RETRACTED ARTICLE: P16INK4a Deletion Ameliorated Renal Tubulointerstitial Injury in a Stress-induced Premature Senescence Model of Bmi-1 Deficiency by Jianliang Jin, Jianguo Tao, Xin Gu, Zhenzhen Yu, Rong Wang, Guoping Zuo, Qing Li, Xianhui Lv, Dengshun Miao

“…Our results demonstrated that p16INK4a deletion largely rescued renal aging phenotypes caused by Bmi-1 deficiency, including impaired renal structure and function, decreased proliferation, increased apoptosis, senescence and SASP, DNA damage, NF-κB and TGF-β1/Smad signal activation, inflammatory cell infiltration, and tubulointerstitial fibrosis and tubular atrophy. …”
Get full text

A Novel Eco-Friendly Process for the Synthesis and Purification of Ascorbyl-6-Oleates by Ha-Eun Ji, Se-Young Kim, Heejin So, Vivian Prayitno, Ki-Teak Lee, Jung-Ah Shin

“…FT-IR confirmed the presence of the ester bond (1733 cm⁻¹) and olefin structure (3006 cm⁻¹) of OA, and LC-ESI-MS/MS identified AO peaks at <i>m/z</i> 439.3. …”
Get full text

Area deprivation and premature cardiovascular mortality: a nationwide population-based study in South Korea by Hyeon Chang Kim, Hokyou Lee, Eunji Kim, Donald Lloyd-Jones, Young Gyu Ko, Byoung Gwon Kim

“…Mortality rates for CVD and its subtypes, namely ischaemic heart diseases, other heart diseases and cerebrovascular diseases, in adults under 65 years were directly standardised by sex and age, referencing the total population structure. Municipalities were categorised by urbanicity, and adjustments for the number of hospitals and geographical area size were made using log-linear regression models.Results The most deprived municipalities showed 41.6% excess mortality for CVD, 30.3% for ischaemic heart diseases, 60.7% for other heart diseases and 36.9% for cerebrovascular diseases compared with the least deprived municipalities. …”
Get full text

Multi-omics analyses identify gut microbiota-fecal metabolites-brain-cognition pathways in the Alzheimer’s disease continuum by Han Zhao, Xia Zhou, Yu Song, Wenming Zhao, Zhongwu Sun, Jiajia Zhu, Yongqiang Yu

“…We also observed progressive gray matter atrophy in broadly distributed gray matter regions and gradual micro-structural integrity damage in widespread white matter tracts along the AD continuum. …”
Get full text

Biomechanical Evaluation of Clival Screw Fixation for Occipitocervical Instablity: A Finite Element Analysis by Weipeng Lin, Jianying Zheng, Meichao Zhang, Panjie Xu, Hang Xiao, Wei Ji

“…ABSTRACT Objective The clivus is trapezoidal in shape with uneven bone structure, the optimal number and position of screws for clival fixation are not clear. …”
Get full text

Abnormal Circadian Modification of Aδ-Fiber Pathway Excitability in Idiopathic Restless Legs Syndrome by Catello Vollono, Giacomo Della Marca, Elisa Testani, Anna Losurdo, Daniela Virdis, Diana Ferraro, Valerio Brunetti, Paolo M. Rossini, Domenica Le Pera, Salvatore Mazza, Massimiliano Valeriani

“…This study confirms the structural integrity of Aδ nociceptive system in idiopathic RLS, but it also suggests that RLS patients present circadian modifications in the pain system. …”
Get full text

Peroxiredoxin 6 maintains mitochondrial homeostasis and promotes tumor progression through ROS/JNK/p38 MAPK signaling pathway in multiple myeloma by Dandan Gao, Yang Lv, Fei Hong, Dong Wu, Ting Wang, Gongzhizi Gao, Zujie Lin, Ruoyu Yang, Jinsong Hu, Aili He, Pengyu Zhang

“…In addition, oxidative stress decreased mitochondrial membrane potential (MMP), reduced gene expression levels of oxidative phosphorylation (OXPHOS), and increased in the density of mitochondrial crumpling, leading to mitochondrial structural abnormalities and dysfunction. Furthermore, PRDX6 deficiency combined with bortezomib induced a robust anti-tumor effect in MM cell lines. …”
Get full text

Expression Profile of Long Noncoding RNAs and Circular RNAs in Mouse C3H10T1/2 Mesenchymal Stem Cells Undergoing Myogenic and Cardiomyogenic Differentiation by Mingshan Li, Zijie Pei, Hongtao Zhang, Jing Qu

“…Results. Myotube-like structure was formed after 5-AZA treatment of C3H10T1/2 cells. …”
Get full text

Zero-Shot Remote Sensing Scene Classification Based on Automatic Knowledge Graph and Dual-Branch Semantic Correlation Supervision by Chao Wang, Jiajun Yang, Tanvir Ahmed, Yang Zhao, Tong Zhang, Bing Sun, Tao Xie, Jie Wang, Tianyu Chen

“…On this basis, the dual-branch semantic correlation supervised zero-shot remote sensing scene classification network (DBSS) supervises the mapping of semantic features to the visual space via both global and local branches, ensuring the visual space reflects the correlation structure of the semantic space. Extensive experiments on the UCM, AID, and NWPU datasets demonstrate that AKG-DBSS achieves class average accuracy and overall accuracy of up to 98&#x0025;, and 59.56&#x0025;, respectively, for the classification of unseen class scenes, with standard deviations below 6.91&#x0025;, significantly outperforming four other advanced comparative methods. …”
Get full text

Fabrication of Cu: ZnO thin film sensor for ethanol vapor detection by Robin Simkhada, Dalton R. Gibbs, Soma Dhakal, Dipak Oli, Rishi Ram Ghimire, Deependra Das Mulmi, Leela Pradhan Joshi

