Oncometabolite D-2HG drives tumor metastasis and protumoral macrophage polarization by targeting FTO/m6A/ANGPTL4/integrin axis in triple-negative breast cancer by Siyue Zhang, Ning Zhang, Tong Wan, Yinqiao He, Jie Hao, Yiwei Liu, Yidong Liu, Bing Chen, Wenjing Zhao, Lijuan Wang, Dan Luo, Chao Gao, Qifeng Yang

“…A joint MeRIP-seq and RNA-seq strategy was used to identify the target genes regulated by D-2HG-mediated N6-methyladenosine (m6A) modification. …”
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The contrasted impacts of grasshoppers on soil microbial activities in function of primary production and herbivore diet by Ibanez, Sébastien, Foulquier, Arnaud, Brun, Charles, Colace, Marie-Pascale, Piton, Gabin, Bernard, Lionel, Gallet, Christiane, Clément, Jean-Christophe

“…The least productive sites were characterized by conservative plants, high soil C content, and by microbes having a resource acquisition strategy (more extracellular enzymes, higher PNM). …”
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Integrated multiomics signatures to optimize the accurate diagnosis of lung cancer by Mengmeng Zhao, Gang Xue, Bingxi He, Jiajun Deng, Tingting Wang, Yifan Zhong, Shenghui Li, Yang Wang, Yiming He, Tao Chen, Jun Zhang, Ziyue Yan, Xinlei Hu, Liuning Guo, Wendong Qu, Yongxiang Song, Minglei Yang, Guofang Zhao, Bentong Yu, Minjie Ma, Lunxu Liu, Xiwen Sun, Yunlang She, Dan Xie, Deping Zhao, Chang Chen

“…Furthermore, the clinic-RadmC-guided strategy could reduce the unnecessary invasive procedures for benign IPLs by 10.9% ~ 35%, and avoid the delayed treatment for lung cancer by 3.1% ~ 38.8%. …”
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Evaluation of the Sterile Insect Technique for the Control of the Melon Fly (<i>Bactrocera cucurbitae</i>) Under Laboratory and Semi-Field Conditions in Sri Lanka by Muditha Nawarathne, Lahiru Udayanga, Hasini Ekanayake, Bader Alhafi Alotaib, Ananda Pathirage, Nayana Siriwardena, Athula Jayarathne, Hassan Ammouneh, Mohamed M. M. Najim, Abou Traore, Tharaka Ranathunge

“…This study was conducted to determine the ideal irradiation dose to be used to set up a Sterile Insect Technique (SIT)-based strategy to control <i>B. cucurbitae</i> outbreaks in Sri Lanka. …”
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Comparative efficacy of repurposed drugs lopinavir-ritonavir and darunavir-ritonavir in hospitalised COVID-19 patients: insights from a tertiary centre cohort by Dóra Paróczai, Dóra Paróczai, András Bikov, András Bikov, Andreea Blidaru, Emanuel Bobu, Ana Lascu, Ana Lascu, Cristian Ion Mot, Cristian Ion Mot, Stefan Mihaicuta, Stefan Mihaicuta, Stefan Frent, Stefan Frent

“…BackgroundDrug repurposing has become a widely adopted strategy to minimise research time, costs, and associated risks. …”
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A Systematic Review on Poisoned Patients as Potential Organ Donors by Kattamreddy Ananth Rupesh, Anirudh Suseel Nalumaru, Mohit Kumar Moses Thathapudi, Omkarnath Sivarchaka, Deekshitha Alla

“…Materials and Methods: A comprehensive search was conducted across PubMed, Web of Science, ProQuest, Cochrane Library, and Scopus using a meticulously designed search strategy. Studies that included patient data, focused on deceased poisoned donors, and provided access to full-text articles in English were included. …”
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Rapid depletion of “catch-and-release” anti-ASGR1 antibody in vivo by Siva Charan Devanaboyina, Peng Li, Edward L. LaGory, Carrie Poon-Andersen, Kevin D. Cook, Marcus Soto, Zhe Wang, Khue Dang, Craig Uyeda, Ryan B. Case, Veena A. Thomas, Ronya Primack, Manuel Ponce, Mei Di, Brian Ouyang, Joelle Kaner, Sheung Kwan Lam, Mina Mostafavi

