A comparison of drug‐eluting stent and coronary artery bypass grafting in mildly to moderately ischemic heart failure by Kun Wang, Le Wang, Hongliang Cong, Jingxia Zhang, Yuecheng Hu, Yingyi Zhang, Rui Zhang, Wenyu Li, Wei Qi

“…Abstract Aims The best revascularization strategy for patients with ischaemic heart failure (IHF) remains unclear. …”
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Cost-effectiveness of leveraging existing HIV primary health systems and community health workers for hypertension screening and treatment in Africa: An individual-based modeling s... by Matthew D Hickey, James Ayieko, Jane Kabami, Asiphas Owaraganise, Elijah Kakande, Sabina Ogachi, Colette I Aoko, Erick M Wafula, Norton Sang, Helen Sunday, Paul Revill, Loveleen Bansi-Matharu, Starley B Shade, Gabriel Chamie, Laura B Balzer, Maya L Petersen, Diane V Havlir, Moses R Kamya, Andrew N Phillips

“…For our primary analysis, we used a cost-effectiveness threshold of US $500 per disability-adjusted life-year (DALY) averted, a 3% annual discount rate, and a 50-year time horizon. A strategy was considered cost-effective if it led to the lowest net DALYs, which is a measure of DALY burden that takes account of the DALY implications of the cost for a given cost-effectiveness threshold. …”
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Predicting recurrence of non-muscle invasive bladder urothelial carcinoma: predictive value of the optimal cut-off value of Ki67 by Rende Peng, Yaoyu Zhang, Mingzhu Jia, Xinping Yi, Xiaoyao Yi, Shadan Li, Jiangchuan Pi, Wenjun Meng

“…This cut-off value can more accurately predict the risk of recurrence and has the potential clinical value for guiding the postoperative adjuvant treatment and follow-up strategy of NMIBUC.…”
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Kaempferol protects against high-salt-induced hypertension and vascular endothelial injury by inhibiting ferroptosis through the ATF4/ACSL4 pathway by Qiuer Liang, Minghao Chen, Guangtian Chen, Pengli Xu, Lai Kwan Lam, Pengcheng Xie, Ting Xie, Wanqing Tu, Tianhao Liu, Xiaopeng Peng, Haoyao Yuan, Liguo Chen, Ya Xiao

“…In summary, our findings suggest that Kae mitigates high-salt-induced hypertension by inhibiting endothelial ferroptosis via the ATF4/ACSL4 pathway, providing a potential therapeutic strategy for hypertensive vascular injury.…”
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Factors associated with cervical cancer screening among women of reproductive age in Moshi municipality, Kilimanjaro, Tanzania: a cross-sectional study by Sia E Msuya, Jeremiah John Hhera, Regina Dahaye, Witness Erasto Zakayo, Yohana Z Kazula, Seif Abdul, Redempta Mamseri

“…Objective Screening for cervical cancer has been a globally advocated preventive strategy to reduce cervical cancer morbidity and mortality. …”
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Geochemical signatures and nanomechanical properties of echinoid tests from nearshore habitats of Florida: environmental and physiological controls on echinoid biomineralization by Przemysław Gorzelak, Luis Torres Jr., Dorota Kołbuk, Tobias B. Grun, Michał Kowalewski

“…Such heterogeneity in Mg distribution within single specimens cannot be ascribed solely to environmental changes, indicating that these echinoids actively regulate their intraskeletal Mg content: the higher magnesium concentration at the tubercles relative to that of the underlying stereom may be interpreted as a strategy for enhancing their mechanical strength to withstand surface friction and wear. …”
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Dual inhibition of BET and EP300 has antitumor activity in undifferentiated pleomorphic sarcomas and synergizes with ferroptosis induction by Stéphanie Verbeke, Aurélien Bourdon, Mathilde Lafon, Vanessa Chaire, Bertolo Frederic, Amina Naït Eldjoudi, Marie-Alix Derieppe, Francis Giles, Antoine Italiano

“…The identification of new therapeutic strategies is therefore an important medical need. Epigenetic modifiers has been extensively investigated in recent years leading to the development of novel therapeutic agents. …”
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Hydrothermal Pre-Carbonization Triggers Structural Reforming Enabling Pore-Tunable Hierarchical Porous Carbon for High-Performance Supercapacitors by Cuihua Kang, Mingyuan Zuo, Chang Qiu, Fanda Zeng, Yuehui Wang, Zhuo Chen, Tingting Liang, Daping Qiu

“…Herein, we have successfully transformed jujube pits into hierarchical porous carbon (HJPC-4) with excellent capacitive properties via a unique hydrothermal–carbonization–activation strategy. Hydrothermal pretreatment is essential to regulate the supermesoporous and macroporous structure of samples and their superior electrochemical performances. …”
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Appropriate nitrogen application under ridge-furrow plastic film mulching planting optimizes spring maize growth characteristics by improving soil quality in the Loess Plateau of C... by Fan Zhang, Mengru Chen, Yingying Xing, Xiukang Wang

“…Given the factors of crop growth, yield, yield compositions, resource utilization efficiency, economic benefits, and SQI, the application of 180 kg ha−1 nitrogen under RF was recommended as a viable strategy for achieving high yield, high efficiency, and sustainable development of spring maize in the region. …”
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Cysticerci Drive Dendritic Cells to Promote In Vitro and In Vivo Tregs Differentiation by Laura Adalid-Peralta, Asiel Arce-Sillas, Gladis Fragoso, Graciela Cárdenas, Marcos Rosetti, Didier Casanova-Hernández, Claudia Rangel-Escareño, Laura Uribe-Figueroa, Agnes Fleury, Edda Sciutto

