Engaging the private sector as part of HIV pre-exposure prophylaxis service delivery in Vietnam: a comparative analysis of uptake, persistence and HIV seroconversion from 2018 to 2... by Bao Ngoc Vu, Kimberly Green, Huong Phan, Long Tran, Phuong Phan, Tham Tran, Linh Doan, Yen Vu, Chau Pham, Dao Nguyen, Anh Doan, Trang Ngo, Phuong Tran, Vuong Nguyen, Bieu Nguyen, Thai Phan, Ha Nguyen

“…Private sector engagement (PSE) in PrEP service delivery was deployed as a strategy from the start to increase PrEP access. We assessed the effectiveness of this approach to inform ongoing efforts to accelerate epidemic control by 2030.MethodsWe implemented a process evaluation with longitudinal design using retrospective programmatic data collected and uploaded onto a secure online system (HMED) from 23 public and 17 private PrEP clinics in Hanoi, Ho Chi Minh City (HCMC), and Dong Nai. …”
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Leptin decreases Th17/Treg ratio to facilitate neuroblastoma via inhibiting long-chain fatty acid catabolism in tumor cells by Meng Li, Di Li, Hai-Yun Wang, Weixin Zhang, Zhenjian Zhuo, Huiqin Guo, Jiabin Liu, Yue Zhuo, Jue Tang, Jing He, Lei Miao

“…These findings highlight that excess leptin contributes to lipid metabolism dysfunction in NB cells and subsequently misdirects CD4+ T cell differentiation in tumor micro-environment (TME), indicating that targeting leptin could be a therapeutic strategy for retarding NB progression.…”
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Seroprevalence of Borrelia burgdorferi sensu lato antibodies in English adult blood donors: A nationwide cross-sectional study, 2021–2022 by Eilish Hart, John Tulloch, Daniel Bailey, Tim Brooks, Heli Harvala, Peter Simmonds, Roberto Vivancos, Neil French, Amanda Semper

“…Methods: The prevalence of Bbsl-specific antibodies in the English population was estimated in a cross-sectional cohort, selected from an archive of residual NHS blood donor plasma samples (age range 17 - 84, collected between 2021 - 2022). 10,000 samples were randomly selected proportionate to the population size of each of the nine English administrative regions. 9,994 samples were tested using a standard two-tiered testing strategy, with an IgG/IgM ELISA followed by an IgG immunoblot (array) test for any sera with positive or indeterminate reactivity in the ELISA. …”
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A Promising Approach to Ultra‐Flexible 1 Ah Lithium–Sulfur Batteries Using Oxygen‐Functionalized Single‐Walled Carbon Nanotubes by Junyoung Heo, Jeong‐Won Hong, Ha Won Gu, Junghwan Sung, Dong‐Hee Kim, Jung Hoon Kim, Sung Kang, You‐Jin Lee, Hye Young Choi, Doohun Kim, Kang‐Jun Baeg, Joong Tark Han, Jun‐Woo Park

“…Employing Ox‐SWCNTs in both cathodes and interlayers, the study achieves high‐capacity Li‐S pouch cells that consistently deliver a capacity of 1.06 Ah and a high energy density of 909 mAh g−1 over 50 charge‐discharge cycles. This strategy not only significantly enhances the electrochemical performance of Li‐S batteries but also maintains excellent mechanical flexibility under severe deformation, positioning this Ox‐SWCNT‐based architecture as a viable, light‐weight, and ultra‐flexible energy storage solution suitable for commercializing rechargeable Li‐S batteries.…”
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A logistic regression model to predict long-term survival for borderline resectable pancreatic cancer patients with upfront surgery by Jin-Can Huang, Shao-Cheng Lyu, Bing Pan, Han-Xuan Wang, You-Wei Ma, Tao Jiang, Qiang He, Ren Lang

“…There still has been a debate about which predictive strategy is better in patients with borderline resectable pancreatic cancer (BRPC). …”
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Strength Training Session Induces Important Changes on Physiological, Immunological, and Inflammatory Biomarkers by Ayla Karine Fortunato, Washington Martins Pontes, Débora Maria Soares De Souza, Jéssica Santos Ferreira Prazeres, Lucas Soares Marcucci-Barbosa, Júlia Miranda Mól Santos, Érica Leandro Marciano Veira, Eduardo Bearzoti, Kelerson Mauro De Castro Pinto, André Talvani, Albená Nunes Da Silva

“…Strength exercise is a strategy applied in sports and physical training processes. …”
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One-Pot Synthesis and Enhanced Vis-NIR Photocatalytic Activity of NiTiO₃/TiO₂ Templated by Waste Tobacco Stem-Silks by Weidong Yuan, Xiaohong Chen, Yi Zhao, Ying Fang, Han Zhang, Daomei Chen, Jiaqiang Wang

