Sharath M Manya, Prasanna Mithra, Jayashree K

“…Smartphone Addiction Scale – short version (SAS-SV) to evaluate PSU and a content validated semi-structured proforma to evaluate gender identity, sexual orientation, sources of information on pubertal changes, and exposure to pornographic content was used. …”
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Efficient Self-Assembly of mPEG End-Capped Porous Silica as a Redox-Sensitive Nanocarrier for Controlled Doxorubicin Delivery by Anh Khoa Nguyen, Thi Hiep Nguyen, Bui Quoc Bao, Long Giang Bach, Dai Hai Nguyen

“…In this report, PNS was surface conjugated with adamantylamine (ADA) via disulfide bridges (-SS-), PNS-SS-ADA, which was further modified with cyclodextrin-poly(ethylene glycol) methyl ether conjugate (CD-mPEG) to form a core@shell structure PNS-SS-ADA@CD-mPEG for redox triggered delivery of doxorubicin (DOX), DOX/PNS-SS-ADA@CD-mPEG. …”
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Translation, cross-cultural adaptation, and psychometric properties of the Finnish version of the Malocclusion Impact Questionnaire (MIQ) by Lucas Arrais Campos, Terhi Kaikkonen, Kaisa Ylitervo, Leena Ylikontiola, Anna- Sofia Silvola

“…Psychometric properties were estimated using factorial validity (confirmatory factor analysis [CFA]), convergent validity (Average Variance Extracted [AVE]), and reliability (αordinal and ω). Structural Equation Model estimated the effect of demographic characteristics on malocclusion impact. …”
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Caffeic acid phenethyl ester restores mitochondrial homeostasis against peritoneal fibrosis induced by peritoneal dialysis through the AMPK/SIRT1 pathway by Ying Lu, Luyan Gao, Wenwen Zhang, Ying Zeng, Ji Hu, Kai Song

“…Our results suggest that CAPE maintains mitochondrial homeostasis by upregulating the AMPK/SIRT1 pathway, which alleviates oxidative stress and MMT, thereby mitigating the damage to the peritoneal structure and function caused by PD. These findings suggest that adding CAPE to PDF may prevent and treat peritoneal fibrosis.…”
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Effects of early neonatal proinflammatory stress on the expression of BDNF transcripts in the brain regions of prepubertal male rats by D. I. Peregud, S. V. Freiman, A. O. Tishkina, L. S. Sokhranyaeva, N. A. Lazareva, M. V. Onufriev, M. Y. Stepanichev, N. V. Gulyaeva

“…No changes in the expression of the transcripts containing exons I and VI were observed in any brain structure studied. We suggest that specific alterations in BDNF expression may be involved in the susceptibility to the development of behavioral impairments of animals subjected to early proinflammatory stress.…”
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Study on the Adsorption Mechanism of Hydrophobic SiO2 Nanoparticles: A Molecular Dynamics Study by Runnan Zhou, Yuyuan Wang, Dong Zhang, Peng Ye, Jianguang Wei

“…Despite many experiments that have proved that nanoparticles can be adsorbed on the rock surface in a macroscopic perspective, the adsorption mechanism and the effects of molecular structure on the adsorption behavior of nanoparticles on rock surfaces remain scarce. …”
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A numerical investigation of heat transfer performance in a prismatic battery cooling system using hybrid nanofluids by B. Venkateswarlu, Santosh Chavan, Sang Woo Joo, Sung Chul Kim, Kottakkaran Sooppy Nisar

“…The governing flow model equations for momentum and energy are derived based on the microtube cooling channel of the battery structure, incorporating convection, heat generation, and viscous dissipation. …”
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Adipocytes from New Zealand Obese Mice Exhibit Aberrant Proinflammatory Reactivity to the Stress Signal Heat Shock Protein 60 by Tina Märker, Jennifer Kriebel, Ulrike Wohlrab, Volker Burkart, Christiane Habich

“…Hsp60 binding involved conserved binding structure(s) and Hsp60 epitopes and was strongest to NZO mouse-derived mature adipocytes. …”
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Validation Spanish of the Post-Traumatic Stress Disorder Scale in the Postpartum - City BITS by Ayelén Acosta, Aquiles Pérez Delgado, Mercedes Lotufo, Angela Zayas, Sandro Giovanazzi

“…Confirmatory factor analysis supported the two-factor structure. The scale showed high internal consistency (total α = .903), with α = .872 for 'birth-related symptoms' and α = .886 for 'general symptoms'. …”
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Evaluation of the current status and risks of aquatic ecology in the Jialing River Basin based on the characteristics and succession trends of phytoplankton communities by Maojin Huang, Fei Xu, Jia Xia, Xue Yang, Fubin Zhang, Siyao Liu, Tuo Zhang

“…The results showed that 1) Bacillariophyta, Cryptophyta, and Chlorophyta were the dominant phyla in the Jialing River, followed by Cyanobacteria. The structure of the phytoplankton community was affected by seasonal changes and differences in the tributary and mainstem. 2) Overall, the autumn phytoplankton community α-diversity index was significantly higher than that of spring (P < 0.05). …”
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Intensification of Natural Disasters in the State of Pará and the Triggering Mechanisms Across the Eastern Amazon by Everaldo B. de Souza, Douglas B. S. Ferreira, Luciano J. S. Anjos, Alan C. Cunha, João Athaydes Silva, Eliane C. Coutinho, Adriano M. L. Sousa, Paulo J. O. P. Souza, Waleria P. Monteiro Correa, Thaiane S. Silva Dias, Alexandre M. C. do Carmo, Carlos B. B. Gutierrez, Giordani R. C. Sodré, Aline M. M. Lima, Edson J. P. Rocha, Bergson C. Moraes, Luciano P. Pezzi, Tercio Ambrizzi

“…Furthermore, we conducted a comprehensive composite analysis on the tropical ocean–atmosphere dynamic structure that elucidated the various triggering mechanisms of disasters arising from Inundations, Droughts, and Forest fires (on seasonal scale), and Flash floods and Heavy rainfall (on sub-monthly scale) in Pará. …”
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Comprehensive identification, characterization and expression analyses of the class III POD gene family in water lily (Nymphaea colorata) by Wasi Ullah Khan, Wasi Ullah Khan, Latif Ullah Khan, Noor Muhammad Khan, Ji Zhang, Wang Wenquan, Wang Wenquan, Fei Chen, Fei Chen

“…Exon-intron and motif analyses exhibited the structural and functional diversity among the sub-groups. …”
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Use of digital data from open sources during the investigation of criminal offenses: certain aspects by Basysta I., Havrylyuk L., Hutnyk A., Khytra A.

“…Comparative-legal, functional, system-structural, graphic methods were used in the process of scientific research. …”
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Science-based communication and education needed to improve forest carbon science, policy, and management outcomes by Chad C Papa, Kylie Clay, Lauren T Cooper, Scott C Stark

“…Here, we use a survey, semi-structured interviews, and a review of relevant policy literature to assess the nature and extent of, as well as possibilities to bridge, the science-practice gap with regards to forest carbon science, management, and policy. …”
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Claim Amount Forecasting and Pricing of Automobile Insurance Based on the BP Neural Network by Wenguang Yu, Guofeng Guan, Jingchao Li, Qi Wang, Xiaohan Xie, Yu Zhang, Yujuan Huang, Xinliang Yu, Chaoran Cui

“…This paper uses a genetic algorithm to optimize the structure of the BP neural network at first, and the calculation speed is significantly improved. …”
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