“…Targeting antigens with antibodies exhibiting pH/Ca2+-dependent binding against an antigen is an attractive strategy to mitigate target-mediated disposition and antigen buffering. …”
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Classification of risk for transmission of vaccine-preventable diseases in Brazilian municipalities: comparative analysis before and after the national movement for vaccination and... by Ana Catarina de Melo Araújo, Thales Philipe Rodrigues da Silva, Janaina Fonseca Almeida Souza, Krishna Mara Rodrigues Freire, Fernanda Penido Matozinhos, Eder Gatti Fernandes

“…The municipalities were classified into risk strata for transmission of vaccine-preventable diseases before and after the strategy proposed by the Ministry of Health. Results The study found an increase in median vaccination coverage (VC) for all vaccines evaluated, except for the varicella vaccine. …”
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Integration of ordered porous materials for targeted three-component gas separation by Xue Jiang, Yu Wang, Hui Wang, Lu Cheng, Jian-Wei Cao, Jin-Bo Wang, Rong Yang, Dong-Hui Zhang, Run-Ye Zhang, Xiu-Bo Yang, Su-Hang Wang, Qiu-Yu Zhang, Kai-Jie Chen

“…We introduced a pore integration strategy of modularizing ordered pore structures with specific functions for on-demand assembly to deal with complex multi-component separation systems, which are unattainable by each individual pore. …”
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Digital light processing three-dimensional printing with acrylic–titanium composite powders for multiscale porous scaffolds by Guangbin Zhao, Yanlong Wu, Bochen Li, Hang Tian, Bo Li, Xiao Li, Xu Chen, Tao Zhou, Yaning Wang, Yichao Gong, Dingchang Hou, Yaxiong Liu, Xuewen Zong, Bingheng Lu

“…Herein, we propose a strategy for 3D printing of titanium scaffolds featuring multiscale porous internal structures via powder modification and digital light processing (DLP). …”
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Sequential bioaugmentation of the dominant microorganisms to improve the fermentation and flavor of cereal vinegar by Ao Zhang, Wenqing Zhang, Xiaorui Guo, Jiao Wang, Kai Liang, Yaao Zhou, Fanfan Lang, Yu Zheng, Min Wang

“…Through sequential bioaugmentation strategy, bacterial diversity was regulated due to minimizing acetic acid inhibition in the early stages, and the non-volatile acid was targetedly improved by Lactobacillus. …”
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Identification of serum metabolite biomarkers in premature infants with bronchopulmonary dysplasia: protocol for a multicentre prospective observational cohort study by Ping Zhou, Jun Chen, Ying Liu, Cheng Chen, Xin Guo, Zhangbin Yu, Jiebo Liu, Yanping Guo, Dan Dan Rao, Shengnan He, Xudong Yan, Wanxiang He, Songzhou Xu, Ruolin Zhang

“…A three-step analysis strategy—discovery, validation and clinical testing—will be used to identify and validate the clinical utility of novel biomarkers. …”
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Structure-Function Relationship between Cluster Mean Defect and Sector Peripapillary Retinal Nerve Fiber Layer Thickness in Primary Open Angle Glaucoma by Jing Han, Wenjiu Yang, Dabo Wang, Haiqing Bai

“…Method. 39 healthy eyes (control group), 43 early POAG eyes (global MD ≤ 6 dB, early group), 30 moderate POAG eyes (global MD between 6 and 12 dB, moderate group), and 53 advanced POAG eyes (global MD > 12 dB, advanced group) underwent visual field (VF) examination with Octopus perimeter (dynamic strategy/G2 pattern) and peripapillary retinal nerve fiber layer thickness measurements with RTVue-100 FD-OCT. …”
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Application of Six Sigma in the management of caregivers of inpatients in Department of Neurology during the COVID-19 outbreak (六西格玛管理法在新型冠状病毒肺炎疫情防控期间神经内科住院患者陪护人员管理中的应用)... by PAN Xi (潘习), XU Lan (徐岚), WANG Zhi (王稚)

