RIPK1 expression and inhibition in tauopathies: implications for neuroinflammation and neuroprotection by Ignacio Silva-Llanes, Ignacio Silva-Llanes, Ignacio Silva-Llanes, Enrique Madruga, Enrique Madruga, Ana Martínez, Ana Martínez, Isabel Lastres-Becker, Isabel Lastres-Becker, Isabel Lastres-Becker, Isabel Lastres-Becker

“…Furthermore, we investigated the potential of using a RIPK1 inhibitor, known as GSK2982772, in a mouse model as a novel treatment strategy for FTD. The data showed that GSK2982772 treatment effectively reduced the reactive astrocyte response triggered by TAUP301L overexpression. …”
Get full text

Toxicological Effects of Commonly Used Mosquito Coil Smoke on Liver and Lung Function in Rats by Hadiza Abubakar, Yahuza Gimba Muhammed, Alhassan Muhammad Wudil, Dayyabu Shehu, Murtala Yaú

“…The utilization of mosquito coils as a household-level strategy for mosquito control is widely practiced in malaria-endemic regions spanning Africa, Asia, and South America. …”
Get full text

The relationship between vision status and its influencing factors among primary and secondary school students: The masking effect of physical activity level and the moderating eff... by Jiyan Xu, Yanjun Li, Siyuan Ma, Shimeng Dai, Weiwei Xu, Mengjiao Sang, Kaijie Feng

“…The impact of lifestyle behaviors on vision status is controlled by physical activity level and academic stress. A strategy of coordinated education involving families, schools, and communities should be implemented. …”
Get full text

Regional disparities of full pentavalent vaccine uptake and the determinants in Ethiopia: Mapping and spatial analysis using the EDHS data. by Getasew Mulat Bantie, Melaku Tadege, Teshager Zerihun Nigussie, Ashenafi Abate Woya, Abay Kassa Tekile, Amare Alemu Melese, Simeneh Ayalew, Belay Bezabih Beyene, Gizachew Yismaw Wubetu

“…<h4>Background</h4>The full pentavalent (DPT-HepB-Hib) vaccination is the main strategy to prevent five communicable diseases in early childhood, especially in countries with huge communicable disease burdens like Ethiopia. …”
Get full text

Sterol‐Targeted Laboratory Evolution Allows the Isolation of Thermotolerant and Respiratory‐Competent Clones of the Industrial Yeast Saccharomyces cerevisiae by Isabel‐Elena Sánchez‐Adriá, Jose A. Prieto, Gemma Sanmartín, Miguel Morard, Estéfani García‐Ríos, Francisco Estruch, Francisca Randez‐Gil

“…Using a targeted evolution strategy involving fluconazole (FCNZ), an inhibitor of the sterol biosynthesis pathway, and the immunosuppressant FK506, we aimed to enhance thermotolerance in an industrial baker's yeast population by modifying their sterol composition. …”
Get full text

Comparison of Intranasal Outer Membrane Vesicles with Cholera Toxin and Injected MF59C.1 as Adjuvants for Malaria Transmission Blocking Antigens AnAPN1 and Pfs48/45 by Michael Pritsch, Najib Ben-Khaled, Michael Chaloupka, Sebastian Kobold, Nicole Berens-Riha, Annabell Peter, Gabriele Liegl, Sören Schubert, Michael Hoelscher, Thomas Löscher, Andreas Wieser

“…This study provides the rationale for further development of OMV as a vaccination strategy in malaria and other diseases.…”
Get full text

Effects of <i>Cordyceps cicadae</i> Polysaccharide on Gut Microbiota, the Intestinal Mucosal Barrier, and Inflammation in Diabetic Mice by Lijia Sun, Huaibo Yuan, Huiqing Ma, Yani Wang

“…<b>Conclusions:</b> In conclusion, it is demonstrated that in this murine model, the treatment of diabetes with <i>C. cicadae</i> polysaccharide can effectively regulate intestinal microbiota imbalance, protect intestinal mucosal barrier function, and reduce inflammation in vivo, suggesting this natural product can provide a suitable strategy for the treatment of T2D-induced gut dysbiosis and intestinal health.…”
Get full text

Potential Target Antigens for a Universal Vaccine in Epithelial Ovarian Cancer by Renee Vermeij, Toos Daemen, Geertruida H. de Bock, Pauline de Graeff, Ninke Leffers, Annechien Lambeck, Klaske A. ten Hoor, Harry Hollema, Ate G. J. van der Zee, Hans W. Nijman

“…Immunotherapeutic treatment using a cocktail of antigens has been proposed as a “universal” vaccine strategy. We determined the expression of tumor antigens in the context of MHC class I expression in 270 primary tumor samples using tissue microarray. …”
Get full text

Giant Photoluminescence Enhancement of Ga‐Doped ZnO Microwires by X‐Ray Irradiation by Siyuan He, Shuiyan Cao, Ying Liu, Wenfa Chen, Pin Lyu, Weidian Li, Jincheng Bao, Wenhui Sun, Caixia Kan, Mingming Jiang, Yanpeng Liu

“…Herein, a simple and effective X‐ray irradiation strategy is demonstrated for enhancing the photoluminescence of Ga‐doped ZnO microwire in ambient conditions. …”
Get full text

Big Data-Driven Risk Analysis of Environmental Grievances in the Palm Oil Industry for Sustainable Decision-Making by Muhammad Syahmi Idris, Muhamad Shahrul Md Nor, Syazwani Ali, Norazman Mat Ali, Siew Wai Yoong, Mohd Nazli Mohd Nor, Mohd Suffian Mohd Muhili, Muhamad Fairus Noor Hassim

