Individualized brain radiomics-based network tracks distinct subtypes and abnormal patterns in prodromal Parkinson's disease by Lin Hua, Canpeng Huang, Xinglin Zeng, Fei Gao, Zhen Yuan

“…Then, the dissociated patterns of clinical manifestations, anatomical structure alterations, and gene expression between these two subtypes were evaluated. …”
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Challenges of healthcare financing in the world’s largest refugee camp: a mixed-method study among healthcare stakeholders for Rohingya refugees in Bangladesh by Isabel Smith, Imdadul Haque Talukdar, Sayeeda Tarannum, M A Rifat, Priyanka Boga, Jubayer Mumin, Pablo André Veronés, Ziba Mahdi, Syeda Saima Alam, Arif Faysal Khan

“…Objectives This study aimed to increase the understanding of healthcare stakeholders’ viewpoints on the challenges and potential solutions regarding healthcare financing for the Rohingya refugees in Cox’s Bazar.Design A mixed-method approach, containing semi-structured interviews with healthcare stakeholders and review of financial documents, was employed. …”
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Optimal OCR coordination in a high penetration distribution power system using a refined immune algorithm with an auto-tuning reproductive mechanism by Tung-Sheng Zhan, Yih-Der Lee, Jheng-Lun Jiang

“…The proposed approach involved tracking the connectivity of the system structure to establish a relay numbering sequence, which served as a tracking route. …”
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Expression Profiling Using a cDNA Array and Immunohistochemistry for the Extracellular Matrix Genes FN-1, ITGA-3, ITGB-5, MMP-2, and MMP-9 in Colorectal Carcinoma Progression and D... by Suzana Angelica Silva Lustosa, Luciano de Souza Viana, Renato José Affonso, Sandra Regina Morini Silva, Marcos Vinicius Araujo Denadai, Silvia Regina Caminada de Toledo, Indhira Dias Oliveira, Delcio Matos

“…Colorectal cancer dissemination depends on extracellular matrix genes related to remodeling and degradation of the matrix structure. This investigation intended to evaluate the association between FN-1, ITGA-3, ITGB-5, MMP-2, and MMP-9 gene and protein expression levels in tumor tissue with clinical and histopathological neoplastic parameters of cancer dissemination. …”
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Investigation of the Effects of Freeze-Thaw Cycles on Geomechanical and Acoustic Characteristics of Tuff Specimens under Different Stress Paths by Yong-gang Xiao, Chang-hong Li, Jie Cao, Yu Wang, Zhi-qiang Hou, Nan Hu

“…In the process of development and construction of open-pit mine slope in the high altitude and cold area, freeze-thaw (F-T) cycles have an important impact on rock engineering structure. F-T cycles lead to the decrease in physical and mechanical properties of rock, which is closely related to the stability of open-pit slope. …”
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Cortical Gyrification and Cognitive Decline in the Human Brain With Type 2 Diabetes Mellitus by Weiye Lu, Yuna Chen, Zidong Cao, Zhizhong Sun, Wenbin Qiu, Limin Ge, Xin Tan, Yi Liang, Shijun Qiu

“…ABSTRACT Introduction Type 2 diabetes mellitus (T2DM) is linked to abnormal brain structure and cognitive dysfunction. However, there is a lack of studies conducted to assess the impact of diabetes on cortical gyrification and cognition. …”
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Comprehensive Analysis of DDoS Anomaly Detection in Software-Defined Networks by Abdinasir Hirsi, Mohammed A. Alhartomi, Lukman Audah, Adeb Salh, Nan Mad Sahar, Salman Ahmed, Godwin Okon Ansa, Abdullahi Farah

“…The survey provides a layer-by-layer analysis of DDoS detection techniques, covering the application, control, and infrastructure layers, and offers a structured overview that clarifies the applicability and effectiveness of each method. …”
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Enhancing efficiency in double perovskite solar cells through bandgap reduction via organic polymer doping by Ihtisham-ul-Haq, M.I. Khan, Ali Mujtaba, Asad Ullah, Badriah Ali, Muhammad Atif, M.S. Hasan

“…The solar cells of these films have been prepared and compared to their efficiency. The structure of the solar cell is Au/Spiro-OMeTAD/Cs2AgBiBr6/TiO2/FTO/glass. …”
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Improving the binding affinity of plastic degrading cutinase with polyethylene terephthalate (PET) and polyurethane (PU); an in-silico study by Deves Sabari V L, Gokulnath Rajmohan, Roshine S B, Srivaishnavi S, Kishore Nagasubramanian, Senthil Kumar G, Ponnusami Venkatachalam

“…The cutinase of Thermobifida fusca was found to degrade both PET and PU polymers. The crystallized structure of cutinase was retrieved from PDB, and PET, PU ligands were docked using Schrodinger. …”
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Combined MSC and GLP-1 Therapy Modulates Collagen Remodeling and Apoptosis following Myocardial Infarction by Elizabeth J. Wright, Nigel W. Hodson, Michael J. Sherratt, Moustapha Kassem, Andrew L. Lewis, Christine Wallrapp, Nadim Malik, Cathy M. Holt

“…After four weeks, infarcted areas were imaged using atomic force microscopy, demonstrating significant alterations between groups in the structure of collagen fibrils and resulting scar. Conclusions. …”
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Anisodamine ameliorates crystalline silica-exposed pulmonary inflammation and fibrosis via the α7nAChR/JAK2/STAT3 signaling pathway by Meng Liu, Hui Liu, Hong Kang, Juan Wu, Puhua Xing, Xiaorui Ding, Yangyang Wei, Xiaomei Kong

