Ruxolitinib and oHSV combination therapy increases CD4 T cell activity and germinal center B cell populations in murine sarcoma by Ravi Dhital, Yeaseul Kim, Doyeon Kim, Ilse Hernandez-Aguirre, Jack Hedberg, Alexia Martin, Kevin A. Cassady

“…RUX+oHSV therapy also increased cytokine-expressing CD4(+) populations, predominantly granzyme B(+) cytotoxic-like, interferon (IFN)-γ(+) T helper type 1 (Th1)-like, and interleukin (IL)-21(+) T follicular helper (Tfh)-like phenotypes, within the tumor infiltrates, suggestive of potential tertiary lymphoid structure development in the treated tumors. Here, we illustrate the utility of a high-dimensional spectral flow cytometry panel that permits simultaneous evaluation of intratumoral CD4/CD8 T cell, Treg, γδ-T cell, natural killer T (NKT) cell, B cell, NK cell, monocyte, macrophage, granulocyte, myeloid-derived suppressor cell (MDSC), and dendritic cell functional changes from RUX+oHSV-treated MPNSTs.…”
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Diagnostics and Treatment of Esophageal Achalasia (Clinical Guidelines of the Russian Gastroenterological Association, Russian Scientific Medical Society of Internal Medicine, Russ... by V. T. Ivashkin, A. S. Trukhmanov, I. V. Maev, O. M. Drapkina, A. I. Martynov, O. A. Storonova, E. A. Godgello, M. P. Korolev, T. L. Lapina, P. V. Pavlov, A. V. Paraskevova, I. A. Tarasova, E. D. Fedorov, A. T. Tskhovrebov, M. P. Shapka, A. L. Shestakov, A. V. Yurasov

“…Treatment of achalasia can be pharmacological, endoscopic (pneumatic balloon dilation, peroral endoscopic myotomy, botulinum toxin injection), aimed at regulating the tone and motility of the esophagus and cardia while preserving all anatomical structures, and surgical (laparoscopic esophagocardiomyotomy, esophagectomy), in which the muscle fibers of the esophagus and esophagogastric junction are intersected or the altered esophagus is completely removed with simultaneous formation of an artificial esophagus from the stomach or colon (esophagoplasty).Conclusion. …”
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PHAST. The Panchromatic Hubble Andromeda Southern Treasury. I. Ultraviolet and Optical Photometry of over 90 Million Stars in M31 by Zhuo Chen, Benjamin Williams, Dustin Lang, Andrew Dolphin, Meredith Durbin, Julianne J. Dalcanton, Adam Smercina, Léo Girardi, Claire E. Murray, Eric F. Bell, Martha L. Boyer, Richard D’Souza, Karoline Gilbert, Karl Gordon, Puragra Guhathakurta, Francois Hammer, L. Clifton Johnson, Tod R. Lauer, Margaret Lazzarini, Jeremiah W. Murphy, Ekta Patel, Amanda Quirk, Mariangelly Díaz Rodríguez, Julia Christine Roman-Duval, Robyn E. Sanderson, Anil Seth, Tobin M. Wainer, Daniel R. Weisz

“…We also present seamless population maps of the entire M31 disk, which show relatively well-mixed distributions for stellar populations older than 1–2 Gyr, and highly structured distributions for younger populations. The combined PHAST + PHAT photometry catalog of ∼0.2 billion stars is the largest ever produced for equidistant sources and is available for public download by the community.…”
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Practice patterns among early-career primary care (ECPC) physicians and workforce planning implications: protocol for a mixed methods study by Richard J Gibson, Tara Sampalli, Tara Kiran, Richard H Glazier, Agnes Grudniewicz, Kimberlyn McGrail, David Snadden, Ian Scott, M Ruth Lavergne, Laurie J Goldsmith, David Rudoler, Emily Gard Marshall, Megan Ahuja, Doug Blackie, Fred Burge, Steve Hawrylyshyn, Lindsay Hedden, Jacalynne Hernandez-Lee, Kathleen Horrey, Mike Joyce, Adrian MacKenzie, Maria Mathews, Rita McCracken, Madeleine McKay, Charmaine McPherson, Goldis Mitra, Gail Tomblin Murphy, Sabrina T Wong

