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  1. 25721

    Physicochemical Properties, Antioxidant Activity, and Flavor Profile of Strawberry Fruit-Based Novel Drinking Jelly Made with <i>Gracilaria fisheri</i> Seaweed as a Gelling Agent a... by Narin Charoenphun, Paramee Noonim, Somwang Lekjing, Chawakwan Nitikornwarakul, Nam Hoang Pham, Karthikeyan Venkatachalam

    Published 2025-01-01
    “…The results demonstrated that GF concentration significantly affected the color characteristics, structural development, and flavor profiles of the drinking jelly samples. …”
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  2. 25722

    Corticostriatal maldevelopment in the R6/2 mouse model of juvenile Huntington's disease by Carlos Cepeda, Sandra M. Holley, Joshua Barry, Katerina D. Oikonomou, Vannah-Wila Yazon, Allison Peng, Deneen Argueta, Michael S. Levine

    Published 2025-01-01
    “…There is a growing consensus that brain development in Huntington's disease (HD) is abnormal, leading to the idea that HD is not only a neurodegenerative but also a neurodevelopmental disorder. Indeed, structural and functional abnormalities have been observed during brain development in both humans and animal models of HD. …”
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  3. 25723

    Comparative Study of the Chemical Composition Disparities Between Fast-twitch and Slow-twitch Muscles in Marine Teleost Fishes by Huan WANG, Shufang LIU

    Published 2025-02-01
    “…Being the most ancient vertebrates, fish inhabit aquatic environments, where their skeletal muscles serve as structural and locomotor organs and as a crucial source of high-quality protein for human consumption. …”
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  4. 25724

    In vitro functional validation of anti-CD19 chimeric antigen receptor T cells expressing lysine-specific demethylase 1 short hairpin RNA for the treatment of diffuse large B cell l... by Zhi Guo, Zhi Guo, Mingxin He, Ning Liu, Yiqing Yang, Rui Sun, Jianxun Wang, Qiang Wang

    Published 2025-01-01
    “…Epigenetic modifications can regulate T cell activation, maturation and depletion; they can be applied to reduce T cell depletion, improve infiltration, and promote memory phenotype formation to reduce relapse after CAR-T cell therapy.PurposeWe propose to develop and validate in vitro the function of novel CAR-T cells for the treatment of DLBCL, which simultaneously express an anti-CD19 CAR with lysine-specific demethylase 1 (LSD1) short hairpin (sh)RNA to prevent depletion and prolong the survival of CAR-T cells.MethodsWe designed an shRNA sequence targeting LSD1 mRNA, and created a vector with the following elements: the U6 promoter driving expression of the LSD1 shRNA sequence, the EF1a promoter driving a second-generation anti-CD19 CAR sequence encoding an anti-CD19 single-chain variable fragment (FMC63), the CD8 hinge and transmembrane structural domains, the CD28 co-stimulatory structural domain, and the CD3ζ-activating structural domain. …”
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  5. 25725

    Effect and Mechanism of Action of Pushing Method on Rats with Skeletal Muscle Overuse Injury based on Wnt/β-catenin Signaling Pathway by DUAN Miaomiao, HUANG Bo, RUAN Lei, MU Pangpang, CHEN Yiming, PENG Liang

    Published 2024-01-01
    “…Catenin protein expression levels.Results(1) Comparison of motor function:compared with the blank group, the time of passing through the balance beam and the number of times of sliding paw were significantly increased in the model group and intervention group after intervention, and the difference was statistically significant (<italic>P</italic>&lt;0.05); compared with the model group, the time of passing through the paw and the number of times of sliding paw were significantly decreased in the intervention group after intervention, and the difference was statistically significant (<italic>P</italic>&lt;0.05). (2) Gastrocnemius muscle histopathological changes:the model group can be seen in the gastrocnemius muscle a large number of myocytes can be seen within the cracks, myogenic fibers fracture; compared with the model group, the degree of damage to the gastrocnemius muscle tissues in the intervention group to reduce the degree of damage, can be seen in the form of myofibers is regular, neatly arranged. (3) Ultrastructural changes in gastrocnemius muscle tissue:local myogenic fiber bundles were broken and dissolved, and a small amount of Z-line structure was dissolved and blurred; compared with the model group, the gastrocnemius muscle cells in the intervention group were slightly edematous, and the structure of the myogenic fiber bundles was clear; part of the myogenic fiber bundles were broken, and the structure of the Z-lines was clear and more neatly arranged. (4) Gastrocnemius muscle tissue MyoD, MyoG and Pax7 mRNA transcript levels:compared with the blank group, MyoD, MyoG and Pax7 mRNA transcript levels were significantly higher in both the model group and the intervention group (<italic>P</italic>&lt;0.05); compared with the model group, MyoD, MyoG and Pax7 mRNA transcript levels were significantly higher in the intervention group (<italic>P</italic>&lt;0.05). (5) Gastrocnemius muscle tissue MyoD, MyoG and Pax7 protein expression level:compared with the blank group, MyoD, MyoG and Pax7 protein expression water were significantly higher in both the model group and the intervention group (<italic>P</italic>&lt;0.05); compared with the model group, MyoD, MyoG and Pax7 protein expression level was significantly higher in the intervention group (<italic>P</italic>&lt;0.05). (6) Wnt3a, Axin2 and β-catenin protein expression levels in gastrocnemius muscle tissues:compared with the blank group, Wnt3a, Axin2 and β-catenin protein expression levels were significantly higher in both the model group and the intervention group (<italic>P</italic>&lt;0.05); compared with the model group, Wnt3a, Axin2 and β-catenin protein expression levels were significantly higher in the intervention group (<italic>P</italic>&lt;0.05).ConclusionPushing method can improve the gastrocnemius muscle injury and motor function in rats with overuse injury model, and its mechanism may be related to the activation of Wnt/β-catenin signaling pathway.…”
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  6. 25726
  7. 25727

