Single-molecule two- and three-colour FRET studies reveal a transition state in SNARE disassembly by NSF by Sudheer K. Cheppali, Chang Li, Wenjing Xing, Ruirui Sun, Mengyi Yang, Yi Xue, Si-Yao Lu, Jun Yao, Shan Sun, Chunlai Chen, Sen-Fang Sui

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Hypersensitive intercellular responses of endometrial stromal cells drive invasion in endometriosis by Chun-Wei Chen, Jeffery B Chavez, Ritikaa Kumar, Virginia Arlene Go, Ahvani Pant, Anushka Jain, Srikanth R Polusani, Matthew J Hart, Randal D Robinson, Maria Gaczynska, Pawel Osmulski, Nameer B Kirma, Bruce J Nicholson

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NHSL3 controls single and collective cell migration through two distinct mechanisms by Nikita M. Novikov, Jinmei Gao, Artem I. Fokin, Nathalie Rocques, Giovanni Chiappetta, Karina D. Rysenkova, Diego Javier Zea, Anna Polesskaya, Joelle Vinh, Raphael Guerois, Alexis M. Gautreau

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Structure of an ex vivoDrosophila TOM complex determined by single-particle cryoEM by Agalya Periasamy, Pamela Ornelas, Thomas Bausewein, Naomi Mitchell, Jiamin Zhao, Leonie M. Quinn, Werner Kuehlbrandt, Jacqueline M. Gulbis

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Dichotomous Effect of Caffeine, Curcumin, and Naringenin on Genomic DNA of Normal and Diabetic Subjects by Debarati Chattopadhyay, Ashok Somaiah, Divya Raghunathan, Kavitha Thirumurugan

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PARP‐1 Inhibition Increases Oxidative Stress in Ets‐1‐Expressing MDA‐MB‐231 Breast Cancer Cells by Magalie Hervieu, Arnaud J. Legrand, Emilie Floquet, Thierry Idziorek, Corentin Spriet, Didier Monté, Vincent Villeret, Marc Aumercier, Souhaila Choul‐li

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The Structural, Biophysical, and Antigenic Characterization of the Goose Parvovirus Capsid by Korosh Jabbari, Mario Mietzsch, Jane Hsi, Paul Chipman, Jianming Qiu, Robert McKenna

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Recombinant expression systems for production of stabilised virus-like particles as next-generation polio vaccines by Lee Sherry, Mohammad W. Bahar, Claudine Porta, Helen Fox, Keith Grehan, Veronica Nasta, Helen M. E. Duyvesteyn, Luigi De Colibus, Johanna Marsian, Inga Murdoch, Daniel Ponndorf, Seong-Ryong Kim, Sachin Shah, Sarah Carlyle, Jessica J. Swanson, Sue Matthews, Clare Nicol, George P. Lomonossoff, Andrew J. Macadam, Elizabeth E. Fry, David I. Stuart, Nicola J. Stonehouse, David J. Rowlands

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Potential effects of induced focal ischemia in the motor cortex of rats undergoing experimental periodontitis by Victória dos Santos Chemelo, Marco Aurelio M. Freire, Leonardo Oliveira Bittencourt, Deborah Ribeiro Frazão, Deiweson Souza-Monteiro, Sabrina C. Cartagenes, Walace Gomes-Leal, Cristiane do Socorro Ferraz Maia, Gabriel S. Rocha, Daniel Falcao, Rafael Rodrigues Lima

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PCR Amplification and Transcription for Site-Specific Labeling of Large RNA Molecules by a Two-Unnatural-Base-Pair System by Michiko Kimoto, Rie Yamashige, Shigeyuki Yokoyama, Ichiro Hirao

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Spontaneous base flipping helps drive Nsp15’s preferences in double stranded RNA substrates by Zoe M. Wright, Kevin John Butay, Juno M. Krahn, Isha M. Wilson, Scott A. Gabel, Eugene F. DeRose, Israa S. Hissein, Jason G. Williams, Mario J. Borgnia, Meredith N. Frazier, Geoffrey A. Mueller, Robin E. Stanley

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Targeted detection of endogenous LINE-1 proteins and ORF2p interactions by Mathias I. Nielsen, Justina C. Wolters, Omar G. Rosas Bringas, Hua Jiang, Luciano H. Di Stefano, Mehrnoosh Oghbaie, Samira Hozeifi, Mats J. Nitert, Alienke van Pijkeren, Marieke Smit, Lars ter Morsche, Apostolos Mourtzinos, Vikram Deshpande, Martin S. Taylor, Brian T. Chait, John LaCava

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Solution Structures of PPARγ2/RXRα Complexes by Judit Osz, Maxim V. Pethoukhov, Serena Sirigu, Dmitri I. Svergun, Dino Moras, Natacha Rochel

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Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability by Wei-Ching Liang, Hongkang Xi, Dawei Sun, Luigi D’Ascenzo, Jonathan Zarzar, Nicole Stephens, Ryan Cook, Yinyin Li, Zhengmao Ye, Marissa Matsumoto, Jian Payandeh, Matthieu Masureel, Yan Wu

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SAMHD1 shapes deoxynucleotide triphosphate homeostasis by interconnecting the depletion and biosynthesis of different dNTPs by Claudia McCown, Corey H. Yu, Dmitri N. Ivanov

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A higher order PUF complex is central to regulation of C. elegans germline stem cells by Chen Qiu, Sarah L. Crittenden, Brian H. Carrick, Lucas B. Dillard, Stephany J. Costa Dos Santos, Venkata P. Dandey, Robert C. Dutcher, Elizabeth G. Viverette, Robert N. Wine, Jennifer Woodworth, Zachary T. Campbell, Marvin Wickens, Mario J. Borgnia, Judith Kimble, Traci M. Tanaka Hall

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Adenine, a key player in biology and medicinal chemistry by Fillion, Alexandra, Vichier-Guerre, Sophie, Arimondo, Paola Barbara

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A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins by Xiuxiu Lu, Monika Chandravanshi, Venkata R. Sabbasani, Snehal Gaikwad, V. Keith Hughitt, Nana Gyabaah-Kessie, Bradley T. Scroggins, Sudipto Das, Wazo Myint, Michelle E. Clapp, Charles D. Schwieters, Marzena A. Dyba, Derek L. Bolhuis, Janusz W. Koscielniak, Thorkell Andresson, Michael J. Emanuele, Nicholas G. Brown, Hiroshi Matsuo, Raj Chari, Deborah E. Citrin, Beverly A. Mock, Rolf E. Swenson, Kylie J. Walters

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Fragment Screening Identifies Novel Allosteric Binders and Binding Sites in the VHR (DUSP3) Phosphatase by Jiaqian Wu, Marek R. Baranowski, Alexander E. Aleshin, Eta A. Isiorho, Lester J. Lambert, Laurent J. S. De Backer, Ye Na Han, Ranajit Das, Douglas J. Sheffler, Andrey A. Bobkov, Alexis M. Lemberikman, Daniel A. Keedy, Nicholas D. P. Cosford, Lutz Tautz

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MCM2-7 ring closure involves the Mcm5 C-terminus and triggers Mcm4 ATP hydrolysis by Sarah V. Faull, Marta Barbon, Audrey Mossler, Zuanning Yuan, Lin Bai, L. Maximilian Reuter, Alberto Riera, Christian Winkler, Indiana Magdalou, Matthew Peach, Huilin Li, Christian Speck

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