CircHipk3 serves a dual role in macrophage pyroptosis by promoting NLRP3 transcription and inhibition of autophagy to induce abdominal aortic aneurysm formation by Donghua Cai, Chuling Li, Yingyuan Zhang, Sisi He, Yihai Guo, Wangjun Liao, Yulin Liao, Jianping Bin, Xiang He

“…Targeting CircHipk3 may offer a novel therapeutic strategy to prevent pyroptosis and AAA development, positioning it as a potential treatment target.…”
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The Modular and Integrated Data Assimilation System at Environment and Climate Change Canada (MIDAS v3.9.1) by M. Buehner, J.-F. Caron, E. Lapalme, A. Caya, P. Du, Y. Rochon, S. Skachko, M. Bani Shahabadi, S. Heilliette, M. Deshaies-Jacques, W. Chang, M. Sitwell

“…<p>The Modular and Integrated Data Assimilation System (MIDAS) software (version 3.9.1) is described in terms of its range of functionality, modular software design, parallelization strategy, and current uses within real-time operational and experimental systems. …”
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Proteostasis Decline and Redox Imbalance in Age-Related Diseases: The Therapeutic Potential of NRF2 by Brigitta Buttari, Antonella Tramutola, Ana I. Rojo, Niki Chondrogianni, Sarmistha Saha, Alessandra Berry, Letizia Giona, Joana P. Miranda, Elisabetta Profumo, Sergio Davinelli, Andreas Daiber, Antonio Cuadrado, Fabio Di Domenico

“…Given NRF2’s role in mitigating proteotoxic stress, the pharmacological modulation of NRF2 has emerged as a promising therapeutic strategy, even in aged preclinical models. By inducing NRF2, it is possible to mitigate the damaging effects of oxidative stress, metabolic dysfunction, and inflammation, thus reducing protein misfolding. …”
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A Multifunctional MIL-101-NH2(Fe) Nanoplatform for Synergistic Melanoma Therapy by Shang J, Chen Y, Wang F, Yang J, Li Y, Yang L, Liu X, Zhong Z, Yue C, Zhou M

“…In vivo studies confirmed the superior antitumor efficacy of MIL@DOX@ICG + NIR treatment, synergistically harnessing chemotherapy, photothermal therapy, photodynamic therapy, and chemodynamic therapy effects while maintaining excellent biocompatibility.Conclusion: Our findings underscore the potential of MIL-101-NH2(Fe) nanoparticles as a versatile and effective platform for synergistic melanoma therapy, offering a promising strategy for overcoming the limitations of conventional treatment modalities.Keywords: melanoma, MIL-101-NH2(Fe), chemotherapy, photothermal therapy, photodynamic therapy, chemodynamic therapy…”
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EV Hybrid Battery With Integrated Multilevel Neutral-Point-Clamped Interfacing and Lossless Intermodule State-of-Charge Balancing by Gabriel Garcia-Rojas, Sergio Busquets-Monge, Alber Filba-Martinez, Turev Sarikurt, Salvador Alepuz, Josep Bordonau

“…The novel topology is presented, and a suitable power converter modulation and control strategy is developed. The feasibility and benefits of such configuration are demonstrated and illustrated. …”
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Advanced approach to primary microsurgical debridement of extensive scleral lacerations involving simultaneous vitrectomy and chorioretinal wound closure by S.S. Shamkin, S.N. Subbotina, A.B. Stepanyants, D.V. Salov

“…Salov</b>^<b>2</b><b> </b> </p> <b> </b> <p> ¹Central City Clinical Hospital № 23, Yekaterinburg, Russian Federation </p> <p> ²Ural State Medical University, Yekaterinburg, Russian Federation </p> <p> <b>Background</b>: the current strategy for managing extensive zone 3 scleral lacerations implies delayed subtotal vitrectomy. …”
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Solvent-Free Synthesis of Co-Based Zeolitic Imidazolate Framework (ZIF-9) for the Removal of Congo Red from Water by Khoa Dang Tran, Hoan Tuan Phan, Chi Thi Kim Nguyen, Bao Chi Nguyen, Ha Vu Le, Khoa Dang Nguyen

“…Besides, the adsorption capacity of prepared ZIF-9 still remained stable after three cycles. This strategy was a simple method compared to conventional methods in terms of reducing the amount of used solvents, energy requirements, and the duration of the synthetic process.…”
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Depot-specific acetylation profiles of adipose tissues—therapeutic targets for metabolically unhealthy obesity by Haoyue Guo, Zhiyi Zhang, Juntao Yang, Jiangfeng Liu, Hongwei Lin, Ningbei Yin

