A Spike-Based mRNA Vaccine Encapsulated in Phospholipid 1,2-Dioleoyl-sn-Glycero-3-PhosphoEthanolamine Containing Lipid Nanoparticles Induced Potent B- and T-Cell Responses Associat... by Afshana Quadiri, Swayam Prakash, Latifa Zayou, Nisha Rajeswari Dhanushkodi, Amruth Chilukuri, Gemma Ryan, Kelly Wang, Hawa Vahed, Aziz A. Chentoufi, Lbachir BenMohamed

“…Background: Nucleoside-modified mRNA encapsulated in lipid nanoparticles (LNPs) have emerged as a promising vaccine strategy, especially for COVID-19. While the LNPs protect mRNA from degradation and efficiently deliver the mRNA to antigen-presenting cells, the effect of lipid composition on the immunogenicity and protective efficacy of mRNA/LNP vaccines is not well characterized. …”
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Intelligent fault diagnosis method for rolling bearings based on flexible residual neural network by Chuang CHEN, Xianfeng LI, Jiantao SHI, Dongdong YUE

“…Second, a DSABO with a dynamic position update strategy is proposed for parameter optimization of the above FResNet with the flexible residual module. …”
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Salvianolic Acid D Alleviates Cerebral Ischemia-Reperfusion Injury by Suppressing the Cytoplasmic Translocation and Release of HMGB1-Triggered NF-κB Activation to Inhibit Inflammat... by Wen Zhang, Junke Song, Wan Li, Dewen Kong, Yu Liang, Xiaoyue Zhao, Guanhua Du

“…Inflammatory response participates in the overall pathophysiological process of stroke. It is a promising strategy to develop antistroke drugs targeting inflammation. …”
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Inhibition of Mitochondrial Fission Reverses Simulated Microgravity-Induced Osteoblast Dysfunction by Enhancing Mechanotransduction and Epigenetic Modification by Qiusheng Shi, Yaxin Song, Jingqi Cao, Jing Na, Zhijie Yang, Xinyuan Chen, Ziyi Wang, Yubo Fan, Lisha Zheng

“…Therefore, targeting mitochondrial fission emerges as a promising therapeutic strategy to alleviate osteoblast dysfunction under SMG conditions, providing novel approaches to maintain bone health during prolonged space missions and safeguard the astronaut well-being.…”
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Meaningfulness, feasibility, and usability of quality-of-care measures for maternal and infant health: A structured mixed-methods review by Ryan P. Theis, Rahma S. Mkuu, Hannah Marmol, Lauren Silva, Callie Reeder, Jessica Bahorski, Erica Smith, John C. Smulian, Tony S. Wen, Amanda Redinger, Tabresha Blake, Elizabeth A. Shenkman, Dominick J. Lemas

“…We assessed discrete elements relevant to meaningfulness, feasibility, and usability following AHRQ National Quality Strategy (NQS) criteria, with input from researcher, clinician, and citizen scientist investigators. …”
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Ligilactobacillus salivarius LZZAY01 accelerated autophagy and apoptosis in colon cancer cells and improved gut microbiota in CAC mice by Wenhong Yang, Tao Li, Shixiang An, Rong Chen, Yuxin Zhao, Jiaxian Cui, Mingyu Zhang, Jingkun Lu, Yunpeng Tian, Lili Bao, Pengwei Zhao

“…Probiotics could provide a potential strategy to prevent and treat CRC. The impact of LZZAY01 on cancer cell lines CT-26, HCT-116, and SW-620 was evaluated by conducting cytotoxicity and clonogenicity tests. …”
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Enhanced energy storage performance in Ag(Nb,Ta)O3 films via interface engineering by Xiao Zhai, Jun Ouyang, Weijie Kuai, Yinxiu Xue, Kun Wang, Nengneng Luo, Hongbo Cheng, Hanfei Zhu, Chao Liu, Limei Zheng