“…This finding points toward the need for the formation of a private consortium among identified key players and local government in the high-risk region as a new strategy to improve management of environmental sustainability issues that predominantly involve deforestation.   …”
Get full text

Des bidonvilles aux sites de relogement à Témara : la quête d’une identité urbaine légitime by Aziz Benkorti

“…This is largely linked to the authorities’ objective of deconstructing habitats considered to be both a spatial and social evil without putting in place a more adequate social support strategy that meets the expectations of the population. …”
Get full text

Molecular identification and antibiotic clearance of Mycoplasma arginini and Mycoplasma orale from cell cultures infected with Rickettsia or Ehrlichia species by Michelle E. J. Allerdice, Savannah L. Shooter, Maria F. B. M. Galletti, Joy A. Hecht, Sandor E. Karpathy, Christopher D. Paddock

“…As such, the comprehensive strategy for Mycoplasma arginini and Mycoplasma orale elimination presented here can improve laboratory efficiency for in vitro research with intracellular bacteria.…”
Get full text

Transcriptomic analysis of Andrias davidianus meat and experimental validation for exploring its bioactive components as functional foods by Changge Guan, Zhenglin Tan, Shucheng Li, Yi Wang, Naoyuki Yamamoto, Chong Zhang, Songjun Wang, Junjie Chen, Xin-Hui Xing

“…This study suggested that transcriptomic analysis can be used as a reference to guide polypeptide mining in CGS meat, thereby providing a powerful mining strategy for the bioresources with unknown genomic and proteomic sequences.…”
Get full text

Vasoreactive testing prevalence and characteristics in patients with idiopathic pulmonary arterial hypertension by Goncharova Natalia, Kirill Lapshin, Aelita Berezina, Irina Zlobina, Anton Ryzhkov, Zhaneta Matakaeva, Elizaveta Andreeva, Olga Moiseeva

“…INTRODUCTION: The choice of treatment strategy in patients with idiopathic pulmonary arterial hypertension (IPAH)/HPAH/DPAH (Hereditary pulmonary arterial hypertension/ Drug-induced pulmonary arterial hypertension) II-III functional class (FC) (WHO) based on an acute vasoreactive testing result (VRT). …”
Get full text

Divergent Adsorption Regulation in Metal–Organic Frameworks for Highly Efficient CF4/C2F6 Separation by Guihong Xu, Tian Ke, Rongrong Fan, Kaiyuan Tan, Wenjun Zhang, Baogen Su, Zhiguo Zhang, Zongbi Bao, Qilong Ren, Qiwei Yang

“…Focusing this challenge on the critical task of purifying perfluorocarbons in electronics industry, a divergent regulation strategy is reported that significantly improves the separation efficiency of low‐concentration hexafluoroethane (C2F6) from tetrafluoromethane (CF4). …”
Get full text

Endogenous endophthalmitis associated with autoimmune hepatitis: case report by D.F. Belov, V.G. Korotkov, P.A. Nikitin, I.V. Terekhova, Ya.S. Konenkova

“…The timely diagnosis of EE is important for selecting an effective treatment strategy that involves intravitreal antibiotics and vitrectomy. …”
Get full text

Evaluating the Association Between Methylenetetrahydrofolate Reductase (Rs1801131 and Rs1801133) Gene Polymorphisms and Severity of Coronary Lesions in Patients With STEMI and NSTE... by Behnam Nazarzadeh, Saeedeh sadat Ghazanfari, Farzaneh Karimi, Seyed ali Moezibady, Fatemeh Salmani, Kazem Dastjerdi, Hamidreza Mohammadi

“…The Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) score is also an appropriate predictor for revascularization strategy in patients with complex CAD. The aim of this study is to investigate the correlation between rs1801131 and rs1801133 with the severity of coronary lesions in patients with ST‑Elevation Myocardial Infarction (STEMI) and Non‑ST‑Elevation Myocardial Infarction (NSTEMI) based on the SYNTAX score. …”
Get full text

A conceptual model for advanced/metastatic gastric or gastroesophageal junction cancer: a review of qualitative studies and results from patient interviews by France Ginchereau Sowell, Thom de Milliano, Keri J. S. Brady, Ginamarie Foglia, Medha Sasane, Samira Bensfia, Matthew Reaney

“…This can guide the clinical outcome assessment strategy for the development of innovative treatments more comprehensively than input from physicians alone, to ensure treatments improve both patients’ survival and HRQoL. …”
Get full text

The Feasibility and Acceptability of an HIV Web- Based Screening Program in Iran by Roya Sahebi, Hossein Dehghanian, Alireza Mirahmadizadeh, Leyla Sahebi, Reza Yousefi Farkhad, Simin Khayatzadeh-Safaie, Nazila Sattari, Leila Jahangiry, Hamid Sharifi

“…Notably, this group’s five individuals (2.8%) reported visiting VCT centers after completing the questionnaire.Conclusion: Developing an educational website combined with targeted promotion appears to be a feasible and potentially effective strategy for increasing awareness of HIV and motivating individuals to seek testing. …”
Get full text

Ten proposed measures to improve vaccination: Health care providers’ perspectives on promoting the vaccination intake of children with special healthcare needs in China by Xiang Guo, Tianxing Feng, Meiyi Chen, Xuran Zhao, Xiangshi Wang, Yanling Ge, Zhonglin Wang, Zhuoying Huang, Mei Zeng

“…A purposive sampling strategy was used to recruit interviewees including primary care providers, paediatricians and immunisation programme administrators. …”
Get full text