Engineered macrophage nanoparticles enhance microwave ablation efficacy in osteosarcoma via targeting the CD47-SIRPα Axis: A novel Biomimetic immunotherapeutic approach by Xiongfa Ji, Xin Qian, Guowen Luo, Wenjie Yang, Wenhan Huang, Zehua Lei, Jiaqi Zhou, Guoqing Zhong, Jielong Zhou, Nan Liu, Limin Ma, Mei Li, Xiangmei Liu, Shuilin Wu, Yu Zhang

“…This action restores macrophage phagocytosis with M1 polarization, triggering potent immune responses. Our strategy holds considerable promise when it comes to improving the efficacy of microwave ablation through immune modulation, while reducing thermal damage to adjacent normal tissue and minimizing the risk of tumor recurrence. …”
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Engineering aortic valves via transdifferentiating fibroblasts into valvular endothelial cells without using viruses or iPS cells by Peng Tang, Fuxiang Wei, Weihua Qiao, Xing Chen, Chenyang Ji, Wanzhi Yang, Xinyu Zhang, Sihan Chen, Yanyan Wu, Mingxing Jiang, Chenyu Ma, Weiqiang Shen, Qi Dong, Hong Cao, Minghui Xie, Ziwen Cai, Li Xu, Jiawei Shi, Nianguo Dong, Junwei Chen, Ning Wang

“…How to generate differentiated cells such as valvular endothelial cells (VECs) has remained a major challenge.Utilizing a combinatorial strategy of selective soluble chemicals, cytokines and substrate stiffness modulation, mouse embryonic fibroblasts are directly and efficiently transdifferentiated into induced aortic endothelial cell-like cells (iAECs), or human primary adult fibroblasts are transdifferentiated into induced valvular endothelial cell-like cells (hiVECs), without expressing pluripotency stem cell markers. …”
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Bioinspired hierarchical porous tough adhesive to promote sealing of high-pressure bleeding by Yinghao Li, Dongling Xiao, Weixi Yan, Meilin Jiang, Ju Tan, Zhongliang Qin, Jingting Zhou, Yue Sun, Mingcan Yang, Guanyuan Yang, Yawei Gu, Yong Liu, Chuhong Zhu

“…Our findings present a promising biomimetic strategy for engineering biomechanically compatible and tough adhesive hydrogels, facilitating prompt and effective treatment of hemorrhagic wounds.…”
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The American Society of Pain and Neuroscience (ASPN) Guidelines and Consensus on the Definition, Current Evidence, Clinical Use and Future Applications for Physiologic Closed-Loop... by Pope JE, Deer TR, Sayed D, Antony AB, Bhandal HS, Calodney AK, Chakravarthy K, Costandi S, Diep J, Durbhakula S, Fishman MA, Gilligan C, Goree JH, Guirguis M, Hagedorn JM, Hunter CW, Kallewaard JW, Kapural L, Lam CM, Li S, Mayrsohn B, Nijhuis H, Nikolic S, Petersen EA, Poree LR, Puri SK, Reece DE, Rosen SM, Russo MA, Shah JM, Staats PS, Verrills P, Vu CM, Levy RM, Mekhail N

“…The modified USPSTF evidence and recommendation grading strategy previously utilized was again employed.Results: Four studies were identified for review, 2 prospective, one retrospective, and one randomized controlled study with at least 12-month follow-up.Conclusion: PCLC neuromodulation is an innovation that requires a responsible introduction. …”
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The pattern of elementary teachers' insight in online education, using foundational data theory by reyhaneh bazrafshan delijan, Mohammad Ghafari Mejlej, seyyed javad mortazavi amiri

“…This transition also required the rapid development of new models and strategies for effective distance teaching and learning. …”
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Resting fMRI-guided TMS evokes subgenual anterior cingulate response in depression by Romain J. Duprat, Kristin A. Linn, Theodore D. Satterthwaite, Yvette I. Sheline, Ximo Liang, Gabriela Bagdon, Matthew W. Flounders, Heather Robinson, Michael Platt, Joseph Kable, Hannah Long, Morgan Scully, Joseph A. Deluisi, Michael Thase, Mario Cristancho, Julie Grier, Camille Blaine, Almaris Figueroa-González, Desmond J. Oathes

“…Conclusions: rsFC-based targeting is a viable strategy to causally modulate the sgACC. Assuming an anti-depressive mechanism working through modulation of the sgACC, the field's exclusive focus on sites anticorrelated with the sgACC for treating depression should be broadened to explore positively-connected sites.…”
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Identifying the components of the administrative system employee empowerment model based on organizational intelligence and interpersonal relationships by fatemeh khoshhal, ali reza sargolzaie, zahra vazife

