Group a Streptococcus remains viable inside fibrin clots and gains access to human plasminogen for subsequent fibrinolysis and dissemination by Henry M. Vu, Thomas E. Moran, Zhong Liang, Yun-Juan Bao, Paulina G. Carles, Jessica C. Keane, Madelyn G. Cerney, Caitlyn N. Dahnke, Ana L. Flores-Mireles, Victoria A. Ploplis, Francis J. Castellino, Shaun W. Lee

“…Our findings reveal for the first time that GAS can engage a latent, growth-suspended phase whereby physical structures such as fibrin clots that immobilize an invading pathogen allow bacteria to remain viable until sufficient access to plasminogen allows it to initiate fibrinolysis and escape into surrounding blood system and tissues.IMPORTANCEGroup A Streptococcus (GAS) is a human-specific bacterial pathogen that causes infections ranging in severity from mild to severe infections that can often be fatal. …”
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Sinensetin attenuates hepatic ischemia-reperfusion injury through suppressing GRP78/CHOP-mediated endoplasmic reticulum (ER) stress in mice by Yihong Yang, Guanghua Xiong, Huangqi Shi, Yulin Peng, Jinghong Liu, Yaxuan Jiang, Min Lu, Hongbo Liu, Yong Liu

“…Molecular docking simulation showed theoretical binding between SEN-GRP78 and SEN-IRE1α in three-dimensional structures. Ultimately, the use of 4-PBA to pharmacologically inhibit ER stress may substantially reduce liver damage caused by HIRI in mice.ConclusionTaken together, our results suggested that sinensetin could alleviate HIRI injury through suppressing GRP78/CHOP-mediated ER stress, which may provide a novel therapeutic strategy for treating liver ischemia-reperfusion injury in clinical practice.…”
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Qualitative application of the diffusion of innovation theory to maternity waiting homes in rural Zambia by Jeanette L. Kaiser, Rachel M. Fiorillo, Taryn Vian, Thandiwe Ngoma, Kayla J. Kuhfeldt, Michelle L. Munro-Kramer, Davidson H. Hamer, Misheck Bwalya, Viviane R. Sakanga, Jody R. Lori, Eden Ahmed Mdluli, Peter C. Rockers, Godfrey Biemba, Nancy A. Scott

“…Half lived in catchment areas where new quality MWHs were constructed, half in catchment areas with standard of care (ranging from low quality community structures to no MWH). We applied content analysis to identify themes. …”
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Building resilient cattle through better management of buffalo health by Alfredo Sánchez, Merilio Montero

“…This resilience must be strengthened through handling strategies and by implementing specific and strategic health plans built on solid foundations of diagnostic structures to promote prevention and contribute to more ethical and rational treatments, stimulating a unique association (environment - pathogen - buffalo). …”
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Rat Model of Cystic Neutrophilic Granulomatous Mastitis by Corynebacterium Kroppenstedtii by Wang M, Zeng Y, Liu M, Zhang D, Zhao D, Wang J, Liu Y, Zhao W

“…The expression levels of C-reactive protein and interleukin-1 beta were detected.Results: Rats in groups A, D, and E exhibited breast masses with erythema, with some showing ulceration, and granulomatous structures in pathological. Lipid vacuoles and Gram-positive rods observed in groups D and E. …”
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Research on the Seismic Response Law of Complete Morphology of Butted Well Salt Cavern for Large-Scale Underground Energy Storage by Haitao Li, Dewen Zheng, Kang Li, Qiqi Wanyan, Lina Ran, Yanxia Kou, Song Bai, Jianan Wu, Jianchao Jia, Yunfei Wen, Yuanqing Wang, Hongyan Xing, Kuoyuan Zhu, Jingen Deng

“…The three-dimensional seismic techniques excel in identifying complex geological structures but have a limited understanding of underground old salt cavity morphology, thus the seismic forward simulation method is utilized to study their seismic response patterns. …”
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Enhanced energy storage performance in Ag(Nb,Ta)O3 films via interface engineering by Xiao Zhai, Jun Ouyang, Weijie Kuai, Yinxiu Xue, Kun Wang, Nengneng Luo, Hongbo Cheng, Hanfei Zhu, Chao Liu, Limei Zheng

