Recommendations of the Russian Gastroenterological Association on Clinical Use of High-Resolution Manometry in Diagnosis of Esophageal Disorders by V. T. Ivashkin, I. V. Mayev, A. S. Trukhmanov, O. A. Storonova, S. A. Abdulkhakov, D. N. Andreev, D. S. Bordin, E. R. Valitova, I. L. Klyaritskaya, V. V. Krivoy, Yu. A. Kucheryavyi, T. L. Lapina, S. V. Morozov, O. A. Sablin, E. V. Semenikhina, Yu. P. Uspenskiy, A. A. Sheptulin

“…It enables a medical professional to obtain evidence that may critically affect the choice of optimal patient care strategy and effective treatment. Current recommendations are based on an extensive review of up-to-date information and will be updated with new corpus of clinical data and assessment emerging in evidential medicine to provide gastroenterologists country-wide with latest scientific and practical guidelines.…”
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Proceedings of the 14th European immunogenicity platform open symposium on immunogenicity of biopharmaceuticals by Sophie Tourdot, Daniel Baltrunkonis, Sofie Denies, Viswanath Devanarayan, Joanna Grudzinska-Goebel, Arno Kromminga, Gregor P. Lotz, Laurent Malherbe, Lydia Michaut, Karin N. Weldingh, Joao A. Pedras-Vasconcelos, Laura. I. Salazar-Fontana, Sebastian Spindeldreher, Zuben Sauna, Veerle Snoeck, Daniela Verthelyi, Daniel Kramer

“…With the rapid diversification and complexification of biologics, which today include modalities such as multi-domain antibodies, cell-based products, AAV delivery vectors, and nucleic acids, developers are faced with the challenge of establishing a risk assessment strategy sometimes in the absence of specific regulatory guidelines. …”
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Extracellular Vesicles from Amnion-Derived Mesenchymal Stem Cells Ameliorate Hepatic Inflammation and Fibrosis in Rats by Masatsugu Ohara, Shunsuke Ohnishi, Hidetaka Hosono, Koji Yamamoto, Kohei Yuyama, Hideki Nakamura, Qingjie Fu, Osamu Maehara, Goki Suda, Naoya Sakamoto

“…AMSC-EV administration should be considered as a new therapeutic strategy for chronic liver disease.…”
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Low-exhaustion peripheral circulating γδ T cells serve as a biomarker for predicting the clinical benefit rate of non-small cell lung cancer (NSCLC) patients to chemotherapy or tar... by Dongdong Zhang, Guichao Liu, Jinhui Ye, Ke Li, Guojun Zhang, Qiang Quan, Xinhai Zhu, Peng Li

“…Targeting Vδ2 T cells may represent a promising strategy for enhancing therapeutic clinical benefit rates in NSCLC patients.…”
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The use of a benign fast-growing cyanobacterial species to control microcystin synthesis from Microcystis aeruginosa by Hakyung Lee, Vincent Xu, Jinjin Diao, Runyu Zhao, Moshan Chen, Tae Seok Moon, Haijun Liu, Kimberly M. Parker, Young-Shin Jun, Yinjie J. Tang

“…Second, this biological strategy became less effective at 23°C, where S. elongatus grew more slowly. …”
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On-chip integration of metasurface-doublet for optical phased array with enhanced beam steering by Wang Zhizhang, Ji Jitao, Ye Xin, Chen Yuxin, Li Xueyun, Song Wange, Fang Bin, Chen Ji, Zhu Shining, Li Tao

“…A miniaturized compact strategy to enlarge the beam steering angle is quite desirable for the solid-state OPA technique. …”
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Microbial assisted alleviation of nickel toxicity in plants: A review by Xinyu Mao, Bilal Ahmad, Sabir Hussain, Farrukh Azeem, Muhammad Waseem, Yousef Alhaj Hamoud, Hiba Shaghaleh, Amany H.A. Abeed, Muhammad Rizwan, Jean Wan Hong Yong

