Experiences of ‘traditional’ and ‘one-stop’ MRI-based prostate cancer diagnostic pathways in England: a qualitative study with patients and GPs by Fiona M Walter, Stephanie Archer, Willie Hamilton, Samuel William David Merriel, John McGrath, Alice S Forster, Hashim Uddin Ahmed, David Eldred-Evans

“…Objectives This study aimed to understand and explore patient and general practitioner (GP) experiences of ‘traditional’ and ‘one-stop’ prostate cancer diagnostic pathways in England.Design Qualitative study using semi-structured interviews, analysed using inductive thematic analysisSetting Patients were recruited from National Health Service (NHS) Trusts in London and in Devon; GPs were recruited via National Institute for Health Research (NIHR) Clinical Research Networks. …”
Get full text

Optimization of Black Garlic Protein Extraction Process and Exploration of Its Properties and Functions with Enzymatic Hydrolysis Products by Jian Liu, Yuanyuan Wang, Bo Wang, Wei Zhang, Xiaoyu Ren, Youchuang Zhang, Lijun Jiang, Chunming Dong, Guihong Zhao

“…Fourier-transform infrared (FTIR) spectroscopy revealed that the dual enzymatic hydrolysis hydrolysate (BGPH-PT) exhibited the most stable structure. Compared to BGP, the hydrolysates demonstrated significantly improved solubility, water-holding capacity, and foaming ability (<i>p</i> < 0.05), while their emulsifying activity, emulsion stability, DPPH radical scavenging capacity, and hypoglycemic activity decreased. …”
Get full text

Decision-making under epistemic, strategic and institutional uncertainty during COVID-19: findings from a six-country empirical study by Clare Wenham, Alexandra L Phelan, Winifred Ukponu, Sumegha Asthana, Tahmina Shirin, Claire J Standley, Adachioma Chinonso Ihueze, Sanjana Mukherjee, Ibrahim B Gobir, Mohannad Al Nsour, JJ Woo, Mohammad Mushtuq Husain, Nevashan Govender, Roujia Lin, Sumit Asthana, Renee Vongai Mutare

“…Decision-making under institutional uncertainty involved using or adapting pre-existing experiences, structures and relationships and establishing new institutions and processes.Conclusions We contribute to the theory and practice of public health crisis decision-making by presenting a unified national-level applied decision-making framework for events involving uncertainty. …”
Get full text

Lipid nanoparticles deliver DNA-encoded biologics and induce potent protective immunity by Dafei Chai, Junhao Wang, Jing Ming Lim, Xiaohui Xie, Xinfang Yu, Dan Zhao, Perry Ayn Mayson Maza, Yifei Wang, Dana Cyril-Remirez, Ken H. Young, Yong Li

“…The LNP formulation used in Moderna’s Spikevax mRNA vaccine (LNP-M) demonstrated a stable nanoparticle structure, high expression efficiency, and low toxicity. …”
Get full text

Intense Pulsed Light Therapy with Optimal Pulse Technology as an Adjunct Therapy for Moderate to Severe Blepharitis-Associated Keratoconjunctivitis by Fang Ruan, Yunxiao Zang, Ruti Sella, Hongshuang Lu, Shang Li, Ke Yang, Tao Jin, Natalie A. Afshari, Zhiqiang Pan, Ying Jie

“…Safety outcome measures included visual acuity, intraocular pressure, eye structure damage, and facial skin appearance at each visit. …”
Get full text

Cryptic species and hybridisation in corals: challenges and opportunities for conservation and restoration by Riginos, Cynthia, Popovic, Iva, Meziere, Zoe, Garcia, Vhon, Byrne, Ilha, Howitt, Samantha M., Ishida, Hisatake, Bairos-Novak, Kevin, Humanes, Adriana, Scharfenstein, Hugo, Richards, Thomas, Briggs, Ethan, Clark, Vanessa, Lei, Chuan, Khan, Mariam, Prata, Katharine E.

