hBMSC-EVs alleviate weightlessness-induced skeletal muscle atrophy by suppressing oxidative stress and inflammation by Mengyuan Chang, Ruiqi Liu, Bingqian Chen, Jin Xu, Wei Wang, Yanan Ji, Zihui Gao, Boya Liu, Xinlei Yao, Hualin Sun, Feng Xu, Yuntian Shen

“…Extracellular vesicles derived from bone marrow mesenchymal stem cells (BMSC-EVs) possess anti-inflammatory and antioxidant properties, offering a potential strategy for combating weightless muscular atrophy. …”
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Influence of Socio-Demographic, Occupational and Lifestyle Variables on Sleep Time by Dutheil F, Saint-Arroman C, Clinchamps M, Flaudias V, Fantini ML, Pereira B, Berthon M, Laporte C, Baker JS, Charkhabi M, Cocco P, Lecca R, Puligheddu M, Figorilli M, Zak M, Ugbolue UC, Ubago-Guisado E, Gracia-Marco L, Bouillon-Minois JB, Vialatte L

“…Physical activity ≥ 2.5 hours/week tended to decrease the risk of being a short sleeper by 35%.Conclusion: We demonstrated the concomitant impact of sociodemographic, occupational and lifestyle behavior on sleep, which may help to build efficient preventive strategy.Keywords: total sleep time, sociodemographic variables, occupational variables, mental health…”
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Safety and efficacy of edoxaban monotherapy after bioabsorbable polymer everolimus-eluting stent implantation in a human-like coronary atherosclerotic porcine model by Daisuke Kitano, Suguru Migita, Yuxin Li, Yutaka Koyama, Katsunori Fukumoto, Sayaka Shimodai-Yamada, Akira Onishi, Daiichiro Fuchimoto, Shunichi Suzuki, Yoshiyuki Nakamura, Atsushi Hirayama, Hiroyuki Hao, Yasuo Okumura

“…These results provide important preclinical evidence supporting the potential of DOAC monotherapy as an antithrombotic strategy after DES implantation and warrant further investigation in clinical trials.…”
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Remarkable Phytochemical Characteristics of Chi-Nan Agarwood Induced from New-Found Chi-Nan Germplasm of Aquilaria sinensis Compared with Ordinary Agarwood by Meng Yu, Yangyang Liu, Jian Feng, Deli Chen, Yun Yang, Peiwei Liu, Zhangxin Yu, Jianhe Wei

“…However, the comprehensive research on chemical composition of wild Chi-Nan agarwood is limited. An integrated strategy using SHS-GC-MS and UPLC-Q/Tof-MS was applied to explore the phytochemical characteristics of a kind of agarwood induced from a newly identified germplasm of Chi-Nan A. sinensis. …”
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Biomimetic Targeted Co‐Delivery System Engineered from Genomic Insights for Precision Treatment of Osteosarcoma by Tianqi Luo, Zhijin Fan, Anyu Zeng, Anqi Wang, Yuanwei Pan, Yanyang Xu, Hongmin Chen, Weiqing Chen, Dingmeng Nie, Jiaming Lin, Anfei Huang, Ming Gong, Yufeng Huang, Yun Ding, Xiaojun Zhu, Lang Rao, Jin Wang

“…In summary, the co‐delivery system is an effective therapeutic strategy and holds promise as a novel approach for osteosarcoma treatment.…”
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An aggregation-induced emission-active lysosome hijacker: Sabotaging lysosomes to boost photodynamic therapy efficacy and conquer tumor therapeutic resistance by Hang Zou, Pingping Wang, Zhihao Bai, Liping Liu, Jingtong Wang, Yanfang Cheng, Bairong He, Zujin Zhao, Lei Zheng

“…This innovative “lysosome hijacking” strategy significantly maximizes the efficacy of photodynamic therapy, conquering therapeutic resistance and boosting the synergistic therapeutic effect when integrated with conventional radiotherapy or chemotherapy. …”
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Evaluation of a peer support group programme for vulnerable host population and refugees living with diabetes and/or hypertension in Lebanon: a before-after study by Leah Anku Sanga, Carla Njeim, Éimhín Ansbro, Rima Kighsro Naimi, Ali Ibrahim, Benjamin Schmid, Jasmin Lilian Diab, Jytte Roswall, Tim Clayton, Lars Bruun Larsen, Pablo Perel

