Deciphering the generation of heterogeneity in esophageal squamous cell carcinoma metastasis via single-cell multiomics analysis by Kaiwen Sheng, Jun Chen, Ruitang Xu, Haoqiang Sun, Ran Liu, Yongjie Wang, Wenwen Xu, Jiao Guo, Miao Zhang, Shuai Liu, Juan Lei, Yawen Sun, Yang Jia, Dianhao Guo

“…Results Our study identified enhancer-specific activation within epithelial cells orchestrated by the three-dimensional structure of chromatin that regulates SERPINH1 transcription, and promotes the epithelial-mesenchymal transition (EMT) and metastasis of ESCC. …”
Get full text

Nomenclatural issues concerning cultured yeasts and other fungi: why it is important to avoid unneeded name changes by Andrey Yurkov, Artur Alves, Feng-Yan Bai, Kyria Boundy-Mills, Pietro Buzzini, Neža Čadež, Gianluigi Cardinali, Serge Casaregola, Vishnu Chaturvedi, Valérie Collin, Jack W. Fell, Victoria Girard, Marizeth Groenewald, Ferry Hagen, Chris Todd Hittinger, Aleksey V. Kachalkin, Markus Kostrzewa, Vassili Kouvelis, Diego Libkind, Xinzhan Liu, Thomas Maier, Wieland Meyer, Gábor Péter, Marcin Piątek, Vincent Robert, Carlos A. Rosa, Jose Paulo Sampaio, Matthias Sipiczki, Marc Stadler, Takashi Sugita, Junta Sugiyama, Hiroshi Takagi, Masako Takashima, Benedetta Turchetti, Qi-Ming Wang, Teun Boekhout

“…But viable type material is important not only for yeasts, but also for other cultivable Fungi that are characterized by particular morphological structures (a specific type of spores), growth properties, and secondary metabolites. …”
Get full text

In Vitro Susceptibility and Florfenicol Resistance in Citrobacter Isolates and Whole-Genome Analysis of Multidrug-Resistant Citrobacter freundii by Wangxiao Zhou, Qianqian Chen, Changrui Qian, Kai Shen, Xinyi Zhu, Danying Zhou, Wei Lu, Zhewei Sun, Hongmao Liu, Kewei Li, Teng Xu, Qiyu Bao, Junwan Lu

“…Sequencing and comparative analysis of the plasmids from a multidrug-resistant C. freundii isolate named R47 showed that the floR-containing region in the plasmid pR47-54 was a truncated transposon-like structure and could be found on both plasmids and chromosomes of bacteria of either animal or human origin. …”
Get full text

Atacama Large Aperture Submillimeter Telescope (AtLAST) science: Our Galaxy [version 2; peer review: 2 approved] by Pamela Klaassen, Maria Beltrán, Alessio Traficante, Mark Booth, Kate Pattle, Jonathan Marshall, Joshua Lovell, Brandt Gaches, Alvaro Hacar, Nicolas Peretto, Caroline Bot, Doris Arzoumanian, Thomas Stanke, Gaspard Duchêne, Ana Duarte Cabral, Antonio Hales, David Eden, Patricia Luppe, Jens Kauffmann, Elena Redaelli, Sebastian Marino, Álvaro Sánchez-Monge, Andrew Rigby, Dmitry Semenov, Eugenio Schisano, Mark Thompson, Silvia Spezzano, Claudia Cicone, Friedrich Wyrowski, Martin Cordiner, Tony Mroczkowski, Doug Johnstone, Luca Di Mascolo, Minju Lee, Eelco van Kampen, Thomas Maccarone, Daizhong Liu, Matthew Smith, Amélie Saintonge, Sven Wedemeyer, Alexander Thelen

“…Here we present a plan for observing the Galactic Plane and circumstellar environments to quantify the physical structure, the magnetic fields, the dynamics, chemistry, star formation, and planetary system evolution of the galaxy in which we live with AtLAST; a concept for a new, 50m single-dish sub-mm telescope with a large field of view which is the only type of facility that will allow us to observe our Galaxy deeply and widely enough to make a leap forward in our understanding of our local ecology.…”
Get full text

Contribution of Spatial Heterogeneity and Temporal-Spatial Change of Ecosystems to the Thermal Environment of Tourist Destinations: A Case Study of Sichuan-Chongqing Region, China by Dechao Chen, Xinliang Xu, Huailong Jiang, Zongyao Sun, Luo Liu, Zhi Qiao