“…Animal experiments demonstrated that ANI significantly reduced alveolar structure damage and the formation of silicosis nodules in affected mice, as confirmed by pathological slides. …”
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Characterization of Bozitinib as a potential therapeutic agent for MET-amplified gastric cancer by Hang Lin, Lingzhi Qu, Hudie Wei, Ming Guo, Xiaojuan Chen, Qianmeng Lin, Huajun Zhang, Shuyan Dai, Yongheng Chen

“…Bozitinib demonstrates a strong effect on MET-amplified gastric cancer cells by blocking the c-Met signaling pathway, leading to the inhibition of cell proliferation and survival, as well as the induction of G0/G1 phase arrest and apoptosis. Structurally, bozitinib is optimally embedded in the ATP pocket of c-Met and firmly binds via an extensive interaction network. …”
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Psychological, psychiatric, and behavioral sciences measurement scales: best practice guidelines for their development and validation by Alberto Stefana, Stefano Damiani, Umberto Granziol, Umberto Provenzani, Marco Solmi, Marco Solmi, Marco Solmi, Marco Solmi, Marco Solmi, Eric A. Youngstrom, Eric A. Youngstrom, Eric A. Youngstrom, Paolo Fusar-Poli, Paolo Fusar-Poli, Paolo Fusar-Poli

“…Finally, in the Finalization Phase, the optimal item sequence is decided, and a comprehensive inventory manual is prepared. In sum, this structured approach provides researchers and clinicians with a comprehensive methodology for developing reliable, valid, and user-friendly psychological, psychiatric, and behavioral sciences measurement scales.…”
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Investigation of in situ gelling alginate formulations as a sustained release vehicle for co-precipitates of dextromethrophan and Eudragit S 100 by Maghraby Gamal Mohamed El, Elzayat Ehab Mostafa, Alanazi Fars Kaed

“…Alginate vehicles are capable of forming a gel matrix in situ when they come into contact with gastric medium in the presence of calcium ions. However, the gel structure is pH dependent and can break after gastric emptying, leading to dose dumping. …”
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Tuberculosis Mimicking-Musculoskeletal Tumor of The Hand: An Uncommon Case of Extrapulmonary Tuberculosis by Andy Lesmana, Hapsari Retno Dewanti, Lenty BR Perangin Angin, Muhamad Irvan Muzakky, Stefi Geovani Valentin Hayon, Mentari Maratus Sholihah, Muhammad Ifham Hanif

“…The histopathology study revealed a chronic granulomatous structure surrounded by epitheloid cells, datia Langhans cells, and caseating necrosis. …”
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Unveiling the charge density wave mechanism in vanadium-based Bi-layered kagome metals by Yi-Chen Yang, Soohyun Cho, Tong-Rui Li, Xiang-Qi Liu, Zheng-Tai Liu, Zhi-Cheng Jiang, Jian-Yang Ding, Wei Xia, Zi-Cheng Tao, Jia-Yu Liu, Wen-Chuan Jing, Yu Huang, Yu-Ming Shi, Soonsang Huh, Takeshi Kondo, Zhe Sun, Ji-Shan Liu, Mao Ye, Yi-Lin Wang, Yan-Feng Guo, Da-Wei Shen

“…Our finding not only comprehensively maps the electronic structure of V-based bi-layer kagome metals but also provides constructive experimental evidence for the unique origin of CDW in this system.…”
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Unraveling TEOSINTE BRANCHED1/CYCLOIDEA/PROLIFERATING CELL FACTOR Transcription Factors in Safflower: A Blueprint for Stress Resilience and Metabolic Regulation by Lili Yu, Xintong Ma, Mingran Dai, Yue Chang, Nan Wang, Jian Zhang, Min Zhang, Na Yao, Abdul Wakeel Umar, Xiuming Liu

“…Comparative phylogenetics, conserved motif, and gene structure analyses revealed a high degree of evolutionary conservation and functional divergence within the gene family. …”
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Exploring the relationship between cultural ecosystem services and human well-being of Qiandao Lake in China: insights from tourists and residents by Jie Wang, Kuan Wang, Shuangjin Li, Huiyong Song, Shuang Ma, Weiwu Han, Di Pang

“…The relationship between CES and Human Well-Being (HWB) was examined using Structural equation Modeling (SEM), followed by the application of the Importance-Performance Analysis (IPA) method to identify which aspects should be targeted in management strategies. …”
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Chinese nurses’ perspectives on child-friendly healthcare practice assessment: a qualitative study by Wei Xiao Huang, Mei Chan Chong, Li Yoong Tang, Xiao Xia Liu, Mei Fang, Yun Yun Shen, Xiao Li Guo

“…Method This descriptive qualitative study employed purposive and snowball sampling methods to recruit 14 pediatric nurses from six hospitals in Zhejiang province, Southeast China. Individual semi-structured interviews were conducted face-to-face between January and June 2024. …”
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Alleviating effects and mechanisms of action of large-leaf yellow tea drinking on diabetes and diabetic nephropathy in mice by Guangshan Zhao, Jianyuan Teng, Ruixia Dong, Qiuyan Ban, Lian Yang, Kang Du, Yifei Wang, Hanlin Pu, Chung S. Yang, Zhe Ren

“…The underlying mechanisms involve downregulation of gluconeogenesis (lower protein levels of TXNIP and FBP and enzyme activity of FBP), upregulation of lipid catabolism (higher protein levels of CPT-1α and PPARα), downregulation of lipogenesis (lower protein level of SREBP-1), and modification of the structure and abundance of gut microbiota to modulate metabolic homeostasis. …”
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