“…Treg induction is a strategy that parasites have evolved to modulate the host’s inflammatory environment, facilitating their establishment and permanence. …”
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Humanities education reform exploration and practice under outcomes-based education (OBE) by P. Yang

“…More universities and colleges are pursuing a quality improvement strategy focused on three main components – learning outcomes, student personality and continuous improvement. …”
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Adeno-associated virus mediated artificial circular RNA for triggering cancer immunotherapy to treat prostate cancer by Chujin Ye, Chujin Ye, Zhiye Liu, Zhiye Liu, Qifan Xie, Qifan Xie, Yanlin Tang, Yanlin Tang, Jiayi Zeng, Jiayi Zeng, Ziwei Feng, Ziwei Feng, Jiumin Liu, Jiumin Liu, Haibiao Xie, Haibiao Xie

“…IntroductionSpecifically regulating endogenous molecules is a potential molecular therapeutic strategy. Naturally occurring circular RNAs (circRNAs) are structurally stable and have been proved to serve as highly efficient miR-sponges and protein-sponges in cancer cells.MethodsWe chemically synthesized circRNA (ScircRNA) in vitro to achieve therapeutic dysfunction by targeting specific miRNAs. …”
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Cross-Talk between NOK and EGFR: Juxtamembrane and Kinase domain interactions enhancing STAT3/5 signaling in breast cancer tumorigenesis by Yinyin Wang, Bingdong Zhang, Chunhua He, Bo Tian, Sihan Liu, Jianghua Li, Jiayu Wang, Shigao Yang, Bingtao Zhu, Xiaoguang Wang, Zhijie Chang, Chenxi Cao

“…Our finding introduces a new cross interaction manner of EGFR-NOK via juxtamembrane (JM) domains and kinase domains, uncovers a mechanism by which NOK coordinates EGFR to enhance EGF-STAT3/5 signaling during tumorigenesis and metastasis, and proposes a potential strategy for targeting NOK-EGFR in breast cancer treatment.…”
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Surgical decompression for endocrine ophthalmopathy: state-of-the-art by A.A. Krylova, O.I. Krivosheina

“…</i> </p> <p> <i>The choice of surgical strategy and surgical volume in endocrine ophthalmopathy depends on the s everity of clinical manifestations, expected clinical functional outcomes, and risks of potentional complications.…”
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Interstep Variations of Stairways and Associations of High-Contrast Striping and Fall-Related Events: Observational Study by Sara A Harper, Chayston Brown, Shandon L Poulsen, Tyson S Barrett, Christopher J Dakin

“…ConclusionsThese data support the premise that a vision-based strategy (ie, striping) may counteract fall risk associated with interstep riser height and tread depth variation. …”
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Molecular ferroelectric self-assembled interlayer for efficient perovskite solar cells by Chang Xu, Pengjie Hang, Chenxia Kan, Xiangwei Guo, Xianjiang Song, Chenran Xu, Guofeng You, Wei-Qiang Liao, Haiming Zhu, Dawei Wang, Qi Chen, Zijian Hong, Ren-Gen Xiong, Xuegong Yu, Lijian Zuo, Hongzheng Chen

“…Herein, we develop a strategy using a self-assembled ferroelectric layer to modify the interfacial properties of PSCs. …”
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Methylprednisolone substituted lipid nanoparticles deliver C3 transferase mRNA for combined treatment of spinal cord injury by Haoru Dong, Zongxing He, Shiyi Cai, Haiqiang Ma, Lili Su, Jianfeng Li, Huiying Yang, Rong Xie

“…In this study, we introduce an innovative approach by substituting cholesterol with MP to engineer a novel Lipid Nanoparticle (MP-LNP). This strategy aims to enhance the localization and concentration of MP at the injury site, thereby amplifying its therapeutic efficacy while mitigating systemic side effects. …”
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The effect of lavender inhalation aromatherapy on systolic and diastolic blood pressure in patients with prehypertension by Amir Musarezaie, Mohammad Javad Tarrahi, Masoumeh Sadeghi, Sedigheh Farzi, Tahere Momeni-Ghale Ghasemi, Amir Hossein Saeidi, Maryam Sadat Shahshahani

“…Conclusion: Considering the rising trend of high blood pressure and its widespread complications, along with the positive effects of aromatherapy as a cost-effective and accessible intervention, lavender inhalation aromatherapy is recommended as a complementary treatment strategy in conjunction with other methods.…”
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Blockades of effector T cell senescence and exhaustion synergistically enhance antitumor immunity and immunotherapy by Xia Liu, Emily Shaw, Fusheng Si, Guangyong Peng, Yan Tao, Feiya Ma, David Bagley, Yuanqin Zhang

“…Therefore, a better understanding of the molecular mechanism responsible for T cell senescence in the TME and development of novel strategies to prevent effector T cell senescence are urgently needed for cancer immunotherapy.Methods Senescent T cell populations in the TMEs in mouse lung cancer, breast cancer, and melanoma tumor models were evaluated. …”
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Engineering of SauriCas9 with enhanced specificity by Xiaoqi Zhang, Chen Tao, Miaomiao Li, Sufang Zhang, Puping Liang, Yan Huang, Huihui Liu, Yongming Wang

“…To validate its efficacy, we employed SauriCas9-R253A to disrupt three genes (B2M, TRAC, and PDCD1), a strategy integral to the development of allogeneic chimeric antigen receptor T cell (CAR-T) therapies. …”
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