Stochastic demethylation and redundant epigenetic suppressive mechanisms generate highly heterogeneous responses to pharmacological DNA methyltransferase inhibition by Mie K. Jakobsen, Sofie Traynor, Aaraby Y. Nielsen, Christina Dahl, Mette Staehr, Simon T. Jakobsen, Maria S. Madsen, Rasmus Siersbaek, Mikkel G. Terp, Josefine B. Jensen, Christina B. Pedersen, Anup Shrestha, Jonathan R. Brewer, Pascal H. G. Duijf, Odd L. Gammelgaard, Henrik J. Ditzel, Alexei F. Kirkin, Per Guldberg, Morten F. Gjerstorff

“…Mechanistic insights were further gained through DNA methylation profiling and chromatin structure analysis. Results We show that breast cancer tumors and cell cultures exhibit a highly heterogenous response to DNA methyltransferase inhibitors, persisting even under high drug concentrations and efficient DNA methyltransferase depletion. …”
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The impact of staple crop price instability and fragmented policy on food security and sustainable development: a case study from Bangladesh by Zia Ahmed, Abdul Kadir, Rafiul Alam, Hafiz-Al-Rezoan, Md. Aminul Haque Laskor

“…A review of national policy reveals that food stability, a key pillar of food security, is often overlooked, with no structured system for monitoring market prices. Integrating agricultural and climate policies could enhance resilience and productivity in agriculture. …”
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Curtailing the spread of COVID-19 in Nigeria using digital framework and data driven approaches by Bolanle Adefowoke Ojokoh, Benjamin S. Aribisala, Oluwafemi A. Sarumi, Tobore V. Igbe, Abimbola H. Afolayan, Arome J. Gabriel, Abiola Ezekiel Taiwo, Olatunji M. Omisore, Uchechukwu M. Chukwuocha, Olusola T. Babalola, Tolulope A. Adebayo

“…Additionally, this study provided insights into the practical implementation of such frameworks and the challenges associated with their nationwide deployment. A structured user-oriented questionnaire was distributed to participants across different geopolitical zones in Nigeria. …”
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Using stone dust as an improvement material for cement gravel column by Raksiri Sukkarak, Pornkasem Jongpradist, Panich Voottipruex, Pitthaya Jamsawang, Suraparb Keawsawasvong, Teerawut Pansuwannakun, Ittipon Meepon

“…A cement gravel (CG) column was employed for ground improvement in foundation engineering, offering increased load-bearing capacity and structure stability. This research explores the feasibility of incorporating stone dust into cement gravel columns to enhance their mechanical properties and sustainability profile. …”
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Learning and Teaching Geological Field Skills in a Virtual World: Insights From an Undergraduate Virtual Fieldtrip in Kinlochleven, Scotland by Matthew J. Genge, Valentin Laurent, Philippa J. Mason, Alan R. T. Spencer, Mark D. Sutton, Alex C. Whittaker

“…We describe the development of a virtual fieldtrip to Kinlochleven in Scotland to teach undergraduate students geological mapping skills in a structurally complex, polyphase deformed metamorphic terrain. …”
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Three local plants adapt to ecological restoration of abandoned lead-zinc mines through assembly of rhizosphere bacterial communities by Wei Gao, Shuyi Chen, Xin Yu, Sumin Chen, Caijing Wan, Ying Wang, Peng Wu, Qiang Li

