Thermodynamic and experimental evaluation of the sustainable recycling of magnesium alloy scrap by vacuum distillation based on vapor-liquid equilibrium by Lipeng Wang, Dong Liang, Yang Tian, Jianxue Chai, Rui Li, Shuji Wu, Bin Yang, Baoqiang Xu, Yong Deng

“…Therefore, an optimization strategy for vacuum distillation recycling: lower temperatures and higher system pressures for Zn separation in the early stage, and the early termination of the recovery process in the later stage or a continuous supply of raw melt can also prevent contamination during recycling. …”
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Estimation of yield and nitrogen use efficiencies in hybrid maize varieties through site specific nitrogen management based on leaf color chart (LCC) by Suhail Fayaz, Raihana Habib Kanth, Tauseef A. Bhat, Eajaz Ahmad Dar, Zahoor Ahmad Shah, Moneesa Bashir, Aijaz Nazir, Bilkees Jamsheed, Mohd. Salim Mir, Zahoor A. Dar, Shailja Sharma, Aabid Hussain Lone, Dawood Yousuf, Nadhir Al-Ansari, Mohamed A. Mattar, Ali Salem

“…Therefore, site-specific nutrient management through LCC proved to be an effective strategy to maximize yield and nitrogen use efficiency in hybrid maize.…”
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The Role of Potassium Phosphite in Enhancing the Activity of Defense Enzymes in Rice Infected by Sheath Blight by Milad Habibi Daronkolaei, Mohammad Ali Tajick Ghanbary, Valiollah Babaeizad, Heshmatollah Rahimian, Ali Dehestani

“…Therefore, the utilization of biocompatible chemical compounds is regarded as an innovative and effective strategy for integrated product management and combating various stressors. …”
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Modified Bloom's Taxonomy: Perspective of a Doctor of Philosophy Scholar by Wafa Omer

“…It promotes a change from learning only theory to a more comprehensive strategy that emphasises real-world application and ongoing development.6 To promote a culture of creativity and lifelong learning, educational programs would concentrate not only on the creation of knowledge but also on how that information may be applied to other professional sectors.7 Current Dilemma The most prominent challenge that is being faced in the thesis being written by PhD scholars is that the new innovative discovery never finds its way into the clinical practice or the workplace. …”
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African army ants at the forefront of virome surveillance in a remote tropical forest by Fritz, Matthieu, Reggiardo, Bérénice, Filloux, Denis, Claude, Lisa, Fernandez, Emmanuel, Mahé, Frédéric, Kraberger, Simona, Custer, Joy M., Becquart, Pierre, Mebaley, Telstar Ndong, Kombila, Linda Bohou, Lenguiya, Léadisaelle H., Boundenga, Larson, Mombo, Illich M., Maganga, Gael D., Niama, Fabien R., Koumba, Jean-Sylvain, Ogliastro, Mylène, Yvon, Michel, Martin, Darren P., Blanc, Stéphane, Varsani, Arvind, Leroy, Eric, Roumagnac, Philippe

“…In this study, we used a predator-enabled metagenomics strategy to sample the virome of a remote and difficult-to-access densely forested African tropical region. …”
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Electrophysiology-based screening identifies neuronal HtrA serine peptidase 2 (HTRA2) as a synaptic plasticity regulator participating in tauopathy by Naizhen Zheng, Kun Li, Jing Cao, Zijie Wang, Liang Zhang, Zihao Zhao, Jiawei He, Yong Wang, Xiang Zhu, Yiqing Chen, Jian Meng, Dongdong Zhao, Mengxi Niu, Hong Luo, Xian Zhang, Hao Sun, Yun-wu Zhang

“…Our study not only indicates that HTRA2 in neurons plays an important role in regulating synaptic plasticity under both physiological and pathological conditions, but also provides a novel, electrophysiology-based strategy to identify proteins regulating synaptic plasticity systematically.…”
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In vitro functional validation of anti-CD19 chimeric antigen receptor T cells expressing lysine-specific demethylase 1 short hairpin RNA for the treatment of diffuse large B cell l... by Zhi Guo, Zhi Guo, Mingxin He, Ning Liu, Yiqing Yang, Rui Sun, Jianxun Wang, Qiang Wang

