The near-optimal adjustment of carbon and nitrogen allocations into different organs in early-season rice cultivars with drastically different yield components under nitrogen appli... by Wen Ning, Wen Ning, Lin Su, Lin Su, Dandan Shi, Dandan Shi, Meina Ji, Meina Ji, Xiang Ouyang, Qingfeng Song, Caihong Shao, Xin-Guang Zhu, Shuoqi Chang, Shuoqi Chang

“…Early season rice can be used as a model system to study the growth strategy selection of plants to changing environment conditions.…”
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Effectiveness of antimicrobial agent combinations against carbapenem-producing Klebsiella pneumoniae with KPC variants in China by Congcong Liu, Congcong Liu, Yuchen Wu, Yanyan Zhang, Zelin Yan, Danxia Gu, Danxia Gu, Hongwei Zhou, Ning Dong, Chang Cai, Gongxiang Chen, Rong Zhang

“…Antimicrobial agent combinations have been promoted as a potential therapeutic strategy for infections. The most effective antimicrobial combinations against CRKP strains producing different carbapenemases are currently unclear, particularly those producing the KPC variant carbapenemases. …”
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Colossal permittivity with ultra-wide temperature stability in Bi + Ca co-doped BaTiO3 by Tingting Fan, Qi Shi, Wenrong Xiao, Guangzu Zhang, Feng Huang, Wenlin Wang, Wen Dong, Shenglin Jiang, Jing Wang

“…As a result, the dielectric loss was reduced and the temperature stability was further extended. This strategy breaks the traditional limitation of single/noncomprehensive enhancement by single-polarization mechanism, and is of great theoretical and practical significance to promote the research and application of high-performance BaTiO3-based ceramic materials.…”
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Effectiveness and Safety of Preoperative Halo Gravity Traction-Assisted Posterior Spinal Fusion Surgery for Severe and Rigid Scoliosis: A Comparative Matched-Cohort Study by Yangpu Zhang, Bo Han, Jianqiang Wang, Yuzeng Liu, Yiqi Zhang, Yong Hai, Lijin Zhou

“…This study showed that the use of HGT, as a feasible and safe strategy, has superior efficacy and safety for treating severe and rigid scoliosis and can reduce the level of osteotomy used during surgery to some extent.…”
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Leveraging machine learning to uncover multi-pathogen infection dynamics across co-distributed frog families by Daniele L. F. Wiley, Kadie N. Omlor, Ariadna S. Torres López, Celina M. Eberle, Anna E. Savage, Matthew S. Atkinson, Lisa N. Barrow

“…Overall, our study highlights the use of machine learning techniques and a broad sampling strategy for identifying important factors related to infection in multi-host, multi-pathogen systems.…”
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Lipopolymers as the Basis of Non-Viral Delivery of Therapeutic siRNA Nanoparticles in a Leukemia (MOLM-13) Model by Panadda Yotsomnuk, Amarnath Praphakar Rajendran, Daniel Nisakar Meenakshi Sundaram, Luis Carlos Morales, Cezary Kucharski, Mohammad Nasrullah, Wanwisa Skolpap, Xiaoyan Jiang, Spencer B. Gibson, Joseph Brandwein, Hasan Uludağ

“…Small interfering RNA (siRNA) therapy in acute myeloid leukemia (AML) is a promising strategy as the siRNA molecule can specifically target proteins involved in abnormal cell proliferation. …”
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Preclinical model for evaluating human TCRs against chimeric syngeneic tumors by Olivier Michielin, Philippe Guillaume, Melita Irving, Patrick Reichenbach, Vincent Zoete, Elise Gray-Gaillard, Evangelos Stefanidis, Aikaterini Semilietof, Julien Pujol, Alessia D'Esposito

“…A variety of approaches are being taken to augment tumor control by ACT including TCR affinity-optimization and T-cell coengineering strategies to address the suppressive tumor microenvironment (TME). …”
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Strontium–Alix interaction enhances exosomal miRNA selectively loading in synovial MSCs for temporomandibular joint osteoarthritis treatment by Wenxiu Yuan, Jiaqi Liu, Zhenzhen Zhang, Chengxinyue Ye, Xueman Zhou, Yating Yi, Yange Wu, Yijun Li, Qinlanhui Zhang, Xin Xiong, Hengyi Xiao, Jin Liu, Jun Wang

“…The insight into trace element-driven, site-specific miRNA selectively loading in SMSC-EXOs proposes a promising therapeutic enhancement strategy for TMJOA.…”
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TILTomorrow today: dynamic factors predicting changes in intracranial pressure treatment intensity after traumatic brain injury by Shubhayu Bhattacharyay, Florian D. van Leeuwen, Erta Beqiri, Cecilia A. I. Åkerlund, Lindsay Wilson, Ewout W. Steyerberg, David W. Nelson, Andrew I. R. Maas, David K. Menon, Ari Ercole, the CENTER-TBI investigators and participants

“…We developed the TILTomorrow modelling strategy, which leverages recurrent neural networks to map a token-embedded time series representation of all variables (including missing values) to an ordinal, dynamic prediction of the following day’s five-category therapy intensity level (TIL(Basic)) score. …”
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Realization of a cascade treatment algorithm for glaucoma in St. Petersburg by A.V. Antonova, V.P. Nikolaenko, V.V. Brzheskiy

“…In addition to the obvious drawbacks of a laissez-faire strategy (irreversible vision loss), the risk of surgical failure significantly increases. …”
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Chimeric cytokine receptor TGF-β RⅡ/IL-21R improves CAR-NK cell function by reversing the immunosuppressive tumor microenvironment of gastric cancer by Yaojun Ren, Min Xue, Xinhui Hui, Xiuyu Liu, Muhammad Asad Farooq, Yiran Chen, Yuzhou Ji, Yixin Duan, Iqra Ajmal, Jie Yao, Wenzheng Jiang

