Enhancing the Solubility of Co-Formulated Hydrophobic Drugs by Incorporating Functionalized Nano-Structured Poly Lactic-<i>co</i>-glycolic Acid (<i>nf</i>PLGA) During Co-Precipitat... by Mohammad Saiful Islam, Somenath Mitra

“…<b>Background/Objectives</b>: The co-formulation of active pharmaceutical ingredients (APIs) is a growing strategy in biopharmaceutical development, particularly when it comes to improving solubility and bioavailability. …”
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Minimally Manipulated Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis: A Systematic Review of Clinical Evidence by B. Di Matteo, F. Vandenbulcke, N. D. Vitale, F. Iacono, K. Ashmore, M. Marcacci, E. Kon

“…The use of laboratory-expanded mesenchymal stem cells (MSCs) is subject to several restrictions, resulting in “minimal manipulation” methods becoming the current most popular strategy to increase the use of MSCs in an orthopaedic practice. …”
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Making the most of existing research: an evidence gap map of the effects of food systems interventions in low-income and middle-income countries by Birte Snilstveit, Ingunn Gilje Storhaug, Charlotte Lane, Nick Moore, Mark Engelbert, Thalia Morrow Sparling, Amber Franich, Heike Rolker

“…Among studies in a specific age group, infants were most frequently included (19%); 14% of these also considered mothers.Few evaluations considered qualitative or cost analysis; 75% used randomisation as the main identification strategy.Discussion The uneven distribution of research means that some interventions have established impacts while other interventions, often affecting large populations, are underevaluated. …”
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Environmental awareness factor of used cell phones by N. Wibowo, R. Nurcahyo, D.S. Gabriel

“…Therefore, to develop a new strategy, the findings of this study can provide insights into the e-waste problem and citizen’s awareness of e-waste management.…”
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Continuous decoupled redox electrochemical CO2 capture by Tao Liu, Yunpeng Wang, Yifan Wu, Wenchuan Jiang, Yuchao Deng, Qing Li, Cheng Lan, Zhiyu Zhao, Liangyu Zhu, Dongsheng Yang, Timothy Noël, Heping Xie

“…In this study, we propose a scalable strategy that addresses these limitations by transforming the conventional single-step electrochemical redox reaction into a stepwise electrochemical-chemical redox process. …”
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Enhancing immunotherapy efficacy in colorectal cancer: targeting the FGR-AKT-SP1-DKK1 axis with DCC-2036 (Rebastinib) by Xiguang Chen, Qiting Zeng, Liyang Yin, Bingru Yan, Chen Wu, Jianbo Feng, Ying Wu, Jun He, Wenjun Ding, Jing Zhong, Yingying Shen, Xuyu Zu

“…Consequently, targeting the FGR-AKT-SP1-DKK1 pathway with DCC-2036 could potentiate immunotherapy by enhancing CD8+ T cell functionality and their tumor infiltration. This strategy may contribute significantly to the refinement of therapeutic approaches for CRC, potentially improving patient prognoses.…”
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Investigating the encapsulation of lead bromide perovskite with poly(3-bromothiophene) for improved aqua stability and enhanced fluorescence memory by Debasis Brahma, Jit Satra, Sayan Basak, Subhadeep Chakraborty, Rahul Chatterjee, Suman Acharya, Debdipta Basu, Abhijit Bandyopadhyay

“…These findings provide a practical, non-interacting encapsulation strategy that enhances both the environmental and thermal stability of FAPbBr₃ while preserving its emission characteristics, offering potential to support the further development of perovskite-based optoelectronic devices for practical applications.…”
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Identification of natural phytochemicals as AKT2 inhibitors using molecular docking and dynamics simulations as potential cancer therapeutics by Jibon Kumar Paul, Mahir Azmal, Md Naimul Haque Shohan, Mohua Mrinmoy, ANM Shah Newaz Been Haque, Omar Faruk Talukder, Ajit Ghosh

“…Therefore, targeting AKT2 for inhibition is a promising strategy for cancer therapy. This study utilized molecular docking and dynamics simulations to identify natural phytochemicals that inhibit AKT2. …”
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HLA-G Expression on Blasts and Tolerogenic Cells in Patients Affected by Acute Myeloid Leukemia by Grazia Locafaro, Giada Amodio, Daniela Tomasoni, Cristina Tresoldi, Fabio Ciceri, Silvia Gregori

“…This is the first report describing HLA-G-expressing DC-10 and CD4+ T cells in AML patients, suggesting that they may represent a strategy by which leukemic cells escape the host’s immune system. …”
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Risk Factors Influencing Cognitive Function in Elderly Patients With Late‐Life Depression: A Scoping Review by Ping Jiang, Yunfeng Gao, Lin Wang, Xiaojun Shao, Lei Zhang, Gang Zhu, Li Duan

“…Objective The purpose of this study is to examine the current state of negative influencing factors and assessment tools for cognitive impairment in patients with late‐life depression (LLD), thereby providing a theoretical framework for the construction of subsequent targeted intervention programs. Methods The search strategy employed in this study followed an evidence‐based approach, utilizing a systematic scoping review to thoroughly explore six English and four Chinese databases up until November 2023. …”
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Access to HIV testing and factors associated among sexual minority women in a metropolitan region of the Brazilian Amazon by Janaína de Freitas Vale, Wanderson Santiago de Azevedo Júnior, Paula Regina Barbosa de Almeida, Adinaldo Moreira Martins, Flavine Evangelista Gonçalves, Eliã Pinheiro Botelho, Fabianne de Jesus Dias de Sousa, Cintia Yolette Urbano Pauxis Aben-Athar, Luiz Fernando Almeida Machado, Glenda Roberta Oliveira Naiff Ferreira