“…The boosting photocatalytic activity has been shown to be attributed to efficient charge separation and transfer across a direct Z-scheme heterojunction between NiTiO₃ and TiO₂ and enhanced light-harvesting ability of special flaky structure reduplicated from tobacco stem-silks. This reported strategy provides a new idea for the multifunctional utilization of waste tobacco stem-silks and the synthesis of novel photocatalysts for the potential application in wastewater treatment.…”
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Implementation of model-informed precision dosing for tamoxifen therapy in patients with breast cancer: A prospective intervention study by Ruben Y.M. van Nijnatten, Sanne M. Buijs, Bram C. Agema, Raphaël M.J. Fischer, Inge Ghobadi Moghaddam-Helmantel, Caroline M.E. Contant, Felix E. de Jongh, Auke M.T. Huijben, Manon Kop, Annemieke van der Padt-Pruijsten, Hanneke J.M. Zuetenhorst, Ron H.N. van Schaik, Birgit C.P. Koch, A. Jager, Stijn L.W. Koolen, Ron H.J. Mathijssen

“…Endoxifen samples that were acquired 4–6 weeks after treatment initiation, are informative of steady-state endoxifen levels and can be used to inform MIPD and adjust tamoxifen dosing prior to steady-state attainment.In this first MIPD implementation study for patients treated with tamoxifen, MIPD did lead to more patients achieving endoxifen levels ≥16 nM as compared to the one-dose-fits-all strategy, albeit insignificant. This may partly be explained by a larger proportion of patients who were recommended to switch to an aromatase inhibitor (AI) in the intervention cohort. …”
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Strong-weak dual interface engineered electrocatalyst for large current density hydrogen evolution reaction by Shaorou Ke, Ruiyu Mi, Xin Min, Xinyu Zhu, Congyi Wu, Xin Li, Bozhi Yang, Xiaowen Wu, Yangai Liu, Zhaohui Huang, Minghao Fang

“…This strong-weak dual interface engineering strategy shows potential for overall water splitting and proton exchange membrane water electrolyzer, advancing the design of efficient supported nanocatalysts.…”
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Multi‑omics identification of a novel signature for serous ovarian carcinoma in the context of 3P medicine and based on twelve programmed cell death patterns: a multi-cohort machin... by Lele Ye, Chunhao Long, Binbing Xu, Xuyang Yao, Jiaye Yu, Yunhui Luo, Yuan Xu, Zhuofeng Jiang, Zekai Nian, Yawen Zheng, Yaoyao Cai, Xiangyang Xue, Gangqiang Guo

“…Abstract Background Predictive, preventive, and personalized medicine (PPPM/3PM) is a strategy aimed at improving the prognosis of cancer, and programmed cell death (PCD) is increasingly recognized as a potential target in cancer therapy and prognosis. …”
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Prevention and management of cytomegalovirus infection and disease in kidney transplant: A consensus statement of the Transplantation Society of Taiwan by Mu-Chi Chung, Cheng-Hsu Chen, Shen-Shin Chang, Chih-Yuan Lee, Ya-Chung Tian, Mei-Yi Wu, Hsu-Han Wang, Chia-Cheng Yu, Teng-Wei Chen, Chien-Chang Kao, Chih-Yang Hsu, Yang-Jen Chiang, Ming-Ju Wu, Yen-Ta Chen, Mai-Szu Wu

“…Kidney transplant recipients have an increased risk of cytomegalovirus (CMV) infection and disease. A strategy for mitigating the risk of CMV infection in kidney transplant recipients has not yet been established in Taiwan. …”
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Effectiveness of a nurse-led coaching in self-care intervention for elderly undergoing total laryngectomy: a randomised controlled trial by Yan Liu, Lai Wei, Xue Li, Jian Chen, Huifen Wang, Liyuan Zheng, Shu'e Liu, Danxia Peng, Sanxia Ye, Yuchen Lu, Zhidan Mei, Chun Xu

“…No adverse events (AEs) were observed in either group.Conclusion Nurse-led SC intervention for elderly patients with TL is an effective strategy that can bring multidimensional benefits, including higher self-efficacy, stronger SC ability to actively solve health problems, better QoL and nutritional status, as well as shorter hospital stays.Trial registration number ChiCTR2100043731.…”
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Lactate accumulation promotes immunosuppression and fibrotic transformation of bone marrow microenvironment in myelofibrosis by Mariarita Spampinato, Cesarina Giallongo, Sebastiano Giallongo, Enrico La Spina, Andrea Duminuco, Lucia Longhitano, Rosario Caltabiano, Lucia Salvatorelli, Giuseppe Broggi, Elisabetta P. Pricoco, Vittorio Del Fabro, Ilaria Dulcamare, Antonio Massimo DI Mauro, Alessandra Romano, Francesco Di Raimondo, Giovanni Li Volti, Giuseppe A. Palumbo, Daniele Tibullo