“…The morphology study showed their porous and granular surface structure. These films' elemental analysis demonstrated the good incorporation of Cu into the ZnO matrix. …”
Get full text

An illustrated key for identification of colour aberrations in alcids with a revision of nomenclature used by K. Cieślińska, P. Bodson, E. Gruber, K. Piening, M. Syposz, K. Wojczulanis-Jakubas, D. Jakubas

“…In this study we review colour aberrations of integumentary structures (plumage and bare parts: beak, eye iris, legs) in a group of pelagic seabirds, alcids. …”
Get full text

The effect of political will, information technology, and the quality of financial reporting information on fraud prevention by Haliah, Hasnawiya Hasan, Syamsuddin, Fatmawati, Andi Ratna Sari Dewi, Muhammad Alief Fahdal Imran Oemar, Linda Arisanty Razak

“…Data analysis was conducted using partial least squares structural equation modeling with the help of the SmartPls 4.0 application. …”
Get full text

Profiling of pathogenic variants in Japanese patients with sarcoglycanopathy by Rui Shimazaki, Yoshihiko Saito, Tomonari Awaya, Narihiro Minami, Ryo Kurosawa, Motoyasu Hosokawa, Hiroaki Ohara, Shinichiro Hayashi, Akihide Takeuchi, Masatoshi Hagiwara, Yukiko K. Hayashi, Satoru Noguchi, Ichizo Nishino

“…Genetic analyses were performed using a combination of targeted resequencing with a hereditary muscle disease panel, whole genome sequencing, multiplex ligation-dependent probe amplification, and long-read sequencing. The structures of transcripts with aberrant splicing were also determined by RT-PCR, RNA-seq, and in silico prediction. …”
Get full text

Molecular Mechanism of Germinated Foxtail Millet Bioactive Peptides in Attenuating Copper-induced Oxidative Damage in Caenorhabditis elegans by Huiqi ZHANG, Xiao CHEN, Xueling JIN, Jingjing LI, Juanli YUAN, Jinyan GAO, Hongbing CHEN, Yong WU

“…At the genetic level, GRBPs mainly regulated the structural constituent of cuticle and the expression of genes related to cytochrome enzyme P450 in C. elegans. …”
Get full text

No-tillage practice enhances soil total carbon content in a sandy Cyperus esculentus L. field by Cong Wang, Yuxiang Hu, Hui Wu, Zhirui Wang, Jiangping Cai, Heyong Liu, Wei Ren, Ning Yang, Zhengwen Wang, Yong Jiang, Hui Li

“…The variations in soil bacterial community structure were investigated by 16S rRNA amplicon sequencing. …”
Get full text

Characterization of squash polysaccharide and the anti-diabetic effect on type 2 diabetic rat revealed by urine metabolomics analysis by Li Liang, Fuming Zhang, Quanhong Li, Baoguo Sun, Yuyu Zhang, Robert J. Linhardt

“…The present study reports the structural characteristics of 3 polysaccharide fractions (SPS-F1, SPS- F2 and SPS-F3) isolated and purified from squash. …”
Get full text

Salvage radiofrequency ablation followed by external beam radiotherapy for inoperable recurrent differentiated thyroid cancer by Chung-Shih Chen, Sheng-Dean Luo, Yen-Hsiang Chang, Chen Kai Chou, Shun-Yu Chi, Shao-Chun Wu, Yen-Hao Chen, Johnson Chia-Shen Yang, Eng-Yen Huang, Yu-Ming Wang, Wei-Che Lin

“…For lesions invading critical structures intolerant to ‘en bloc’ high-temperature RFA, limited-field EBRT using 6‐ or 10‐MV photons was used for adjuvant treatment at a dose of 66 Gy in 33 daily fractions. …”
Get full text

Interfacial charge transfer on hierarchical synergistic shell wall of MXene/MoS2 on CdS nanospheres: heterostructure integrity for visible light responsive photocatalytic H2 evolut... by Kugalur Shanmugam Ranjith, Ali Mohammadi, Ganji Seeta Rama Raju, Yun Suk Huh, Young-Kyu Han

“…The dual surface wrapping of MXe/MoS2 over CdS nanospheres confirmed the structural durability that remained intact throughout the photocatalytic reaction, promoting approximately 93.1% of its catalytic property even after five repeatable cycles. …”
Get full text

In-Hospital Macro-, Meso-, and Micro-Drivers and Interventions for Antibiotic Use and Resistance: A Rapid Evidence Synthesis of Data from Canada and Other OECD Countries by Rosa Stalteri Mastrangelo, Anisa Hajizadeh, Thomas Piggott, Mark Loeb, Michael Wilson, Luis Enrique Colunga Lozano, Yetiani Roldan, Hussein El-Khechen, Anna Miroshnychenko, Priya Thomas, Holger J. Schünemann, Robby Nieuwlaat

“…We found that hospital structures and policies may influence antibiotic utilization and variations in antimicrobial management. …”
Get full text

Amyloidogenic immunoglobulin light chains disturb contractile function and calcium transients in a human cardiac spheroid model of light chain (AL) amyloidosis by Mélanie Bézard, Jean-Sébastien Vartanian-Grimaldi, Julien Henri, Denisa Calin, Amira Zaroui, Mounira Kharoubi, Thibaud Damy, Onnik Agbulut, Ekaterini Kordeli

“…LC-treated hiPSC-CM cultures and LC-containing spheroids presented structural and functional defects including: (1) decreased levels and subcellular disorganization of sarcomeric protein alpha-actinin; (2) abnormal accumulation of calcium handling SERCA2a protein; (3) impaired contractility of spheroids and altered calcium transients. …”
Get full text