Effects of repetitive thermal loads on microstructure and mechanical properties of potassium-doped tungsten alloy as plasma facing material by Hui Wang, Zhuo-Ming Xie, Da-Huan Zhu, Mu-Lan Yu, Yin-Juan Fu, Rui Liu, Xian-Ping Wang, Qian-Feng Fang, Chang-Song Liu, Xue-Bang Wu

“…The present work offers a physical depiction of K bubble evolution in W–K alloys under thermal fatigue conditions relevant to fusion environments, suggesting a strategy for optimizing their mechanical properties by promoting the formation of nano-sized, interface-dislocation-decorated K bubbles.…”
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Clinical outcomes of chimeric antigen receptor T-cell therapy following autologous hematopoietic stem cell transplantation in 38 patients with refractory/relapsed primary or second... by Jiaying Wu, Wanying Liu, Yang Cao, Yang Yang, Zhen Shang, Mi Zhou, Yicheng Zhang, Fankai Meng, Xiaojian Zhu, Yi Xiao

“…Abstract Background Several reports have indicated that chimeric antigen receptor (CAR) T-cell therapy following autologous hematopoietic stem cell transplantation (ASCT) is a promising strategy for refractory/relapsed (r/r) central nervous system lymphoma (CNSL), but the number of reported cases is limited. …”
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CAD-Q (COPD-Asthma Differentiation Questionnaire): Performance of a new diagnostic score to differentiate between COPD and asthma in adults by Alejandra Lozano-Forero, Eduardo Tuta-Quintero, Alirio R. Bastidas, Blanka Pacheco, Juan Cordero, Kamil Faizal, Miguel Molina, Irma Méndez, Andrés Cardona, Nicoll Navarro, Gabriela Bonilla, Manuela Franco, Juan Samboní, Julio de La Hoz, Georgina Doumat, David Portilla, Hannah Eljach

“…Utilizing clinical questionnaires to identify and differentiate patients with COPD and asthma for further diagnostic procedures has emerged as an effective strategy to address this issue. We developed a new diagnostic tool, the COPD-Asthma Differentiation Questionnaire (CAD-Q), to differentiate between COPD and asthma in adults. …”
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Ultraviolet-C-based sanitization is a cost-effective option for hospitals to manage health care-associated infection risks from high touch mobile phones by David C. Cook, David C. Cook, Matthew Olsen, Oystein Tronstad, Oystein Tronstad, Oystein Tronstad, John F. Fraser, John F. Fraser, John F. Fraser, John F. Fraser, John F. Fraser, Adrian Goldsworthy, Adrian Goldsworthy, Rashed Alghafri, Rashed Alghafri, Simon J. McKirdy, Lotti Tajouri, Lotti Tajouri, Lotti Tajouri

“…The first strategy required all staff to sanitize their hands after every contact with a mobile phone. …”
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Comparison of IMO vifa24plus(1-2) and Humphrey Field Analyzer 24-2 by Takagi Y, Asano R, Yamashita K, Sakai Y, Yokoyama S, Ichikawa K, Ichikawa K

“…On the same day, the HFA 24– 2 test using the Swedish Interactive Threshold Algorithm Standard and the IMO vifa 24plus(1– 2) test using the Ambient Interactive Zippy Estimated strategy were performed. A Wilcoxon signed-rank test was used to compare fixation, false positives, false negatives, and total test time for both eyes between the HFA and IMO vifa tests. …”
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Mechanism of Exogenous Silicon in Enhancing Cold Stress Tolerance in <i>Solanum lycopersicum</i> L. Seedlings: Insights from Resistance and Quality Indicators by Fan Zhang, Yihong Zhao, Yuanbo Zhang, Yu Shi, Leiping Hou, Abid Khan, Ruixing Zhang, Yi Zhang

