Hypoxia-tropic delivery of nanozymes targeting transferrin receptor 1 for nasopharyngeal carcinoma radiotherapy sensitization by Ruofei Zhang, Yanfang Shen, Xiaoying Zhou, Jianru Li, Hanqing Zhao, Zixia Zhang, Jun Zhao, Hongjun Jin, Shuanshuan Guo, Hui Ding, Guohui Nie, Zhe Zhang, Ying Wang, Xiyun Yan, Kelong Fan

“…Nanozymes, nanomaterials with catalase-like activity, have emerged as a promising strategy for radiosensitization by converting elevated hydrogen peroxide in the tumor microenvironment into oxygen. …”
Get full text

Monitoring of microvascular calcification by time-resolved photoacoustic microscopy by Haigang Ma, Yinshi Yu, Yahui Zhu, Hongjun Wu, Haixia Qiu, Ying Gu, Qian Chen, Chao Zuo

“…The feasibility study of monitoring MC by the TR-PAM proves that this technique has potential to be developed as a superficial microvascular bio-mechanical assessment method to supplement current clinical strategy for prediction and monitoring of some diseases.…”
Get full text

CC16 alleviates PM2.5-induced lung epithelial cell injury and airway inflammation in asthmatic mice by inhibiting ferroptosis by Aili Wang, Jianling Liu, Zhangwen Li, Ze Qian, Shuo Yang, Shaohua Luo, Jinle Lin, Jian Wu

“…Conclusion: CC16 demonstrates promise as a therapeutic agent for PM2.5-induced asthma by modulating ferroptosis and alleviating airway inflammation, thereby providing a novel strategy for asthma management.…”
Get full text

The guided fire from within: intratumoral administration of mRNA-based vaccines to mobilize memory immunity and direct immune responses against pathogen to target solid tumors by Renhao Li, Jing-Chu Hu, Li Rong, Yige He, Xiaolei Wang, Xuansheng Lin, Wenjun Li, Yangfan Wu, Chaiyaporn Kuwentrai, Canhui Su, Thomas Yau, Ivan Fan-Ngai Hung, Xiang Gao, Jian-Dong Huang

“…Abstract We investigated a novel cancer immunotherapy strategy that effectively suppresses tumor growth in multiple solid tumor models and significantly extends the lifespan of tumor-bearing mice by introducing pathogen antigens into tumors via mRNA-lipid nanoparticles. …”
Get full text

Comparative transcriptomics reveal stage-dependent parasitic adaptations in the myxozoan Sphaerospora molnari by Monika M. Wiśniewska, Jiří Kyslík, Gema Alama-Bermejo, Alena Lövy, Martin Kolísko, Astrid S. Holzer, Anush Kosakyan

“…Abstract Background Parasitism as a life strategy has independently evolved multiple times within the eukaryotic tree of life. …”
Get full text

Presenting a Model for Color Effectiveness in Marketing Using Consumer Neuroscience: A Sequential Exploratory Mixed-Methods Approach by Allahyar Ghasemi, Ahmad Rahchamani, Hamidreza Saeednia

“…The research approach, in the qualitative phase, was inductive, and the research strategy was the classic grounded theory or Glaser approach. …”
Get full text

A multicenter, randomized, open label, two formulation, crossover bioequivalence trial of doxorubicin hydrochloride liposomal injection in Chinese patients with metastatic breast c... by Jingshu Wang, Xiuping Lai, Herui Yao, Hui Yang, Xiaolong Cao, Xiaochen Wang, Ying Wang, Weiqi Nian, Xiaodong Zheng, Qingxiu Mai, Anding Liu, Xiaozhi Lv, Xiaoying Bi, Junyi Chen, Junyan Wu, Suiwen Ye

“…Methods To achieve these goals, the trial employed a randomized, open-label, two-formulation crossover dosing strategy among Chinese patients with metastatic breast cancer. …”
Get full text

A new peptide inhibitor of C1QBP exhibits potent anti‐tumour activity against triple negative breast cancer by impairing mitochondrial function and suppressing homologous recombina... by Xingxing Li, Yue Wu, Min Zhang, Fengliang Wang, Hong Yin, Yanrong Zhang, Shuli Zhao, Jiehua Ma, Mingming Lv, Cheng Lu

“…In this study, we have unveiled a new peptide, PDBAG1, derived from the precursor protein GPD1, employing a peptidomics‐based drug screening strategy. PDBAG1 has demonstrated substantial efficacy in suppressing triple‐negative breast cancer (TNBC) both in vitro and in vivo. …”
Get full text

Geodynamics of basins above subducted slabs: An integrated modelling study of tectonics, sedimentation, and magmatism in the Timok Magmatic Complex by Stojadinović Uroš, Toljić Marinko, Trivić Branislav, Pantović Radoje, Srećković-Batoćanin Danica, Krstekanić Nemanja, Kostić Bojan, Velojić Miloš, Stefanović Jelena, Ranđelović Nikola, Maleš Maja

“…The new model of the TMC basin’s geodynamic evolution will quantitatively advance the strategy of prospecting and exploration of world‐class porphyry copper‐ gold deposits, which have been actively exploited in this region for more than a century. …”
Get full text

Spatial Distribution Characteristics of Micronutrients and Their Deficiency Effect on the Root Morphology and Architecture in Citrus Rootstock by Gaofeng Zhou, Yiping Fu, Mei Yang, Yanhong Li, Jing Zhang

