Generation of Chicken IgY against SARS-COV-2 Spike Protein and Epitope Mapping by Yan Lu, Yajun Wang, Zhen Zhang, Jingliang Huang, Meicun Yao, Guobin Huang, Yuanyuan Ge, Peichun Zhang, Huaxin Huang, Yong Wang, Huiliang Li, Wen Wang

“…Notably, epitope SIIAYTMSL, one of the identified epitopes, partially overlaps the S1/S2 cleavage region in SARS-CoV-2 S and is located on the surface of S trimer in 3D structure, close to the S1/S2 cleavage site. Thus, antibody binding at this location could physically block the access of proteolytic enzymes to S1/S2 cleavage site and thereby impede S1/S2 proteolytic cleavage, which is crucial to subsequent virus-cell membrane fusion and viral cell entry. …”
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Development and Evaluation of selective nitroxanthone Derivatives: A promising compound for Targeting MCF-7 breast cancer cells by Pavithren Devakrishnan, Nadiah Mad Nasir, Johnson Stanslas, Muhammad Alif M. Latif, Ahmad Zaidi Ismail, Fatin Farhana Baharuddin

“…Molecular docking analysis showed that compound 1 binds more efficiently to the target enzyme aromatase compared to other derivatives, likely due to its optimal number of nitro groups, orientations, and polarizabilities. Crystal structure analysis revealed that compound 1 crystallizes in the monoclinic system with the C2/c space group. …”
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ASSESSING THE RESULTS OF TRAINING IN DIGITAL ENTREPRENEURSHIP IN THE AGE OF HIGH AND DEEP TECH by Oleg Kaminsky, Julia Yereshko, Sergii Kyrychenko, Maryna Duchenko

“…It was concluded that in the framework of modern technical evolution, in the conditions of high-tech, and especially deep tech structures, competencies in digital entrepreneurship are, if not key, then very important. …”
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Bacteria Assemble: Investigating Soil Bacterial Diversity and Interactions in a Sarawakian Oil Palm Plantation for Climate-Resilient Soil Management by Zahidah Ayob, Nor Azizah Kusai, Han Ming Gan, Wan Nurul‘Ain Wan Mohd Nor, Hasimah Mos, Vijaya Subramaniam, Meilina Ong Abdullah

“…Redundancy Analysis (RDA) revealed that pH, moisture content, and bulk density were significant factors that influence the microbial community structure. At the phylum level, Acidobacteriota showed a close association with pH, while Proteobacteria was associated with higher moisture content. …”
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On the Fractional Dynamics of Kinks in Sine-Gordon Models by Tassos Bountis, Julia Cantisán, Jesús Cuevas-Maraver, Jorge Eduardo Macías-Díaz, Panayotis G. Kevrekidis

“…In particular, we modified the order <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi>β</mi></semantics></math></inline-formula> of the temporal derivative to that of a Caputo fractional type and found that, for <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>1</mn><mo><</mo><mi>β</mi><mo><</mo><mn>2</mn></mrow></semantics></math></inline-formula>, this imposes a dissipative dynamical behavior on the coherent structures. We also examined the variation of a fractional Riesz order <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi>α</mi></semantics></math></inline-formula> on the spatial derivative. …”
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Formation of the Figge Maar Seafloor Crater During the 1964 B1 Blowout in the German North Sea by Jens Karstens, Jens Schneider von Deimling, Christian Berndt, Christoph Böttner, Michel Kühn, Benedict T. I. Reinardy, Axel Ehrhardt, Jonas Gros, Bettina Schramm, Dirk Klaeschen, Judith Elger, Matthias Haeckel, Mark Schmidt, Sven Heinrich, Philipp Müller, Frithjof Bense

“…Although seafloor craters formed by fluid flow are very common structures, little is known about their formation dynamics. …”
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A missense variant in the SOX5 gene (c.221C > T) is associated with intellectual disability by Xiujuan Yang, Zhongzhi Gan, Xiaoling Guo, Xiang Huang, Juan Liu, Yingchun Zheng, Xiaoqiang Zhou, Jingli Lian, Yue Liu, Tingting Yang, Chao Li, Fenying Chen, Fei He, Xiangmin Xu, Yasi Zhou, Qian Liu, Xingkun Yang, Fu Xiong