“…We will conduct semi-structured in-depth interviews with family medicine residents and early-career PCPs and analyse survey data collected by the College of Family Physicians of Canada. …”
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A qualitative study on the impact and participation in the AGELESS multidomain intervention: Insights from older adults with cognitive frailty and their caregivers by Ying Qian Ong, Suzana Shahar, A’isyah Mohd Safien, Norhayati Ibrahim, Ai-Vyrn Chin, Francesca Mangialasche, Miia Kivipelto, Devinder Kaur Ajit Singh

“…Methods This qualitative study was conducted following the completion of AGELESS multidomain intervention. Semi-structured interviews covering domains such as perceptions, benefits, barriers, facilitators, and program preferences were conducted among 17 older adults with CF and 10 caregivers following the completion of the intervention. …”
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Time to act: Institutional mental health support for Ukrainian academic staff during wartime by Natalia Tsybuliak, Volodymyr Vakhitov, Hanna Mytsyk, Hanna Lopatina, Maryna Nesterenko, Artem Polulyakhov, Yuriy Petrushenko

“…The study underscores the importance of structured mental health support in fostering resilience within the academic community, with implications for policy and practice in war-affected educational environments. …”
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Cancer-associated fibroblasts and their role in tumor progression by M. S. Ermakov, A. A. Nushtaeva, V. A. Richter, O. A. Koval

“…The stromal elements of a malignant tumor can promote cancer progression and metastasis. The structure of the tumor stroma includes connective tissue elements, blood vessels, nerves, and extracellular matrix (ECM). …”
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Distribution Characteristics of Nutrients and Eutrophication Assessment in Yueqing Bay by YAO Kaixue, YIN Rui, WANG Yang, CHEN Feng, LI Zhenhua

“…Based on the Marine environment monitoring data of Yueqing Bay in spring, summer, autumn and winter from 2018 to 2019, the spatial and temporal distribution characteristics of nutrient salts (dissolved inorganic nitrogen, DIN) and active phosphate (DIP) in the sea were analyzed, and the pollution degree, eutrophication degree and nutrient structure of the sea area were evaluated by single factor index method, eutrophication index method and potential eutrophication model. …”
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Ion beam induced secondary electron tomography of acrylonitrile-styrene-acrylate/polycarbonate polymer blends for fused filament fabrication and injection moulding by J. Hernández-Saz, D. Moreno-Sanchez, L. M. Valencia, Y. Gómez, S. I. Molina, M. Herrera

“…Blends obtained by FFF exhibit strong directionality and a co-continuous morphology, whereas IM objects present a droplet-matrix structure. Also, the interface area between the ASA and PC is quantified to be of 3200 μm² for the FFF sample and 1400 μm² for the IM sample, approximately double in FFF than in IM. …”
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Geological disaster risk assessment based on ecological niche model: A case study of Longhui County, Shaoyang City by Yun ZHANG, Feng ZI, Jiehua GUO, Yunjiang CAO, Jiuling DUAN, Zhigang GUO, Long TANG

“…The study considered various disaster-inducing factors and selected 13 assessment criteria from topography and geomorphology, geological structure, engineering geology of geotechnical bodies, and human engineering activities. …”
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The Effects of Tormentic Acid and Extracts from Callistemon citrinus on Candida albicans and Candida tropicalis Growth and Inhibition of Ergosterol Biosynthesis in Candida albicans by Chido Bvumbi, Godloves Fru Chi, Marc Y. Stevens, Molly Mombeshora, Stanley Mukanganyama

“…Modifications of the structure of tormentic acid to increase its antifungal potency may be explored in further studies.…”
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Person-centered support for patients with a pituitary tumor following surgery by Sofie Jakobsson, Oskar Ragnarsson, Tobias Hallén, David Krabbe, Ann-Charlotte Olofsson, Daniel S Olsson, Penelope Trimpou, Thomas Skoglund, Gudmundur Johannsson

“…The study does, however, suggest that the intervention may reduce anxiety 12 months after surgery and that certain subgroups of patients may benefit more from a structured person-centered practice following pituitary surgery.…”
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Early determination of potential critical quality attributes of therapeutic antibodies in developability studies through surface plasmon resonance-based relative binding activity a... by Shuai Wang, Yanqiu Wang, Zhenzhen Li, Ye Hong, Zhaohui Wang, Jiteng Fan, Qiong Wang, Yuanjie Ge, Xiaofeng Zhao, Guangcun Cheng, Changyan Chen, Yadan Wu, Yayuan Fu