“…Tourism development activities affect the structure and functions of ecosystems directly triggering changes in the thermal environment of tourism destinations and raising a need for sustainable development of the tourism industry. …”
Get full text

Correlations among PPAR𝜸, DNMT1, and DNMT3B Expression Levels and Pancreatic Cancer by Valerio Pazienza, Francesca Tavano, Giorgia Benegiamo, Manlio Vinciguerra, Francesca Paola Burbaci, Massimiliano Copetti, Fabio Francesco di Mola, Angelo Andriulli, Pierluigi di Sebastiano

“…Furthermore, high levels of DNMT3B expression were significantly associated with a lower mortality in the whole population (HR=0.485; 95%CI=0.262–0.895, 𝑃=0.02) and in the subgroup of patients without perineural invasion (HR=0.314; 95%CI=0.130–0.758; 𝑃=0.01), while such association was not observed in patients with tumor invasion into perineural structures (𝑃=0.70). In conclusion, in vitro and in vivo PPARγ and DNMTs appear interrelated in PC, and this interaction might influence cell phenotype and disease behavior.…”
Get full text

High and Low Taxa Specificity of Rhizosphere Bacteria Communities of Mangrove (Rhizophora mucronata) from Kuala Langsa and Telaga Tujuh Island, East Aceh by Siti Maysaroh, Meutia Samira Ismet, Rita Andini, Nurlita Anggraini, Beginer Subhan

“…Abstract The focus of this study on understanding the structure and dynamics of rhizosphere bacteria in mangrove ecosystems is driven by the increasing acknowledgment of the crucial roles these microorganisms play in ecosystem functioning. …”
Get full text

Challenges of Beekeeping in Arid Regions by Salim Hitouche, Mohamed Ridha Messak, Azzouzi Imane, Messaoud Lazereg

“…Due to availability issues and time constraints, beekeepers that were unable to attend scheduled meetings via telephone also reached out. A semi-structured survey was conducted involving 41 local beekeepers and a descriptive analysis of the qualitative and quantitative data gathered. …”
Get full text

Acute Myocardial Infarction Reduces Respiration in Rat Cardiac Fibers, despite Adipose Tissue Mesenchymal Stromal Cell Transplant by Camila I. Irion, Eduarda L. Martins, Michelle L. A. Christie, Cherley B. V. de Andrade, Alan C. N. de Moraes, Raphaela P. Ferreira, Cibele F. Pimentel, Grazielle D. Suhett, Antonio Carlos C. de Carvalho, Rafael S. Lindoso, Adalberto Vieyra, Antonio Galina, Regina C. S. Goldenberg

“…Transmission electron microscopy showed disorganized mitochondrial cristae structure, which was more accentuated in IZ but also important in BZ. …”
Get full text

Interior and Gravity Field Models for Uranus Suggest a Mixed-composition Interior: Implications for the Uranus Orbiter and Probe by Zifan Lin, Sara Seager, Benjamin P. Weiss

“…The interior composition and structure of Uranus are ambiguous. It is unclear whether Uranus is composed of fully differentiated layers dominated by an icy mantle or has smooth compositional gradients. …”
Get full text

High quality genome assembly of the brown hare (Lepus europaeus) with chromosome-level scaffolding by Michell, Craig, Collins, Joanna, Laine, Pia K., Fekete, Zsófia, Tapanainen, Riikka, Wood, Jonathan M. D., Goffart, Steffi, Pohjoismäki, Jaakko L. O.

“…The genome was assembled using 25X PacBio HiFi sequencing data and scaffolded utilizing a Hi-C chromosome structure capture approach. After manual curation, the assembled genome length was 2,930,972,003 bp with N50 scaffold of 125.8 Mb. 93.16% of the assembly could be assigned to 25 identified chromosomes (23 autosomes plus X and Y), matching the published karyotype. …”
Get full text

Multi‐Scale Geomagnetic Forcing Derived From High‐Resolution Observations and Their Impacts on the Upper Atmosphere by Cheng Sheng, Yue Deng, William A. Bristow, Yukitoshi Nishimura, Roderick A. Heelis, Christine Gabrielse

