Intensive Blood Pressure Control and Diabetes Mellitus Incidence for Patients with Impaired Fasting Glucose: A Secondary Analysis of SPRINT by Beiru Lin, Xiaochuan Liu, Sichen Yao, Zhigang Pan

“…This kind of impact should be considered when implementing the strategy, especially for those with high risks of developing T2D. …”
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FSTL1 aggravates high glucose-induced oxidative stress and transdifferentiation in HK-2 cells by Baoyuan Zhang, Hang Geng, Kai Zhao, Moussa Omorou, Shuang Liu, Zhihui Ye, Fanting Zhang, Haiyan Luan, Xuesong Zhang

“…Targeting FSTL1 may represent a novel therapeutic strategy for preventing or mitigating DN progression.…”
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CRISPR/Cas12a-based method coupled with isothermal amplification to identify Alternaria spp. isolated from wheat grain samples by Aisha Shaizadinova, Aisha Shaizadinova, Meruyert Amanzholova, Meruyert Amanzholova, Irina Rukavitsina, Sailau Abeldenov, Anuar Rysbekovich Zhumakayev

“…Efficient pest management relies on timely detection and identification of phytopathogens in plant and grain samples, facilitating prompt selection of a crop protection strategy. Conventional identification tools, such as morphological characterization and identification based on polymerase chain reaction (PCR)-based methods, are time-consuming and laboratory-bound, limiting their implementation for on-site diagnostics essential in the agricultural industry. …”
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Combining a Risk Factor Score Designed From Electronic Health Records With a Digital Cytology Image Scoring System to Improve Bladder Cancer Detection: Proof-of-Concept Study by Sandie Cabon, Sarra Brihi, Riadh Fezzani, Morgane Pierre-Jean, Marc Cuggia, Guillaume Bouzillé

“…Second, we investigated 3 strategies (logistic regression, decision tree, and a custom strategy based on score interpretation) to combine the model’s score with the score from an image-based model to produce a robust bladder cancer scoring system. …”
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Growing meat on autoclaved vegetables with biomimetic stiffness and micro-patterns by Ye Liu, Anqi Gao, Tiantian Wang, Yongqian Zhang, Gaoxiang Zhu, Sida Ling, Zhaozhao Wu, Yuhong Jin, Haoke Chen, Yuming Lai, Rui Zhang, Yuchen Yang, Jianyong Han, Yulin Deng, Yanan Du

“…Here we propose an autoclaving strategy to transform common vegetables into muscle- and adipose-engineering scaffolds, without undergoing conventional plant decellularization. …”
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Genetic Rescue of the Dinaric Lynx Population: Insights for Conservation From Genetic Monitoring and Individual‐Based Modelling by Elena Pazhenkova, Matej Bartol, Barbara Boljte, Urša Fležar, Andrea Gazzola, Tomislav Gomerčić, Marjeta Konec, Ivan Kos, Miha Krofel, Jakub Kubala, Ladislav Paule, Mihai Pop, Hubert Potočnik, Barbara Promberger, Robin Rigg, Teodora Sin, Magda Sindičić, Vedran Slijepčević, Astrid Vik Stronen, Ira Topličanec, Tomaž Skrbinšek

“…Reinforcement of populations by translocating individuals from larger populations is a viable strategy for reducing inbreeding, increasing genetic diversity and potentially saving populations from extinction. …”
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MicroRNA-140-5p inhibits cellular proliferation, migration and invasion by downregulating AKT/STAT3/NF-κB pathway in breast carcinoma cells by Hou Lingli, Liu Qi, Zhao Ying, Yang Hongwei, Meng Qingying, Yu Fei

“…Taken the present study results together, we can conclude that miR-140-5p may act as a novel target in microRNA-targeting anticancer strategy for the treatment of breast cancer.…”
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A covalent peptide-based lysosome-targeting protein degradation platform for cancer immunotherapy by Youmei Xiao, Zhuoying He, Wanqiong Li, Danhong Chen, Xiaoshuang Niu, Xin Yang, Wenxuan Zeng, Mengfan Wang, Yuzhen Qian, Ye Su, Feiyu Luo, Guanyu Chen, Juan Liu, Xinghua Sui, Xiuman Zhou, Yanfeng Gao

“…Abstract The lysosome-targeting chimera (LYTAC) strategy provided a very powerful tool for the degradation of membrane proteins. …”
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Life cycle embodied carbon evaluation of a two-bedroom house construction in Ghana: A comparison between stabilized laterite and sancrete building by Theophilus Frimpong Adu, Mohammed D.H. Zebilila, Peter Adzakey, Wilson Ofori Sarkodie, Zakari Mustapha

“…This study highlights that replacing cement and paint with lower embodied carbon materials could be a promising strategy for sustainable construction. Further research is recommended to include the entire building life cycle, encompassing not only the construction phase but also the operational and end-of-life stages. …”
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Throughout Maximization for IRS-Assisted WPCN With Hybrid TDMA-NOMA Scheme by Yizheng Ma, Ruoyi Wu, Yi Zhang, Yupeng Shang, Linzhen Zhu

“…A novel hybrid multiple access strategy is conceived, where the IRS set the time-division multiple access (TDMA) to allocate its phase shifts, each of which performs the non-orthogonal multiple access for multiple Internet of Things (IoT) devices. …”
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Comprehensive chemical and bioactive investigation of Chinese peony flower: a case of valorization of by-products as a new food ingredient from Chinese herb by Meng-ling Peng, Ming-Jiong Gong, Jing Zhang, Anastassiya V. Gadetskaya, Qian-Wen Liang, Pei-Wen He, Xiao-Hui Qiu, Zhi-Hai Huang, Wen Xu, Wen Xu

