Cancellation of cloud shadow effects in the absorbing aerosol index retrieval algorithm of TROPOMI by V. J. H. Trees, V. J. H. Trees, P. Wang, P. Stammes, L. G. Tilstra, D. P. Donovan, D. P. Donovan, A. P. Siebesma

“…We conclude that a potential cloud shadow correction strategy for the TROPOMI AAI would therefore be complicated if not unnecessary.…”
Get full text

Unveiling immunogenic characteristics and neoantigens in endometrial cancer with POLE hotspot mutations for improved immunotherapy by Jian Huang, Shuangna Song, Yihua Yin, Yinyan He, Huimin Wang, Ye Gu, Laman He, Xintao Wang, Xiaocao Miao, Zhigang Zhang, Xueli Zhang, Yiran Li, Yiran Li

“…Importantly, by using an organoid model of EC, we further confirmed the antitumor potential of T cells that were specific to the POLEP286R mutation.ConclusionsOur study uncovers the pronounced immunogenicity of POLE-mutant EC and characterizes neoantigens that are unique to the POLEP286R mutation, thus providing a promising new immunotherapeutic strategy for EC.…”
Get full text

ALKBH5 acts a tumor-suppressive biomarker and is associated with immunotherapy response in hepatocellular carcinoma by Hehua Ma, Yuxin Hong, Zhenzhen Xu, Zuyi Weng, Yuanxun Yang, Dandan Jin, Zhiyou Chen, Xuan Zhou, Zhi Xu, Fei Fei, Wei Song, Juan Li

“…Abstract As immune-checkpoint inhibitors (ICIs) therapy has made great strides in hepatocellular carcinoma (HCC) treatment, improving patient response to this strategy has become the main focus of research. Accumulating evidence has shown that m6A methylation plays a crucial role in the tumorigenesis and progression of HCC, while the precise impact of the m6A demethylase ALKBH5 on the tumor immune microenvironment (TIME) of HCC remains poorly defined. …”
Get full text

NOS inhibition sensitizes metaplastic breast cancer to PI3K inhibition and taxane therapy via c-JUN repression by Tejaswini Reddy, Akshjot Puri, Liliana Guzman-Rojas, Christoforos Thomas, Wei Qian, Jianying Zhou, Hong Zhao, Bijan Mahboubi, Adrian Oo, Young-Jae Cho, Baek Kim, Jose Thaiparambil, Roberto Rosato, Karina Ortega Martinez, Maria Florencia Chervo, Camila Ayerbe, Noah Giese, David Wink, Stephen Lockett, Stephen Wong, Jeffrey Chang, Savitri Krishnamurthy, Clinton Yam, Stacy Moulder, Helen Piwnica-Worms, Funda Meric-Bernstam, Jenny Chang

“…Our findings suggest that combined inhibition of iNOS and PI3K is a unique strategy to decrease chemoresistance and improve clinical outcomes in MpBC.…”
Get full text

Biometry and Intraocular Lens Power Calculation by Combined Scheimpflug-Placido Disc versus Optical Interferometry Devices by Mehlan Juliane, Lehman Anne-Isabel, Cichocki Myriam, Druchkiv Vasyl, Katz Toam, Stephan J Linke

“…Conclusion: Both the laser interferometry/keratometry performed by the IOL Master and the interferometry/raytracing biometry strategy performed by the Galilei G6 demonstrated equal results when executing the IOL power calculation before cataract surgery in eyes with no prior ocular surgery.…”
Get full text

Managing Water-Ecosystem-Food Nexus using participatory approaches: insights from an innovative methodological approach developed in two Mediterranean areas by Dimitrios Malamataris, Vassilios Pisinaras, Alessandro Pagano, Valentina Baratella, Silvia Vanino, Manuel Bea, Konstantinos Babakos, Anna Chatzi, Stefano Fabiani, Raffaele Giordano, Petros Kafkias, Estrella López-Moya, Christina Papadaskalopoulou, Ivan Portoghese, Dimitris Tassopoulos, Andreas Panagopoulos