“…After stimulation via U-2932 cell co-culture, both RNAU6 anti-CD19 CAR-T and LSD1 shRNA anti-CD19 CAR-T populations had increased proportions of cells with the TCM phenotype, with a higher percentage among LSD1 shRNA anti-CD19 CAR-T cells.ConclusionWe developed a novel, feasible CD19-LSD1 shRNA CAR-T cell strategy for the treatment of DLBCL. Our in vitro assay results showed that LSD1 shRNA anti-CD19 CAR-T cells more effectively killed target cells than RNAU6 anti-CD19 CAR-T cells, and developed a higher proportion of TCM phenotype cells. …”
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Current AAV-mediated gene therapy in sensorineural hearing loss by Jieyu Qi, Xiaolong Fu, Liyan Zhang, Fangzhi Tan, Nianci Li, Qiuhan Sun, Xiaojie Hu, Zuhong He, Ming Xia, Renjie Chai

“…With the development of genetic engineering technology, gene therapy has brought a promising treatment strategy for many previously intractable diseases. …”
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Monitoring of Circulating Tumor DNA and Indication of De-Escalation Adjuvant Targeted Therapy for EGFR-Mutated NSCLC After Complete Resection by Song Dong, PhD, Bingfa Yan, PhD, Si-Yang Liu, PhD, Xuan Gao, PhD, Hui-Zhao Hong, MD, Hong-Ji Li, MD, Wei Gao, PhD, Hong-Hong Yan, PhD, Si-Yang Maggie Liu, PhD, Hai-Yan Tu, PhD, Yi Pan, PhD, Qing Zhou, PhD, Xue-Ning Yang, PhD, Xue-Feng Xia, PhD, Xin Yi, PhD, Wen-Zhao Zhong, PhD, Yi-Long Wu, MD, Jia-Tao Zhang, PhD

“…Nevertheless, adapting this approach to include a molecular residual disease (MRD)-guided de-escalation strategy warrants further investigation. Methods: From January 2019 to December 2022, 71 patients with stages I to III NSCLC and EGFR (exon 19 deletion or L858R) mutations were enrolled in this observational study. …”
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Repeated low-intensity noise exposure exacerbates age-related hearing loss via RAGE signaling pathway by Jianbin Sun, Na Sai, Tong Zhang, Chaoying Tang, Shuhang Fan, Qin Wang, Da Liu, Xianhai Zeng, Juanjuan Li, Weiwei Guo, Shiming Yang, Weiju Han

“…Our findings suggest that TTS caused by repeated low-intensity noise exposure correlates with a severe sensorineural hearing loss during aging; targeting the RAGE signaling pathway may be a promising strategy to mitigate damage from low-intensity noise and slow down the progression of age-related hearing loss.…”
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The role of teachers and administrators in supporting the adaptation of students with special needs in mainstream high schools by Amir Mahmood, Xiao Huang, Nadia Rehman

“…Understanding these relationships is crucial for identifying gaps, challenges and opportunities within the current educational system, thereby contributing to the development of more effective strategies for inclusive education in Pakistan. Design/methodology/approach – This study used a correlational research strategy to investigate the effects of administrative and teacher support on the adaptation capabilities of high school students with special needs. …”
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IL-2-armored peptide-major histocompatibility class I bispecific antibodies redirect antiviral effector memory CD8+ T cells to induce potent anti-cancer cytotoxic activity with lim... by John S. Schardt, Even Walseng, Kim Le, Chunning Yang, Pooja Shah, Ying Fu, Kausar Alam, Cathryn R. Kelton, Yu Gu, Fengying Huang, Jia Lin, Wenhai Liu, Andrew Dippel, Hanzhi Zhang, Kathy Mulgrew, Stacy Pryts, Vijaykumar Chennupati, Hung-Chang Chen, Jessica Denham, Xiaoru Chen, Pallab Pradhan, Yuling Wu, Colin Hardman, Chihao Zhao, Michael Kierny, Yang Song, Simon J. Dovedi, Saso Cemerski, Yariv Mazor

“…One attractive approach to circumvent the systemic activation of pan CD3+ T cells and reduce the risk of cytokine release syndrome is to redirect specific subsets of T cells. A promising strategy is the use of peptide-major histocompatibility class I bispecific antibodies (pMHC-IgGs), which have emerged as an intriguing modality of TCE, based on their ability to selectively redirect highly reactive viral-specific effector memory cytotoxic CD8+ T cells to eliminate cancer cells. …”
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Effects of Optimized Fertilization and Organic Fertilizer Subsitution Technology on the Growth and Soil Fertility of Chinese Flowering Cabbage by Lan WEI, Zehuang WANG, Weisheng CHEN, Lianxi HUANG, Lihua TIAN, Zhongzhen LIU, Dongtian LAO, Qing HUANG

“…【Objective】The optimized fertilization and organic fertilizer substitution technology is a national strategy to achieve environmental friendliness and maintain the quality of cultivated land, which is of great significance to achieving sustainable agricultural development. …”
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Life Cycle Assessment (LCA) of Carbon Emission of Garden Pavement by Peiyong WANG, Ruixing LU