“…This study underscores the therapeutic potential of TRII/21R-modified CAR-NK cells as a breakthrough strategy for combating cancer.…”
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Reticulocyte hemoglobin content: a new frontier in iron deficiency diagnostics for major surgical patients by Suma Choorapoikayil, Mischa J. Kotlyar, Lisa Kawohl, Paul P. Pratz, Denana Mehic, Peter Kranke, Florian Rumpf, Lea V. Blum, Jan A. Kloka, Kai Zacharowski, Vanessa Neef, Patrick Meybohm

“…Treatment of ID is straightforward, however implementing a comprehensive anemia management strategy within clinical routines is complex. Recently, reticulocyte hemoglobin content (Ret-He) has been evaluated as an early marker for ID diagnosis. …”
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Targeting deubiquitinase USP7-mediated stabilization of XPO1 contributes to the anti-myeloma effects of selinexor by Junying Wang, Mengping Chen, Jinxing Jiang, Yike Wan, Xin Li, Minyue Zhang, Fei Xiao, Lu Zhong, Hua Zhong, Zhaoyu Qin, Jian Hou

“…Abstract Background Targeting exportin1 (XPO1) with Selinexor (SEL) is a promising therapeutic strategy for patients with multiple myeloma (MM). However, intrinsic and acquired drug resistance constitute great challenges. …”
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Analysis of Prognostis Factors and Effect of Pulmonary Rehabilitation in Patients with Chronic Obstructive Pulmonary Disease by Yiming XU, Honghua SHEN, Jingbo DU, Lei REN

“…Objective:To evaluate the rehabilitation effect of different intensity aerobic exercise on patients with chronic obstructive pulmonary disease (COPD), and explore an appropriate pulmonary rehabilitation strategy for COPD patients with different degrees of pulmonary function in alleviating period.Methods:A total of 529 COPD patients were from the respiratory department of Shanghai Fourth Rehabilitation Hospital. …”
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Molecular hydrogen reduces dermatitis-induced itch, diabetic itch and cholestatic itch by inhibiting spinal oxidative stress and synaptic plasticity via SIRT1-β-catenin pathway in... by Linlin Zhang, Fangshi Zhao, Yize Li, Zhenhua Song, Lingyue Hu, Yuanjie Li, Rui Zhang, Yonghao Yu, Guolin Wang, Chunyan Wang

“…Taken together, this study uncovers that molecular hydrogen protects against chronic pruritus and spinal pruriceptive sensitization by reducing oxidative damage via up-regulation of SIRT1-dependent β-catenin deacetylation in mice, implying a promising strategy in translational development for itch control.…”
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Ten simple rules for working with high resolution remote sensing data by Mahood, Adam L., Joseph, Maxwell B., Spiers, Anna I., Koontz, Michael J., Ilangakoon, Nayani, Solvik, Kylen K., Quarderer, Nathan, McGlinchy, Joe, Scholl, Victoria M., St. Denis, Lise A., Nagy, Chelsea, Braswell, Anna, Rossi, Matthew W., Herwehe, Lauren, Wasser, Leah, Cattau, Megan E., Iglesias, Virginia, Yao, Fangfang, Leyk, Stefan, Balch, Jennifer K.

“…In order to implement a consistent strategy, we outline ten rules with examples from Earth and environmental science to help academic researchers and professionals in industry work more effectively and competently with high-resolution data. …”
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Epigenetics disruptions enabled by porphyrin-derived metal-organic frameworks disarm resistances to sonocatalytic ROS anti-tumor actions by Yan Zhang, Dou Du, Chao Fang, Xin Yu, Yujia Fang, Xinyu Liu, Di Ou, Haohao Yin, Hui Liu, Taixia Wang, Lu Lu, Xiaolong Li, Kun Zhang

“…Herein, we proposed an epigenetic deubiquitination disruption strategy to disarm the ubiquitination-deubiquitination balance-induced resistances to ROS production and ROS-based anti-tumor action for potentiating sonodynamic treatment (SDT) efficiency. …”
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ALKBH5, an m6A demethylase, attenuates tumor growth and inhibits metastasis in papillary thyroid carcinoma by Yong Zhuang, Qingyan Cai, Xin Hu, Huibin Huang

“…Moreover, effective inhibition of m6A modification of ALKBH5 might constitute a potential treatment strategy for PTC.…”
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Efficacy of total transanal laparoscopic pull‑through and pure transanal endorectal pull‑through in the treatment of common‑type Hirschsprung disease by Guizhen Huang, Wenqian Huang, Chi Sun, Meng Li, Chaosheng He, Yi Su, Weili Xu, Suolin Li

“…Aim: We aimed to compare the short-term and long-term efficacy of 2 surgical approaches to the treatment of common-type HD: total transanal laparoscopic pull-through (TTLP, which falls under the category of NOTES), and pure transanal endorectal pull-through (PTEP; not classified as NOTES) in order to provide a reference for clinical strategy selection. Materials and methods: We retrospectively evaluated clinical data and follow-up results of 60 children with common-type HD who underwent TTLP or PTEP. …”
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The Rise of Accounting Administration and Its Impact on the Profitability of Microeconomic Management by R. Acosta Velarde, M. Campaña Lara, E. Melendres Medina, J. Flores Dávila

“…Based on the results, we proposed a strategy for the efficient management of the microeconomy that is made up of four tools: conscious strategic planning, administration without tax barriers, efficient accounting tools, and the sustainable development of the company. …”
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