Identification of a binding site for small molecule inhibitors targeting human TRPM4 by Babatunde Ekundayo, Prakash Arullampalam, Christian E. Gerber, Anne-Flore Hämmerli, Sabrina Guichard, Mey Boukenna, Daniela Ross-Kaschitza, Martin Lochner, Jean-Sebastien Rougier, Henning Stahlberg, Hugues Abriel, Dongchun Ni

“…We determine three cryo-EM structures of full-length human TRPM4 embedded in native lipid nanodiscs without inhibitor, bound to NBA, and an anthranilic acid derivative, IBA. …”
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带部分螺纹的螺杆伸入螺孔中的连接承载力分析 by 徐忠根, 陈千, 邓长根, 陈荣毅

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Enhancing Periodontal Ligament Regeneration via PDLSC Delivery Using Electrospun PCL/Collagen/Cellulose Acetate Scaffolds and Collagen Hydrogel Incorporated with Curcumin-Loaded ZI... by Lan X, Wang Y, Yin M

“…Histological analysis confirmed the formation of organized PDL structures and improved bone-cementum integration that arekey indicators of successful periodontal regeneration.Conclusion: The developed scaffold-hydrogel system facilitates PDL regeneration by modulating inflammation and promoting pro-healing factor expression. …”
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Emerging PET Radiotracers and Targets for Imaging of Neuroinflammation in Neurodegenerative Diseases: Outlook Beyond TSPO by Vidya Narayanaswami PhD, Kenneth Dahl PhD, Vadim Bernard-Gauthier PhD, Lee Josephson PhD, Paul Cumming PhD, Neil Vasdev PhD

“…We now review the lead structures in radiotracer development for PET studies of neuroinflammation targets for neurodegenerative diseases extending beyond TSPO, including glycogen synthase kinase 3, monoamine oxidase-B, reactive oxygen species, imidazoline-2 binding sites, cyclooxygenase, the phospholipase A2/arachidonic acid pathway, sphingosine-1-phosphate receptor-1, cannabinoid-2 receptor, the chemokine receptor CX3CR1, purinergic receptors: P2X 7 and P2Y 12 , the receptor for advanced glycation end products, Mer tyrosine kinase, and triggering receptor expressed on myeloid cells-1. …”
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Method and Spatiotemporal Analysis for Impervious Surface Extraction Based on an Improved DeepLabV3+ Model by Xueyi Wang, Bowen Fan, Yanguo Fan, Ran Xu, Guangyue Feng, Qingchun Guan

“…However, existing methods face significant challenges handling high-resolution remote sensing images, especially in distinguishing impervious surfaces from regions with complex building structures and similar texture features. These challenges often lead to omission, misclassification, and blurred boundaries, affecting the accuracy and reliability of segmentation results. …”
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Study on Mechanical Performance of Prestressed UHPFRC U-Beam Bridges by Mengying Liu, Eugen Brühwiler, Fengkun Cui, Yue Xu

“…Then, the finite element model considering material nonlinearity and structural ductility is established using Midas FEA software. …”
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新型喷头式节点抗弯性能及其幂函数模型研究 by 李韧, 肖志成, 李会军, 李宝辉

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钢管混凝土基本构件承载力的设计计算——各国规程比较(Ⅰ) by 韩林海, 陶忠, 尧国皇, 杨有福

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Hydrophobic deep eutectic solvents as novel, sustainable aids for intracellular protein release from Saccharomyces cerevisiae by Tjalling Gijsbert Tjalsma, Yannick Patrice Didion, Ziran Su, Magdalena Malankowska, Pablo Torres-Montero, José Luis Martínez, Manuel Pinelo

“…Despite the similar structures of the hydrogen bond acceptor (HBA) and hydrogen bond donor (HBD), DESs with L-menthol and lidocaine as HBA and a fatty acid as HBD exhibited superior performance compared to DESs consisting solely of L-menthol and lidocaine or those derived from fatty acids only. …”
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Highly corrosion-resistant and photocatalytic hybrid coating on AZ31 Mg alloy via plasma electrolytic oxidation with organic-inorganic integration by Talitha Tara Thanaa, Mohammad Aadil, Alireza Askari, Arash Fattah-alhosseini, Mohammad Alkaseem, Mosab Kaseem