“…Additionally, protein stability was evaluated using I-Mutant, and 3D protein structures were modeled with I-TASSER. Western blots and QPCR were employed to assess gene expression and protein stability. …”
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Genetic Diversity of <i>Diaphorina citri</i> and Its Endosymbiont Across Diffusion Frontier and Epidemic Areas of Citrus Huanglongbing in China by Jin Yang, Ai-Jun Huang, Jun Zhou, Ping You, Xiang Li, Han Luo, Long Yi

“…To understand the genetic diversity and population structure of <i>D. citri</i> in the context of HLB diffusion, we analyzed 13 populations from the HLB diffusion frontier and 25 populations from epidemic areas in China. …”
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Acupuncture mediates the “gut–testis axis” to improve asthenozoospermia by Jianheng Hao, Jianheng Hao, Huichao Xu, Boya Chang, Jia Ren, Haijun Wang, Laixi Ji, Laixi Ji

“…In addition, gut microbiome and metabolomics were used to study the impact of acupuncture on the gut microbiota structure, serum, and testicular metabolites in asthenozoospermic mice. …”
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Features and evolutionary adaptations of the mitochondrial genome of Garuga forrestii W. W. Sm by Rong Chen, Rong Chen, Rong Chen, Rong Chen, Rui Rao, Rui Rao, Rui Rao, Rui Rao, Chun Wang, Chun Wang, Chun Wang, Chun Wang, Dongbo Zhu, Dongbo Zhu, Dongbo Zhu, Dongbo Zhu, Fen Yuan, Fen Yuan, Fen Yuan, Fen Yuan, Liangliang Yue, Liangliang Yue, Liangliang Yue, Liangliang Yue

“…The study also investigates RNA editing sites and evolutionary patterns.ResultsThe mitochondrial genome exhibits a low proportion of repetitive sequences (3.30%), suggesting a highly conserved structure. A high copy number of the trnM-CAT gene (4 copies) is noted, which may contribute to genomic rearrangement and adaptive evolution. …”
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Distinct subcellular localization of tau and alpha-synuclein in lewy body disease by D. Luke Fischer, Marissa Menard, Omar Z. Abdelaziz, Nicholas M. Kanaan, Virginia G. Cobbs, Richard E. Kennedy, Geidy E. Serrano, Thomas G. Beach, Laura A. Volpicelli-Daley

“…In the rare cases pathologic α-syn and pathologic tau were found in the same Lewy body or Lewy neurite, tau appeared to surround α-syn but did not colocalize within the same structure. The relationship between tau and α-syn copathology is important for explaining clinical symptoms, severity, and progression, but there is no evidence for frequent, direct protein-protein interactions in the middle temporal gyrus.…”
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Experimental study of partially oxidized sodium alginate gel combined with myogenic stem cells to improve cardiac function in aged rats with myocardial infarction by Xinxin Ma, Xiaolu Hou, Peixin Dong, Jiayan Ye, Yangyang Gao, Ling Huang, Xiuping Bai

“…[Methods] The models of myocardial infarction in aged rats were established by ligating the coronary arteries and divided randomly into the group of saline control group, sodium alginate group, myogenic stem cells group and sodium alginate combined with myogenic stem cells group(joint group), each had 30 rats.The same amount of corresponding material was injected into the myocardial infarction area of rats in each group respectively.The cardiac structure and function of the rats were evaluated by echocardiography 8 weeks after the operation, and then the rats were executed.The hearts were removed to observe the differences in ventricular remodeling by histological analysis and the angiogenesis and collagen secretion of the ventricular slices were further analyzed. …”
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Central Pain in Parkinson’s Disease: Behavioral and Cognitive Characteristics by N. Vila-Chã, S. Cavaco, A. Mendes, A. Gonçalves, I. Moreira, J. Fernandes, J. Damásio, L. F. Azevedo, J. M. Castro-Lopes

“…Material and Methods. A structured interview was used to identify and characterize pain in a cohort of 260 consecutive PD patients. …”
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Eco-friendly synthesis of chitosan NPs from Fioria vitifolia (L.) L: Potential to antibacterial, antioxidant, cytotoxicity properties of HepG2 cells and their evaluation of safety... by Mohamed Imath, Chinnasamy Ragavendran, Chinnaperumal Kamaraj, Ramalingam Karthik Raja, Gholamreza abdi