“…The regulation of acetylated modifications in white adipose tissue (WAT), particularly for the differential Kac sites enriched in ECM remodeling and inflammation-related pathways, may serve as an effective intervention strategy for MUO, with NDST1 emerging as a promising therapeutic target. …”
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Effects of virtual reality technology on early mobility in critically ill adult patients: a systematic review and meta-analysis by Yansha He, Yansha He, Qin Yang, Xiaoxia Dai, Tian Chen, Huan Wu, Kunjie Li, Shiqiong Zhu, Yanlin Liu, Hua Lei

“…ObjectiveThe study aimed to explore the effects of virtual reality (VR) technology on motor function rehabilitation in critically ill patients.MethodsAdhering to the PRISMA systematic evaluation method for developing the literature ranking criteria and search strategy, the following databases were systematically searched: PubMed, Embase, Web of Science, the Cochrane Library, CNKI, Wanfang Data, Chinese Medical Journal Full-Text Database, and SINOMED. …”
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Integrating single-cell RNA-seq and bulk RNA-seq to explore prognostic value and immune landscapes of methionine metabolism-related signature in breast cancer by Yanxian Gao, Ziyu Feng, Hailong Zhao, Xinghai Liu, Muyu Zhu, Xiafei Yu, Xiaoan Liu, Xian Wu, Jing Tao

“…Breast cancer cell lines have been identified as methionine-dependent, and methionine restriction has been proposed as a potential cancer treatment strategy.MethodsWe integrated transcriptomic and single-cell RNA sequencing (ScRNA-seq) analyses based on The Cancer Genome Atlas (TCGA) database and Gene Expression Omnibus (GEO) datasets. …”
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MSC-EXs inhibits uranium nephrotoxicity by competitively binding key proteins and inhibiting ROS production by Xinrui Yang, Jing Liu, Yaru Yin, Luxun Yang, Mingquan Gao, Zifei Wu, Binghui Lu, Shenglin Luo, Weidong Wang, Rong Li

“…This study identifies MSC-EXs as a novel therapeutic strategy against depleted uranium poisoning, presenting potential advancements in treatment methodologies.…”
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Desire for labor companionship and its associated factors among pregnant women attending antenatal care at public health facilities in Debre Berhan City: a cross-sectional study by Mulualem Silesh, Tesfanesh Lemma Demisse, Kidist Ayalew Abebe, Birhan Tsegaw Taye, Tebabere Moltot, Moges Sisay Chekole, Fetene Kasahun, Abebayehu Melesew Mekuriyaw, Tirusew Nigussie Kebede, Kibret Hailemeskel

“…BackgroundAllowing women to have a companion of their choice during labor and delivery is a cost-effective strategy to enhance the quality of maternal care and promote a positive birth experience. …”
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USP35 promotes the growth of ER positive breast cancer by inhibiting ferroptosis via BRD4-SLC7A11 axis by Jiawei Cao, Tao Wu, Tong Zhou, Zewei Jiang, Yinrui Ren, Jiawei Yu, Jiayi Wang, Changrui Qian, Guang Wu, Licai He, Hongzhi Li, Rixu Lin, Min Liu, Haihua Gu

“…Targeting USP35 together with ferroptosis inducer may represent a potential promising strategy for treating ER+ breast cancer that does not respond to endocrine therapies.…”
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Fatty acid synthase inhibition improves hypertension-induced erectile dysfunction by suppressing oxidative stress and NLRP3 inflammasome-dependent pyroptosis through activating the... by Jiaochen Luan, Mengchi Yu, Qi Gu, Xuan Zhou, Yunqiang Shao, Tong Chen, Jiayi Zhang, Zheng Zhu, Ninghong Song, Jie Yang

“…In vivo, C75 treatment restored endothelial function and reversed erectile dysfunction, accompanied by decreased oxidative stress and pyroptosis in the penile corpus cavernosum.ConclusionThese findings suggest that Fasn inhibition may offer a promising therapeutic strategy for hypertension-induced ED by alleviating oxidative stress and suppressing NLRP3 inflammasome-dependent endothelial cell pyroptosis via activation of the Nrf2/HO-1 pathway.…”
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FOXC1-mediated serine metabolism reprogramming enhances colorectal cancer growth and 5-FU resistance under serine restriction by Zhukai Chen, Jiacheng Xu, Kang Fang, Hanyu Jiang, Zhuyun Leng, Hao Wu, Zehua Zhang, Zeyu Wang, Zhaoxing Li, Mingchuang Sun, Ziying Zhao, Anqi Feng, Shihan Zhang, Yuan Chu, Lechi Ye, Meidong Xu, Lingnan He, Tao Chen