“…Consequently, the study advocates for the application of 50 mg·L⁻¹ ionic Si fertilizer as a strategy to mitigate the impact of low-temperature stress on tomato plants. …”
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PD-1 cis-targeted IL-2v in combination with radiotherapy inhibits lung cancer growth and remodels the immune microenvironment by Pedro J Romero, Sara Labiano, Gregory Verdeil, Christian Klein, Pablo Umana, Tania Wyss, Christine Trumpfheller, Marie-Catherine Vozenin, Céline Godfroid, Jackeline Romero, Vincent Roh, Genrich V Tolstonog, Chia-Hsien Chuang, Andrea Kelemen, Laura Codarri Deak

“…The study of the clonal dynamics of tumor cells during disease progression and therapy highlighted a clonal selection upon HRT+muPD1-IL2v therapy.Conclusions We demonstrated that HRT+muPD1-IL2v combination is a potent therapeutic strategy to delay tumor growth and increase survival in a metastatic lung cancer model, but additional studies are required to completely understand the resistance mechanisms associated with the lack of complete response in this model.…”
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Incorporation of reduced glutathione to the extender improves frozen-thawed sperm function and fertility potential in mandarin fish (Siniperca chuatsi) by Sen Yang, Wenjie Xu, Yanglin Hua, Qingxin Ruan, Zining Meng

“…Supplementation of antioxidant in the freezing medium is suggested to be an effective strategy against cryodamage. Therefore, the objective of this study was to investigate the potential effects of reduced glutathione (GSH) on post-thaw sperm quality and fertility in mandarin fish (Siniperca chuatsi). …”
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Edaravone dexborneol alleviates pericyte-mediated fibrosis depositing extracellular matrix through TGF-β1/IL-11 in cerebral small vessel disease by Qingrui Duan, Zhiyang Liu, Yuxuan Xing, Haifeng Huang, Lin Zhu, Jiaxuan Liu, Peikun He, Guixian Ma, Yuhu Zhang, Kun Nie, Yuyuan Gao, Lijuan Wang

“…EDB treatment, targeting pericytes fibrosis, may be a novel therapeutic strategy for CSVD.…”
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Key considerations based on pharmacokinetic/pharmacodynamic in the design of antibody-drug conjugates by Yangyang Gao, Yuwei Xia, Yixin Chen, Shiqi Zhou, Yingying Fang, Jieru Yu, Leyin Zhang, Leyin Zhang, Leitao Sun, Leitao Sun, Leitao Sun

“…However, complexity of its structural composition poses a greater difficulty for drug design studies.ObjectivesPharmacokinetic/pharmacodynamic (PK/PD) based consideration of ADCs has increasingly become a hot research topic for optimal drug design in recent years, providing possible ideas for obtaining ADCs with desirable properties.MethodsFrom the assessment of the ADC action process based on PK/PD, we introduce the main research strategies of ADCs. In addition, we investigated the strategies to solve the prominent problems of ADC in the clinic in recent years, and summarized and evaluated the specific ways to optimize various problems of ADC based on the PK/PD model from two perspectives of optimizing the structure and properties of the drugs themselves. …”
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Effects of a nutrition education intervention on nutrition knowledge and attitude among overweight and obese primary schoolchildren: a cluster randomized controlled trial by Rusidah Selamat, Nur Azlina Abdul Aziz, Junidah Raib, Norlida Zulkafly, WNurul Ashikin W. Mohamad, Ainan Nasrina Ismail, Muhammad Yazid Jalaludin, Fuziah Md. Zain, Zahari Ishak, Abqariyah Yahya, Abdul Halim Mokhtar

“…Abstract Background School-based obesity interventions are a promising strategy for combating childhood obesity. In this study, we examined the efficacy of the “My Body is Fit and Fabulous at School” (MyBFF@school) program with a nutrition education intervention (NEI) for improving nutrition knowledge and attitude among overweight and obese primary schoolchildren. …”
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Analisis Loyalitas Pelanggan Berbasis Model Recency, Frequency, dan Monetary (RFM) dan Decision Tree pada PT. Solo by Basri Basri, Windu Gata, Risnandar Risnandar

