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20521
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20522
Influenza A virus hemagglutinin: from classical fusion inhibitors to proteolysis targeting chimera-based strategies in antiviral drug discovery
Published 2024-02-01“…To this end, attention will primarily be focused on the analysis of the X-ray crystallographic structures of HA bound to fusion inhibitors. Furthermore, this study also aims to highlight the efforts made in exploiting the structural information in conjunction with molecular modeling techniques to discern the mechanism of action of the fusion inhibitors and to assist the design and interpretation of structure-activity relationships of novel lead compounds will be highlighted. …”
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20523
<sup>Et</sup>IDip (<sup>Et</sup>IPr)—Synthesis, Characterisation and Reactivity of a Robust, Backbone-Modified N-Heterocyclic Carbene and Group 13 Element Complexes
Published 2025-01-01“…The properties of the <sup>Et</sup>IDip and IDip ligands are compared and the molecular structures of (DipNCEt)<sub>2</sub>, [<sup>Et</sup>IDipH]Cl, [<sup>Et</sup>IDipH]I, <sup>Et</sup>IDip, [<sup>Et</sup>IDipCl]Cl, <sup>Et</sup>IDipF<sub>2</sub>, <sup>Et</sup>IDipO, <sup>Et</sup>IDipBBr<sub>3</sub>, <sup>Et</sup>IDipAlI<sub>3</sub>, <sup>Et</sup>IDipGaI<sub>3</sub>, and <sup>Et</sup>IDipAlH<sub>3</sub> have been determined.…”
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20524
Designing host-associated microbiomes using the consumer/resource model
Published 2025-01-01“…For example, there has been a boom in machine-learning models aiding in the design of proteins with user-specified structures or functions. Host-associated microbiomes play important roles in animal health and disease, as well as the productivity and environmental footprint of livestock species. …”
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20525
A Blueprint for the Problem Formulation Phase of EPA-Type Ecological Risk Assessments for 316(b) Determinations
Published 2002-01-01“…We describe the EPA’s ecological risk assessment framework and recommend that this framework be used to more effectively address differences in management objectives and structure §316(b) determinations. We provide a blueprint for the problem formulation phase of EPA-type ecological risk assessments for cooling-water intake structures (CWIS) at existing power plant facilities. …”
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20526
Effects of non-contact electric fields on the kidneys and livers of tumour-bearing rats [version 6; peer review: 1 approved, 2 approved with reservations, 1 not approved]
Published 2025-02-01“…Therefore, this study aimed to investigate the effects of non-contact electric field exposure on kidney and liver structures. Methods Female rats were randomly divided into one control group and three treatment groups with six replications each. …”
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20527
Involving national stakeholders in a systems approach to map drivers of childhood obesity and actions to prevent childhood obesity in Denmark: the Generation Healthy Kids Study
Published 2025-01-01“…To facilitate a shared understanding of the complex structures and relationships that determine children’s weight development, systems approaches have shown promising potential. …”
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20528
Intra-articular Glenoid Fracture Managed by Arthroscopic Fixation and Open Reduction and Internal Fixation Techniques: An Analytical Study
Published 2024-01-01“…Due to complex anatomy and neurovascular structures in vicinity, operative treatment is relatively uncommon. …”
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20529
"ANAPUS KANTO": M. FOUCAULT NAUJOJI MORALĖS GENEALOGIJA
Published 2003-01-01“…Foucault in his genealogy investigates historical structures of morality. In every historical culture he discerns the same repeating structural contours of morality. …”
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20530
Challenges of Corporate Misconduct: The Organisational, Social, Economic and Financial Dynamics of Workplace Sexual Harassment in the Restaurant Industry in the USA
Published 2024-12-01“…It highlights the pervasive and structural issues contributing to workplace harassment in this sector, characterized by hierarchical systems and demanding environments that often enable misconduct. …”
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20531
Management Control System and Financial Performance of Micro Finance Institutions in Central Region Uganda
Published 2019“…The study confirmed efficient control system factor structure of observed variables and the latent variables. …”
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20532
Dépôts et pratiques symboliques dans l’établissement aristocratique gaulois de Varennes-sur-Seine, la Justice (Seine-et-Marne)
Published 2021-12-01“…The decomposing juices from the meat were likely intended as nourishment for the subterranean deities, which makes it possible to compare this structure to the hollow altars of Latin sanctuaries. …”
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20533
How autocrats compete : parties, patrons, and unfair elections in Africa /
Published 2018Table of Contents: “…The puzzle of electoral authoritarian competition -- Ruling parties, international patrons, and electoral authoritarian competition -- Electoral authoritarian competition and the African experience -- The origins and structure of ruling parties in Tanzania, Cameroon, and Kenya -- Ruling party credibility and the management of elite competition -- Ruling party credibility and the sources of voter support -- The electoral consequences of international patronage -- Authoritarian competition in Africa's former single-party regimes -- Conclusions: the comparative study of electoral authoritarianism.…”
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20534
Determinants of continuation on HIV pre-exposure propylaxis among female sex workers at a referral hospital in Uganda: a mixed methods study using COM-B model
Published 2025-01-01“…Integration of PrEP with other services and scale up of community PrEP delivery structures may improve its continuation.…”
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20535
A ‘torn bag mechanism’ of small extracellular vesicle release via limiting membrane rupture of en bloc released amphisomes (amphiectosomes)
Published 2025-02-01“…We previously found evidence that human colorectal cancer cells in vivo release large multivesicular body-like structures en bloc. Here, we tested whether this large EV type is unique to colorectal cancer cells. …”
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20536
Effect of Planting Systems on the Physicochemical Properties and Bioactivities of Strawberry Polysaccharides
Published 2025-01-01“…These findings suggest that different planting systems significantly affect both the molecular structures and functionalities of SPs, with GP-SP demonstrating enhanced hypoglycemic and anti-glycation properties. …”
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20537
L’alimentation hydraulique de Saint-Romain-en-Gal (Rhône), quartier de Vienne antique (Isère)
Published 2023-12-01“…They would then have been absorbed or integrated into the urban structure that developed from the Augustan era onwards. …”
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20538
Technical Report on the New Ultrasound Lateral Mid-Shaft Approach to the Sciatic Nerve: A Never-Ending Story
Published 2025-01-01“…By targeting the mid-thigh area, the ultrasound beam accesses anatomical structures that are more superficial, improving the technique’s efficacy. …”
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20539
Parejas heterosexuales serodiscordantes en Chiapas, México. La influencia del género en la expresión de la agencia/Heterosexual HIV-Discordant Couples in Chiapas, Mexico. The Influ...
Published 2019-06-01“…Based on the assumption that people do not lack the power to confront and occasionally transform social structures, this study was carried out in order to explore and compare the strategies followed by two men and two women with HIV, in forming couples, with people who did not have it (HIV-discordant couple). …”
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20540
Diagnostics and Treatment of Esophageal Achalasia (Clinical Guidelines of the Russian Gastroenterological Association, Russian Scientific Medical Society of Internal Medicine, Russ...
Published 2025-02-01“…Treatment of achalasia can be pharmacological, endoscopic (pneumatic balloon dilation, peroral endoscopic myotomy, botulinum toxin injection), aimed at regulating the tone and motility of the esophagus and cardia while preserving all anatomical structures, and surgical (laparoscopic esophagocardiomyotomy, esophagectomy), in which the muscle fibers of the esophagus and esophagogastric junction are intersected or the altered esophagus is completely removed with simultaneous formation of an artificial esophagus from the stomach or colon (esophagoplasty).Conclusion. …”
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