A miR-activated hydrogel for the delivery of a pro-chondrogenic microRNA-221 inhibitor as a minimally invasive therapeutic approach for articular cartilage repair by Shan An, Claudio Intini, Donagh O'Shea, James E. Dixon, Yiran Zheng, Fergal J. O'Brien

“…These results provide evidence of the potential of the miR-activated hydrogel as a minimally invasive therapeutic strategy for articular cartilage repair.…”
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The Impact of Hyperoxia on Outcome of Patients Treated with Noninvasive Respiratory Support by Seyhan Pala Cifci, Yasemin Urcan Tapan, Bengu Turemis Erkul, Yusuf Savran, Bilgin Comert

“…Conservative oxygen therapy strategy can be suggested to decrease the hyperoxia prevalence and mortality rates.…”
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Socio-economic inequalities in access to COVID-19 tests in France in 2020: evidence from the EPICOV socio-epidemiological cohort by Pierre-Yves Geoffard, Pierre-Yves Geoffard, Florence Jusot, Antoine Sireyjol, Josiane Warszawski, Nathalie Bajos

“…However, there was no link between testing and income, education, or ethno-racial status.InterpretationWhen an individual experiences symptoms but has no close relative who is positive, the motivation to test to avoid transmitting the virus to relatives by isolating oneself is particularly strong. This strategy makes sense when there are actual possibilities to isolate, which may explain why higher income and education positively impact the propensity to test. …”
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Identifying Organizational Factors and Components Influencing Customer Experience Management Maturity: A Meta-synthesis Approach by Payam Mardazad Navi, Kambiz Heidarzadeh Hanzaee, Seyyed Buik Mohammadi, Mohsen Khoon Siavash

“…Customer experience vision, strategy and goals, 5. Customer experience governance, 6. …”
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Educating the digital generation: the role of virtual communities by E. M. Kharlanova, N. V. Sivrikova, S. V. Roslyakova, E. G. Chernikova

“…Moreover, the article established that the strategy of digital educational transformation should set a course to the transition from ensuring accessibility and security in a virtual environment to managing virtual communities for the purpose of the self-development and self-realization.                …”
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Direct and moderation effects on U.S. apparel manufacturers’ engagement in network ties by Nancy J. Miller, Carol Engel-Enright, David A. Brown

“…The intent of this research is to fill some of the gaps in interorganizational networking strategy by analyzing five antecedents that have been suggested in the literature as individually associated with entrepreneurs’ engagement in network ties. …”
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Molecular Characterization, Oxidative Stress-Mediated Genotoxicity, and Hemato-Biochemical Changes in Domestic Water Buffaloes Naturally Infected with <i>Trypanosoma evansi</i> Und... by Waqas Ahmad, Muhammad Yasin Tipu, Muti ur Rehman Khan, Haroon Akbar, Aftab Ahmad Anjum, Muhammad Ovais Omer

“…This study is the first to assess the genetic relationships of <i>T. evansi</i> in naturally affected buffaloes from Multan district, Pakistan, using ITS-1 primers and evaluating the effects of parasitemia and oxidative stress on DNA damage and hematobiochemical changes in infected buffaloes. (2) Methods: Blood samples were collected from 167 buffaloes using a multi-stage cluster sampling strategy, and trypomastigote identification was performed through microscopy and PCR targeting RoTat 1.2 and ITS-1 primers. …”
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Toward evidence-informed medical curricula: A scoping review protocol on social skills and emotional regulation by Thaysa Castro Molina, William Donegá Martinez, Vinicíus Araújo Pereira, Alba Regina de Abreu Lima, Vânia Maria Sabadoto Brienze, Emerson Roberto dos Santos, Valdir Carlos Severino Júnior, Camila Borge, Júlio César André

“…Relevant studies will be searched in electronic databases (EMBASE, ERIC, PubMed, Science Direct, Scopus, and Web of Science) and gray literature sources. The search strategy will use descriptors in English, Portuguese, and Spanish, combined with Boolean operators. …”
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Engineering of l-threonine and l-proline biosensors by directed evolution of transcriptional regulator SerR and application for high-throughput screening by Wei Pu, Jinhui Feng, Jiuzhou Chen, Jiao Liu, Xuan Guo, Lixian Wang, Xiaojia Zhao, Ningyun Cai, Wenjuan Zhou, Yu Wang, Ping Zheng, Jibin Sun