“…IntroductionIn the present study, the flower of Chinese peony (CPF), major waste by-product of Chinese Herb Radix paeoniae, was comprehensively investigated for the first time.MethodsA validated UHPLC Orbitrap Mass spectrometry combined a three-levels characterization strategy were used to analyze CPF samples from four representative cultivars. …”
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Programmes to support transitions in community care for children with complex care needs: a scoping review by Shelley Doucet, Jennifer Splane, Patricia Charlton, Alison Luke, Janet A Curran, Christine Cassidy, Sydney Breneol, Shelley McKibbon, Holly McCulloch, Jessie-Lee McIsaac, Angela Riveroll

“…Objective This scoping review aimed to map the range of programmes in the literature to support children and youth with complex care needs and their families during transitions in care in the community.Design A scoping review of the literature.Context This review included programmes that supported the transition in care to home and between settings in the community.Data sources We implemented our strategy to search five databases: (1) PubMed; (2) CINAHL; (3) ERIC; (4) PyscINFO and (5) Social Work Abstracts. …”
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Examining the integration of refugees into the national health system in Uganda: an analysis using the policy triangle framework by Henry Komakech, Shatha Elnakib, Lama Bou Karroum, Evelyn Nyachwo, Winnie Adoch, Sarah Sali, Godfrey Goddie Okeny, Christopher Garimoi Orach

“…This paper chronicles the history of policies and strategies that have influenced the integration of refugees into the national health system in Uganda and investigates factors that impacted policy evolution and progression. …”
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Spatial-temporal evolution and multi-scenario prediction of carbon emissions from land use in the adjacent areas of nature reserves by Yuan Li, Yu-Ling Peng, Wei-Ying Cheng, Hao-Na Peng

“…Notably, the carbon source control scenario exhibited the smallest net carbon emissions from land use, underscoring the significance of carbon reduction as the fundamental strategy for achieving carbon neutrality goals. This research can offer insightful experience for simulating land use patterns and estimating carbon emissions in adjacent areas with similar nature reserves, contributing to the proposal of targeted carbon neutrality policies and management measures, thereby facilitating the transition of nature reserves and their surrounding areas towards a low-carbon development path.…”
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Mogroside ⅡE, an in vivo metabolite of sweet agent, alleviates acute lung injury via Pla2g2a-EGFR inhibition by Weichao Lü, Guoqing Ren, Kuniyoshi Shimizu, Renshi Li, Chaofeng Zhang

“…Pla2g2a may represent a potential target for M2E in the improvement of LPS-induced lung injury, which may represent a promising strategy to treat ALI.…”
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Biogenic synthesis of titanium nanoparticles by Streptomyces rubrolavendulae for sustainable management of Icerya aegyptiaca (Douglas) by Enayat M. Elqady, Eman El-said, Asmaa A. Tharwat, Lina A. Abou El-Khashab, Inas M. Y. Mostafa, Fatma Z. Hamed, Wesam M. Morsi, Mohamed M. Rezk, Inas M. Abou El-Enain

“…The application of TiO2-NPs by MNC2 offers a new alternative strategy to control I. aegyptiaca and is considered a modern approach to nanotechnology.…”
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The Geographical Distribution of Global Biobanks by Farzad Parvizpour, Sarvenaz Salahi, Mohammad Amin Mahmanzar, Karim Rahimian, Neda Esfandiari, Zahra Fatahi, Niousha Khoshdast, Reyhaneh Yarmohammadi, Mohamad Amir Amirkhani, Arefeh Jafarian

“…Developing a search strategy to identify biobanks from each continent,ii. …”
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iPSC-derived exosomes as amphotericin B carriers: a promising approach to combat cryptococcal meningitis by Jingyu Zhao, Jingyu Zhao, Wei Fang, Yangjie Gao, Jiquan Chen, Guizhen Wang, Julin Gu

“…Its MIC against Cryptococcus was over eight times lower than conventional AmB, significantly reducing fungal burden in the mouse brain and lowering serum inflammatory factors.ConclusionThe iPSC-Exo/AmB complex is a promising therapeutic strategy that enhances AmB efficacy while reducing toxicity, offering new hope for treating CM and other refractory fungal infections of the central nervous system.…”
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AM1241 inhibits chondrocyte inflammation and ECM degradation through the Nrf2/HO-1 and NF-κB pathways and alleviates osteoarthritis in mice by Zhuan Zou, Songmu Pan, Changzheng Sun, Jiyong Wei, Yi Xu, Kaizhen Xiao, Jinmin Zhao, Ronghe Gu

“…The remarkable efficacy of AM1241 in alleviating murine OA positions it as a potential therapeutic strategy in the clinical management of OA diseases.…”
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Effectiveness of multimethod, community-based educational interventions on the knowledge and attitude to birth preparedness and complications readiness among women in southwest Nig... by Bosede B Afolabi, Ifeoma P Okafor, Mobolanle R Balogun, Adekemi O Sekoni, Duro C Dolapo, Claudia A Hawkins

“…Background Birth preparedness and complications readiness (BP/CR) is an effective strategy to reduce maternal and newborn morbidity and mortality.Aim To assess the effect of educational interventions on women’s knowledge and attitude regarding BP/CR in southwest Nigeria.Methods A quasi-experimental study was carried out over 1 year (May 2019–April 2020) in Lagos, southwest Nigeria. …”
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