“…In this work, we propose an interface engineering strategy to mitigate the breakdown field issue. A Ag(Nb,Ta)O3/BaTiO3 bilayer film is proposed, where the BaTiO3 layer acts as a p-type semiconductor while Ag(Nb,Ta)O3 layer is n-type, together with the n-type LaNiO3 buffer layer on the substrate, forming an n-p-n heterostructure. …”
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Inhibition of microRNA-139-5p Improves Fibroblasts Viability and Enhances Wound Repair in Diabetic Rats Through AP-1 (c-Fos/c-Jun) by Mo J, Zhang J, Meng X, Wang F, Tang W, Liu Y, Fu L, Liang F, Mo Z

“…Our study further verified that microRNA-139-5p regulated the migration of human skin fibroblasts by modulating c-Fos.Conclusion: Inhibiting microRNA-139-5p improves fibroblasts viability and promotes diabetic wound healing, suggesting that this may be a therapeutic strategy for diabetic foot ulcer. Keywords: miR-139-5p, diabetes, wound healing, AP-1, fibroblasts…”
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Application of crisis management in patient complaint management in the pediatric dentistry clinic (危机管理在儿童口腔门诊投诉管理中的应用) by ZHOU Lina (周莉娜), LUO Sha (罗莎), WANG Yan (王雁)

“…Conclusion The crisis management is effective to reduce the rate of patient complaint and improve the nursing quality in the pediatric dentistry clinic. It is an effective strategy to facilitate the healthy and stable development of pediatric dentistry clinic (目的 探讨危机管理理论在儿童口腔科门诊患者投诉管理中的应用效果。…”
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Investigating Falls Risk Awareness in Hospitals Using the Self‐Awareness of Falls Risk Measure (SAFRM): Empirical Research Quantitative by Elissa Dabkowski, Simon J. Cooper, Jhodie Duncan, Karen Missen

“…Methods Using a purposive sampling strategy, patients were eligible to participate if aged ≥ 40 years, English‐speaking, and have ambulatory capacity prior to hospital admission. …”
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Tratamento Diretamente Observado para a Tuberculose na Atenção Primária à Saúde: discursos e práticas by Ingrid Gabriel Grigorio, Kalyta Michaelly Silva Glória, Milena de Oliveira Simões, Katiuscia Cardoso Rodrigues, Flávia Rodrigues Pereira

“…ABSTRACT Objective: To define Directly Observed Treatment for Tuberculosis from the perspective of Primary Health Care professionals in Governador Valadares, Minas Gerais, Brazil, and to present the actions related to this treatment strategy that they implement. Method: This is a qualitative and descriptive study based on an action-research approach, conducted with Primary Health Care health professionals in the municipality of Governador Valadares, MG. …”
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Role of Epidural Electrode Stimulation in Three Patients with Incomplete AIS D Spinal Cord Injury by Yu-Chen Chen, Xiang-Ling Huang, Hung-Yu Cheng, Ciou-Chan Wu, Ming-Yung Wu, Lian-Cing Yan, Shin-Yuan Chen, Sheng-Tzung Tsai, Shinn-Zong Lin

“…<b>Conclusions</b>: Thus, EES may be an effective strategy for sensory impairment recovery, as well as muscular activity and strength improvement. …”
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Identification of ALEKSIN as a novel multi-IRF inhibitor of IRF- and STAT-mediated transcription in vascular inflammation and atherosclerosis by Aleksandra Antonczyk, Katarzyna Kluzek, Natalia Herbich, Mahdi Eskandarian Boroujeni, Bart Krist, Dorota Wronka, Anna Karlik, Lukasz Przybyl, Adam Plewinski, Joanna Wesoly, Hans A. R. Bluyssen

“…Based on their promoting role in atherosclerosis, we hypothesized that the inhibition of pro-inflammatory target gene expression through multi-IRF inhibitors may be a promising strategy to treat CVDs. Using comparative in silico docking of multiple IRF–DNA-binding domain (DBD) models on a multi-million natural compound library, we identified the novel multi-IRF inhibitor, ALEKSIN. …”
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Early Detection of Oncological Diseases of the Digestive System (Guidelines of the Russian Gastroenterological Association and the Russian Association of Oncologists for Primary Ca... by V. T. Ivashkin, I. V. Mayev, A. D. Kaprin, M. Yu. Agapov, D. N. Andreev, A. S. Vodoleev, M. Yu. Zharkova, M. P. Korolev, Yu. A. Kucheryavyi, T. L. Lapina, M. V. Mayevskaya, A. V. Okhlobystin, Ch. S. Pavlov, A. V. Paraskevova, S. S. Pirogov, E. A. Poluektova, D. E. Rumyantseva, A. S. Trukhmanov, P. V. Tsarkov, A. A. Sheptulin, O. S. Shifrin