“…PT Solo yang bergerak di bidang bisnis ATKS harus memiliki strategi dalam setiap persaingan usaha, khususnya dalam meraih loyalitas pelanggan. …”
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GAMG alleviates liver fibrosis through inducing ferroptosis in inflammatory macrophages via the IRF1/SLC7A11 signaling pathway by Qing Pang, Shuai Zhou, Yong Wang, Hongtao Pan, Zhixin Wang, Xilaing Qin, Chao Zhu, Shilei Chen, Huichun Liu, Xiaosi Hu, Hao Jin

“…Therefore, GAMG induces ferroptosis of inflammatory macrophages by activating the IRF1/SLC7A11 axis, which provides a new strategy for the treatment of LF.…”
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Hydra Radio Access Network (H-RAN): Multi-Functional Communications and Sensing Networks, Initial Access Implementation, and Task-2 Approach by Rafid I. Abd, Daniel J. Findley, Kwang Soon Kim

“…However, conventional RANs typically implement a uniform strategy when dealing with diverse communication scenarios. …”
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Carotenoids in the treatment of age-related macular degeneration: a drug delivery system does matter by M.L. Maximov, Zh.G. Oganezova, I.D. Kanner, Voznesenskaya A.A

“…It is important for the ophthalmologist to be aware of modifiable risk factors and thus to collect a comprehensive medical history, interact with patients using motivational interviewing and to involve promptly other healthcare specialists into the patient management strategy. Etiopathogenesis of AMD is still not entirely understood. …”
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Identification and validation of the important role of KIF11 in the development and progression of endometrial cancer by Biying Wang, Lunmin Bao, Xiaoduo Li, Guang Sun, Wu Yang, Nanzi Xie, Ling Lei, Wei Chen, Hailong Zhang, Man Chen, Xing Zhao, Xiufang Wan, Rui Yuan, Hongmei Jiang

“…Our current research explored the prognostic value, biological function and targeting strategy of KIF11 in EC through approaches including bioinformatics, machine learning and experimental studies. …”
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Enhanced Biomechanical Stability in Proximal Humeral Fractures: Finite Element Analysis of a Novel Endosteal Anatomical Support Nail for Improved Fixation in Elderly Patients by Jiawen Chen, Zhonghe Wang, Changda Li, Peiyu He, Zhongxuan Chen, Lijun Sun, Xiaoyan Cao, Na Tian, Xiang Dong, Peifu Tang, Hua Chen

“…Conclusions This study introduces a novel EAS concept to enhance the anti‐varus and anti‐rotational capabilities of the humeral head and distribute stress at the bone–implant interface in treating elderly PHFs. This strategy shows promise based on our limited analysis.…”
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The histone demethylase KDM5C enhances the sensitivity of acute myeloid leukemia cells to lenalidomide by stabilizing cereblon by Lu Zou, Dan Cao, Qing Sun, Wenjun Yu, Bingzong Li, Guoqiang Xu, Liang Zhou

“…Conclusions This study provides a possible strategy for a combination treatment with MLN4924 and Len for leukemia.…”
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TDP43 augments astrocyte inflammatory activity through mtDNA-cGAS-STING axis in NMOSD by Zhuhe Liu, Yunmeng Bai, Bingtian Xu, Haixia Wen, Kechun Chen, Jingfang Lin, Yuanyuan Wang, Jiangping Xu, Haitao Wang, Fudong Shi, Jigang Wang, Honghao Wang

“…Therefore, targeting TDP43 represents a compelling therapeutic strategy for NMOSD.…”
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OLIG2 mediates a rare targetable stem cell fate transition in sonic hedgehog medulloblastoma by Kinjal Desai, Siyi Wanggou, Erika Luis, Heather Whetstone, Chunying Yu, Robert J. Vanner, Hayden J. Selvadurai, Lilian Lee, Jinchu Vijay, Julia E. Jaramillo, Jerry Fan, Paul Guilhamon, Michelle Kushida, Xuejun Li, Gregory Stein, Santosh Kesari, Benjamin D. Simons, Xi Huang, Peter B. Dirks

“…We demonstrate that targeting transition from quiescence to proliferation at the level of the tumorigenic cell could be a pivotal medulloblastoma treatment strategy.…”
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