Distinct gut microbial signature and altered short chain fatty acid metabolism at disease onset in a rat preclinical model of superimposed preeclampsia by Moumen M. Alhasan, María S. Landa, Silvia I. García, Roman G. Gerlach, Hani Harb, Fabian B. Fahlbusch, Melanie L. Conrad, Gabriela Barrientos

“…The blood pressure profile, renal function parameters and fetal phenotype were evaluated in pregnant Stroke-prone Spontaneously Hypertensive Rats (SHRSP) and their normotensive controls. …”
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Association of Premature Ventricular Contraction (PVC) with hematological parameters: a data mining approach by Nafiseh Hosseini, Sara Saffar Soflaei, Pooria Salehi-Sangani, Mahdiyeh Yaghooti-Khorasani, Bahram Shahri, Helia Rezaeifard, Habibollah Esmaily, Gordon A. Ferns, Mohsen Moohebati, Majid Ghayour-Mobarhan

“…In this study, 9,035 participants were enrolled in the Mashhad stroke and heart atherosclerotic disorder (MASHAD) cohort study. …”
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Lights and Siren Transport and the Need for Hospital Intervention in Nontrauma Patients: A Prospective Study by Olivier Bertholet, Mathieu Pasquier, Elina Christes, Damien Wirths, Pierre-Nicolas Carron, Olivier Hugli, Fabrice Dami

“…Since 2013, rapid transportation from the field, fast-track, is currently used for patients with acute ST-elevation myocardial infarction, suspicion of acute stroke and out-of-hospital cardiac arrest. The aim of this study was to determine whether the use of LST was associated with the realization of TCHI for nontrauma cases within 15 minutes of hospital arrival, to quantify overtriage (LST without TCHI) and to identify the predictors of TCHI. …”
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M2 Macrophages as a Potential Target for Antiatherosclerosis Treatment by Ying Bi, Jixiang Chen, Feng Hu, Jing Liu, Man Li, Lei Zhao

“…Atherosclerosis is a chronic progressive inflammation course, which could induce life-threatening diseases such as stroke and myocardial infarction. Optimal medical treatments for atherosclerotic risk factors with current antihypertensive and lipid-lowering drugs (for example, statins) are widely used in clinical practice. …”
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Percutaneous Intervention or Bypass Graft for Left Main Coronary Artery Disease? A Systematic Review and Meta-Analysis by Waqas Ullah, Yasar Sattar, Irfan Ullah, Ammu Susheela, Maryam Mukhtar, M. Chadi Alraies, Mamas A. Mamas, David L. Fischman

“…PCI was associated with a lower overall rate of a stroke, while the risk of all-cause mortality was not significantly different between the two groups at 1- (p = 0.75), 5- (p = 0.72), and 10-years (p = 0.20). …”
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Synthesis, H2S releasing properties, antiviral and antioxidant activities and acute cardiac effects of nucleoside 5′-dithioacetates by Miklós Bege, Miklós Lovas, Dániel Priksz, Brigitta Bernát, Ilona Bereczki, Rasha Ghanem Kattoub, Richárd Kajtár, Simon Eskeif, Levente Novák, Jan Hodek, Jan Weber, Pál Herczegh, István Lekli, Anikó Borbás

“…Dithioacetyl-adenosine and its metabolite showed similar acute cardiac effects as adenosine, however, it is noteworthy that both 5′-thio modified adenosines increased left ventricular ejection fraction or stroke volume, which was not observed with native adenosine.…”
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Oncostatin M and TLR-4 Ligand Synergize to Induce MCP-1, IL-6, and VEGF in Human Aortic Adventitial Fibroblasts and Smooth Muscle Cells by David Schnittker, Karen Kwofie, Ali Ashkar, Bernardo Trigatti, Carl D. Richards

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Serum NFL and neuropsychological performance over ∼8 years in women with and without HIV: a longitudinal repeated measures studyResearch in context by Deborah R. Gustafson, Xuantao Li, Alison E. Baird, Henrik Zetterberg, Kaj Blennow, Jinbing Zhang, Amanda Blair Spence, Pauline Maki, Anjali Sharma, Kathleen Weber, Recai Yucel

