Gene drive-based population suppression in the malaria vector Anopheles stephensi by Xuejiao Xu, Jingheng Chen, You Wang, Yiran Liu, Yongjie Zhang, Jie Yang, Xiaozhen Yang, Bin Chen, Zhengbo He, Jackson Champer

“…Combination of the homing suppression drive and a vasa-Cas9 line boosts the drive conversion rate of the homing drive to 100%, suggesting the use of similar systems for population suppression in a continuous release strategy with a lower release rate than SIT or fsRIDL techniques. …”
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The effect of physical activity on markers of oxidative and antioxidant stress in cancer patients: a systematic review and meta-analysis by Laerte Jônatas Leray Guedes, Victória Brioso Tavares, Saul Rassy Carneiro, Laura Maria Tomazi Neves

“…Abstract Background Prescribing physical exercise as part of the clinical treatment of cancer patients has become an important strategy in the therapeutic arsenal available in the main health centers specialized in neoplastic diseases, but there is still uncertainty regarding the role of regular physical activity in modifying oxidative stress markers and antioxidants, as high levels of oxidative stress can lead to the development of carcinogens. …”
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Regulatory Role of GSK-3β on NF-κB, Nitric Oxide, and TNF-α in Group A Streptococcal Infection by Yu-Tzu Chang, Chia-Ling Chen, Chiou-Feng Lin, Shiou-Ling Lu, Miao-Huei Cheng, Chih-Feng Kuo, Yee-Shin Lin

“…The inhibition of GSK-3β to moderate the inflammatory effect might be an alternative therapeutic strategy against GAS infection.…”
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Transcription factor Hap2p regulates antioxidant stress responses to maintain miconazole resistance in Candida albicans by Yulin Qin, Quanzhen Lv, Hongtao Xu, Yongbing Cao, Bing Han

“…The above results indicate that the transcription factor Hap2p was required for the resistance of C. albicans to azoles, which could provide a new strategy to solve the clinical azoles resistance.…”
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Engineered a dual-targeting biomimetic nanomedicine for pancreatic cancer chemoimmunotherapy by Meng Wang, Qida Hu, Junmin Huang, Xinyu Zhao, Shiyi Shao, Fu Zhang, Zhuo Yao, Yuan Ping, Tingbo Liang

“…Improvement of chemotherapeutic efficacy by targeting tumor-associated macrophage and reprograming tumor microenvironment to enhance their efficacy may become a promising strategy. To this end, we developed a biomimetic dual-targeting nanomedicine (PG@KMCM) where gemcitabine-loaded poly (lactic-co-glycolic acid) (PLGA) nanoparticles are coated with a layer of bioengineered cancer cell membrane that stably expresses peptides targeting M2-like macrophages (M2pep) while reserving tumor-associated antigens (TAAs). …”
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Self-selected vs. prescribed aerobic exercise intensity: impacts on pleasure in women with obesity by Carlos Eduardo Rosa Da Silva, Wilian Jesus Santana, Gustavo Almeida, Adriano Verame, Antonio Roberto Doro, Eduardo Barbosa, Leonardo Lima, Helton Magalhães Dias, Marcelo Callegari Zanetti, Aylton Figueira Junior

“…Affective responses were more positive perceived in SGS and ISS protocols.ConclusionWe conclude that intensity self-selection is a safe, effective, and comparable strategy to prescribed intensity at moderate levels, providing a more enjoyable experience that may contribute to greater adherence to aerobic training.…”
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Impact of Notch3 Activation on Aortic Aneurysm Development in Marfan Syndrome by Kathryn Jespersen, Chenxin Li, Rishi Batra, Christopher A. Stephenson, Paul Harding, Kylie Sestak, Ryan T. Foley, Harrison Greene, Trevor Meisinger, Jason R. Cook, B. Timothy Baxter, Wanfen Xiong

“…Our results suggest that inhibiting Notch3 activation may provide a strategy to prevent and treat aortic aneurysms in MFS.…”
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A chemical genetic screen with the EXO70 inhibitor Endosidin2 uncovers potential modulators of exocytosis in Arabidopsis by Xiaohui Li, Diwen Wang, Xianglin Yin, Mingji Dai, Christopher J. Staiger, Chunhua Zhang

“…Through a whole‐genome sequencing‐based mapping strategy, 14 nonallelic es2s mutants were mapped and the candidate mutations reported here. …”
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Survey situation of mental health of pregnant women with breast cancer: A systematic review study by Nasim Khademi, Farzaneh Rahimi, Shadi Goli

“…All documents were assessed for eligibility by titles or abstracts according to the search strategy, with the terms, such as mental health, pregnant woman, and pregnancy with breast cancer. …”
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Machine learning assisted plasmonic metascreen for enhanced broadband absorption in ultra-thin silicon films by Waqas W. Ahmed, Haicheng Cao, Changqing Xu, Mohamed Farhat, Muhammad Amin, Xiaohang Li, Xiangliang Zhang, Ying Wu

“…This inverse design strategy helps to tune the absorption for selective spectral functionalities. …”
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Goal-oriented care for patients with chronic conditions or multimorbidity in primary care: A scoping review and concept analysis. by Dagje Boeykens, Pauline Boeckxstaens, An De Sutter, Lies Lahousse, Peter Pype, Patricia De Vriendt, Dominique Van de Velde, Primary Care Academy

