TAD-SIE: sample size estimation for clinical randomized controlled trials using a Trend-Adaptive Design with a Synthetic-Intervention-Based Estimator by Sayeri Lala, Niraj K. Jha

“…Methods To remove this obstacle from the drug development cycle, we present a new algorithm called Trend-Adaptive Design with a Synthetic-Intervention-Based Estimator (TAD-SIE) that powers a parallel-group trial, a standard RCT design, by leveraging a state-of-the-art hypothesis testing strategy and a novel trend-adaptive design (TAD). Specifically, TAD-SIE uses synthetic intervention (SI) to estimate individual treatment effects and thereby simulate a cross-over design, which makes it easier for a trial to reach target power within trial constraints (e.g., sample size limits). …”
Get full text

Activating CD137 Signaling Promotes Sprouting Angiogenesis via Increased VEGFA Secretion and the VEGFR2/Akt/eNOS Pathway by Bo Li, Yue Zhang, Runting Yin, Wei Zhong, Rui Chen, Jinchuan Yan

“…Combination of antiangiogenesis and immunotherapy may be an effective strategy for treatment of solid tumors. Our previous work reported that activation of CD137 signaling promotes intraplaque angiogenesis. …”
Get full text

Graph Deep Active Learning Framework for Data Deduplication by Huan Cao, Shengdong Du, Jie Hu, Yan Yang, Shi-Jinn Horng, Tianrui Li

“…To fill this research gap, we propose a novel graph deep active learning framework for data deduplication, which is based on similarity algorithms combined with the bidirectional encoder representations from transformers (BERT) model to extract the deep similarity features of multi-source data records, and first introduce the graph active learning strategy to build a clean graph to filter the data that needs to be labeled, which is used to delete the duplicate data that retain the most information. …”
Get full text

Care, conflict, and coexistence: Human–wildlife relations in community forests by Madison Stevens, Shalini Rawat, Terre Satterfield

“…Characterizing community forests as important sites of interaction and coexistence, residents identified community‐led forest conservation as a primary strategy for mitigating HWC. These multifaceted human–wildlife relationships, shaped by encounters in a shared landscape, inform communities' decisions and coping strategies for coexisting with their wild neighbours. …”
Get full text

Restriction of mitochondrial oxidation of glutamine or fatty acids enhances intracellular growth of Mycobacterium abscessus in macrophages by Ho Won Kim, Ji Won Lee, Hoe Sun Yoon, Hwan-Woo Park, Young Ik Lee, Sung Ki Lee, Jake Whang, Jong-Seok Kim

“…By manipulating host mitochondrial metabolism, we identify a potential host-directed therapeutic strategy against Mab, offering a promising alternative to conventional treatments beleaguered by drug resistance. …”
Get full text

<i>Gigaspora roseae</i> and <i>Coriolopsis rigida</i> Fungi Improve Performance of <i>Quillaja saponaria</i> Plants Grown in Sandy Substrate with Added Sewage Sludge by Guillermo Pereira, Diyanira Castillo-Novales, Cristian Salazar, Cristian Atala, Cesar Arriagada-Escamilla

“…These results highlight the potential of combined microorganism and residual sludge application as a sustainable strategy for enhancing plant growth and reducing waste.…”
Get full text

On Cattaneo-Chrystov heat flux model for nanofluid flow on Darcy–Forchheimer porous medium past unsteady stretching cylinder by Sreedhar Sobhanapuram, S.V.V Rama Devi, Charankumar Ganteda, Rajyalakshmi Kottapalli, Vediyappan Govindan, Haewon Byeon, Busayamas Pimpunchat

“…After that, the shooting strategy and the Runge-Kutta fourth order are used to numerically solve the system of initial value problems. …”
Get full text

Microbial Composition Change and Heavy Metal Accumulation in Response to Organic Fertilization Reduction in Greenhouse Soil by Qin Qin, Jun Wang, Lijuan Sun, Shiyan Yang, Yafei Sun, Yong Xue

“…These results indicate that reducing excessive organic manure input is an effective strategy to control heavy metal accumulation, enhance soil fertility, and optimize microbial community structure.…”
Get full text

Pelvic Radiotherapy in Rectal Cancer Patients With Synchronous Potentially Treatable Liver Metastases by Yayu Huang, Genwen Chen, Xian Zhang, Yang Qian, Jian Wang

“…ABSTRACT Background The optimal management strategy for Stage IV rectal cancer with potentially treatable liver metastases remains controversial, particularly regarding the role of pelvic radiotherapy (RT). …”
Get full text

Patient education and follow-up units in Iran: A quality improvement project by Elham Almassi Ghaleh, Susan Jamshidi Farsani, Parastoo Ariamloo, Nasrin Mehrnoosh, Maryam Rassouli, Abbas Ebadi