“…Following the planting of the three types of ecologically restored plants, the soil bacterial community structure partially recovered. In addition, different plants have been found to have different functions in the lead-zinc ecological restoration process, including iron complex transport system-permitting proteins and ATP binding cassettes.DiscussionThis study confirms for the first time that plants adapt to the remediation process of abandoned lead-zinc mines by non-randomly assembling rhizosphere bacterial communities and functions, providing a reference for screening microbial remediation bacterial resources and plant microbe joint bioremediation strategies for lead-zinc mines.…”
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Strategic SWOT analysis of the University of Nigeria Teaching Hospital using Modified Delphi Technique: implications for strengthening national and regional health systems by Cyril Chukwudi Dim, Chinyere Ojiugo Mbachu, Nympha Onyinye Enebe, Wilson Chukwukasi Kassy, Johnpaul Ejikeme Nnagbo, Ikechukwu Emmanuel Obi, Nkiruka Pauline Onodugo, Nwamaka Ngozika Lasebikan, Obinna Donatus Onodugo

“…This was followed by a structured ranking of the SWOTs by 109 staff of UNTH to isolate the priority assets and needs of the organization. …”
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Characterizing a complex buildup in the Pearl River Mouth Basin of the northern South China Sea: an interplay of carbonates and igneous rocks by Beichen Chen, Leyi Xu, Baojun Liu, Lili Zhang, Dong Xiao, Ya Gao, Ya Gao, Feng Wu, Xueqi Yang, Yaming Zou, Yongkun Ma, Yinglin Zhang

“…We propose that volcanic rocks can be distinguished from carbonates by the temporal and spatial coupling of typical features: (a) surface volcanic rocks and subsurface intrusive bodies are inseparable, with igneous rocks identifiable through faults and volcanic conduits; (b) carbonates typically display symmetrical structures on both sides of the highland and exhibit better stratification away from igneous activity; (c) carbonates generally show a convex clinoform and steep slope at the platform margin, while volcanic mounds exhibit concave gentle slopes. …”
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Exploring the impact of fulvic acid and humic acid on heavy metal availability to alfalfa in molybdenum contaminated soil by Mengmeng Wang, Gangfu Song, Zhihong Zheng, Xiao Mi, Zhixin Song

“…As a result, the proportion of non-residual Mo fractions (exchangeable, reducible, and oxidizable) decreased from 87.48% to 80.30-87.35%, while residual fractions increased from 12.52% to 12.65–19.70%. Additionally, the structure of the soil bacterial community was primarily influenced by changes in soil properties such as cation exchange capacity, available phosphorus, and ammonium nitrogen levels. …”
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An improved U-net and attention mechanism-based model for sugar beet and weed segmentation by Yadong Li, Ruinan Guo, Rujia Li, Rongbiao Ji, Mengyao Wu, Dinghao Chen, Cong Han, Ruilin Han, Yongxiu Liu, Yuwen Ruan, Jianping Yang, Jianping Yang

“…To address this issue, this paper proposes an efficient crop-weed segmentation model based on an improved UNet architecture and attention mechanisms to enhance both recognition accuracy and processing speed.MethodsThe model adopts the encoder-decoder structure of UNet, utilizing MaxViT (Multi-Axis Vision Transformer) as the encoder to capture both global and local features within images. …”
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Induction of annexin-1 at transcriptional and post-transcriptional level in rat brain by methylprednisolone and the 21-aminosteroid U74389F by P. H. Voermans, K. G. Go, G. J. Ter Horst, M. H. J. Ruiters, E. Solito, L. Parente

“…An opposite profile was shown by the Anx-1 immunoreactivity, the protein was present in control animals as well as the steroid-pretreated animals, suggesting that here the protein was either from systemic origin, or has diffused from adjacent structures. The results indicated that Anx-1 mRNA transcription is upregulated by either steroid, and that in the untreated animals there is a resting level of Anx-1 mRNA transcription, presumably reflecting physiological influences on Anx-1 expression.…”
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Biomineral additives for self-healing of concrete by T. N. Chernykh, K. A. Gorbachevskykh, M. V. Kriushin, A. A. Orlov, M. V. Komelkova, P. O. Platkovskii

“…The reasons for the reduction of durability of flexural structures due to the violation of the protective layer of reinforcement are considered. …”
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A novel cytoprotective organ perfusion platform for reconstructing homeostasis of DCD liver while alleviating IRI injury by Tingting Lan, Mingxing Yu, Tao Ming, Hong Wang, Juan Deng, Shuhan Cheng, Zhongyang Shen, Deling Kong

