dyphAI dynamic pharmacophore modeling with AI: a tool for efficient screening of new acetylcholinesterase inhibitors by Yasser Hayek-Orduz, Dorian Armando Acevedo-Castro, Dorian Armando Acevedo-Castro, Juan Sebastián Saldarriaga Escobar, Brandon Eli Ortiz-Domínguez, María Francisca Villegas-Torres, Paola A. Caicedo, Álvaro Barrera-Ocampo, Natalie Cortes, Edison H. Osorio, Andrés Fernando González Barrios

“…Experimental results revealed that molecules, 4 (P-1894047), with its complex multi-ring structure and numerous hydrogen bond acceptors, and 7 (P-2652815), characterized by a flexible, polar framework with ten hydrogen bond donors and acceptors, exhibited IC₅₀ values lower than or equal to that of the control (galantamine), indicating potent inhibitory activity. …”
Get full text

The effect of Ocimum basilicum on the prevention of postpartum depression symptoms and sleep quality: A triple-blind randomized controlled clinical trial by Monireh Abdi, Elham Rezaei, Mojgan Mirghafourvand, Fatemeh Ebrahimi, Laleh Payahoo, Alireza Shafiei-Kandjani, Solmaz Ghanbari-Homaie

“…The EPDS and postpartum sleep quality scale were completed through structured interviews at eight weeks postpartum. The Mann-Whitney U test was used to compare the mean postpartum depression scores before and after the intervention, and ANCOVA was used to compare the mean postpartum sleep quality scores. …”
Get full text

How to teach the anatomy of the inguinal canal? A multimodal approach by Shina Yeo Qing Chun, Nathaniel Dexter Salim, Lai YuFu Jarrell, Joshua Koh Zhi Yuan, Eng-Tat Ang, Davide Lomanto

“…Current teaching via didactic lectures may not suffice for optimal learning, and visualization of the complicated 3D-structure of the inguinal canal. Hence, we investigated the efficacy of a low-fidelity model creation to improve the teaching. …”
Get full text

An exploration of governance in teaching hospitals in the Netherlands focused on educational objectives by L. M. van der Baaren, R. E. Gifford, N. A. van der Baan, M. N. Sosef, J. H. Blaauw, R. J. Bennink, I. C. Heyligers

“…Methods We conducted an exploratory qualitative study of educational governance structures in all teaching hospitals in the Netherlands with at least three training programs. …”
Get full text

An innovative approach to hospital-wide interprofessional capacity building: Côte d’Ivoire National Cancer Center project by Jiyoung Han, Innocent Adoubi, Mee Joo Kang, Sarang Lee, So-Youn Jung, Chong Woo Yoo

“…The qualitative assessment indicated the importance of contextually relevant curriculum development with a special focus on establishing hospital operational plans, maintaining trainee autonomy and motivation, building mutual trust and cooperation between partner countries, engaging stakeholders actively, and providing effective leadership and support structures through a dedicated coordinating team were crucial factors for program success. …”
Get full text

Co-Digestion of Tea Extracts with Omega-3 Fatty Acids Enhances Digestive Stability and Intestinal Absorption of Omega-3 Fatty Acids by Increasing Antioxidant Activity and Micelle S... by In-Su Na, Hyun Woo Jeong, Jin-Oh Chung, Byung-Fhy Suh, Jonghee Sohn, Soon-Mi Shim

“…The results from the current study suggest that the co-intake of ω-3 FAs with various tea extracts could increase the bioavailability of ω-3 FAs by preventing oxidation, stabilizing micelle structures, and minimizing intestinal efflux.…”
Get full text

Is there a mental health diagnostic crisis in primary care? Current research practices in global mental health cannot answer that question by Brandon A. Kohrt, Dristy Gurung, Ritika Singh, Sauharda Rai, Mani Neupane, Elizabeth L. Turner, Alyssa Platt, Shifeng Sun, Kamal Gautam, Nagendra P. Luitel, Mark J.D. Jordans

“…We recommend evaluating multiple conditions, statistically adjusting prevalence estimates generated from self-report tools, and consistently using structured clinical interviews as a gold standard. We propose clinically meaningful detection as ‘good-enough’ diagnoses incorporating multiple conditions accounting for context, health system and types of interventions available. …”
Get full text

