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47701
Endo 180 participates in collagen remodeling of the periodontal ligament during orthodontic tooth movement
Published 2024-12-01“…Collagen remodeling plays a crucial role during this process, allowing for the necessary changes in the PDL’s structure and function. Endo180, an urokinase plasminogen activator receptor-associated protein, is a transmembrane receptor regulated collagen remodeling. …”
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47702
Biliary atresia susceptibility gene EFEMP1 regulates extrahepatic bile duct elastic fiber formation and mechanics
Published 2025-01-01“…We examined extrahepatic bile duct structure and mechanics in three models: neonatal vs. adult rat ducts (n = 6 each), elastase-treated adult rat ducts (n = 6-7 each), and Efemp1+/- vs. wild-type mouse ducts (n = 6 each). …”
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47703
Antibacterial Potential of Honeybee Venom and <i>Monascus purpureus</i> Extracellular Metabolites Against Multidrug-Resistant Pathogenic Bacteria
Published 2024-12-01“…Furthermore, GC–MS-based analysis revealed that the chemical composition of BV and RD extracts exhibited highly diverse structures, including complex polycyclic systems, porphyrins, steroids, and esters. …”
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47704
Exploration of Degradation Mechanism of Chlorogenic Acids in Stevia Based on UPLC-QTOF MS/MS
Published 2025-01-01“…In acidic or alkaline conditions, hydrolysis and structural transformations are common degradation pathways observed. …”
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47705
An analytical cross-sectional study on optimal (timely or cumulative age-appropriate) routine childhood immunization coverage in the communities of Ebonyi state, Nigeria
Published 2025-01-01“…Data was collected using structured interviewer-administered questionnaire in KoBoCollect in android devices. …”
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47706
MT2A promotes angiogenesis in chronically ischemic brains through a copper–mitochondria regulatory mechanism
Published 2025-02-01“…HUVEC activity and mitochondrial structure and function were detected to explore the ability of MT2A to alleviate CPO-induced damage. …”
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47707
First assessment of biofouling assemblages in the northern Red Sea, an important region for marine non-indigenous species transfer
Published 2025-02-01“…At each site and time, three settlement structures, each with a PVC panel attached to a brick and rope, were sampled after 3-months deployment. …”
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47708
Effects of Chemical Fertilizer Reduction Combined with Straw and Organic Fertilizer Application on Soil Acidification Mitigation and Erosion Control
Published 2024-12-01“…[Conclusion] Based on soil acidification improvement, fertility enhancement, structural improvement, and rapeseed economic benefits, chemical fertilizer reduction (30%) coupled with straw returning (6 000 kg/hm2) and 3 000 kg/hm2 organic fertilizer application can be recommended as the optimal management strategy. …”
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47709
Rat models of postintracerebral hemorrhage pneumonia induced by nasal inoculation with Klebsiella pneumoniae or intratracheal inoculation with LPS
Published 2025-01-01“…Disruptions of the intestinal structure and gut barrier and the reductions of the protective intestinal IL-17A-producing γδT cells were also observed. …”
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47710
Mid-Infrared High-Power InGaAsSb/AlGaInAsSb Multiple-Quantum-Well Laser Diodes Around 2.9 μm
Published 2025-01-01“…Furthermore, a novel epitaxial laser structure was designed to acquire low optical absorption loss by decreasing the optical confinement factor in the cladding layer and implementing gradient doping in the p-type cladding layer. …”
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47711
Genomic characteristics of ST6115 carbapenem-resistant Klebsiella pneumoniae coharboring blaNDM-1 and blaIMP-4
Published 2025-02-01“…Annotation and analysis of the genome enabled the identification of the plasmid structure and the comparative analysis of the genetic background. …”
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47712
Food choice motivations and perceptions of healthy eating: a cross-sectional study among consumers in the UAE
Published 2025-02-01“…Based on distinct motivational structures identified through cluster analysis, personalised approaches can encourage healthier dietary practices. …”
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47713
Targeting the G-quadruplex as a novel strategy for developing antibiotics against hypervirulent drug-resistant Staphylococcus aureus
Published 2025-02-01“…Physicochemical assessments using UV–visible, circular dichroism, and nuclear magnetic resonance spectroscopy confirmed that the G4-motif present in the mraZ promoter formed an intramolecular parallel G4 structure, interacting with NMM. In vivo reporter followed by coupled in vitro transcription/translation (IVT) assays confirmed the role of mraZ G4 as a target interacting NMM to impose extreme antibacterial activity against both the gram-positive and -negative bacteria. …”
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47714
Comparative analysis of the human microbiome from four different regions of China and machine learning-based geographical inference
Published 2025-01-01“…The composition and structure of the bacteria at these three body sites were well characterized and found to differ regionally. …”
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47715
Carbohydrate ligand engagement with CD11b enhances differentiation of tumor-associated myeloid cells for immunotherapy of solid cancers
Published 2023-06-01“…Importantly, we observed that the BG34-200-CD11b engagement triggered endocytosis of the binding complexes in TAIMs, which induced intracellular F-actin cytoskeletal rearrangement, effective phagocytosis, and intrinsic ICAM-1 (intercellular adhesion molecule I) clustering. These structural biological changes resulted in the differentiation in TAIMs into monocyte-derived dendritic cells, which play a crucial role in T-cell activation in the tumor microenvironment.Conclusions Our research has advanced the current understanding of the molecular basis of CD11b activation in solid cancers, revealing how it converts the differences in BG34 carbohydrate ligands into immune signaling responses. …”
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47716
Benefits, limits, and risks of ChatGPT in medicine
Published 2025-01-01“…This heterogeneity in evidence quality necessitates a structured approach to future research and implementation.…”
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47717
Harmful newborn cord care practices and associated factors among mothers who gave birth in the last six months in Chencha town, Southern Ethiopia: a mixed-methods study
Published 2025-01-01“…Quantitative data was collected through structured interview questionnaires from 312 randomly selected mothers. …”
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47718
Deciphering the functional roles of PE18 and PPE26 proteins in modulating Mycobacterium tuberculosis pathogenesis and immune response
Published 2025-01-01“…Further studies focusing on their structure-function relationships and interactions with host proteins could accelerate the development of innovative therapeutic strategies.…”
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47719
Continuous theta-burst stimulation demonstrates language-network-specific causal effects on syntactic processing
Published 2025-02-01“…Hierarchical syntactic structure processing is proposed to be at the core of the human language faculty. …”
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47720
Assessing Heat Resistance and Selecting Heat-Resistant Individuals of Largemouth Bass (<i>Micropterus salmoides</i>) with Tiered Thermal Exposure
Published 2025-01-01“…To correlate the changes in tissue structure and gene expression with the heat resistance, a new batch of LMB juveniles (average body weight 23.66 ± 6.98 g) were subjected to tiered heat exposure. …”
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