“…Abstract Pump is a vital component for expelling the perfusate in small animal isolated organ normothermic machine perfusion (NMP) systems whose flexible structure and rhythmic contraction play a crucial role in maintaining perfusion system homeostasis. …”
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Fine Particulate Matter Deposition in 3D Out-of-Plane Bifurcation Lung Airway by Chun-Chih Chuang, Justus Kavita Mutuku, Chih-Che Chueh, Anurita Selvarajoo, Wei-Hsin Chen

“…While the in-plane airway structures of human lungs are usually used in numerical models, a 3D out-of-plane layout that can geometrically represent triple bifurcations airways of the so-called Weibel model is developed in the present study with the presence of fine particles inside. …”
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Exploring the Expediency of Waste Materials as Modifiers for Bitumen Mixes by Lukman Olaide Salami, Ifedolapo Omowumi Ameen, Afeez Adefemi Bello

“…The XRF revealed an enhancement in the adhesion and interlocking in the mineral structure. Exploring WPB and WSW as a modifier for the bitumen mixtures is feasible due to the improved performance of the bitumen mixes. …”
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Agroecological mapping of livestock feed resources for sustain productivity and climate resilience in Benin (West Africa) by Marthe Montcho, Alassan S. Assani, Jean de Dieu Ainamon, André B. Aboh, Pascal A. Olounladé, Brice Sinsin

“…Data were collected through discussions with agropastoralists, structured questionnaires, secondary data and observations. …”
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Complex bacterial diversity of Guaymas Basin hydrothermal sediments revealed by synthetic long-read sequencing (LoopSeq) by John E. Hinkle, John E. Hinkle, Jeffrey P. Chanton, Molly A. Moynihan, Molly A. Moynihan, S. Emil Ruff, S. Emil Ruff, Andreas Teske

“…Previous studies of microbial community structure in hydrothermal sediments have typically used short-read sequencing approaches. …”
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Stakeholders’ Views on Factors Influencing Nutrition Policy: a Qualitative Study Across Ten European Countries by Jeruszka-Bielak Marta, Sicińska Ewa, Wit Liesbeth de, Ruprich Jiří, Řehůřková Irena, Brown Kerry A., Timotijevic Lada, Sonne Anne-Mette, Haugaard Pernille, Guzzon Antonella, Garcia Noé Brito, Alevritou Eleni, Hermoso Maria, Sarmant Yuliya, Lähteenmäki Liisa, Roszkowski Wojciech, Raats Monique M.

“…Study was carried out during Jan-Nov 2010 in European countries: the Czech Republic, Denmark, England, Germany, Greece, Italy, the Netherlands, Norway, Poland and Spain. Semi-structured qualitative interviews were conducted with representatives of stakeholders involved in the vitamin D, folate and iodine policy making process. …”
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Effects of dietary supplementation with novel organic rare earths on growth performance, gut and liver health, gut microbiota in golden pompano by Ming Li, Hui Liang, Rui Xia, Jian Zhang, Jie Chen, Wenhao Zhou, Qianwen Ding, Yalin Yang, Zhen Zhang, Yuanyuan Yao, Chao Ran, Zhigang Zhou

“…In conclusion, our study found that novel organic rare earths enhanced the growth performance of golden pompano and gut-liver health, altered the structure and function of the gut microbiota to alleviate microbiota imbalance. …”
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Ankylosing Spondylitis by Nazanin Ebrahimiadib, Sahar Berijani, Mohammadreza Ghahari, Fatemeh Golsoorat Pahlaviani

“…Inflammation mostly affects the axial joints, entheses, and extra-articular structures such as uveal tract, gastrointestinal tract, mucocutaneous tissue, and heart. …”
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