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Results from the Population-Based Gutenberg Health Study Revealing Four Altered Autoantibodies in Retinal Vein Occlusion Patients by Katharina Bell, Vanessa M. Beutgen, Stefan Nickels, Katrin Lorenz, Yvonne Scheller, Hisham Elbaz, Tunde Peto, Katharina A. Ponto, Andreas Schulz, Philipp S. Wild, Thomas Münzel, Karl J. Lackner, Irene Schmidtmann, Manfred Beutel, Norbert Pfeiffer, Franz H. Grus, Alexander K. Schuster

“…We found several autoantibodies associated with RVO, targeting proteins and structures possibly involved in RVO pathogenesis.…”
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Observations of Loki Patera by Juno during Close Flybys by Alessandro Mura, Rosaly M. C. Lopes, Federico Tosi, Francesca Zambon, Roberto Sordini, Peter J. Mouginis-Mark, Julie Rathbun, Scott Bolton, Jani Radebaugh, Alberto Adriani, Andrea Cicchetti, Davide Grassi, Melissa Mirino, Raffaella Noschese, Giuseppe Piccioni, Christina Plainaki, Giuseppe Sindoni

“…Loki shows a thermal structure unlike other active lava lakes previously reported, with some brightening near the lake’s perimeter but lacking the continuous “hot ring” seen at other paterae. …”
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In-Season Automated Mapping of Xinjiang Cotton Based on Cumulative Spectral and Phenological Characteristics by Yongsheng Huang, Yaozhong Pan, Yu Zhu, Xiufang Zhu, Xingsheng Xia, Qiong Chen, Jufang Hu, Hongyan Che, Xuechang Zheng, Lingang Wang

“…In this study, Xinjiang Province, with a planted area of 25 000 km² and 84.94% of China's total production, was selected as the study area, and fully automated mapping experiments were performed using Sentinel-2 time-series images at four experimental sites with different planting structures. The overall accuracies of cotton classification at the four sites were 91.20%, 90.45%, 93.00%, and 91.80%, and the F1-scores were 90.85%, 90.33%, 92.62%, and 92.26%, respectively. …”
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Chemical Synthesis, Efficacy, and Safety of Antimalarial Hybrid Drug Comprising of Sarcosine and Aniline Pharmacophores as Scaffolds by Jean Baptiste Niyibizi, Peter G. Kirira, Francis T. Kimani, Fiona Oyatsi, Joseph K. Ng’ang’a

“…This suggests the need to develop new antimalarial drugs that are effective against malaria parasites based on the new mode of action, molecular targets, and chemical structures. In silico studies have shown that sarcosine is able to bind to unique plasmodia proteins (P. falciparum ATCase), whereas aniline can be a ligand to target protein (enoyl acyl carrier protein reductase), hence suppressing the progression of the disease. …”
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A generative whole-brain segmentation model for positron emission tomography images by Wenbo Li, Zhenxing Huang, Hongyan Tang, Yaping Wu, Yunlong Gao, Jing Qin, Jianmin Yuan, Yang Yang, Yan Zhang, Na Zhang, Hairong Zheng, Dong Liang, Meiyun Wang, Zhanli Hu

“…However, the low resolution of PET images may have limited the segmentation accuracy of multiple brain structures. Therefore, we propose a generative multi-object segmentation model for brain PET images to achieve automatic and accurate segmentation. …”
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Phytochemical and pharmacological review of Erica Genus (L.) Ericaceae plants by Francis Adu-Amankwaah, Hleziphi V. Mpundu, Kudakwashe Nyambo, Paula Strauss, Kudzanai Ian Tapfuma, Ndivhuwo Tshililo, Motunrayo Victoria Badejo, Lawrence Mabasa, Vuyo Mavumengwana, Lucinda Baatjies

“…All plant names were verified through ''The Plant List'' (http://www.theplantlist.org/) and PlantZAfrica (https://pza.sanbi.org/), while chemical structures were confirmed using ChemDraw Ultra and PubChem(https://pubchem.ncbi.nlm.nih.gov/). …”
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Mapping and Analysis of Exit Strategy Research: A Bibliometrics and Systematic Review by Alireza Valipour, Ali Heidari, Mohammad Ali Shahhosseini, Asadollah Kordnaiej