“…This paper presents and analyses an effective stakeholder engagement strategy, based on the Learning & Action Alliances (LAA) scheme and aimed at identifying Water-Ecosystems-Food (WEF) Nexus challenges and selecting NbS in two case studies in the Mediterranean area (Greece and Italy). …”
Get full text

Spatiotemporal evolution of landscape ecological risk and its driving factors of the Beijing–Tianjin–Hebei major mineral belt, 1985–2022 by Yilin Wang, Xiaohong Wang, Wei Zhang, Weidong Man, Mingyue Liu, Linlin Jiao

“…Effective monitoring and assessment of the regional landscape ecological risk can provide a scientific basis for an ecological protection strategy for the environmental protection of the Beijing-Tianjin-Hebei major mineral belt. …”
Get full text

Economic burden of Type 2 diabetes in Iran in 2022 by Amin Mohammadi, Mahshad Goharimehr, Ali Darvishi, Ramin Heshmat, Ensieh Nasli Esfahani, Gita Shafiee, Afshin Ostovar, Rajabali Daroudi

“…To successfully address this burden, a comprehensive strategy is needed, which includes programs to prevent diabetes, better access to healthcare services, and increased social support for individuals with this long-term condition.…”
Get full text

Two-Dimensional Transition Metal Dichalcogenide: Synthesis, Characterization, and Application in Candlelight OLED by Dipanshu Sharma, Sanna Gull, Anbalagan Ramakrishnan, Sushanta Lenka, Anil Kumar, Krishan Kumar, Pin-Kuan Lin, Ching-Wu Wang, Sinn-Wen Chen, Saulius Grigalevicius, Jwo-Huei Jou

“…These results highlight the potential of incorporating 2D TMDs, especially MoS₂, into OLED technology as a promising strategy to enhance energy efficiency. This approach aligns with environmental, social, and governance (ESG) goals by emphasizing reduced environmental impact and promoting ethical practices in technology development. …”
Get full text

Resilience Informatics in Public Health: Qualitative Analysis of Conference Proceedings by Maiya G Block Ngaybe, Lidia Azurdia Sierra, Andrew McNair, Myla Gonzalez, Mona Arora, Kacey Ernst, Enrique Noriega-Atala, M Sriram Iyengar

“…Future directions include focused discussions to yield concrete outputs such as implementation guidelines and tool designs, reshaping public health strategies in the face of emerging threats.…”
Get full text

Monitoring and evaluation in disaster management courses: a scoping review by George Teo Voicescu, Hamdi Lamine, Andra Elena Loșonți, Eugenia Maria Lupan-Mureșan, Sonia Luka, José García Ulerio, Luca Ragazzoni, Francesco Della Corte, Marta Caviglia

“…The primary objective of this review was to document the existing M&E strategies for DM training. Methods The authors conducted a systematic literature search on June 28, 2023, on the PubMed, Scopus, Embase and Cochrane databases, including studies that described the learning objectives and the M&E strategy of DM training. …”
Get full text

Biomimetic Versatile Anisotropic, Electroactive Cellulose Hydrogel Scaffolds Tailored from Fern Stem Serving as Nerve Conduit and Cardiac Patch by Qinghui Liang, Shuhui Chen, Shaofeng Hua, Weihong Jiang, Jiamian Zhan, Chunyi Pu, Rurong Lin, Yutong He, Honghao Hou, Xiaozhong Qiu

“…Accordingly, the biomimetic strategy of D. linearis to NGC and D. linearis to ECP is first proposed, opening a new horizon for constructing tissue engineering using natural sources.…”
Get full text

An Integrated Na₂S−Electrocatalyst Nanostructured Cathode for Sodium–Sulfur Batteries at Room Temperature by Sichang Ma, Yueming Zhu, Yadong Yang, Dongyang Li, Wendong Tan, Ling Gao, Wanwei Zhao, Wenbo Liu, Wenyu Liang, Rui Xu