Charting the path to the implementation of universal health coverage policy in Nigeria through the lens of Delphi methodology by Jibril M. Bashar, Sulaiman Hadiza, Ozoilo J. Ugochi, Lawal S. Muhammad, Adeoye Olufemi, Ukoh Eberechi, Yakubu Agada-Amade, Alhassan Yusuf, Abdulhamid H. Abdullahi, Hassan S. Musa, Ahmad A. Ibrahim, Kalu-Umeh Nnennaya, Jennifer Anyanti, Dayyabu Yusuf, Kenneth Okoineme, Jennifer Adebambo, Samuel O. Ikani, Dennis Aizobu, Musa Abubakar, Babandi S. Zaharaddeen, Lawal Aminu, Yusuf H. Wada

“…These seven priority areas that have been identified include enrolment, equity, organizational health and structure, data and technology, quality, market efficiency, and citizen engagement. …”
Get full text

Exploring transversal competencies in engineering students through international experiences by Guillermo M. Chans, Guillermo M. Chans, Ana Paula Valle-Arce, Salvador Salas-Maxemín, Patricia Caratozzolo, Patricia Caratozzolo, Claudia Camacho-Zuñiga, Claudia Camacho-Zuñiga

“…Data were collected through a 43-question semi-structured interview with 13 undergraduate engineering students experiencing an abroad study program. …”
Get full text

Perceived coercion amongst healthcare workers during the COVID-19 pandemic by Andrea S. Stoltenberg, Veronica Ranieri, Hege Kristine N. Dahlen, Eleni Nastouli, SAFER Investigators, Roger Almvik, Sarah J. L. Edwards, Sunjeev K. Kamboj

“…The exploratory conceptual and psychometric structure was confirmed in a separate sample of HCWs from the UK and Norway (N = 483). …”
Get full text

Challenges and barriers to physician decision-making for prescribing and deprescribing among patients with multimorbidity in eastern China’s primary care settings: a qualitative st... by Ming Yan, Zhijie Xu, Andrew Farmer, Yu Xia, Mi Yao, Lingyan Wu, Xinmei Zhou, Liyan Han

“…We aimed to investigate the experiences and perceptions of primary care physicians (PCPs) regarding their decision-making processes in prescribing and deprescribing medications for patients with multimorbidity, and identify the challenges and barriers they face.Design From 5 October 2023 to 27 January 2024, this qualitative study was conducted through semi-structured interviews that encouraged in-depth exploration of the participants’ experiences and perspectives. …”
Get full text

Synesis as a framework to enable safety interventions in complex healthcare environments by Jamie Cargill, Aarti Bavare, Tiffany Wrenn, Anne Lam, Lauren Salinas, Itode Idowu, Asma Razavi, Venessa Lynn Pinto, Eric Williams

“…Background Despite wide adoption in the healthcare of safety event report (SER) systems, there is a paucity of unified structures for prompt analysis and action while retaining reporter confidentiality. …”
Get full text

Effectiveness of the ARTHE-e app for exercise adherence in people with knee osteoarthritis: protocol for a randomised controlled trial by Bruno Pereira, Charlotte Lanhers, Emmanuel Coudeyre, Lech Dobija, Mathilde Pelletier-Visa, Alexis Bonhomme

“…Introduction Osteoarthritis, the most prevalent joint disease, poses a significant challenge due to its progressive nature and impact on the whole joint and periarticular structures. Although exercise is crucial for symptom improvement and progression slowdown, adherence to exercise programmes remains a concern. …”
Get full text

Lake Baikal amphipods and their genomes, great and small by P. B. Drozdova, E. V. Madyarova, A. N. Gurkov, A. E. Saranchina, E. V. Romanova, J. V. Petunina, T. E. Peretolchina, D. Y. Sherbakov, M. A. Timofeyev

“…The next important steps should be (i) the assembly of whole genomes for different species of Baikal amphipods, which is at the moment hampered by complicated genome structures with high repeat content, and (ii) updating species taxonomy taking into account all the data.…”
Get full text