“…The knowledge of clinical manifestations and risk factors in the development of digestive system neoplasms allows a physician to suspect cancer and devise a timely and adequate diagnostic strategy, including laboratory and instrumental studies at specialised clinical centres.…”
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Reasons and countermeasures of nursing disputes in the nucleic acid testing clinic (核酸检测门诊护理纠纷的原因与对策研究) by ZHAO Jialu (赵佳璐), WANG Huaxin (王华新), ZHOU Jie (周洁), TANG Ling (唐玲), MA Kexin (马可欣), ZENG Chunfeng (曾春凤)

“…The incidence of nursing disputes had decreased from2. 35 to 1. 56 after implementation of optimal management strategy. Conclusion In order to reduce the incidence of nursing disputes and improve the nursing quality in the nucleic acid testing clinic, it is required to enhance the nursing staff’s sense of responsibility and effective communication with patients, standardize the nursing operation process, strengthen cooperation between various departments and improve the hospital workplace environment. …”
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Accumulation of advanced oxidation protein products aggravates bone-fat imbalance during skeletal aging by Yu-Sheng Huang, Jia-Wen Gao, Rui-Feng Ao, Xin-Yu Liu, Di-Zheng Wu, Jun-Long Huang, Chen Tu, Jing-Shen Zhuang, Si-Yuan Zhu, Zhao-Ming Zhong

“…The translational potential of this article: Reducing AOPPs accumulation and its cascading effects on MSCs might be an attractive strategy for delaying skeletal aging.…”
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New insights into the immunomodulatory potential of sialic acid on monocyte-derived dendritic cells by Zélia Silva, João Amorim Rabaça, Vanessa Luz, Rita Adubeiro Lourenço, Mariolina Salio, Alexandra Couto Oliveira, Pedro Bule, Sebastian Springer, Paula Alexandra Videira

“…These findings provide insights into the potential of sialic acid manipulation as a rapid immunomodulatory strategy, offering promising avenues for targeted interventions in inflammatory contexts.…”
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Pengembangan Jadwal Shift Staf Editor Video pada Stasiun Televisi Nasional Trans7 berbasis Android menggunakan Algoritma Ant Colony dengan Firebase by Rizal Rizal, Eliyani Eliyani

“…Perusahaan bisnis bidang broadcasting atau tepatnya stasiun televisi memiliki strategi untuk menayangkan tayangan acara yang paling ditunggu oleh penonton setianya, yaitu berupa tayangan acara yang up to date dan cepat dalam penyiarannya. …”
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The Role of Bronchoalveolar Lavage in Therapeutic Antimicrobial Choices for Hematologic Patients with Pulmonary Infiltrates by Filippo Patrucco, Mattia Bellan, Davide Martinotti, Giuseppe Ielo, Paola Rebecca Iovine, Martina Mascheroni, Francesco Todisco, Martina Ubaldi, Nadia Castaldo, Francesco Gavelli, Alberto Fantin

“…This study aimed to determine the diagnostic yield of BAL in hematological patients for microbiological purposes and its influence on modifying the therapeutic strategy. <i>Material and Methods:</i> This multicenter, retrospective, observational study included data from 193 consecutive patients from two centers from January 2020 to October 2022. …”
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KMO-driven metabolic reconfiguration and its impact on immune cell infiltration in nasopharyngeal carcinoma: a new avenue for immunotherapy by Nijun Chen, Yuan Zong, Chen Yang, Lei Li, Yang Yi, Jiawen Zhao, Xiaoyu Zhao, Xianfei Xie, Xingmei Sun, Ning Li, Liting Jiang

“…As a potential prognostic biomarker, KMO may offer valuable predictive insights, and targeting KMO could represent a promising therapeutic strategy for NPC, potentially enhancing the efficacy of immunotherapies.…”
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