“…The current developability assessment strategy provided comprehensive, precise characterization of antibody binding activity in the stability studies, enabling us to perform correlation analysis and establish the structure–function relationship between relative binding activity and quality attributes. …”
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Investigation in blood-brain barrier integrity and susceptibility to immune cell penetration in a mouse model of Dravet syndrome by Cristina Alonso, Alicia García-Culebras, Valentina Satta, Inés Hernández-Fisac, Álvaro Sierra, José A. Guimaré, Ignacio Lizasoain, Javier Fernández-Ruiz, Onintza Sagredo

“…However, the levels of endogenous IgG in this brain structure were significantly elevated in DS mice compared to controls, directly indicating the occurrence of extravasation into the brain parenchyma and indirectly that the BBB in DS mice may be relatively affected, a fact confirmed by the reduction in the levels of BBB-related proteins such as ZO-1 in these mice. …”
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Enhancing the strength and transparency of egg white gels: mechanistic insights into the role of sodium decanoate by Yuting Du, Xuan Yao, Qianying Ding, Gan Hu, Chunmei Wang, Yizi Yuan, Zhifeng Zhao, Fang Geng

“…C10 promotes the formation of smooth and dense gel network structure mainly by enhancing the hydrophobic interactions of egg white protein (EWP), thus effectively improving the gel properties. …”
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Task-shifted approaches to postdiagnostic dementia support: a qualitative study exploring professional views and experiences by Louise Robinson, Greta Rait, Claire Bamford, Jill Manthorpe, Rachael Frost, Jane Wilcock, Karen Harrison Dening, Martin Knapp, Sube Banerjee, Joy Adamson, Alistair Burns, Raphael Wittenberg, Kate Walters, Alison Wheatley, Greta Brunskill, Louise Allan, Lynne Corner, Donna Buxton, Katherine Jacques, Doug Lewins, Sue Tucker

“…Objectives To explore the views of commissioners, service development leads, service managers and senior staff in selected dementia services on increasing the role of primary care in postdiagnostic support for people with dementia.Design Qualitative semi-structured telephone interviews and a focus group.Setting Participants were drawn from National Health Service (NHS) Clinical Commissioning Groups, social care commissioning and a range of dementia services across primary care, secondary mental healthcare, social care and the third sector. …”
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Optimization of photocatalytic degradation of Eriochrome Black T from aqueous solution using TiO2-biochar composite by Mohammednur Abdu, Solomon Tibebu, Saeideh Babaee, Abebe Worku, Titus A.M. Msagati, Jemal Fito Nure

“…The synthesis resulted in an anatase phase crystal structure, a reduced band gap of 2.69 eV, and a significant surface area increase from 38 m²/g to 78 m²/g. …”
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Carbon finance for forest resilience in California by Micah Elias, Ethan Yackulic, Katharyn Duffy, Katharyn Duffy, Phil Saksa, Daniel L. Sanchez, Nicholas Pevzner, Spencer Plumb, Jillian Dyszynski, Carina Bracer

“…Restoring a resilient forest structure in California’s American River watershed in the Sierra Nevada mountains can generate up to $6,100 per acre in carbon revenue from increased forest carbon and market-ready biomass utilization pathways, potentially fully funding forest management. …”
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Prevalence of Cholelithiasis and Associated Factors of Gallstone Formation after Laparoscopic Sleeve Gastrectomy in the Gastroenterology and Hepatology Teaching Hospital-Baghdad by Abdulrahman M. Mohammed, Abdulnaser M. Mohammed, Tuka Y. Hassan

“…Data was collected using a structured questionnaire. Results: The mean age of patients was 36.5±5.21 (17–54) for females and 41.6 ±3.04 (24–58) for males. …”
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Transcriptional Systems Vaccinology Approaches for Vaccine Adjuvant Profiling by Diogo Pellegrina, Heather L. Wilson, George K. Mutwiri, Mohamed Helmy

“…Over the following decades, oil emulsions, vesicles, oligodeoxynucleotides, viral capsids, and other complex organic structures have been shown to have adjuvant potential. …”
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