“…These diverse approaches are likely to offer more effective and sustainable remediative strategy to ecologically restore the nickel-contaminated environments.…”
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The effectiveness of non-invasive brain stimulation in enhancing lower extremity function in children with spastic cerebral palsy: Protocol for a systematic review and meta-analysi... by Clàudia Arumí-Trujillo, Francisco José Verdejo-Amengual, Oriol Martínez-Navarro, Jord J.T. Vink, Fran Valenzuela-Pascual

“…A systematic search will be conducted in databases including MEDLINE, CINAHL Plus, EMBASE, Scopus, ISI Web of Science, and the Cochrane Central Register of Controlled Trials. The search strategy will follow the PICO framework (Participants, Intervention, Comparison, Outcomes), focusing on randomized controlled trials (RCTs). …”
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Correlation and diagnostic significance of CD4 T cell subsets and NLRP3 inflammasome in ulcerative colitis: the role of the NLRP3/T-bet/GATA3 axis by Yingnan Hu, Jingyi Tang, Dian Yu, Shuo Su, Jintao Fang, Linying Xia, Wenjun Xu, Weihan Zhu, Ninping Song, Fengyong Wang, Dechang Diao, Wei Zhang

“…Conclusion The NLRP3/T-bet/GATA3 axis provides a referable strategy for multi-targeted combined treatment of UC and may serve as potential biomarkers for enhancing diagnostic accuracy and guiding therapy.…”
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Amantadine modulates novel macrophage phenotypes to enhance neural repair following spinal cord injury by Shijie Yang, Beibei Yu, Qing Zhang, Yongfeng Zhang, Longhui Fu, Bisheng Zhou, Haining Wu, Jianzhong Li, Shouping Gong

“…The modulation of macrophage phenotypes is thus considered a promising therapeutic strategy to mitigate inflammation and promote regeneration. …”
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Reinforcement Learning-Based Generative Security Framework for Host Intrusion Detection by Yongsik Kim, Su-Youn Hong, Sungjin Park, Huy Kang Kim

“…With its advanced capabilities and reliable performance, HIDS is essential to any comprehensive host-based security strategy. Although HIDS can detect insider intrusions, the known HIDS detection methods are limited to specific attacks and may be ineffective against new attack patterns. …”
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Prioritization of potential pharmacological targets for the development of anti-hepatocarcinoma drugs modulating the extrinsic apoptosis pathway: the reconstruction and analysis... by P. S. Demenkov, E. A. Antropova, A. V. Adamovskaya, E. I. Mishchenko, T. M. Khlebodarova, T. V. Ivanisenko, N. V. Ivanisenko, A. S. Venzel, I. N. Lavrik, V. A. Ivanisenko

“…It is known that disruptions in the regulation of apoptosis activation are some of the key features inherent in most cancer cells, which determines the pharmacological induction of apoptosis as an important strategy for cancer therapy. The computer design of chemical compounds capable of specifically regulating the external signaling pathway of apoptosis induction represents a promising approach for creating new effective ways of therapy for liver cancer and other oncological diseases. …”
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Flux Synthesis of A‐site Disordered Perovskite La0.5M0.5TiO3 (M═Li, Na, K) Nanorods Tailored for Solid Composite Electrolytes by Tao Wang, Jiyoung Ock, X. Chelsea Chen, Fan Wang, Meijia Li, Matthew S. Chambers, Gabriel M. Veith, Lauren B. Shepard, Susan B. Sinnott, Albina Borisevich, Miaofang Chi, Amit Bhattacharya, Raphaële J. Clément, Alexei P Sokolov, Sheng Dai

“…However, the synthesis of single crystal, 1D LLTO nanomaterials with cubic symmetry is challenging. Herein, a flux strategy is developed to synthesize La0.5M0.5TiO3 (LMTO, M═Li, Na, and K) single‐crystal nanorods with an A‐site‐disordered, cubic perovskite phase. …”
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Wildlife trade at the interface between deeply-rooted animal-based traditional medicine and unregulated harvesting of wild animals in West Africa by Stanislas Zanvo, Samson Dognimon, Chabi A. M. S. Djagoun, Jiroux Akpatchémè, Akomian Fortuné Azihou, Bruno Djossa, Bruno Djossa, Etotépé A. Sogbohossou, Brice Sinsin