“…Although the testing prevalence was below 50%, the study identified that the combined prevention strategy has reached the most vulnerable populations.…”
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High light availability offsets low naturalness regarding diversity but cannot compensate for reduced ecological value: A case study of near-natural forests and tree plantations in... by Khanh Vu Ho, Mirjana Ćuk, Andraž Čarni, Dragana Vukov, Miloš Ilić, László Erdös

“…Furthermore, it is advisable to continue with a forestry strategy that involves replacing non-native plantations with native ones, such as Tilia tomentosa, in the Deliblato Sands.…”
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Oral Immunisation With Non‐GMO Surface Displayed SARS‐CoV‐2 Spike Epitopes on Bacteria‐Like Particles Provokes Robust Humoral and Cellular Immune Responses, and Modulated the Gut M... by Robie Vasquez, Ji Hoon Song, Remilyn M. Mendoza, In‐Chan Hwang, Bernadette B. Bagon, Lars Engstrand, Valerie Diane Valeriano, Dae‐Kyung Kang

“…Mucosal vaccines using food‐grade bacteria, such as Lactobacillus spp., are promising strategies for developing safe and effective vaccines against SARS‐CoV‐2. …”
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Nystose attenuates bone loss and promotes BMSCs differentiation to osteoblasts through BMP and Wnt/β-catenin pathway in ovariectomized mice by Qi Zhang, Sijing Hu, Jianjun Wu, Peng Sun, Quanlong Zhang, Yang Wang, Qiming Zhao, Ting Han, Luping Qin, Qiaoyan Zhang

“…Increasing the osteogenic differentiation ability and decreasing the adipogenic differentiation ability of bone marrow mesenchymal stem cells (BMSCs) is a potential strategy for the treatment of osteoporosis (OP). Naturally derived oligosaccharides have shown significant anti-osteoporotic effects. …”
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Characterization of tumor evolution by functional clonality and phylogenetics in hepatocellular carcinoma by Zeynep Kacar, Eric Slud, Doron Levy, Julián Candia, Anuradha Budhu, Marshonna Forgues, Xiaolin Wu, Arati Raziuddin, Bao Tran, Jyoti Shetty, Yotsawat Pomyen, Jittiporn Chaisaingmongkol, Siritida Rabibhadana, Benjarath Pupacdi, Vajarabhongsa Bhudhisawasdi, Nirush Lertprasertsuke, Chirayu Auewarakul, Suleeporn Sangrajrang, Chulabhorn Mahidol, Mathuros Ruchirawat, Xin Wei Wang

“…However, ability to monitor tumor cell evolution is hampered by the presence of numerous passenger mutations that do not provide any biological consequences. Here we develop a strategy to determine the tumor clonality of three independent HCC cohorts of 524 patients with diverse etiologies and race/ethnicity by utilizing somatic mutations in cancer driver genes. …”
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Oral delivery of the non-β-blocking R-carvedilol enantiomer for skin cancer chemoprevention in SKH-1 mice by Pabitra K. Sardar, Steven Yeung, Ruby Tow, Jacqueline Luga, Matthew Huang, Ayaz Shahid, Bradley T. Andresen, Ying Huang

“…Conclusions These data support oral administration of R-carvedilol as a viable strategy for the chemoprevention of skin cancer, given its efficacy and minimal impact on the cardiovascular system. …”
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Enhancing water solubility of phytosterols through Co-amorphization with food-grade coformers by Yuxin Li, Yingting Luo, Xuening Song, Yuzhuo Wang, Simiao Liu, Fazheng Ren, Lingyan Kong, Hao Zhang

“…These findings suggest that the PS-Nic CM system has potential applications in functional foods, offering a feasible strategy to enhance the bioavailability of PS.…”
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The Different Effects of IFN-β and IFN-γ on the Tumor-Suppressive Activity of Human Amniotic Fluid-Derived Mesenchymal Stem Cells by Jingchun Du, Anqi Liu, Rui Zhu, Chengbo Zhou, Heng Su, Guie Xie, Yingshan Deng, Xia Xu

“…Our finding may help to explore a clinical strategy for cancer intervention by understanding the antitumor mechanisms of MSCs and interferon.…”
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Evaluation of Agreement between HRT III and iVue OCT in Glaucoma and Ocular Hypertension Patients by A. Perdicchi, M. Iester, D. Iacovello, A. Cutini, M. Balestrieri, M. G. Mutolo, A. Ferreras, M. T. Contestabile, S. M. Recupero

“…All subjects performed achromatic 30° VF by Octopus Program G1X dynamic strategy and were imaged with HRT III and iVue OCT. …”
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HI-CMAIM: Hybrid Intelligence-Based Multi-Source Unstructured Chinese Map Annotation Interpretation Model by Jiaxin Ren, Wanzeng Liu, Jun Chen, Xiuli Zhu, Ran Li, Tingting Zhao, Jiadong Zhang, Yuan Tao, Shunxi Yin, Xi Zhai, Yunlu Peng, Xinpeng Wang

“…A two-stage transfer learning strategy was employed to tackle the issue of limited training samples. …”
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