“…The hybrid coating exhibited unique twig-like surface structures that contributed to forming a multifunctional coating with high corrosion resistance and superior photocatalytic activity. …”
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可拆装式箱型房屋整体受力性能研究 by 张俊峰, 张英豪, 赵俊杰, 李毅伟

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Liquid-induced heat treatment strategy for eliminating anisotropy of IN718 fabricated by laser powder bed fusion by Zhuoyu Li, Xiaogang Hu, Fan Zhou, Zhifang Shi, Zhiwei Lyu, Zhen Xu, Yu Li, Xin Zhao, Hongxing Lu, Qiang Zhu

“…The laser-based additive manufacturing process often results in highly textured columnar grain structures along the build direction, leading to undesirable anisotropic mechanical properties in most industrial applications. …”
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Identification of a putative novel polycyclic aromatic hydrocarbon-biodegrading gene cluster in a marine Roseobacteraceae bacterium Sagittula sp. MA-2 by Mayuko Abe, Miharu Sakai, Robert A. Kanaly, Jiro F. Mori

“…Catabolic functions of the enzymes encoded in strain MA-2 were predicted through the profiling of phenanthrene biotransformation products by liquid chromatography-electrospray ionization high-resolution mass spectrometry and substrate docking simulations using predicted three-dimensional structures of selected proteins, and phenanthrene biodegradation pathways were proposed. …”
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基于多尺度数值分析方法的连续钢桁梁桥受力性能分析 by 安鹏, 王文炜

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Delayed Supplementation Strategy of Extracellular Vesicles from Adipose-Derived Mesenchymal Stromal Cells with Improved Proregenerative Efficiency in a Fat Transplantation Model by Shan Mou, Yuan Li, Di Sun, Muran Zhou, Jialun Li, Lifeng Chen, Shaokai Liu, Jie Yang, Peng Xiao, Jing Tong, Zhenxing Wang, Jiaming Sun

“…The migration of HUVECs was assessed using the scratch wound healing assay, whereas the length of tubes and number of vessel-like structures formed by HUVECs were determined using tube formation assay. …”
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Storage Insects on Yam Chips and Their Traditional Management in Northern Benin by Y. L. Loko, A. Dansi, M. Tamo, A. H. Bokonon-Ganta, P. Assogba, M. Dansi, R. Vodouhè, A. Akoegninou, A. Sanni

“…To further promote the production of yam chips, diversification of insect-resistant yam varieties, conception, and use of health-protective natural insecticides and popularization of modern storage structures were proposed.…”
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Genome-Wide Study of Plant-Specific PLATZ Transcription Factors and Functional Analysis of <i>OsPLATZ1</i> in Regulating Caryopsis Development of Rice (<i>Oryza sativa</i> L.) by Tao Yang, Xin-Tong Xu, Li-Jun Tang, Wen-Tao Wei, Yuan-Yuan Zhao, Jin-Xin Liu, Xue-Feng Yao, Heng Zhao, Chun-Ming Liu, Ai-Ning Bai

“…An analysis of protein structures and sequence motifs showed that OsPLATZs were similar within groups, but varied between them. …”
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Experimental and Theoretical Investigations of Hard Rocks at High Temperature: Applications in Civil Engineering by Mambou Ngueyep Luc Leroy, Foguieng Wembe Marius, Ngapgue François

“…It is the reason for which these results may be useful to characterize the damage and thus predict the dramatic consequences of large temperature fluctuations on engineering structures in the rock.…”
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Excess mortality and associated community risk factors related to hurricane Maria in Puerto Rico by Kristen N Cowan, Diego E Zavala, Erick Suarez, José A Lopez-Rodriguez, Omar Alvarez

“…Examining community level characteristics associated with vulnerability to disasters, neighborhoods with higher proportion of people 65 and older, higher proportion of houses being multiunit structures and higher proportion of households with no vehicle, in comparison to other neighborhoods in Puerto Rico,were more likely to have sustained high risk for mortality before and after Maria or increased risk of being a hot spot for chronic disease mortality after Maria.…”
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Multiwideband Bandpass Filter Based on Folded Quad Cross-Stub Stepped Impedance Resonator by Gunawan Wibisono, Teguh Firmansyah, Herudin Herudin, Muh Wildan, Toto Supriyanto, Mudrik Alaydrus, Febrizal Ujang

“…The proposed QC-SSIR is designed on a four-series arrangement of crossed open stub (COS) structures where each open stub is developed with a step impedance resonator (SIR) structure to generate a wide bandwidth. …”
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