“…Summary: Background: Blood-based biomarkers of Alzheimer's disease (AD) and stroke, including serum neurofilament light chain (sNFL), are understudied in women living with and without HIV. …”
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Toll-Like Receptor 9 Promotes Cardiac Inflammation and Heart Failure during Polymicrobial Sepsis by Ralph Lohner, Markus Schwederski, Carolin Narath, Johanna Klein, Georg D. Duerr, Alexandra Torno, Pascal Knuefermann, Andreas Hoeft, Georg Baumgarten, Rainer Meyer, Olaf Boehm

“…Eighteen hours after CASP WT mice developed septic heart failure characterised by reduction of end-systolic pressure, stroke volume, cardiac output, and parameters of contractility. …”
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Deep learning-based prediction of mortality using brain midline shift and clinical information by An-Rong Wu, Sun-Yuan Hsieh, Hsin-Hung Chou, Cheng-Shih Lai, Jo-Ying Hung, Bow Wang, Yi-Shan Tsai

“…Brain midline shift (MLS) indicates the severity of mass effect from intracranial lesions such as traumatic brain injury, stroke, brain tumor, or hematoma. Brain MLS can be used to determine whether patients require emergency surgery and to predict patients' prognosis. …”
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Association of C-Reactive Protein with Short-Term Outcomes in Spontaneous Intracerebral Hemorrhage Patients with or without Infection: From a Large-Scale Nationwide Longitudinal Re... by Du Y, Liu L, Kang K, Lin Y, Gu H, Bian L, Li Z, Zhao X

“…Yang Du,1,2 Lijun Liu,1,2 Kaijiang Kang,1,2 Yijun Lin,1,2 Hongqiu Gu,1,2 Liheng Bian,1,2 Zixiao Li,1,2 Xingquan Zhao1– 4 1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2China National Clinical Research Center for Neurological Diseases, Capital Medical University, Beijing, People’s Republic of China; 3Research Unit of Artificial Intelligence in Cerebrovascular Disease, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China; 4Center of Stroke, Beijing Institute for Brain Disorders, Beijing, People’s Republic of ChinaCorrespondence: Xingquan Zhao; Zixiao Li, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, 119 West Road, South 4th Ring, Fengtai District, Beijing, People’s Republic of China, 100070, Tel +86-10-59975835, Email lizixiao2008@hotmail.com; zxq@vip.163.comAim: To study the relationship between elevated C-reactive protein (CRP) levels, infection, and spontaneous intracerebral hemorrhage (ICH) outcomes.Methods: Patients were classified into four groups (Q1–Q4). …”
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Predicting high sensitivity C-reactive protein levels and their associations in a large population using decision tree and linear regression by Somayeh Ghiasi Hafezi, Toktam Sahranavard, Alireza Kooshki, Marzieh Hosseini, Amin Mansoori, Elham Amir Fakhrian, Helia Rezaeifard, Mark Ghamsary, Habibollah Esmaily, Majid Ghayour-Mobarhan

“…This study was conducted on a population of 9704 males and females aged 35 to 65 years recruited from the Mashhad Stroke and Heart Atherosclerotic Disorder (MASHAD) cohort study. …”
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Hospitalisation from seasonal influenza among persons with type 1 diabetes: a cohort study from the Swedish National Diabetes Register by Katarina Eeg-Olofsson, Björn Eliasson, Hanne Krage Carlsen, Lena Svensson, Magnus Gisslén, Elin Allansson Kjölhede, Oliver Martyn

“…Within the T1D cohort, individuals hospitalised due to influenza were older, were more often smokers, had lower glomerular filtration rate and more often had a previous history of ischaemic heart disease and stroke.Conclusions To our knowledge, this is the first large study to highlight that persons with T1D have a threefold higher risk of hospitalisation due to seasonal influenza compared with matched controls from the general population. …”
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Cardiovascular Therapy Benefits of Novel Antidiabetic Drugs in Patients With Type 2 Diabetes Mellitus Complicated With Cardiovascular Disease: A Network Meta‐Analysis by Saixian Shi, Xiaofeng Li, Ye Chen, Jiahao Li, Yan Dai