“…Moreover, citrus alters its root morphology and biological traits as a nutrient acquisition strategy to maintain maximal micronutrient acquisition and growth. …”
Get full text

Integrative analysis of miRNA expression data reveals a minimal signature for tumour cells classification by Sabrina Napoletano, David Dannhauser, Paolo Antonio Netti, Filippo Causa

“…Beyond advancing the understanding of tumour biology, our step-by-step guide offers a robust tool for a wide range of users to investigate precise diagnostics and promising therapeutic strategies.…”
Get full text

Joint fluid multi-omics improves diagnostic confidence during evaluation of children with presumed septic arthritis by Yolanda Peña-López, Naureen G. Tareen, Bo Zhang, Indu Raman, Carlos A. Arana, Chengsong Zhu, Yang Liu, Pratibha Selvakumar, Nicolai S. C. van Oers, Simrat Morris, Lora V. Hooper, Lawson A. B. Copley, Prithvi Raj

“…Abstract Background An accurate diagnosis of septic versus reactive or autoimmune arthritis remains clinically challenging. A multi-omics strategy comprising metagenomic and proteomic technologies were undertaken for children diagnosed with presumed septic arthritis to advance clinical diagnoses and care for affected individuals. …”
Get full text

Acceptance of multiple micronutrient supplementations (MMS) and iron and folic acid supplement utilisation among pregnant and lactating women in the rural part of Ethiopia, 2022: a... by Zewdie Birhanu, Menen Tsegaw, Stanley Chitekwe, Ramadhani Noor, Rachana Sharma, Finina Abebe, Yordanos Tadesse Kidanemariam, Ahmednasir Abdi, Hiwot Getachew, Asli Hassan Aden, Tesfaye Chuko, Tariku Dejene, Ahmed Mohammed Dawd

“…To ensure accessibility, the product should be sold in all town shops, pharmacies and through home delivery. Additionally, a strategy should be developed to provide access to the product in each adjacent community centre. …”
Get full text

Gut Dysbiosis and Abnormal Bile Acid Metabolism in Colitis-Associated Cancer by Li Liu, Min Yang, Wenxiao Dong, Tianyu Liu, Xueli Song, Yu Gu, Sinan Wang, Yi Liu, Zaripa Abla, Xiaoming Qiao, Wentian Liu, Kui Jiang, Bangmao Wang, Jie Zhang, Hailong Cao

“…Gut dysbiosis might alter the metabolism of bile acids and promote CAC, which would provide a potential preventive strategy of CAC by regulating gut microbiota and bile acid metabolism.…”
Get full text

Effects of Different Light Spectra on Oxidative Stress and Nutritional Quality of the Fish <i>Plectropomus leopardus</i> by Wensheng Li, Zheng Zhang, Baoliang Liu, Yingying Fang, Shuquan Cao, Wenyang Li, Yan Sun, Chengbin He, Chuanxin Zhang, Fan Fei

“…This result provides a theoretical reference for the lighting strategy of an indoor recirculating aquaculture system.…”
Get full text

Traditional Chinese medicine manual therapy for adolescent idiopathic scoliosis: a case report by Bowen Zhu, Miaoxiu Li, Jun Ren, Tianxiang He, Xin Zhou, Shoujian Wang, Lingjun Kong, Min Fang, Min Fang

“…No adverse events during treatment.ConclusionsTCMMT is a conservative treatment option worthy of consideration when considering a conservative treatment strategy for AIS.…”
Get full text

AiGPro: a multi-tasks model for profiling of GPCRs for agonist and antagonist by Rahul Brahma, Sunghyun Moon, Jae-Min Shin, Kwang-Hwi Cho

“…The proposed framework incorporates an innovative dual-label prediction strategy, enabling the simultaneous classification of molecules as agonists, antagonists, or both. …”
Get full text

Melt inclusion bubbles provide new insights into crystallisation depths and CO2 systematics at Soufrière Hills Volcano, Montserrat by TiVonne A. Howe, Thomas E. Christopher, Thomas E. Christopher, Séverine Moune, Séverine Moune, Hugh Tuffen, Federica Schiavi

“…Improved understanding of the magmatic system of Soufrière Hills Volcano, Montserrat (SHV) is needed to inform future hazard management strategy, and remaining uncertainties include the depth of magma storage and the source of ongoing gas emissions. …”
Get full text

Daily home monitoring of potassium, creatinine, and estimated plasma volume in heart failure post‐discharge by Patrick Rossignol, Renaud Fay, Nicolas Girerd, Faiez Zannad

“…The ongoing HERMES HF study (NCT04050904) is assessing the short‐term feasibility and safety of such a monitoring strategy, complemented by a decision support system, and generating recommendations based on ESC clinical guidelines in patients discharged after an episode of worsening heart failure with reduced ejection fraction.…”
Get full text

Technologies for Interoperable Internet of Medical Things Platforms to Manage Medical Emergencies in Home and Prehospital Care: Scoping Review by Mattias Seth, Hoor Jalo, Åsa Högstedt, Otto Medin, Bengt Arne Sjöqvist, Stefan Candefjord

“…Our literature search followed a dual search strategy and was conducted up to August 2023 across 6 electronic databases: IEEE Xplore, PubMed, Scopus, ACM Digital Library, Sage Journals, and ScienceDirect. …”
Get full text