“…Conclusion: The experience of establishing patient education and follow-up units highlights that this strategy during the transition to home is an effective, affordable, and sustainable solution that can improve NSIs. …”
Get full text

A reactive oxygen species-responsive hydrogel loaded with Apelin-13 promotes the repair of spinal cord injury by regulating macrophage M1/M2 polarization and neuroinflammation by Zhiyue Li, Qun Zhao, Jiahui Zhou, Yuyan Li, Yifan Zheng, Linxi Chen

“…The ROS-responsive hydrogel further amplifies these effects, offering a promising therapeutic strategy for SCI.…”
Get full text

Injectable trace minerals administration to beef cattle at arrival: effects on growth performance, respiratory disease and serum antioxidant status by Silvia Grossi, Riccardo Compiani, Marcello Guadagnini, Andrea Rosati, Carlo Angelo Sgoifo Rossi

“…The application of injectable zinc, copper, manganese and selenium (trace minerals - ITMs) at the arrival can be a strategy to boost the antioxidant defences and immune function, with positive effects on production performances, in fattening beef cattle. …”
Get full text

Study insights in the role of PGC-1α in neurological diseases: mechanisms and therapeutic potential by Mi-bo Tang, Yi-xuan Liu, Zheng-wei Hu, Hai-yang Luo, Shuo Zhang, Chang-he Shi, Yu-ming Xu, Yu-ming Xu, Yu-ming Xu

“…Based on the available studies, we propose that targeting PGC-1α could serve as a promising novel therapeutic strategy for one or more neurological diseases.…”
Get full text

Screening for coronary artery disease among cancer survivors: rationale and design of the REDEEM-CAD study by Cheng Hwee Soh, Joel Smith, Shristy Shrestha, Mark Nolan, Joshua Wong, Nitesh Nerlekar, Thomas H. Marwick

“…Participants with high risk or CAC > 400 will be informed about strategies (including lipid-lowering therapy) to manage asymptomatic CAD. …”
Get full text

Efficacy and safety of molecular targeted therapies in nasopharyngeal carcinoma: a network meta-analysis by Htet Htet, Jwala Rebacca James Anaghan, Heethal Jaiprakash, Ismail Abdul Sattar Burud, Thiruselvi Subramaniam, Igor Iezhitsa, Renu Agarwal

“…Conclusion It was observed that targeted therapies were found to be a promising strategy for NPC especially recurrent and/or metastatic NPC, but the most appropriate therapy still needs to be evaluated. …”
Get full text

A META-ANALYSIS: THE UTILIZATION OF NEGATIVE PRESSURE WOUND THERAPY IN DIABETIC FOOT ULCERS by Ni Putu Gita Raditya Sanjiwani, I Putu Krisna Murti

“…Negative pressure wound therapy (NPWT) is a modern therapeutic strategy for managing diabetic foot ulcers. The primary objective of this study is to assess the efficacy and safety by doing a thorough literature review and performing a meta-analysis. …”
Get full text

Impact of Organ Donor Pretreatment With Anti-Thymocyte Globulin in a Murine Model of Allogenic Kidney Transplantation by An He, An He, Yiren Yang, Katja Kotsch, Arne Sattler

“…In summary, our findings are suggestive of a more cell-type-specific depletion strategy in concert with an experimental model better reflecting aspects of clinical transplantation.…”
Get full text

The optimization of calcareous soil cation exchange capacity via the feather hydrolysate and N-P fertilizers integration by Doaa A. Goda, Eman H. El-Gamal, Mohamed Rashad, Yasser R. Abdel-Fattah

“…Then, assess the efficacy of hydrolyzed feather product (as an organic amendment), time, and N-P fertilizers on soil-CEC planted with maize in calcareous soil utilizing an optimization strategy that employed the central composite design and the response surface methodology (RSM). …”
Get full text

Evaluating level of adherence to nicotine replacement therapy and its impact on smoking cessation: a protocol for systematic review and meta-analysis by Michelle Bovill, Gillian Sandra Gould, Amanual Getnet Mersha, Parivash Eftekhari, Daniel Nigusse Tollosa

“…Only studies reporting a valid strategy to control for reverse causality will be included.Discussion This review will provide evidence to support the importance of adherence on rate of smoking cessation and level of adherence to NRT. …”
Get full text

Optimizing ibrutinib bioavailability: Formulation and assessment of hydroxypropyl-β-cyclodextrin-based nanosponge delivery systems by Sunitha Sampathi, Nitiraj Kulkarni, D.V.R.N. Bhikshapathi, Jagadish V. Tawade, Nainaru Tarakaramu, Rzgar Farooq Rashid, Aziz Kubaev

“…Conclusion: IBR-loaded HPβCD NSPs offer a promising strategy for improved drug release and bioavailability, which could significantly benefit melanoma treatment.…”
Get full text