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15101
Targeted inhibition of Aurora kinase A promotes immune checkpoint inhibition efficacy in human papillomavirus-driven cancers
Published 2025-01-01“…This combination enhanced CD8 T-cell infiltration and decreased the frequencies of MDSCs, whereas neither alisertib nor ICIs (anti-PD-1/anti-CTLA-4) alone showed such effects.Conclusion Our study establishes the potential of Aurora A inhibition to sensitize HPV-positive tumors to ICIs, specifically anti-CTLA-4 treatment. This combination strategy resulted in enhanced antitumor efficacy, driven by systemic and intratumoral increases in CD8 T-cell responses and reduced immunosuppressive cell populations, specifically MDSCs. …”
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15102
General practitioner-centered rural obesity management: Design, protocol and baseline data of the German HAPpEN pragmatic trial
Published 2025-01-01“…Objective: HAPpEN aims to implement and evaluate a holistic general practitioner-centered, interdisciplinary obesity management strategy in rural Germany, focusing on feasibility, health outcomes, and economic benefits. …”
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15103
Application of Laparoscopic Radical Resection for Type III and IV Hilar Cholangiocarcinoma Treatment
Published 2020-01-01“…Application of laparoscopic radical resection for III/IV Hilar C is safe and feasible and has good short-term efficacy with adequate preoperative evaluation, appropriate case selection, and precise operative strategy.…”
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15104
TPDTNet: Two-Phase Distillation Training for Visible-to-Infrared Unsupervised Domain Adaptive Object Detection
Published 2025-01-01“…Finally, a distillation training strategy that utilizes pseudodetection labels to calculate target information. …”
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15105
Optimizing Growth and Yield in Mulched Cotton Through Aerated Subsurface Drip Irrigation in Southern Xinjiang
Published 2025-01-01“…In conclusion, from a water conservation and yield enhancement perspective, an irrigation quota of 337.4 mm during the reproductive stage under ASDI is recommended as an effective strategy for “one film three tubes and six rows” mulched cotton in Southern Xinjiang.…”
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15106
Rabies vaccinations at the rural–urban divide: successes and barriers to dog rabies vaccination programs from a rural and urban campaign in Zambia
Published 2025-01-01“…IntroductionDog vaccination against rabies is considered one of the most effective strategies at preventing human deaths from rabies and is a key strategy for eliminating dog-mediated human rabies deaths. …”
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15107
Investigation of gut microbiota in pediatric patients with peanut allergy in outpatient settings
Published 2025-02-01“…These results suggest that modulating the gut microbiota may be a viable therapeutic strategy for managing peanut allergy and highlight the need for further research to explore the clinical implications of these microbial changes.…”
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15108
Integrating Hybrid Team-Based and Case-Based Learning in Dental Education Transformation
Published 2025-02-01“…The research findings indicate that a variety of strategies for TBL are beneficial not just in terms of enhancing students' perception of learning outcomes, but also shows improvement in competencies and efficacy in dental education.3 It is a matter of involving dynamic participation, collaboration, and the development of critical abilities. …”
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15109
Combined Transplantation of Adipose Tissue-Derived Stem Cells and Endothelial Progenitor Cells Improve Diabetic Erectile Dysfunction in a Rat Model
Published 2020-01-01“…Stem cell transplantation is a promising strategy for the treatment of diabetic ED (DED). In this study, we evaluated whether combined transplantation of adipose tissue-derived stem cells (ADSCs) and endothelial progenitor cells (EPCs) could improve the erectile function of the DED rat model. …”
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15110
Gastrointestinal Bleeding due to Pancreatic Disease-Related Portal Hypertension
Published 2020-01-01“…Clinicians should individualize the treatment strategy of LSPH according to the patients’ clinical conditions and nature of pancreatic diseases.…”
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15111
The Potential Role of Regulatory B Cells in Idiopathic Membranous Nephropathy
Published 2020-01-01“…Our review aims at highlighting the correlation between Breg and IMN and proposes potential mechanisms, which can provide a new direction for the discovery of the pathogenesis of IMN, thus providing a new strategy for the prevention and early treatment of IMN.…”
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15112
Vali@mPEG‐TK‐COS: A Dual‐Function Nano‐Pesticide for Fungicidal Action and Plant Immune Modulation
Published 2024-12-01“…This study presents a sophisticated ROS‐responsive controlled‐release nano‐pesticide with dual fungicidal and plant immunomodulatory properties, offering an advanced strategy to enhance the efficiency of existing pesticides and promote sustainable crop production by reducing overall pesticide usage.…”
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15113
The Long-Term Uptake of Home Spirometry in Regular Cystic Fibrosis Care: Retrospective Multicenter Observational Study
Published 2025-01-01“…ConclusionsConsistent uptake of home spirometry in people with CF is low but increases around periods of changing symptoms. A clear strategy for the organization of remote care seemed to improve the long-term uptake of home spirometry. …”
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15114
A Model for Organizational Preparedness of SMEs During COVID-19 Pandemic in Kigezi Sub-region in South Western Uganda.
Published 2023“…The study recommends that SME owners/managers should focus on improving their firms’ features; perfect the way they make decision by providing a critical dynamic resilience strategy framework to manage their SMEs during the crisis period. …”
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Technical Report -
15115
Macrophage-mimicking nanotherapy for attenuation of acute pancreatitis
Published 2025-02-01“…This allows us to envision that the developed biomimetic nanotherapy approach could potentially serve as a novel strategy for pancreatic drug therapy.…”
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15116
Presenting the Model of the Elites' Desertion Factors in Iran's Continental Plateau Oil Company
Published 2024-05-01“…Dari (2022) investigated the identification of effective strategies to maintain and prevent personnel leaving the service in Kashmar municipality. …”
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15117
Discourse Structure Analysis of Hasanak-e-Vazir’s Hanging Tale: A Study based on Van Dijk’s (2007) Socio-Cognitive Approach
Published 2024-09-01“…Stylistic Strategies: Involving tone and word choice. Syntactic Strategies: Covering participant roles, movements of clauses, and verb modality. …”
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15118
Identifying, categorizing and ranking performance indicators of schools using Q method
Published 2024-08-01“…This research was done in two steps; the research strategy in the first step is qualitative content analysis, and the statistical population of the research includes 24 people from four groups of parents, managers and employees of girls' high school, teachers and also the officials of the Yazd City Education Organization, by and targeted sampling; and the sample size continued up to theoretical saturation, and performance indicators were extracted from the semi-structured interview. …”
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15119
Presenting the internal evaluation model on the performance of the banking industry based on the data theory method of the foundation
Published 2024-06-01“…To collect and analyze the data, the foundation's data theory research strategy was used. For data analysis, MAXQDA 2020 software was used to code the interviews. …”
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15120
Contract and Procurement Fraud Investigation Guidebook /
Published 2017Table of Contents: “…Preface -- Acknowledgments -- Author -- Introduction to contracts, procurements and related fraud -- Corruption in contracting -- Source selection and competition schemes -- Contractor and vendor performance schemes -- Contractor and vendor payment schemes -- Investigators, enforcers and statutes -- Investigative sources and resources -- Investigative tools and techniques -- Interviews and interrogations -- Investigative reports and evidence -- Investigative case planning, goals, and strategies -- (the Piper method of conducting thorough and complete investigations*) -- Case presentations and testifying -- Post adjudicative action -- Sample case study-story # 1 -- Sample case study-story # 2 -- Sample case study-story # 3 -- Conclusion -- Appendix: Samples of visual aids for presentations on contract and procurement fraud, collusion and corruption investigations -- Index.…”
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