“…This work highlights an effective strategy for enhancing Na₂S cathodes with embedded catalysts, leading to enhanced reaction kinetics and superior cycling stability.…”
Get full text

Effective Resistivity in Relativistic Reconnection: A Prescription Based on Fully Kinetic Simulations by Abigail Moran, Lorenzo Sironi, Aviad Levis, Bart Ripperda, Elias R. Most, Sebastiaan Selvi

“…This resistivity formulation—which relies only on single-fluid MHD quantities—successfully reproduces the spatial structure and strength of nonideal electric fields and thus provides a promising strategy for enhancing the reconnection rate in resistive MHD simulations.…”
Get full text

Adenoviral Vector-Based Vaccine Expressing Hemagglutinin Stem Region with Autophagy-Inducing Peptide Confers Cross-Protection Against Group 1 and 2 Influenza A Viruses by Wen-Chien Wang, Ekramy E. Sayedahmed, Marwa Alhashimi, Ahmed Elkashif, Vivek Gairola, Muralimanohara S. T. Murala, Suryaprakash Sambhara, Suresh K. Mittal

“…Mice were immunized using a prime-boost strategy with heterologous adenoviral (Ad) vectors. …”
Get full text

Platelet-derived HMGB1 induces NETosis, exacerbating brain damage in the photothrombotic stroke model by Sang-A. Oh, Song-I. Seol, Dashdulam Davaanyam, Seung-Woo Kim, Ja-Kyeong Lee

“…Therefore, targeting NETosis through modulation of HMGB1 presents a promising multipotent therapeutic strategy for mitigating ischemic brain damage.…”
Get full text

Les Jeunes Tunisiens, une contre-expérience de la minoration ? Politisation des langues dans la presse francophone en Tunisie coloniale (1907-1912) by Sarra Zaïed

“…In this perspective, they put into place strategies to escape minoritisation. Thus, I propose to shed light on a strategy that has not yet been explored in the historiography of Tunisian nationalism, namely, the politicisation of language, and of bilingualism in particular. …”
Get full text

Exploring the prognostic significance of lactate-mitochondria-related genes in prostate cancer by Yuan Wang, Ronghui Chen, Feng-Le Jiang, Feng-Le Jiang, Xin Jiang, Xin Jiang, Yuehong Zhou, Yingying Zhou, Xinyi Hong, Chaoying Lin, Wei-Jia Wang, Wei-Jia Wang, Sufang Qiu

“…Additionally, PCa with high MPO expression is highly sensitive to chemotherapeutic agents and mitochondrial inhibitors, highlighting its potential as an improved therapeutic strategy for PCa management.…”
Get full text

Reestablishment of Active Immunity against HBV Graft Reinfection after Liver Transplantation for HBV-Related End Stage Liver Disease by Shi-Chun Lu, Tao Jiang, Wei Lai, Yuan Liu, Jing Zhang, Dao-Bing Zeng, Chuan-Yun Li, Meng-Long Wang, Dong-Dong Lin, Yue Zhu, You-Ping Li, Ning Li

“…Vaccination preventing HBV reinfection for OLT recipients is feasible. The strategy withdrawal of HBIG with induction of active immunity against hepatitis B is reasonable for long-term survivors of OLT; however, discontinuation nucleoside analogues should be cautious.…”
Get full text

Nicotine promotes M2 macrophage polarization through α5-nAChR/SOX2/CSF-1 axis in lung adenocarcinoma by Guiyu Kang, Hui Song, Lei Bo, Qi Liu, Qiang Li, Jingtan Li, Pan Pan, Jingting Wang, Yanfei Jia, Haiji Sun, Xiaoli Ma

“…It is indicated that M2 macrophages are mediated by the new α5-nAChR /SOX2/CSF-1 axis in nicotine-related LUAD, which is a potential therapeutic strategy for cancer.…”
Get full text