“…Further research should focus on how and what goals are set by the patient, how this knowledge could be translated into a tangible workflow and should support the development of a strategy to evaluate the goal-oriented process of care.…”
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Contextual factors influencing the use of digital health by patients and physicians in primary care: a scoping review protocol by Katarzyna Luchowska, Małgorzata Chmielewska, Katarzyna Byszek, Agata Olearczyk, Anna Gawrońska, Barbara Więckowska

“…This review attempts to recognise and map the existing body of research and evidence to identify the determinants that either favour or hinder the deployment and use of digital health technologies by patients and physicians in primary care.Methods and analysis The scoping review will be conducted in accordance with the JBI Manual for Evidence Synthesis (2024 edition introducing nine stages) and with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews checklist. Search strategy will be conducted in PubMed, Embase, Cochrane Database of Systematic Reviews and Scopus in November 2024. …”
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Spin-polarized lasing in manganese doped perovskite microcrystals by Penghao Li, Zhonghao Zhou, Guangliu Ran, Tongjin Zhang, Zhengjun Jiang, Haidi Liu, Wenkai Zhang, Yongli Yan, Jiannian Yao, Haiyun Dong, Yong Sheng Zhao

“…The electron-hole exchange interaction is identified as the decisive spin relaxation mechanism hindering the realization of spin-polarized lasing in perovskite microcrystals. An ion doping strategy is employed accordingly to introduce a new energy level in perovskites, which enables a long carrier spin lifetime by suppressing the electron-hole exchange interaction. …”
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Serological diagnosis of soil-transmitted helminth (Ascaris, Trichuris and hookworm) infections: A scoping review. by Sara Roose, Fiona Vande Velde, Johnny Vlaminck, Peter Geldhof, Bruno Levecke

“…Serological assays offer a potential solution for integrated diagnosis of NTDs, particularly for those requiring mass drug administration (MDA) as primary control and elimination strategy. This scoping review aims (i) to provide an overview of assays using serum or plasma to detect infections with soil-transmitted helminths (STHs) in both humans and animals, (ii) to examine the methodologies used in this research field and (iii) to discuss advancements in serological diagnosis of STHs to guide prevention and control programs in veterinary and human medicine.…”
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In Vitro Differentiation of First Trimester Human Umbilical Cord Perivascular Cells into Contracting Cardiomyocyte-Like Cells by Peter Szaraz, Matthew Librach, Leila Maghen, Farwah Iqbal, Tanya A. Barretto, Shlomit Kenigsberg, Andrée Gauthier-Fisher, Clifford L. Librach

“…Our results indicate that young FTM HUCPVCs have superior cardiomyogenic potential coupled with beneficial immunogenic properties when compared to MSCs of older tissue sources, suggesting that in vitro predifferentiation could be a potential strategy to increase their effectiveness in vivo.…”
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RNA binding protein ILF3 increases CEP55 mRNA stability to enhance malignant potential of breast cancer cells and suppress ferroptosis by Sheng Chen, Yangyong Luo, Simin Ruan, Guosen Su, Guoxing Huang

“…Silencing ILF3 or CEP55 could represent a potential therapeutic strategy for BC treatment. Graphical abstract…”
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A study on beneficial impact of the use of medium-molecular-weight hydroxyethyl starch in granulocyte apheresis using continuous-flow cell separator Spectra Optia: A retrospective... by Amardeep Pathak, Devasis Panda, Narender Tejwani, Anurag Mehta

“…CONCLUSION: In our study, granulocytes with optimum yield can be easily harvested with Spectra Optia cell separator using 6% HES (MMW) and trisodium citrate combination with standard 12-h interval gap between mobilization and harvest. This strategy can also have no or minimal extra cost burden to patients.…”
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Techno-environmental optimal sizing and dynamic behavior of a hybrid system feeding a large-scale SWRO desalination system: The case of Djerba Island, Tunisia by Mohamed Hamdi, Oumayma Gtari, Majdi Hazami

“…The water produced by the most cost-effective strategy with regard to environmental protection for a 25-year project life cycle costs 0.414 $/m 3 against 0.585 $/m 3 for current consumption. …”
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Visualizing stepwise evolution of carbon hybridization from sp 3 to sp 2 and to sp by Wei Xiong, Guang Zhang, De-Liang Bao, Jianchen Lu, Lei Gao, Yusen Li, Hui Zhang, Zilin Ruan, Zhenliang Hao, Hong-Jun Gao, Long Chen, Jinming Cai

“…We also demonstrate the applicability of this strategy on one-dimensional molecular wires and two-dimensional covalent organic framework on different substrates. …”
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Enhanced degradation performance of Ag-loaded BiOI composite photocatalysts for water pollutant removal by Chen Cong, Wang Shenghong, Wang Jiayuan, Sun Changfei, Li Denghui, Zhai Zhenjie

“…Finally, this article discusses the catalytic degradation mechanism of Ag composite catalyst materials based on experimental results, and provides a design strategy for loading heavy metals to improve the catalytic performance of materials.…”
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