“…This study illustrates an effective strategy for the development of transcriptional regulator-based biosensors for amino acids and other chemical compounds.…”
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Aspirin inhibits proteasomal degradation and promotes α-synuclein aggregate clearance through K63 ubiquitination by Jing Gao, Yang Liu, Chenfang Si, Rui Guo, Shouqiao Hou, Xiaosong Liu, Houfang Long, Di Liu, Daichao Xu, Zai-Rong Zhang, Cong Liu, Bing Shan, Christoph W. Turck, Kaiwen He, Yaoyang Zhang

“…Herein, we develop the reversed-pulsed-SILAC strategy to systematically profile protein degradome in response to aspirin. …”
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Dual-stack host discovery method based on SSDP and DNS-SD protocol by Fan SHI, Yao ZHONG, Pengfei XUE, Chengxi XU

“…With the exhaustion of the IPv4 addresses, the promotion and deployment of IPv6 has been accelerating.Dual-stack technology allows devices to enable both IPv4 and IPv6 protocols, which means that users are facing more security risks.Although the existing work can realize the identification and measurement of some dual-stack servers, the following problems still exist.Dual-stack host identification requires deep protocol identification of host services, but this method consumes too much scanning resources.Besides, network service providers may provide consistent services on distributed hosts, making it difficult to guarantee the accuracy of dual-stack host identification through service fingerprints.To solve these problems, the LAN service discovery protocol was used to bind host services to IP addresses, and a dual-stack host discovery method based on SSDP and DNS-SD protocols was proposed.In IPv4 network environment, the target host was induced to actively send a request to the constructed IPv6 server through SSDP protocol, and then the IPv6 address was extracted from the server’s log.Or the service list of the target host and its corresponding AAAA record was enumerated through the DNS-SD protocol and the IPv6 address of the target host was obtained, in order to realize the discovery of the dual stack address pairs.With this method, IPv6 addresses was obtained directly from the IPv4 host, which ensured the accuracy of the discovered dual-stack host.At the same time, only request packets for specific protocols were needed during the discovery process, which greatly saved scanning resources.Based on this method, the SSDP hosts and DNS-SD hosts accidentally exposed to the global IPv4 network were measured.A total number of 158k unique IPv6 addresses were collected, of which 55k were dual-stack host address pairs with globally reachable IPv6 addresses.Unlike existing work that focused on dual-stack servers, this method mainly targeted end-users and client devices, and built a unique set of active IPv6 devices and dual-stack host address pairs that have not been explored so far.Through the analysis of the obtained IPv6 address addressing type, it shows that IPv6 address is mainly generated in a random manner, which greatly reduces the possibility of IPv6 hosts being discovered by scanning.In particular, by measuring the ports and services of dual-stack hosts, we found that the security policy differences of dual-stack hosts on different protocol stacks.Especially, IPv6 protocol stack exposes more high-risk services, expanding the attack surface of hosts.The research results also show that the infeasibility of IPv6 address space traversal scanning mitigates the security risks of IPv6, but incorrect network configuration greatly increases the possibility of these high-risk IPv6 hosts being discovered and users should revisit IPv6 security strategy on dual-stack hosts.…”
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Anti-Interleukin-22-Neutralizing Antibody Attenuates Angiotensin II-Induced Cardiac Hypertrophy in Mice by Jing Ye, Ling Liu, Qingwei Ji, Ying Huang, Ying Shi, Lei Shi, Jianfang Liu, Menglong Wang, Yao Xu, Huimin Jiang, Zhen Wang, Yingzhong Lin, Jun Wan

“…The downregulation of IL-22 may be a novel therapeutic strategy to prevent cardiac hypertrophy.…”
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Therapeutic potential of adipose-derived stem cells for diabetic foot ulcers: a systematic review and meta-analysis by Mohamed A. Abu Elainein, Mohamad Mahmoud Whdan, Mahmoud Samir, Nada G. Hamam, Mohamed Mansour, Mohamed Abdel Mohsen Mohamed, Mahmoud Mostafa Snosy, Mahmoud Ayman Othman, Ahmed Sayed Sobieh, Mahmoud Gamal Saad, Mohamed A. Labna, Salma Allam