“…Here, we investigate the prevalence of cryptic coral groups and assess evidence for their permeability to gene flow (hybridisation) via a structured literature review of genomic studies. Using reproducible criteria to detect distinct genetic groups that are sympatric, we find that 68% of nominal species represented in population genomic studies show evidence for comprising partially reproductively isolated groups and that these distinct groups are often linked by gene flow. …”
Get full text

Designing a glass nanoshell on barium titanium trioxide to suppress nanocrystal growth during sintering for fine-grain dielectric ceramics by Jia Yu, Qi Jiang, Qingchao Jia, Liangzhu Zhang, Wenchun Chiu, Huidan Zeng

“…It is found that the BaTiO3 nanocrystal with average lateral particle size of 70 nm and 200 nm (BT70 and BT200) can be coated with Bi2O3-B2O3-SiO2 (BBS) glass shell to form core-shell structures. The fine crystal of barium titanate ceramics can be achieved under different encapsulation quantities and sintering temperature. …”
Get full text

The Influences of Key Strata Compound Breakage on the Overlying Strata Movement and Strata Pressure Behavior in Fully Mechanized Caving Mining of Shallow and Extremely Thick Seams:... by Junmeng Li, Yanli Huang, Jixiong Zhang, Meng Li, Ming Qiao, Fengwan Wang

“…The research results showed that during the fully mechanized caving mining in shallow and extremely thick seams, the inferior key strata affected by mining movement behaved in the mode of sliding instability and could not form the stable structure of the voussoir beam after breaking and caving. …”
Get full text

Knowledge, willingness to provide service and preparedness for monkeypox infection among medical practitioners working in Bangladesh: a multicentred cross-sectional study by Mohammad Jahid Hasan, Salwa Islam, Mir Susmita Zaman, Jannatul Fardous, Shehab Uddin Al Abid, Tamanna Tabassum, Monirul Hasan, Mohiuddin Sharif

“…Knowledge about monkeypox was assessed by 20 questions, collected through a self-answered paper-based structured questionnaire. Good knowledge was defined by 70% of correct responses among the asked questions. …”
Get full text

Sustainable closed-loop supply chain network design: heuristic hybrid approach with considering inflation and carbon emission policies by Saeid Kalantari, Hamed Kazemipoor, Farzad Movahedi Sobhani, Seyyed Mohammad Hadji Molana

“…Purpose: Establishing the structure and expansion of sustainable closed-loop supply chains is critical to meeting environmental, economic, and social standards to strengthen their position in competitive markets. …”
Get full text

<inline-formula><tex-math notation="LaTeX">$\mathrm{D}^{3}$</tex-math></inline-formula>T: Deep Denoising Dictionary Tensor for Hyperspectral Anomaly Detection by Qiangqiang Shen, Zonglin Liu, Hanzhang Wang, Yanhui Xu, Yongyong Chen, Yongsheng Liang

“…Hyperspectral anomaly detection (HAD) approaches with tensor low-rank representation (TLRR) have shown engaging performance, which are capable of capturing abundant spectral and spatial information and, hence, extracting sparse anomalies from the low-rank background without ruining the intrinsic geometric structures of tensor data. However, existing HAD approaches construct the low-rank representation by a handcrafted dictionary that still contains the anomalies, resulting in an inferior representation. …”
Get full text

Grazing mortality as a controlling factor in the uncultured non-cyanobacterial diazotroph (Gamma A) around the Kuroshio region by T. Sato, T. Sato, T. Yamaguchi, K. Hidataka, S. Sogawa, T. Setou, T. Kodama, T. Kodama, T. Shiozaki, K. Takahashi

“…In this study, we investigated the diazotroph community structure using <i>nifH</i> amplicon sequencing and quantified the growth and microzooplankton grazing mortality rate of Gamma A using a combination of dilution experiments and quantitative polymerase chain reaction (PCR) in well-lit waters at the northern edge of the Kuroshio Current off the southern coast of Japan. …”
Get full text

Early Transcriptional Changes Induced by Wnt/β-Catenin Signaling in Hippocampal Neurons by Eduardo Pérez-Palma, Víctor Andrade, Mario O. Caracci, Bernabé I. Bustos, Camilo Villaman, Matías A. Medina, Miguel E. Ávila, Giorgia D. Ugarte, Giancarlo V. De Ferrari