    Re-engineering change in higher education by David Allen, N. Fifield

    Published 1999-01-01
    “…The conclusions drawn from the research are that the organisational culture and structure of HEIs limit the degree of change sought from a BPR project: the focus of the case study HEIs was on incremental process improvement of administrative services. …”
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  8. 25728

    A neo-positivist theory of scientific change by Michael Bycroft, James Poskett

    Published 2024-01-01
    “…They differ with respect to chronology, geography, narrative structure, favoured disciplines, recent revisionism and epistemology. …”
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  9. 25729

    Biclique cryptanalysis on lightweight block ciphers I-PRESENT-80 and I-PRESENT-128 by Jie CUI, Hai-feng ZUO, Hong ZHONG

    Published 2017-11-01
    “…I-PRESENT was a lightweight SPN block cipher for resource-constraint environments such as RFID tags and sensor networks.The biclique structures of I-PRESENT with sieve-in-the-middle technique was an constracted.The biclique cryptanalysis schemes on full-round I-PRESENT-80 and I-PRESENT-128 were proposed for the first time.The results show that the data complexity of the biclique cryptanalysis on I-PRESENT-80 and I-PRESENT-128 is 2 <sup>26</sup> and 2<sup>36</sup> chosen ciphertexts respectively,and the time complexity on them is 2 <sup>79.48</sup> and 2 <sup>127.33</sup> encryptions respectively.The time and data complexity are better than that of the exhaustive attack.In addition,the time complexity on them can be reduced to 2 <sup>78.61</sup> and 2<sup>126.48</sup> encryptions by using related-key technology of I-PRESENT.…”
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  10. 25730
  11. 25731

    Détection automatique des parcelles sur les plans napoléoniens : comparaison de deux méthodes by Jean-Michel Follin, Élisabeth Simonetto, Anthony Chalais

    Published 2021-05-01
    “…It contains a wealth of information (e.g. cadastre lot structure, lot numbering, rivers and road shapes, toponymy, buildings…) which underpin most historical studies of land usage and transformation. …”
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  12. 25732

    Strategic Antecedents and Consequents for the Performance of E-Business Companies by Elnivan Moreira de Souza, Paulo César de Sousa Batista

    Published 2017-01-01
    “…We tested the proposed model with a sample of 252 observations, using the structural equation modeling. The main results indicate a partial influence of the strategic background in the value proposition through the constructs management positioning, organizational readiness, relative advantage and pressure from stakeholders. …”
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  13. 25733

    Openings: the Act of Modelizing and the Question of Complexity by Emilie Janton

    Published 2010-02-01
    “…Richard Powers’ novels are commonly associated with “systems novels” as Tom LeClair first described them, notably because of the constant compositional use the novelist makes of different extra-textual systems (including various fields such as biology, computer science, or more extensively chaos theory).To what extent do those modelized systems, apparently meant to supply structuring tools to readers keen for interpretive keys, contribute to the novels’ inner complexity, and how does their installation in the texts take place? …”
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  14. 25734

    Face aux pollutions : hiérarchies et solidarités entre fumeuses de poissons à Abidjan by Marie Belland, Alain Bonnassieux

    Published 2022-09-01
    “…In this perspective, relations of dependence structuring women-led activities of the popular economy are analyzed, and especially the practices of entrusting the juvenile workforce, as well as the professional path of young helpers in the face of risks, between exploitation and emancipation. …”
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  15. 25735

    Exploring the Nonlinear Effect of Intellectual Capital on Financial Performance: Evidence from Listed Shipping Companies in China by Jian Xu, Yi Zhang

    Published 2021-01-01
    “…Regarding IC components, human, relational, and innovation capitals have an inverted U-shaped relationship with FP, while the quadratic relationship between structural capital and FP is not significant. In addition, physical capital has a U-shaped relationship with FP. …”
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  16. 25736
  17. 25737

    O rei que esmorece e a rainha sanhuda by Inês Olaia

    Published 2020-01-01
    “…We will study the emotional palette expressed by the kingdom’s official chronicler and perceived by his Portuguese medieval readers in an attempt to understand how it sustains the rise to the throne of the Master of the Military Order of Avis. The work is structured around three royal couples and the emotions expressed and provoked by them: Leonor Teles and D. …”
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  18. 25738

    Ultrawideband Vivaldi Antenna for DVB-T, WLAN, and WiMAX Applications by Dalia M. Elsheakh, Esmat A. Abdallah

    Published 2014-01-01
    “…All simulations are carried out using the EM commercial simulator, high frequency structure simulator (HFSS) ver.13.…”
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  19. 25739
  20. 25740

    Does Brand Awareness Influences Purchase Intention? The Mediation Role of Brand Equity Dimensions by Vitor Azzari, Anderson Pelissari

    Published 2020-01-01
    “…The theoretical hypothesis test was performed by structural equation modeling (PLS-SEM) and ordinary least squares (OLS) regression to analyze the mediation effect. …”
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