“…Since empowerment is a strategy, its prerequisites must be met and the strategies and practical actions must be used for its implementation in the organization; therefore, paying attention to the capabilities of organizational intelligence and interpersonal relationships in the development of employee empowerment is considered vital. …”
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Heterologous vaccination with subunit protein vaccine induces a superior neutralizing capacity against BA.4/5‐included SARS‐CoV‐2 variants than homologous vaccination of mRNA vacci... by Dandan Peng, Tingmei Zhao, Weiqi Hong, Minyang Fu, Cai He, Li Chen, Wenyan Ren, Hong Lei, Jingyun Yang, Aqu Alu, Yanghong Ni, Jian Liu, Jiong Li, Wei Wang, Guobo Shen, Zhiwei Zhao, Li Yang, Jinliang Yang, Zhenling Wang, Yoshimasa Tanaka, Guangwen Lu, Xiangrong Song, Xiawei Wei

“…In conclusion, a third heterologous boosting with RBD–HR/trimer following two‐dose mRNA priming vaccination should be a superior strategy than a third homologous mRNA vaccine. The RBD–HR/trimer vaccine becomes an appropriate candidate for a booster immune injection.…”
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Reactogenicity and Immunogenicity Against MPXV of the Intradermal Administration of Modified Vaccinia Ankara Compared to the Standard Subcutaneous Route by Valentina Mazzotta, Pierluca Piselli, Alessandro Cozzi Lepri, Giulia Matusali, Eleonora Cimini, Rozenn Esvan, Francesca Colavita, Roberta Gagliardini, Stefania Notari, Alessandra Oliva, Silvia Meschi, Rita Casetti, Giulia Micheli, Licia Bordi, Alessandro Giacinta, Germana Grassi, Saba Gebremeskel Tekle, Claudia Cimaglia, Jessica Paulicelli, Alessandro Caioli, Paola Gallì, Giulia Del Duca, Miriam Lichtner, Loredana Sarmati, Enrica Tamburrini, Claudio Mastroianni, Alessandra Latini, Paolo Faccendini, Carla Fontana, Emanuele Nicastri, Andrea Siddu, Alessandra Barca, Francesco Vaia, Enrico Girardi, Fabrizio Maggi, Andrea Antinori

“…Vaccination is a priority to expand protection and enhance control strategies, but the vaccine’s need exceeds the currently available doses. …”
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Implementing Practice Guidelines: A Workshop on Guidelines Dissemination and Implementation with a Focus on Asthma and COPD by Louis-Philippe Boulet, Allan Becker, Dennis Bowie, Paul Hernandez, Andrew McIvor, Michel Rouleau, Jean Bourbeau, Ian D Graham, Jo Logan, France Légaré, Thomas F Ward, Robert L Cowie, Denis Drouin, Stewart B Harris, Robyn Tamblyn, Pierre Ernst, Wan C Tan, Martyn R Partridge, Philippe Godard, Carla T Herrerias, John W Wilson, Liz Stirling, Emily-Brynn Rozitis, Nancy Garvey, Diane Lougheed, Manon Labrecque, Renata Rea, Martin C Holroyde, Danielle Fagnan, Eileen Dorval, Lisa Pogany, Alan Kaplan, Lisa Cicutto, Mary L Allen, Serge Moraca, J Mark FitzGerald, Francine Borduas

“…The objectives of this meeting were to examine the optimal implementation of practice guidelines, review current initiatives for the implementation of asthma and chronic obstructive pulmonary disease (COPD) guidelines in Canada and in the rest of the world, and develop an optimal strategy for future guideline implementation. An impressive group of scientists, physicians and other health care providers, as well as policy makers and representatives of patients’ associations, the pharmaceutical industry, research and health networks, and communications specialists, conveyed their perspectives on how to achieve these goals.…”
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Factors affecting the design of the management dashboard framework with an emphasis on the components of human resources productivity by Hassan Barmaki, Farshad Faezy Razi, Ehtesham Rashidi

“…Dashboard is a set of applications such as strategy map, balanced scorecard and business intelligence to manage the performance of organizations that provides information in a specific format to decision makers (Salgado et al, 2022). …”
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Targeting p62 by sulforaphane promotes autolysosomal degradation of SLC7A11, inducing ferroptosis for osteosarcoma treatment by Qiuming Zou, Xiaofeng Zhou, Jianqin Lai, Haixia Zhou, Jinxuan Su, Zhijing Zhang, Xiaosong Zhuang, Lili Liu, Ruijie Yuan, Sijia Li, Siyu Yang, Xinyi Qu, Jiezhu Feng, Yongqi Liu, Zisheng Li, Shiting Huang, Zhi Shi, Yu Yan, Zhiming Zheng, Wencai Ye, Qi Qi