“…We also found that the national wildlife trade in Benin was supplied from 80% (12/15) West African Economic and Monetary countries, and all the Economic Community of West African States (except Guinea-Bissau) in violation of national laws, CITES, and regional commitments to combat wildlife trafficking (e.g., the West African Strategy for Combatting Wildlife Crime). Our study in Benin is a big step to revealing trade throughout in West Africa. …”
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Design of a Cost-Effective Ultrasound Force Sensor and Force Control System for Robotic Extra-Body Ultrasound Imaging by Yixuan Zheng, Hongyuan Ning, Eason Rangarajan, Aban Merali, Adam Geale, Lukas Lindenroth, Zhouyang Xu, Weizhao Wang, Philipp Kruse, Steven Morris, Liang Ye, Xinyi Fu, Kawal Rhode, Richard James Housden

“…To address these challenges, we developed a cost-effective, lightweight, 3D-printed force sensor and a hybrid position–force control strategy tailored for robotic ultrasound scanning. …”
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Multicentre, 26-week, open-label phase 2 trial of the JAK inhibitor filgotinib in Behçet’s disease, idiopathic inflammatory myopathies and IgG4-related disease: DRIMID study protoc... by Sander W Tas, Joost Raaphorst, Paco M J Welsing, Jacob M van Laar, Rogier M Thurlings, Robbert J Goekoop, César Magro Checa, Jan A M van Laar, Bettina C Geertsema-Hoeve, Nicolle H Rekers, Erik Present

“…Given the activation of the type 1 interferon pathway in BD, IIM and IgG4-RD, inhibition of the Janus kinase (JAK) STAT pathway emerges as a promising therapeutic strategy. The Drug Rediscovery in IMIDs (DRIMID) consortium aims to conduct a prospective pilot basket trial to investigate the effects of filgotinib, a JAK1 preferential inhibitor approved for ulcerative colitis and rheumatoid arthritis, on disease activity, quality of life and safety in patients with refractory BD, IIM and IgG4-RD.Methods and analysis In this investigator-initiated, multicentre, open-label phase 2 study, up to 60 patients with rare IMIDs will be enrolled for a 26-week treatment period with filgotinib 200 mg once daily. …”
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THE PROSPECTS OF THE RUSSIAN-CHINESE HUMANITARIAN COOPERATION IN FRAMEWORK OF “ONE BELT, ONE ROAD” INITIATIVE IMPLEMENTATION by D. A. Smaliakou

“…Special attention was given to education communication strategy as one of the reliable and checked channels of establishment and consolidation of international economic relations. …”
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An exploration and practice of curriculum ideology and politics based on positive psychology in the teaching of Introduction to Nursing (积极心理学在《护理学导论》课程思政教学中的实施策略研究)... by JU Yaya (琚亚亚)

“…Objective To explore the implementation strategy and teaching effect of curriculum ideology and politics based on positive psychology in the teaching of Introduction to Nursing. …”
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Intrinsic PD‐L1 Degradation Induced by a Novel Self‐Assembling Hexapeptide for Enhanced Cancer Immunotherapy by Hongxia Zhang, Ming Ji, Yamei Wang, Mengmeng Jiang, Zongyu Lv, Gongyu Li, Lulu Wang, Zhen Zheng

“…This “carrier‐free” delivery system expands the role of supramolecular hydrogels beyond passive carriers to active immunotherapeutic agents, offering a promising new strategy for cancer therapy.…”
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SRT3025-loaded cell membrane hybrid liposomes (3025@ML) enhanced anti-tumor activity of Oxaliplatin via inhibiting pyruvate kinase M2 and fatty acid synthase by Xiaobin Wang, Shulin Li, Zichen Li, Zhuona Lin, Zhifeng Wang

“…The results indicate that 3025@ML is a promising therapeutic strategy for overcoming OXA’s compromised therapeutic effect and potentially improving cancer treatment outcomes.…”
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