“…Based on these findings, future research avenues include investigating the role of diversification as a driver of business exits, exploring how corporate governance structures influence both firm performance and exit decisions, analyzing factors contributing to non-optimal timing of business exits, examining the potential for reusing resources in new ventures to facilitate exits and minimize negative consequences, investigating the role of organizational capabilities in early detection of exit signals, and conducting a comprehensive exploration of both internal and external consequences of business exits, along with effective response strategies.…”
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Impact of zero-markup consumable policy and national procurement of coronary stents on hospitalization expenses: an interrupted time series analysis by Shao-long Wu, Shao-long Wu, Kun Wang, Xin Yang, Ning Liu, Ning Liu, Wen-xin Zou, Xiao-wei Li, Dan-hua Huang, Tian-hao Yu

“…Currently, research on the zero-markup consumable policy and national procurement of coronary stents for medical consumables at the hospital level lacks analysis of changes in cost structures (other expenses) and studies on hospital response strategies.ObjectiveThis study aims to examine the effects of these reforms on hospitalization expenses for patients undergoing coronary stent implantation, including the specific changes in total hospitalization expenses, the component of total expenses, and the proportion of each expense category following the implementation of the reforms.MethodsData were obtained from the case management system of Guangdong Provincial Second People’s Hospital in China. …”
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Eu:CROPIS AIV Program: Challenges and Solutions for a Spin-Stabilized Satellite Containing Biology by Toni Delovski, Catherin Düvel, Fabian Greif, Ansgar Heidecker, Sebastian Kottmeier, Olaf Mierheim, Falk Nohka, Fabian Orlowski-Feldhusen

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Geohazard Features of the Ionian Calabrian Margin by S. Ceramicola, A. Cova, E. Forlin, N. Markezic, G. Mangano, D. Civile, M. Zecchin, F. Fanucci, E. Colizza, C. Corselli, D. Morelli, A. Savini, A. Caburlotto, O. Candoni, M. Coste, D. Cotterle, S. Critelli, A. Cuppari, M. Deponte, R. Dominici, L. Facchin, E. Gordini, M. Locatelli, F. Muto, D. Praeg, R. Romeo, C. Tessarolo

“…These include multiple coastal landslides, failure scars along open slopes, shelf-indenting retrogressive canyon headwalls and active fluid venting structures, that we investigated by integrating regional high-resolution multibeam sonar and sub-bottom profiling data. …”
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Biomimetic ECM nerve guidance conduit with dynamic 3D interconnected porous network and sustained IGF-1 delivery for enhanced peripheral nerve regeneration and immune modulation by Teng Wan, Qi-Cheng Li, Feng-Shi Zhang, Xiao-Meng Zhang, Na Han, Pei-Xun Zhang

“…However, utilising tailored biomimetic three-dimensional (3D) topological porous structures combined with multiple bio-effect neurotrophic factors to create environments similar to neural tissues, regulate local immune responses, and develop a supportive microenvironment to promote peripheral nerve regeneration and repair poses significant challenges. …”
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Coordination Chemistry of Mixed-Donor Pyridine-Containing Macrocyclic Ligands: From Optical to Redox Chemosensors for Heavy Metal Ions by Alessandra Garau, Alexander J. Blake, Maria Carla Aragoni, Massimiliano Arca, Claudia Caltagirone, Francesco Demartin, Vito Lippolis, Giacomo Picci, Enrico Podda

“…In order to further explore the coordination chemistry of <b>L1</b>, and comparatively, that of its structural analogue 2,11-dithia-5,8-diaza-2,6-pyridinophane (<b>L2</b>), featuring two secondary nitrogen atoms in the macrocyclic unit, the crystal structures of the new synthesised complexes [Pb(<b>L1</b>)(ClO₄)₂]·½CH₃CN, [Cu(<b>L2</b>)](ClO₄)₂·CH₃CN and [Cd(<b>L2</b>)(NO₃)]NO₃ were determined by X-ray diffraction analysis. …”
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From transition management towards just transition and place-based governance. Τhe case of Western Macedonia in Greece by Lefteris Topaloglou, Lefteris Ioannidis

“…The discourse about place, policies, and governance, reveals the need for focusing on a balance and mix of inclusive and multi-scalar policies instead of defining governance structures and bodies in charge for implementing transition policies. …”
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