“…Based on the above results, the garden pavement materials that meet the requirements of low-carbon emission reduction are derived, and the following strategies for low-carbon emission reduction of garden pavements are proposed. …”
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Editorial by Christian Gütl

“… Emre Önal and Abdullah Bülbül from Turkiye cover in their research a computational game unit balancing approach based on game theory to make each game unit equally preferable against a uniform play strategy. Ruchika Malhotra and Madhukar Cherukuri from India look in their research into Software Defect Categorization (SDC) models and apply convolutional neural networks in their empirical study. …”
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Analyzing the efficacy of a novel method for detecting achromatopsia by N.V. Sukhanova, S.I. Rychkova, V.G. Likhvantseva, R.I. Sandimirov, V.V. Kadyshev, R.A. Zinchenko

“…This test provides preliminary differential diagnosis with other eye diseases and determines the most appropriate strategy of further examinations to establish the diagnosis. …”
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miR-449a/miR-340 reprogram cell identity and metabolism in fusion-negative rhabdomyosarcoma by Enrico Pozzo, Laura Yedigaryan, Nefele Giarratana, Chao-chi Wang, Gabriel Miró Garrido, Ewoud Degreef, Vittoria Marini, Gianmarco Rinaldi, Bernard K. van der Veer, Gabriele Sassi, Guy Eelen, Mélanie Planque, Alessandro Fanzani, Kian Peng Koh, Peter Carmeliet, Jason T. Yustein, Sarah-Maria Fendt, Anne Uyttebroeck, Maurilio Sampaolesi

“…Overall, miR-449 and miR-340 orchestrate FN-RMS cell identity, positioning MPC inhibition as a strategy to shift FN-RMS cells toward a non-tumorigenic, quiescent state.…”
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Improving panicle blast resistance and fragrance in a high-quality japonica rice variety through breeding by Junhua Ye, Junhua Ye, Kai Wang, Yi Wang, Zhipeng Zhao, Ying Yan, Hang Yang, Lixia Zhang, Lixia Zhang, Zejun Hu, Zejun Hu, Zhenying Shi, Dapeng Sun, Jianjiang Bai, Liming Cao, Liming Cao, Shujun Wu, Shujun Wu

“…Pigm and Pi-ta are two dominant genes known for their stable broad-spectrum resistance against rice blast fungus Magnaporthe oryzae, while badh2 is the crucial gene that regulates rice aroma.MethodsIn this study, we utilized a molecular marker-assisted selection backcrossing strategy to introduce Pigm, Pi-ta, and badh2 into introgressed lines employing re-sequencing for precise genetic background selection.ResultsFinally, we selected three introgressed lines, including two that carry Pigm with the highest background recovery rates, showing eating and cooking qualities similar to those of HR1212, and one line that pyramids Pigm, Pi-ta, and badh2, which features a strong aroma. …”
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Protocol, rationale and design of DAbigatran for Stroke PreVention In Atrial Fibrillation in MoDerate or Severe Mitral Stenosis (DAVID-MS): a randomised, open-label study by Andrew Ng, Esther W Chan, Duo Huang, Cheung Chi Lam, Ning Tan, Chung Wah Siu, Jo Jo Hai, Ji-yan Chen, Chun Ka Wong, Mi Zhou, Yuk Ming LAU, Chor Cheung Frankie Tam, Yiu Tung Anthony Wong, See Yue Arthur Yung, Ki Wan Kelvin Chan, Yingqing Feng, Chi Yui Yung, Kwok Lun Lee, Chun Wai Choi, Ho Lam, Katherine Fan, Man Hong Jim, Kai Hang Yiu, Bryan P. Yan

“…Nonetheless, the safety and effectiveness of NOACs have not been evaluated in patients with AF with underlying moderate or severe mitral stenosis (MS), hence the recommended stroke prevention strategy remains warfarin therapy.Method and analysis MS remains disproportionately prevalent in Asian countries compared with the developed countries. …”
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Whole blood ratio of CDK1/CX3CR1 mRNA expression combined to lactate refines the prediction of ICU mortality in septic patients in the Sepsis-3 era: a proof-of-concept study by Marie-Angélique Cazalis, Marie-Angélique Cazalis, Louis Kreitmann, Louis Kreitmann, Guillaume Monneret, Guillaume Monneret, Alexandre Pachot, Alexandre Pachot, Karen Brengel-Pesce, Karen Brengel-Pesce, Jean-François Llitjos, Jean-François Llitjos, Jean-François Llitjos

“…In combination with lactate, this novel biomarker strategy may be useful for sepsis patient stratification for personalized medicine trials and ICU management.…”
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