“…Consequently, combining dietary serine restriction with targeted therapy against the ERK1/2-pELK1-FOXC1 axis could be a highly effective strategy for treating CRC, enhancing the efficacy of 5-FU.…”
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The prevalence of cancer in patients with multiple sclerosis (MS) who received rituximab: a systematic review and meta-analysis by O. Mirmosayyeb, V. Shaygannejad, N. Ebrahimi, H. Ghoshouni, M. Ghajarzadeh

“…Methods: We searched PubMed, Scopus, EMBASE, Web of Science, and google scholar along with gray literature up to April 2021.The search strategy included the MeSH and text words as ((“CD20 Antibody” AND Rituximab) OR “Rituximab CD20 Antibody” OR Mabthera OR “IDEC-C2B8 Antibody” OR “IDEC C2B8 Antibody” OR IDEC-C2B8 OR “IDEC C2B8” OR GP2013 OR Rituxan OR rituximab) AND ((Sclerosis AND multiple) OR (sclerosis AND disseminated) OR ''disseminated sclerosis'' OR ''multiple sclerosis'' OR ''acute fulminating''). …”
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YEARS clinical decision rule for diagnosing pulmonary embolism: a prospective diagnostic cohort follow-up study in primary care by Frans H Rutten, Menno V Huisman, Jeanet Blom, Rosanne van Maanen, Frederikus A Klok, Geert-Jan Geersing, Karel Moons, Hannah M la Roi-Teeuw, Melchior Nierman, Tuur Egbers

“…In this study, we evaluated in primary care an alternative and potentially more efficient diagnostic strategy—the YEARS algorithm; a simplified three-item version of the Wells rule combined with a pretest probability adjusted D-dimer interpretation.Design In this comprehensive prospective diagnostic validation study, primary care patients suspected of PE were enrolled by their general practitioner. …”
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Early diagnosis and the effect of treatment compliance on the prognosis and progression of glaucomatous optic neuropathy by S.V. Diordiychuk, A.V. Kuroyedov, N.E. Fomin, O.V. Gapon’ko, V.V. Gorodnichiy, I.V. Kondrakova, N.M. Sol’nov

“…These factors include early diagnosis, accessible and effective screening system, rational management strategy that implies the drug change to prevent the reduction in therapeutic effect, and patient adherence to treatment that involves explaining the causes and characteristics of disease cours e, potential complications with recommendation noncompliance, and a professional work a doctor with a patient.…”
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Health Economic Evaluation of Patients With Colorectal Liver Metastases Randomized to ALPPS or TSH: Analysis From the LIGRO Trial by Kristina Hasselgren, MD, PhD, Martin Henriksson, PhD, Bård I. Røsok, MD, PhD, Peter N. Larsen, MD, PhD, Ernesto Sparrelid, MD, PhD, Gert Lindell, MD, PhD, Nicolai A. Schultz, MD, PhD, Bjorn A. Bjørnbeth, MD, PhD, Bengt Isaksson, MD, PhD, Magnus Rizell, MD, PhD, Anna Lindhoff Larsson, RN, Per Sandström, MD, PhD, Bergthor Björnsson, MD, PhD

“…Estimated costs and QALYs for each treatment strategy were combined into an incremental cost-effectiveness ratio (ICER). …”
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Effects of Chemical Fertilizer Reduction Combined with Straw and Organic Fertilizer Application on Soil Acidification Mitigation and Erosion Control by SHEN Mengxue, HAO Rui, LIU Xinwei, WEI Wanhao, CAO Yunfei, SHU Hujia, HAO Zongyu, WANG Huyu, WANG Ling, SHI Zhihua

“…[Conclusion] Based on soil acidification improvement, fertility enhancement, structural improvement, and rapeseed economic benefits, chemical fertilizer reduction (30%) coupled with straw returning (6 000 kg/hm2) and 3 000 kg/hm2 organic fertilizer application can be recommended as the optimal management strategy. The results of this study can provide a scientific foundation for improving soil acidification and increasing crop yields.…”
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