“…The XRD pattern showed prominent peaks at 2θ locations, confirming the hexagonal wurtzite structure. EDX was analysis confirmed the presence of chitosan in crystalline form for synthesized nanoparticle. …”
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Encoding of cerebellar dentate neuron activity during visual attention in rhesus macaques by Nico A Flierman, Sue Ann Koay, Willem S van Hoogstraten, Tom JH Ruigrok, Pieter Roelfsema, Aleksandra Badura, Chris I De Zeeuw

“…To better understand the heterogeneous relationship between task structure, behavioral performance, and neural dynamics, we constructed a behavioral, an encoding, and a decoding model. …”
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Reasons for Undesirable Pregnancy Outcomes among Women with Appendicitis: The Experience of a Tertiary Center by Baris Mantoglu, Fatih Altintoprak, Necattin Firat, Emre Gonullu, Enis Dikicier, Yesim Akdeniz, Mehmet Aziret, Unal Erkorkmaz

“…In addition to the demographic structure of the patients, surgical technique, the number of pregnancies, multiple pregnancy status, surgical pathologies, laboratory values, radiological imaging methods, and length of hospital stay were evaluated. …”
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Evaluation of Melongosides as Potential Inhibitors of NS2B-NS3 Activator-Protease of Dengue Virus (Serotype 2) by Using Molecular Docking and Dynamics Simulation Approach by Partha Biswas, Ommay Hany Rumi, Dhrubo Ahmed Khan, Md Nasir Ahmed, Nusratun Nahar, Rownak Jahan, Md Nazmul Hasan Zilani, Tridib K Paul, Anamul Hasan, Tohmina Afroze Bondhon, Khoshnur Jannat, Md Nazmul Hasan, Mohammed Rahmatullah

“…However, the 200 ns molecular dynamic simulation experiment indicates significant stability of the protein-ligand interactions with the RMSD values of 2.5 Å, thus suggesting a better docking position and no disruption of the protein-ligand structure. Taken together, melongosides need further attention for more scientific studies as a DENV inhibitory agent, which if proven, in vivo and in clinical trials, can be a useful therapeutic agent against at least DENV-2.…”
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Assessing Knowledge, Attitudes, and Practices of Healthcare Workers regarding Biomedical Waste Management at Biyem-Assi District Hospital, Yaounde: A Cross-Sectional Analytical Stu... by Sylvain Honoré Woromogo, Gwladys Guetsé Djeukang, Félicité Emma Yagata Moussa, Jesse Saint Saba Antaon, Kingsley Ngah Kort, Pierre Marie Tebeu

“…Variables of interest were knowledge, attitudes, and practices of the respondents. A structured and pretested questionnaire was used for data collection. …”
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THE EFFECTIVENESS OF ZINC AND RISEDRONATE ON BONE TURNOVER IN RAT MODEL OF OSTEOPOROSIS ASSESSED WITH THE EXPRESSION OF β-CROSSLAPS by Adam Fajar, Mohammad Rizal Chaidir, Dicky Mulyadi, Ahmad Ramdan, Yoyos Dias Ismiarto

“…Previous research in rat model osteoporosis, Zinc have a potential effect to prevent and rebuild bone structure with osteoblast stimulation in bone formation and osteoclast activity inhibition in bone resorption by increasing Osteoprotegerin production, that inhibit bond between RANKL and RANK. …”
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Long-term maintenance of patient-specific characteristics in tumoroids from six cancer indications by Colin D. Paul, Chris Yankaskas, Pradip Shahi Thakuri, Brittany Balhouse, Shyanne Salen, Amber Bullock, Sylvia Beam, Anthony Chatman, Sybelle Djikeng, Xiaoyu Jenny Yang, Garrett Wong, Isha Dey, Spencer Holmes, Abigail Dockey, Lindsay Bailey-Steinitz, Lina Zheng, Weizhong Li, Vivek Chandra, Jakhan Nguyen, Jason Sharp, Erik Willems, Mark Kennedy, Matthew R. Dallas, David Kuninger

“…Abstract Tumoroids, sometimes referred to as cancer organoids, are patient-derived cancer cells grown as 3D, self-organized multicellular structures that maintain key characteristics (e.g., genotype, gene expression levels) of the tumor from which they originated. …”
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