Solution Structures of PPARγ2/RXRα Complexes by Judit Osz, Maxim V. Pethoukhov, Serena Sirigu, Dmitri I. Svergun, Dino Moras, Natacha Rochel

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Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability by Wei-Ching Liang, Hongkang Xi, Dawei Sun, Luigi D’Ascenzo, Jonathan Zarzar, Nicole Stephens, Ryan Cook, Yinyin Li, Zhengmao Ye, Marissa Matsumoto, Jian Payandeh, Matthieu Masureel, Yan Wu

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SAMHD1 shapes deoxynucleotide triphosphate homeostasis by interconnecting the depletion and biosynthesis of different dNTPs by Claudia McCown, Corey H. Yu, Dmitri N. Ivanov

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Adenine, a key player in biology and medicinal chemistry by Fillion, Alexandra, Vichier-Guerre, Sophie, Arimondo, Paola Barbara

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A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins by Xiuxiu Lu, Monika Chandravanshi, Venkata R. Sabbasani, Snehal Gaikwad, V. Keith Hughitt, Nana Gyabaah-Kessie, Bradley T. Scroggins, Sudipto Das, Wazo Myint, Michelle E. Clapp, Charles D. Schwieters, Marzena A. Dyba, Derek L. Bolhuis, Janusz W. Koscielniak, Thorkell Andresson, Michael J. Emanuele, Nicholas G. Brown, Hiroshi Matsuo, Raj Chari, Deborah E. Citrin, Beverly A. Mock, Rolf E. Swenson, Kylie J. Walters

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Fragment Screening Identifies Novel Allosteric Binders and Binding Sites in the VHR (DUSP3) Phosphatase by Jiaqian Wu, Marek R. Baranowski, Alexander E. Aleshin, Eta A. Isiorho, Lester J. Lambert, Laurent J. S. De Backer, Ye Na Han, Ranajit Das, Douglas J. Sheffler, Andrey A. Bobkov, Alexis M. Lemberikman, Daniel A. Keedy, Nicholas D. P. Cosford, Lutz Tautz

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Bioactive compounds and probiotics–a ray of hope in COVID-19 management by Indu Bhushan, Mahima Sharma, Malvika Mehta, Shivi Badyal, Varun Sharma, Indu Sharma, Hemender Singh, Srinivas Sistla

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Interplay of p23 with FKBP51 and their chaperone complex in regulating tau aggregation by Pijush Chakraborty, Markus Zweckstetter

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1.4 nm gold nanoparticle-antibody conjugates for in situ gold immunolabelling after transduction into living human cells by Groysbeck, Nadja, Haeberlé, Anne Marie, Ory, Stéphane, Hanss, Victor, Eltsov, Mikhael, Schultz, Patrick, Zuber, Guy

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Osteoarthritic Synovial Fluid Modulates Cell Phenotype and Metabolic Behavior In Vitro by Eduardo Branco de Sousa, Gilson Costa dos Santos Junior, Ramon Pinheiro Aguiar, Rafaela da Costa Sartore, Ana Carolina Leal de Oliveira, Fabio Ceneviva Lacerda Almeida, Vivaldo Moura Neto, Diego Pinheiro Aguiar

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Features of “All LNA” Duplexes Showing a New Type of Nucleic Acid Geometry by Charlotte Förster, André Eichert, Dominik Oberthür, Christian Betzel, Reinhard Geßner, Andreas Nitsche, Jens P. Fürste

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CryoEM structure and small-angle X-ray scattering analyses of porcine retinol-binding protein 3 by Vineeta Kaushik, Luca Gessa, Nelam Kumar, Matyáš Pinkas, Mariusz Czarnocki-Cieciura, Krzysztof Palczewski, Jiří Nováček, Humberto Fernandes

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Faecalibacterium prausnitzii regulates carbohydrate metabolic functions of the gut microbiome in C57BL/6 mice by Peiling Geng, Ni Zhao, Yufan Zhou, Reuben S. Harris, Yong Ge

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Leveraging AlphaFold for innovation and sustainable health research in Africa by Emmanuel Nji, Katharina C. Cramer, Nicolas V. Rüffin, Fatoumata G. Fofana, Walid Heiba, Safiétou Sankhe

“…Without addressing the lack of research infrastructure, funding, and supportive science policies, structural biology capacity-building efforts in Africa will continue to be hindered by the persistent challenge of brain drain.…”
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Rabs, Rips, FIPs, and Endocytic Membrane Traffic by Rytis Prekeris

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Molecular and Cellular Mechanisms of Synaptopathies by Alvaro O. Ardiles, Andreas M. Grabrucker, Francisco G. Scholl, Gabby Rudenko, Tiziana Borsello

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Centrosome amplification and aneuploidy driven by the HIV-1-induced Vpr•VprBP•Plk4 complex in CD4+ T cells by Jung-Eun Park, Tae-Sung Kim, Yan Zeng, Melissa Mikolaj, Jong Il Ahn, Muhammad S. Alam, Christina M. Monnie, Victoria Shi, Ming Zhou, Tae-Wook Chun, Frank Maldarelli, Kedar Narayan, Jinwoo Ahn, Jonathan D. Ashwell, Klaus Strebel, Kyung S. Lee

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Applications of liposomes and lipid nanoparticles in cancer therapy: current advances and prospects by Zhe Cheng, Huichao Huang, Meilong Yin, Huaizheng Liu

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The Binding Affinity of Small Molecules with Yam Tyrosinase (Catechol Oxidase): A Biophysical Study by Tabassum Mulla, Sushama Patil, Srinivas Sistla, Jyoti Jadhav

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Proteomic dataset of sorghum leaf and root responses to single and combined drought and heat stress by Ali Elnaeim Elbasheir Ali, Robert E. Sharp, Laura Greeley, Scott C. Peck, David L. Tabb, Ndiko Ludidi

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