“…To assess the association between the implementation of the PSG strategy and changes in clinical outcomes, including systolic blood pressure (SBP), glycated hemoglobin A1c (HbA1c), and body mass index (BMI), analysis of covariance (ANCOVA) models were used, adjusting for age, sex, and the baseline values of the outcome being analyzed (baseline SBP and baseline HbA1c, respectively). …”
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Effectiveness and tolerability of the combined use of anti-VEGF agents in clinical practice by A.V. Kuroyedov, O.V. Gapon’ko, V.V. Gorodnichiy, S.V. Diordiychuk, I.V. Kondrakova, N.M. Sol’nov, N.E. Fomin

“…</i> </p> <p> <i><b>Conclusion</b>: our management strategy for wet AMD is somewhat different from conventional guidelines. …”
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Massively parallel variant-to-function mapping determines functional regulatory variants of non-small cell lung cancer by Congcong Chen, Yang Li, Yayun Gu, Qiqi Zhai, Songwei Guo, Jun Xiang, Yuan Xie, Mingxing An, Chenmeijie Li, Na Qin, Yanan Shi, Liu Yang, Jun Zhou, Xianfeng Xu, Ziye Xu, Kai Wang, Meng Zhu, Yue Jiang, Yuanlin He, Jing Xu, Rong Yin, Liang Chen, Lin Xu, Juncheng Dai, Guangfu Jin, Zhibin Hu, Cheng Wang, Hongxia Ma, Hongbing Shen

“…Our findings not only augment the understanding of the genetic architecture underlying NSCLC susceptibility but also provide strategy to advance NSCLC risk stratification.…”
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The diagnostic value and validation of IL-22 combined with sCD40L in tuberculosis pleural effusion by Yuzhen Xu, Jing Wu, Qiuju Yao, Qianqian Liu, Huaxin Chen, Bingyan Zhang, Yuanyuan Liu, Sen Wang, Lingyun Shao, Wenhong Zhang, Qinfang Ou, Yan Gao

“…Specifically, IL-22 ≥ 18.87 pg/mL and sCD40L ≥ 53.08 pg/mL can be clinically utilized as an efficient diagnostic strategy for distinguishing tuberculosis pleurisy from malignant pleurisy.…”
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Preclinical development of a standardized extract of Ilex paraguariensis A.St.-Hil for the treatment of obesity and metabolic syndrome by Sara E.L. Tolouei, Rodrigo Marcon, Fabiana Cardoso Vilela, Cristina Setim Freitas, Melina Heller, Edineia Lemos de Andrade, Sergio José Macedo Júnior, Adara Áurea dos Santos, Ruth Fernandes Rocha, Guilherme Pasetto Fadanni, Naiani Ferreira Marques, Jarbas Mota Siqueira Júnior, João B. Calixto

“…Considering the multifactorial nature of these diseases, medicinal plants could be a valuable therapeutic strategy as their phytoconstituents interact with multiple and relevant biological targets. …”
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Recommendation for the use of respiratory syncytial virus vaccines by Ping-Ing Lee, Yhu-Chering Huang, Ching-Chuan Liu, Shee-Uan Chen, Po-Ren Hsueh, Shih-Chi Ku, Po-Yen Chen, Chih-Jung Chen, Yi-Tsung Lin, Chun-Yi Lu, Nan-Chang Chiu, Hsin Chi, Yee-Chun Chen, Feng-Yee Chang, Muh-Yong Yen, Chin-Te Lu, Kuang-Yao Yang, Cheng-Hsun Chiu, Kao-Pin Hwang, Wen-Sen Lee, Ting-Yu Yen, Jen-Fu Hsu, Ying-Chin Lin, Ya-Li Hu, Tzou-Yien Lin

“…A committee of experts from related fields was convened by the Taiwan Immunization Vision and Strategy to develop recommendations for RSV vaccination in the elderly and pregnant women.The recommendation is not intended as a sole source of guidance in the prevention of RSV infection in children. …”
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Evaluation of Dynamic Visual Perception of Riverside Interface in Mountainous Cities from the Perspective of Boating by Dan LUO, Ruhong WEI

“…They enable the line of sight to penetrate into more urban space and enrich the changes of architectural level.ConclusionBased on what mentioned above and in combination with the current spatial situation and perception patterns, an overall optimization strategy for readability is proposed from the two aspects of rhythm control and feature optimization. …”
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Gut microbiota derived DCA enhances FOLFOX efficacy via Ugt1a6b mediated enterohepatic circulation in colon cancer by Qian Fang, Xiaoying Hou, Limei Fan, Yufei Deng, Xiaoxuan Li, Hongyun Zhang, Haiping Wang, Zhengqi Fu, Binlian Sun, Xiji Shu, Hongzhi Du, Yuchen Liu