Silicon-based all-solid-state batteries operating free from external pressure by Zhiyong Zhang, Xiuli Zhang, Yan Liu, Chaofei Lan, Xiang Han, Shanpeng Pei, Linshan Luo, Pengfei Su, Ziqi Zhang, Jingjing Liu, Zhengliang Gong, Cheng Li, Guangyang Lin, Cheng Li, Wei Huang, Ming-Sheng Wang, Songyan Chen

“…Such an efficient ionic/electronic transport system also facilitates the uniform release of cycling expansion stresses from the Si particles and stabilizes bulk-phase and interfacial structure of anode. Consequently, the Li21Si5/Si–Li21Si5 anode exhibited a critical current density of 10 mA cm−2 at 45 °C with a capacity of 10 mAh cm−2. …”
Get full text

Anatomical Adaptations of Halophyte Leaves (<i>Nitraria retusa</i> [Forsskal] Asch. and <i>Atriplex halimus</i> L.) in Response to Cement Dust Pollution in Arid Environments by Nouha Krir, Mounira Mkaddem Guedri, Mehrez Romdhane, Manel Abdullah Alshaqha

“…Furthermore, significant correlations between specific heavy metals and histological parameters in <i>A. halimus</i> leaves indicated potential interactions between metal composition and leaf structure, highlighting their role in modulating anatomical adaptations. …”
Get full text

Effects of high-intensity interval and moderate-intensity continuous training on ambulatory blood pressure and cardiovascular outcomes in older adults with hypertension (HEXA Study... by Francisco Dalton-Alves, Maria Beatriz F Araújo, Bruno Erick B Lucena, Gabriel C Souto, Daniele Samara D Lopes, Maria Isabel S Lucena, Raíssa de Melo Silva, Ludmila L P Cabral, Yuri A Freire, Fabíola L Golveia, Telma Maria Araújo Lemos, Rodrigo A V Browne, Eduardo Caldas Costa

“…Secondary cardiovascular outcomes are resting blood pressure, cardiorespiratory fitness, pulse wave velocity, carotid intima-media thickness, heart rate variability and cardiac function/structure. All outcomes are measured at baseline and after a 3-month period. …”
Get full text

Correlation between White Globe Appearance and Clinicopathologic Characteristics in Early Gastric Cancer by Dae Jin Jung, Gwang Ha Kim, Kyungbin Kim, Hye Kyung Jeon, Dong Chan Joo, Moon Won Lee, Bong Eun Lee

“…Background/Aims: Magnifying endoscopy with narrow-band imaging (ME-NBI) enables the visualization of detailed microsurface (MS) and microvascular (MV) structures in the gastrointestinal tract. White globe appearance (WGA) is a small whitish lesion with a globular shape identified during ME-NBI for early gastric cancer (EGC). …”
Get full text

“Sleepless nights are a daily reality for us” how women experiencing homelessness in Addis Ababa, Ethiopia describe street life: a photovoice study by Kalkidan Yohannes, Kalkidan Yohannes, Kalkidan Yohannes, Mats Målqvist, Hannah Bradby, Yemane Berhane, Dagmawit Tewahido, Dagmawit Tewahido, Sibylle Herzig van Wees, Sibylle Herzig van Wees

“…In this study, we aimed to describe women’s experiences of street homelessness in their own terms and their suggestions to address their unmet needs.MethodsThis photovoice study draws on photos, focus group discussions, and semi-structured interviews. We conducted the study in collaboration with women in their reproductive years experiencing homelessness (n = 9). …”
Get full text

Health-related dimensions of fishers for sustainable commercial fisheries in the Atlantic Gulf of Guinea: Ecological and social assessments by Isa Oalekan Elegbede, Saud. M Al Jufaili, Toheeb Lekan Jolaosho, Babalola Tesleem, Awe Folalu Adekunle, Olarinmoye Oluwatosin Modupe, Salisu Monsuru Adekunle, Adedeji-Adenola Halimat

“…Data were gathered from experienced employees of Friend of the Sea (FOS) certified and non-certified (Business-as-Usual, BAU) industrial fisheries through questionnaires, complemented by semi-structured interviews with selected key informants. …”
Get full text