“…Only GLP1RA reduced the risk of nonfatal stroke, and only SGLT2i reduced the risk of HHF.…”
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Impact of Coronary Artery Disease and Percutaneous Coronary Intervention on Transcatheter Aortic Valve Implantation by Anthony G. Matta, Thibault Lhermusier, Francisco Campelo Parada, Frederic Bouisset, Ronan Canitrot, Vanessa Nader, Stéphanie Blanco, Meyer Elbaz, Jerome Roncalli, Didier Carrié

“…The overall prevalence of in-hospital death, stroke, major or life-threatening bleeding, minor bleeding, major vascular complications, minor vascular complications, pacemaker implantation, and acute kidney injury was 2.7%, 2.4%, 2.8%, 3.6%, 3.9%, 7.5%, 12.5%, and 2.7%, respectively. …”
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Safety and effectiveness of appropriately and inappropriately dosed rivaroxaban or apixaban versus warfarin in patients with atrial fibrillation: a cohort study with nested case–co... by Luis Alberto García Rodríguez, Pareen Vora, Luke Roberts, Gunnar Brobert, Samuel Fatoba, María Eugenia Sáez, Antonio González-Pérez

“…Objectives To investigate effects of appropriately and inappropriately dosed apixaban/rivaroxaban versus warfarin on effectiveness and safety outcomes in patients with non-valvular atrial fibrillation (NVAF).Design Cohort study with nested case–control analyses using primary care electronic health records (IQVIA Medical Research Data UK database).Setting UK primary care.Participants Patients aged ≥18 years with NVAF newly prescribed apixaban (N=14 701), rivaroxaban (N=14 288) or warfarin (N=16 175) between 1 January 2012 and 30 June 2018, and followed up to 31 December 2018.Primary and secondary outcome measures Incident cases of ischaemic stroke/systemic embolism (IS/SE) and intracranial bleeding (ICB). …”
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Real-world Data of Antithrombotic Therapy in Neuroendovascular Therapy: Analysis of JR-NET 4 by Nozomi SASAKI, Yukiko ENOMOTO, Hiroshi YAMAGAMI, Koji IIHARA, Akira ISHII, Hirotoshi IMAMURA, Nobuyuki SAKAI, Chiaki SAKAI, Tetsu SATOW, Yuji MATSUMARU, Shinichi YOSHIMURA

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Weekend effect on in-hospital outcomes of transcatheter aortic valve replacement: insights from a propensity-matched national analysis by Guangzhi Cong, Bo Shi, Xueping Ma, Congyan Ye, Rui Yan, Shizhe Fu, Kairu Wang, Haowei Li, Ru Yan, Shaobin Jia, Israel Gitangaza, Abdul Rehman

“…Moreover, weekend admissions had significantly higher adjusted odds for cardiogenic shock, permanent pacemaker implantation, endocarditis, acute kidney injury, acute ischemic stroke, and blood transfusion. There was a trend of higher in-hospital mortality for weekend over weekday admissions throughout the study period. …”
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Measurement and Analysis of Gait Pattern during Stair Walk for Improvement of Robotic Locomotion Rehabilitation System by Sang-Eun Park, Ye-Ji Ho, Min Ho Chun, Jaesoon Choi, Youngjin Moon

“…Robotic locomotion rehabilitation systems have been used for gait training in patients who have had a stroke. Most commercialized systems allow patients to perform simple exercises such as balancing or level walking, but an additional function such as stair-walk training is required to provide a wide range of recovery cycle rehabilitation. …”
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Uncontrolled hypertension among adult hypertensive patients in Addis Ababa public hospitals: A cross-sectional study of prevalence and associated factors. by Asmamaw Deguale Worku, Asinake Wudu Gessese

“…Uncontrolled hypertension can cause stroke, myocardial infarction, heart failure, renal failure, dementia, blindness, and death. …”
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