“…Conclusions In conclusion, our results unveil lactate as a key regulator of immune escape and BM fibrotic transformation in MF patients, suggesting MCT1 blocking as a novel antifibrotic strategy.…”
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The SIRT5-JIP4 interaction promotes osteoclastogenesis by modulating RANKL-induced signaling transduction by Kecheng Zhu, Chunxiang Sheng, Linlin Zhang, Yuying Yang, Xiaojing Chen, Tao Jiang, Jiaxi Song, Deng Zhang, Xiao Wang, Hongyan Zhao, Lihao Sun, Libin Zhou, Bei Tao, Jianmin Liu

“…Taken together, the results of this study reveal that the SIRT5-JIP4 axis is a novel positive regulator that finely regulates RANKL-induced osteoclast differentiation and suggest that targeting this axis is a therapeutic strategy for preventing osteoporotic bone loss. Graphical Abstract…”
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Giant energy storage density with ultrahigh efficiency in multilayer ceramic capacitors via interlaminar strain engineering by Ying Yang, Ke Xu, Bin Yang, Xu Hou, Zhanming Dou, Yuhong Li, Zihao Zheng, Gengguang Luo, Nengneng Luo, Guanglong Ge, Jiwei Zhai, Yuanyuan Fan, Jing Wang, Haoming Yang, Yao Zhang, Jing Wang, Changyuan Wang, Shenglin Jiang, Kanghua Li, Jinming Guo, Houbing Huang, Guangzu Zhang

“…Herein, for the purpose of decoupling the inherent conflicts between high polarization and low electric hysteresis (loss), and achieving high energy storage density and efficiency simultaneously in multilayer ceramic capacitors (MLCCs), we propose an interlaminar strain engineering strategy to modulate the domain structure and manipulate the polarization behavior of the dielectric mediums. …”
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Uncovering the Mechanisms of BaBaoWuDanYaoMo Against Influenza A Virus and Virus-Induced Inflammation Based on Network Pharmacology and Pharmacological Evaluation by Lei B, Su Y, Chen R, Chen Z, Liu B, Chen Y, Zhou M, Wang X, Ma Q

“…This study provided a potential treatment for influenza from BB, and network pharmacology provided a strategy to explore active components and mechanism of TCMs against influenza virus infection. …”
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DET induces apoptosis and suppresses tumor invasion in glioma cells via PI3K/AKT pathway by Rui Zhao, Mengran Wang, Zeyu Wu, Panpan Zhao, Huiling Dong, Yue Su, Chenghui Zhao, Min Qi, Shizhang Ling, Shizhang Ling, Xiaochun Jiang, Xiaochun Jiang

“…Western blot analysis further confirmed the downregulation of EGFR, JUN, and PI3K/AKT.ConclusionDET inhibits GBM cell invasion, proliferation, and apoptosis via modulating the PI3K/AKT signaling pathway, highlighting its potential as a novel therapeutic strategy for GBM treatment.…”
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PINK1 modulates Prdx2 to reduce lipotoxicity‐induced apoptosis and attenuate cardiac dysfunction in heart failure mice with a preserved ejection fraction by Hao Zhang, Tianyu Xu, Xiyuan Mei, Qiming Zhao, Qiling Yang, Xianghui Zeng, Zhuang Ma, Haobin Zhou, Qingchun Zeng, Dingli Xu, Hao Ren

“…Our studies offer valuable insights, opening avenues for the development of innovative therapeutic strategies in the prevention and treatment of HFpEF.…”
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Sustainable aquaculture and sea ranching with the use of vaccines: a review by Alma Alfatat, Kwaku Amoah, Kwaku Amoah, Kwaku Amoah, Kwaku Amoah, Kwaku Amoah, Jia Cai, Jia Cai, Jia Cai, Jia Cai, Jia Cai, Yu Huang, Yu Huang, Yu Huang, Yu Huang, Yu Huang, Muhammad Fachri, Hagai Nsobi Lauden, Shaoliang Lyu, Xuefeng Wang, Sahya Maulu, Berchie Asiedu, Syaifiuddin Syaifiuddin

“…Vaccination is a critical component of immunological preventive strategy essential for the health management of animals. …”
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Optimization of Dual-energy Spectral Lower-extremity Computed Tomography Venography Scanning Protocol: Phantom Study by Shigeng WANG, Renwang PU, Yijun LIU, Xin FANG, Wei WEI, Beibei LI

“…Conclusions: Setting the NI to 11 and reconstructing monoenergetic images at 50 keV combined with 60% ASIR-V is the optimal imaging strategy for dual-energy spectral lower-extremity CTV, which balances between image quality and radiation dose in the current phantom study.…”
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