“…There is an urgent need to identify strategies to improve its therapeutic effectiveness. …”
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Development of an innovative intravaginal model of probiotic inoculation in dairy ovine flocks: positive effects on the vaginal microbiota, vaginitis and fertility by M. Toquet, J. Gomis, E. Jiménez-Trigos, E. Bataller, M. Barba, A. Sánchez, P. González-Torres, Á. Gómez-Martín

“…The results of this study suggest that the use of probiotics via intravaginal inoculation as a strategy to positively modulate the microbiota and vaginal inflammation, derived from the use of intravaginal sponges, is also associated with improved fertility. …”
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β-receptor blocker enhances anti-tumor immunity via inhibiting lactate-induced norepinephrine metabolism of macrophages during malignant pleural effusion by Ru Zhang, Weijia Wang, Aitian Li, Huishang Wang, Xiaoyan Liu, Feifei Fan, Ying Wang, Huanyu Zhang, Jingxia Chang, Yinyin Zhang, Hongmin Wang, Lijun Miao, Bo Huang, Li Yang, Li Yang, Li Yang, Yi Zhang, Yi Zhang, Yi Zhang, Yi Zhang, Yi Zhang

“…Our findings highlight that blocking norepinephrine signaling by β-receptor blockers is an attractive therapeutic strategy to enhance anti-tumor immunity in the context of MPE…”
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Global research trends in Chinese medicine for the treatment of non-alcoholic fatty liver disease (NAFLD): A bibliometric study by Kangjie li, Jie Wang, Ming Dang, Runxin Ren, Maomao Fu, Jing Wang, Qiao Zhang, Chongbo Zhao

“…However, Traditional Chinese Medicine (TCM) has gained attention for its unique theoretical framework and therapeutic strategies, particularly its potential to improve liver health by modulating liver function. …”
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System-and-structural features of the phytobiotaof the fir-beech forests of the Pokuttia Carpathians by Myroslava Soroka, Andrzej Woźniak, Petro Plikhtiak, Anatoliy Goychuk, Ivanna Kulbanska

“…Among plants, vegetatively mobile species (40.0%) with a stress-tolerant life strategy (S) (55%) predominate. The fir-beech forests have a characteristic set of climomorphs – here there is a significant share of hemicryptophytes (46.0%) and cryptophytes (30.0%) and an insignificant participation of chamaephytes (3%). …”
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Frailty-adjusted therapy in Transplant Non-Eligible patients with newly diagnosed Multiple Myeloma (FiTNEss (UK-MRA Myeloma XIV Trial)): a study protocol for a randomised phase III... by Roger Owen, John Jones, David Meads, David A Cairns, Christopher Parrish, Gordon Cook, Neil Rabin, Matthew Jenner, Martin Kaiser, Kevin Boyd, Graham Jackson, Catherine Olivier, Amy Beth Coulson, Kara-Louise Royle, Charlotte Pawlyn, Anna Hockaday, Jennifer Bird, Stella Bowcock, Ruth de Tute, Hayley Gardner, Bryony Dawkins, Rowena Henderson, Phillip Best, Bhuvan Kishore, Mark Drayson

“…Overall, 740 participants will be registered into the trial to allow 720 and 478 to be randomised at induction and maintenance, respectively.All participants will receive IRD induction with the dosing strategy randomised (1:1) at trial entry. Patients randomised to the standard, reactive arm will commence at the full dose followed by toxicity dependent reactive modifications. …”
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Prostate cancer incidence and mortality linked to metalworking fluid exposure: a systematic review and meta-analysis by Zahra Moradpour, Amin Barik, Goljamal Jorjani, Mohammad Reza Taherian, Sepideh Tousizadeh, Sepideh Tousizadeh, Aram Halimi, Aram Halimi, Yaser Soleimani, Mobina Karimian, Tina Khavari, Fateme Azizi Kalankari, Fatemeh Asadipour, Mojtaba Azari, Niloofar Yousefzadeh Shakouri, Saeideh Karamian, Nasser Bahari, Alireza Mosavi Jarrahi

“…A comprehensive search strategy was developed to identify relevant studies from PubMed, Scopus, Embase, and Web of Science. …”
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