“…Both meso‐scale convection and precipitation forcing are found to enhance ionospheric and thermospheric disturbances with prominent structures and magnitudes of a few tens of meters per second in the horizontal neutral winds at 270 km and a few percent in the neutral density at 400 km through comparisons between simulations driven by the original and smoothed high‐resolution forcing patterns.…”
Get full text

Process evaluation of a cross-sectoral, coordinated follow-up care of stroke patients: a qualitative study by Theresa Schrage, Claudia Glissmann, Götz Thomalla, David Leander Rimmele, Holger Schmidt, Michael Rosenkranz, Stefan Boskamp, Martin Härter, Levente Kriston

“…Methods As part of a multicenter interventional trial, this qualitative study was performed in a pre-post design with semi-structured interviews conducted with patients and health care employees. …”
Get full text

Synthesis of thiophene and N-substituted thieno[3,2-d] pyrimidine derivatives as potent antitumor and antibacterial agents by Hafez Hend N., Alsalamah Sulaiman A., El-Gazzar Abdel-Rhman B. A.

“…Pyrrole derivatives/pyrrolopyrimidine/pyrrolotriazolopyrimidine functionalized thiophenes (15–19) were also synthesized. Structures of the newly synthesized compounds were established by elemental analysis and spectral data. …”
Get full text

Effects of Artemisia argyi leaf water extract (AWE) on growth performance, muscle quality, intestinal microbial, and metabolomics of common carp (Cyprinus carpio) by Di Sun, Nanyang Zeng, Yingjia Pan, Qingsong Shu, Jixing Zou, Yingshi Huang, Guoxia Wang, Jun Shi

“…The effects of AWE supplementation were assessed through various parameters including growth performance, flesh quality, biochemical indices, tissue structure, intestinal microbiota composition, and metabolomics analysis. …”
Get full text

Long COVID-19–related and non-COVID-19 postviral olfactory dysfunction a comparative MRI study focusing on the olfactory cleft and bulbs by Yifan Li, Yifan Li, Mengfan Liu, Mengfan Liu, Ruoqi Zhang, Ruoqi Zhang, Yibei Wang, Jianfeng Liu, Jianfeng Liu

“…No significant differences were found in OB morphology, abnormal OB signals, OB volume reduction, or distances between OBs and surrounding structures (p > 0.05). LCOD patients had significantly greater right olfactory sulcus depth than NCPVOD patients (p = 0.026), with negative correlation to age (r = −0.25, p = 0.04). …”
Get full text

Genetic diversity assessment in pea cultivars and lines using the SSR analysis by K. P. Gainullina, B. R. Kuluev, F. A. Davletov

“…Through studying the source material for pea breeding by the SSR analysis the data were obtained that provide additional information about the genetic structure of the collection and the polymorphism of the studied cultivar accessions. …”
Get full text

Psychometric accuracy of the Dutch Child and Adolescent Trauma Screener by Lieke H. Kooij, Irma M. Hein, Cedric Sachser, Samantha Bouwmeester, Madelief Bosse, Ramón J. L. Lindauer

“…Furthermore reliability, convergent-divergent patterns and diagnostic test accuracy were examined.Results: The underlying DSM-5 factor structure with four symptom clusters (re-experiencing, avoidance, negative alterations in mood and cognitions, hyperarousal) was supported by CFA showing a good fit for the selfreport (CFI = .95, TLI = .94), and an acceptable fit for the caregiver report (CFI = .90, TLI = .89). …”
Get full text

Synthesis and Pesticidal Activities of 5-(2-Cyclopropylaminopyrimidin-4-yl)-4-(thiophenyl)thiazole Derivatives by Won-Sik Choi, Seok-Woo Nam, Il-Doo Kim, Seung-Han Kim, Kun-Ho Park, In-Kyung Bae, Eun-Sil Park, Hwang-Ju Jeon, Sung-Eun Lee

“…Compounds designated as XIII-6~XV-7 were newly synthesized and their structures were confirmed by 1H- and 13C-NMR spectroscopy. …”
Get full text

Body size estimation and weight management practices in urban poor communities in Ghana: A cross-sectional study by Grace Agyemang FREMPONG, John K. ANARFI, Delali Margaret BADASU, Samuel Nii Ardey CODJOE

“…Methods: A cross-sectional design was used to collect data among a sample of 395 adults aged 18-70 years. A semi-structured questionnaire was designed for collection of data on socio-demographic characteristics, weight perceptions, and weight management strategies. …”
Get full text