“…Conventional treatments such as traditional dressings often fall short in ensuring satisfactory wound healing, this Meta-analysis investigates the therapeutic potential of Adipose-derived Stem Cells (ADSCs) as a promising strategy for addressing this challenge. Aims To Assess the Therapeutic Potential of Adipose-Derived Stem Cells for Managing Diabetic Foot Ulcers compared to conventional lines of treatments. …”
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Deep learning-based algorithm for classifying high-resolution computed tomography features in coal workers’ pneumoconiosis by Hantian Dong, Biaokai Zhu, Xiaomei Kong, Xuesen Su, Ting Liu, Xinri Zhang

“…Conclusion We successfully applied a data augmentation strategy to develop a deep learning model by combining DenseNet with ECA-Net. …”
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Delivery of FGF18 using mRNA-LNP protects the cartilage against degeneration via alleviating chondrocyte senescence by Keyu Kong, Baixing Li, Yongyun Chang, Chen Zhao, Hua Qiao, Minghao Jin, Xinru Wu, Wenxuan Fan, Liao Wang, Yansong Qi, Yongsheng Xu, Zanjing Zhai, Peixiang Ma, Huiwu Li

“…Conclusions In summary, this study presents a novel approach superior to recombinant protein alone and holds promise as a new therapeutic strategy for OA. Graphical abstract…”
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Harnessing the Power of Machine Learning Guided Discovery of NLRP3 Inhibitors Towards the Effective Treatment of Rheumatoid Arthritis by Sidra Ilyas, Abdul Manan, Chanyoon Park, Hee-Geun Jo, Donghun Lee

“…Targeting NLRP3 has emerged as a promising therapeutic strategy for RA. In this study, a multidisciplinary approach combining machine learning, quantitative structure–activity relationship (QSAR) modeling, structure–activity landscape index (SALI), docking, molecular dynamics (MD), and molecular mechanics Poisson–Boltzmann surface area MM/PBSA assays was employed to identify novel NLRP3 inhibitors. …”
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Internal Facilitation by Health Assistants for the &ldquo;WHO Lay Health Worker Dementia Care&rdquo; in Rural Uganda: A Formative Evaluation by Wakida EK, Obua C, Rukundo GZ, Samantha M, Maling S, Karungi CK, Talib ZM, Haberer J, Bartels SJ

“…They recommended providing the health assistants with job guides, updated reporting templates to collect dementia indicators, and orientation on what they should do during internal facilitation with the lay health workers using the dementia toolkit.Conclusion: Health assistants’ internal facilitation provides a promising strategy for scaling dementia care in rural Uganda by leveraging community-based lay health workers. …”
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Ion bridging enables high-voltage polyether electrolytes for quasi-solid-state batteries by Tianyi Hou, Donghai Wang, Bowen Jiang, Yi Liu, Jia Kong, Yanbing He, Yunhui Huang, Henghui Xu

“…To demonstrate the feasibility of the ion-bridging strategy, a Zn2+ ion-bridged polyether electrolyte (Zn-IBPE) with an extending electrochemical stability window of over 5 V is prepared, which enables good cyclability in 4.5 V Li||LiCoO2 batteries. …”
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Increasing the uptake of long-acting reversible contraception in general practice: the Australian Contraceptive ChOice pRoject (ACCORd) cluster randomised controlled trial longitud... by Danielle Mazza, Angela Taft, Kevin McGeechan, Kathleen Mcnamee, Natalie Amos, Kirsten I Black, Cathy J Watson, Marion Haas, Jeffrey F Peipert, Jayne Lucke

“…The trial follow-up outcomes will be disseminated through formal academic pathways, including journal articles, national and international conferences and reports as well as using more ‘mainstream’ strategies such as seminars, workshops and media engagement. …”
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Unintended pregnancy among women living with HIV and its predictors in East Africa, 2024. A systematic review and meta-analysis. by Eyob Shitie Lake, Mulat Ayele, Abebaw Alamrew, Befikad Derese Tilahun, Besfat Berihun Erega, Alemu Birara Zemariam, Getinet Kumie, Gizachew Yilak

“…<h4>Result</h4>A total of 2140 articles were found by using our search strategies and finally ten studies were included in the SRMA, comprised of 4319 participants. …”
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