“…Our results indicate that Wnt/β-catenin mediated transcription controls multiple biological processes related to neuronal structure and activity that are affected in synaptic dysfunction disorders.…”
Get full text

Recognition and cleavage of human tRNA methyltransferase TRMT1 by the SARS-CoV-2 main protease by Angel D'Oliviera, Xuhang Dai, Saba Mottaghinia, Sophie Olson, Evan P Geissler, Lucie Etienne, Yingkai Zhang, Jeffrey S Mugridge

“…We also determined the structure of an Mpro-TRMT1 peptide complex that shows how TRMT1 engages the Mpro active site in an uncommon substrate binding conformation. …”
Get full text

Ocular Aberrations and Retinal Thickness Variations After Moderate-Term Reading on Electronic Devices by Age by María Arcas-Carbonell, Elvira Orduna-Hospital, María Mechó-García, María Munarriz-Escribano, Ana Sanchez-Cano

“…Background: This study aims to evaluate subjective visual fatigue and objective optical and morphological changes in ocular structures after intermediate-duration reading on an iPad and an Ebook across different age groups. …”
Get full text

PENIAPHOBIA AS A COMPONENT OF THE DESTRUCTIVE DIGITAL MEDIA DISCOURSE IN THE ASIA-PACIFIC REGION by Margarita D. Lagutkina, Zhang Yi, Chang Thi Thu Huong

“…The authors attribute peniaphobia to one of the universal social stigmas that affect the social structure and culture of the community, recognizing that media discourse is actively using open public Internet communication to control public consciousness gently. …”
Get full text

Energy Transition in Northern Netherlands: seeking a balance between top-down and bottom-up initiatives [version 2; peer review: 1 approved, 4 approved with reservations, 1 not app... by Cyril Tjahja, Bas Oldenbroek, Tineke van der Schoor, Ifigenia Psarra

“…Specifically, this qualitative (thematic analysis) research study investigates the mismatch in expectations between a number of local energy initiatives and the municipality of Groningen regarding their roles within the local energy transition context. To this end, semi-structured interviews have been conducted with members of the municipality of Groningen, Grunneger Power (a local energy intermediary), and four local energy initiatives. …”
Get full text

Hybrid Prophet-NAR Model for Short-Term Electricity Load Forecasting by Winita Sulandari, Yudho Yudhanto, Etik Zukhronah, Isnandar Slamet, Hilman Ferdinandus Pardede, Paulo Canas Rodrigues, Muhammad Hisyam Lee

“…The proposed PropNAR integrated the strengths of the Prophet model in capturing deterministic structures, such as trends, seasonality, and holiday effects with the NAR model&#x2019;s ability to handle nonlinear stochastic relationships. …”
Get full text

Research Review and Prospect of Litchi Fruit Cracking by Xiwen LI, Haoshuang SUN, Xuequn PANG, Zhaoqi ZHANG

“…In the future, researches should be strengthened on the relationship between the structure of the suture line and fruit cracking in litchi fruit, and the possible influence of seed type on the susceptibility to fruit cracking.…”
Get full text

Collagen deposition in lung parenchyma driven by depletion of interstitial Lyve-1+ macrophages prevents cigarette smoke-induced emphysema and loss of airway function by Yinebeb Mezgebu Dagnachew, Yinebeb Mezgebu Dagnachew, Yinebeb Mezgebu Dagnachew, Hwee Ying Lim, Hwee Ying Lim, Liao Wupeng, Liao Wupeng, Sheau Yng Lim, Sheau Yng Lim, Sheng Jie Natalie Lim, Sheng Jie Natalie Lim, Chung Hwee Thiam, Chung Hwee Thiam, Shu Wen Tan, Shu Wen Tan, Joan Lau Joo Eng, Joan Lau Joo Eng, Dan Mei, Syaza Hazwany Mohammad Azhar, Wei Siong Ong, Qi Hui Caris Tan, Wai-Shiu Fred Wong, Wai-Shiu Fred Wong, Wai-Shiu Fred Wong, Veronique Angeli, Veronique Angeli

“…IntroductionCollagen is essential for maintaining lung structure and function and its remodeling has been associated with respiratory diseases including chronic obstructive pulmonary disease (COPD). …”
Get full text