“…The implementation rate of management strategy and rate of caregivers-related conflicts and complaints before and after implementation of Six Sigma were compared. …”
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The prevalence of cancer in patients with multiple sclerosis (MS) who received rituximab: a systematic review and meta-analysis by O. Mirmosayyeb, V. Shaygannejad, N. Ebrahimi, H. Ghoshouni, M. Ghajarzadeh

“…Methods: We searched PubMed, Scopus, EMBASE, Web of Science, and google scholar along with gray literature up to April 2021.The search strategy included the MeSH and text words as ((“CD20 Antibody” AND Rituximab) OR “Rituximab CD20 Antibody” OR Mabthera OR “IDEC-C2B8 Antibody” OR “IDEC C2B8 Antibody” OR IDEC-C2B8 OR “IDEC C2B8” OR GP2013 OR Rituxan OR rituximab) AND ((Sclerosis AND multiple) OR (sclerosis AND disseminated) OR ''disseminated sclerosis'' OR ''multiple sclerosis'' OR ''acute fulminating''). …”
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High-fat diet promotes gestational diabetes mellitus through modulating gut microbiota and bile acid metabolism by Lei Yao, Xuefei Zhou, Xianqi Jiang, Hao Chen, Yuanliang Li, Xiao Xiong, Yan Tang, Haogang Zhang, Pengfei Qiao

“…Moreover, Fxr pathway participated in regulating HFD-associated gut microbiota disordered BAs metabolites and aggravating GDM in mice.DiscussionModulating gut microbiota and BAs metabolites could be a potential therapeutic strategy in the prevention and treatment of HFD-associated GDM.…”
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Self-reported determinants for subjective financial distress: a qualitative interview study with German cancer patients by Eva Winkler, Katja Mehlis, Bastian Surmann, Wolfgang Greiner, Andrea Züger, Viktoria Mathies, Sophie Pauge, Luise Richter, Thomas Ernst, Natalja Menold

“…The self-reported determinants can be classified into material (savings, good salary, shared rent through shared living, employed partner, paid-off house, potential financial support from family and friends, work-related specifics, consumer restrictions, out-of-pocket-costs and anticipated financial changes), social (social support from friends and family), systemic (administrative hurdlers and insurance cover) and inner personal determinants (coping strategies, change of attitude, character traits).Conclusion Subjective financial distress depends not only on material but also on social, systemic and inner personal determinants. …”
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Archival Research, Underwater Optical Surveys, and 3D Modelling: Three Stages for Shaping the Wreck of the Steamship <i>Bengala</i> (Isola di Capo Rizzuto, Crotone, Italy) by Salvatore Medaglia, Fabio Bruno, Ana Castelli, Matteo Collina, Barbara Davidde Petriaggi, Luca De Rosa, Julieta Frere, Fabrizio Fuoco, Guillermo Gutiérrez, Antonio Lagudi, Francesco Megna, Raffaele Peluso

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Human-Centered Design of an mHealth Tool for Optimizing HIV Index Testing in Wartime Ukraine: Formative Research Case Study by Nancy Puttkammer, Elizabeth Dunbar, Myroslava Germanovych, Mariia Rosol, Matthew Golden, Anna Hubashova, Vladyslav Fedorchenko, Larisa Hetman, Liudmyla Legkostup, Jan Flowers, Olena Nesterova

“… BackgroundAssisted partner services (APSs; sometimes called index testing) are now being brought to scale as a high-yield HIV testing strategy in many nations. However, the success of APSs is often hampered by low levels of partner elicitation. …”
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Granulocyte-Macrophage Colony-Stimulating Factor-Activated Neutrophils Express B7-H4 That Correlates with Gastric Cancer Progression and Poor Patient Survival by Zhi-guo Shan, Zong-bao Yan, Liu-sheng Peng, Ping Cheng, Yong-sheng Teng, Fang-yuan Mao, Kun Fan, Yuan Zhuang, Yong-liang Zhao

“…Our results illuminate a novel regulating mechanism of B7-H4 expression on tumor-activated neutrophils in GC, suggesting that functional inhibition of these novel GM-CSF-B7-H4 pathways may be a suitable therapeutic strategy to treat the immune tolerance feature of GC.…”
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