“…Identification of novel therapeutic targets and development of targeted drugs are one of the most feasible strategies for OS treatment. Ferroptosis, a recently discovered mode of programmed cell death, has been implicated as a potential strategy for cancer therapy. …”
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Construction and efficacy of recombinant Newcastle disease virus co-expressing VP2 and VP3 proteins of very virulent infectious bursal disease virus by Tongfei Liu, Lin Lin, Yun Pan, Xiaoling Lin, Ming Liang, Guanming Shao, Keyu Feng, Yaxin Liu, Xinheng Zhang, Qingmei Xie

“…Traditional vaccination strategies have limitations, prompting the need for novel approaches. …”
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First-line chemotherapy with selective internal radiation therapy for intrahepatic cholangiocarcinoma: The French ACABi GERCOR PRONOBIL cohort by Nicolas Adamus, Julien Edeline, Julie Henriques, Nadim Fares, Thierry Lecomte, Anthony Turpin, Dewi Vernerey, Mathilde Vincens, Brice Chanez, David Tougeron, Christophe Tournigand, Eric Assenat, Matthieu Delaye, Sylvain Manfredi, Olivier Bouché, Nicolas Williet, Angelique Vienot, Lorraine Blaise, Léo Mas, Cindy Neuzillet, Alice Boilève, Gaël S. Roth

“…The safety and efficacy of this strategy whether as a bridge to intent-to-cure strategies or in a palliative setting, should encourage its adoption in a larger panel of clinical centers, or at very least, prompt clinicians to refer their patients to centers where SIRT is performed. …”
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Reprogramming of iPSCs to NPCEC-like cells by biomimetic scaffolds for zonular fiber reconstruction by Tianhui Chen, Zhongxing Chen, Juan Du, Min Zhang, Zexu Chen, Qingyi Gao, Aodong Chen, Qinghao Meng, Yang Sun, Yan liu, Linghao Song, Xinyue Wang, Pranav Prakash Edavi, Chen Xu, Hongmei Zhang, Jinhai Huang, Yongxiang Jiang

“…This proposed in situ iPSC-based regeneration technique might serve as an innovative therapeutic strategy for clinical EL patients, reduce the cataract surgery rate, and retain the adjustment capacity of inherent lentis.…”
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Inhibition of S100A8/A9 ameliorates neuroinflammation by blocking NET formation following traumatic brain injury by Guihong Shi, Yiyao Cao, Jianye Xu, Bo Chen, Xu Zhang, Yanlin Zhu, Liang Liu, Xilei Liu, Luyuan Zhang, Yuan Zhou, Shenghui Li, Guili Yang, Xiao Liu, Fanglian Chen, Xin Chen, Jianning Zhang, Shu Zhang

“…These findings underscore the critical pathological role of S100A8/A9 in TBI and emphasize the need for further exploration of S100A8/A9 inhibitor Paquinimod as a potential therapeutic strategy for TBI.…”
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Blood and Iron: The Rise and Fall of the German Empire 1871 – 1918 by Arzu Melek Ozgumus

“…Through careful analysis, Hoyer captures the complexities of governance, cultural strategies, and social tensions during this formative period of the German Empire. …”
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Designing a model of effective marketing capabilities based on communication by Yoones Banisaeed, Ghanbar Amirnejad, Morteza mousakhani, Leila Andervazh

“…By implementing these strategies, companies can improve their ability to generate relevant and sustainable product innovations and thus remain competitive in an increasingly complex market. …”
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Small emission sources in aggregate disproportionately account for a large majority of total methane emissions from the US oil and gas sector by J. P. Williams, J. P. Williams, M. Omara, M. Omara, A. Himmelberger, D. Zavala-Araiza, K. MacKay, K. MacKay, J. Benmergui, J. Benmergui, J. Benmergui, M. Sargent, S. C. Wofsy, S. P. Hamburg, S. P. Hamburg, R. Gautam, R. Gautam

“…<p>Reducing methane emissions from the oil and gas (oil–gas) sector has been identified as a critically important global strategy for reducing near-term climate warming. Recent measurements, especially by satellite and aerial remote sensing, underscore the importance of targeting the small number of facilities emitting methane at high rates (i.e., “super-emitters”) for measurement and mitigation. …”
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Presenting the entrepreneurship development model in the national oil refining industry with the approach of environmental damage prevention by Jalal Abdi, Reza Yousefi Saeedabadi, Maryam Taghvaee Yazdi

“…Theoretical Framework Entrepreneurship Development The development of entrepreneurship as a macro strategy in a society requires increasing or improving perceptions, tendencies and entrepreneurial behavior at all individual, team, organizational, industry, etc. levels; especially at the national level. …”
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