Mismatch prime editing gRNA increased efficiency and reduced indels by Jidong Fei, Dongdong Zhao, Caiyi Pang, Ju Li, Siwei Li, Wentao Qiao, Juan Tan, Changhao Bi, Xueli Zhang

“…To address these challenges, we develop a mismatched pegRNA (mpegRNA) strategy that introduces mismatched bases into the pegRNA protospacer, reducing complementarity and secondary structure formation, and preventing sustained activity. …”
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Exosome-loading miR-205: a two-pronged approach to ocular neovascularization therapy by Hui-ying Zhang, Qiu-yang Zhang, Qing Liu, Si-guo Feng, Yan Ma, Feng-sheng Wang, Yue Zhu, Jin Yao, Biao Yan

“…Collectively, our findings highlight miR-205 as a promising therapeutic for ocular neovascularization, with exosome delivery offering a novel and efficient strategy for treating vision-threatening vascular diseases. …”
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Quantifying urbanization-induced dynamics of urban sprawl using spatial metrics method in Adama City, Ethiopia by Shimelis Sishah Dagne, Hurgesa Hundera Hirpha, Addisu Teshome Tekoye, Zenebe Reta Roba, Mitiku Badasa Moisa

“…Urban planners must therefore plan ahead to execute an effective implementation strategy that will keep up with the rate of urban sprawl.…”
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Efficacy and safety of pharmacological treatments in inclusion body myositis: a systematic review by Pedro M Machado, Eduardo José Ferreira Santos, Nicholas Yapp, Pedro Sousa, Bayram Farisogullari, Hermaleigh Townsley

“…Objective To identify the best evidence on the efficacy of treatment interventions for inclusion body myositis (IBM) and to describe their safety.Methods Systematic review of randomised controlled trials (RCTs) of pharmacological treatments of adults with IBM, conducted according to the Cochrane Handbook, updating a previous Cochrane review. The search strategy was run on Cochrane Neuromuscular Disease Group Specialized Register, CENTRAL, MEDLINE and EMBASE, ClinicalTrials.gov and the WHO International Clinical Trials Registry Platform. …”
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A Review on Application of Noble Metal-Free Materials/ZrO2 Nano-photocatalysts for Removal of Organic Pollutants and Heavy Metals by Marjan Tanzifi

“…The combination of ZrO2 with other semiconductors is an effective strategy to tackle these disadvantages. This not only delays the recombination of electron-hole pairs but also reduces the bandgap of the composite, improving light absorption in the visible region in many cases. …”
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Interaction of AURKA with TRIM28 revives dormant LSCC cells via Akt signaling pathway to promote LSCC metastasis by Liyun Yang, Liang Geng, Xinxin Zhang, Jing Lu, Hao Zhang, Geping Wu, Shuixian Huang

“…Conclusion AURKA mediated TRIM28 to revive dormant LSCC cells via Akt signaling pathway to promote LSCC metastasis, targeting TRIM28 might provide a potential treatment strategy for LSCC.…”
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Evaluation of Machinability and Energy Consumption of CK45 Steel Using Synthetic-Based Nanofluid and Minimum Quantity Lubrication Cutting Fluid by Emine Şap, Üsame Ali Usca, Ünal Değirmenci, Serhat Şap, Mahir Uzun

“…This study focused on the effects of a synthetic-based nanofluid cooling strategy and different cutting parameters during the milling of CK45 steel. …”
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Image-guided Control of Transgene Expression Based on Local Hyperthermia by E. Guilhon, B. Quesson, F. Moraud-Gaudry, H. de Verneuil, P. Canioni, R. Salomir, P. Voisin, C. T. W. Moonen

“…Recently, a noninvasive, physical approach has been presented based on local heat in combination with a heat-sensitive promoter. This strategy requires tight temperature control in vivo. …”
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Discussion on the training mode of Traditional Chinese Medicine nursing inheritance talents (中医护理传承人才培养模式探讨) by LI Ye (李野), E HaiYan (鄂海燕), Tang Ling (唐玲)

“…This paper aims to actively explore the TCM nursing inheritance talent cultivation strategy, strive to realize the TCM nursing from generation to generation, promote the innovation and development of TCM inheritance, and provide reference for promoting the construction of make greater contribution to healthy China. …”
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Neurophysiological Endophenotypes, CNS Disinhibition, and Risk for Alcohol Dependence and Related Disorders by Bernice Porjesz, Madhavi Rangaswamy

“…Biological endophenotypes are more proximal to gene function than psychiatric diagnosis, providing a powerful strategy in searching for genes in psychiatric disorders. …”
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Psychological Features of Post-Traumatic Stress Disorder in the Civilian Population of a Region Exposed to Local Military Actions (Using the Example of Mariupol) by A.M. Bogachev, Yu.A. Vysotskaya, T.G. Vintonyuk

“… <p>The work aims to study the relationship between the level of risk of PTSD, coping strategies, psychological defense mechanisms and other manifestations of personality traits. …”
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Some limitations in the use of the mitochondrial DNA cytb gene as a molecular marker for phylogenetic and population genetic studies by the example of the Apodemus genus by A. G. Lapinski, M. V. Pavlenko, L. L. Solovenchuk, V. V. Gorbachev

“…It is suggested that the strategy in the use of the mtDNA cytb gene in population genetics and phylogenetics should be adapted to the degree of the gene variability. …”
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Identification of 24 Unknown Substances (NIAS/IAS) from Food Contact Polycarbonate by LC-Orbitrap Tribrid HRMS-DDMS3: Safety Assessment by Vicent Yusà, Antonio López, Pablo Dualde, Olga Pardo, Igor Fochi, Pablo Miralles, Clara Coscollá

“…Twenty-four substances, mainly NIAS, have been tentatively identified in food contact polycarbonate through the application a new, fast, and automated analytical strategy for the investigation of unknowns in food contact materials. …”
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Effect of plant-based functional foods for the protection against salt-induced endothelial dysfunction by Sheung Yin San, Jennifer. M.F. Wan, Jimmy Chun Yu Louie

“…Salt reduction may still be the most effective strategy to improve vascular health.…”
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Performance of Composite Filters Assembled from Multiple Layers of Basic Filtration Media by Peng Wang, Zhen Liu, Da-Ren Chen

“…In order to help ease the supply demands of these resources, a strategy of using multiple layers of basic filtration media to construct a composite filter that can match the particle collection efficiency offered by a N95 filtering facepiece respirator (FFR) is proposed. …”
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Fast Fault-Tolerant Grid Frequency Measurement by Chris Wembridge, Mark Davies, James Lord, Evan Franklin, Sarah Lyden, Michael Negnevitsky

“…This paper describes in detail a measurement strategy that extracts the continuous phase angle of the positive phase sequence phasor, from voltage signals. …”
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Research on Multi-Channel Spectral Prediction Model for Printed Matter Based on HMSSA-BP Neural Network by Dandan Fan, Hongwu Zhan, Fang Xu, Yifei Zou, Yankang Zhang

“…Second, Hybrid Multi-strategy Sparrow Search Algorithm (HMSSA) is constructed to optimize BPNN, which combines Tent mapping, step size phased control, and chaotic cosine transform factor. …”
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Analyzing Bid and Indicative Prices in Historic Building Reconstructions in the Czech Republic by Hromada Eduard, Brozova Lucie, Heralova Renata Schneiderova, Macek Daniel, Vitasek Stanislav, Strelcova Iveta

“…This approach not only ensured the preservation of the cultural value of historic buildings, but also provided a practical, financially sound strategy for their restoration. The findings of this study provide valuable insights for stakeholders involved in the pricing and budgeting of restoration projects, helping to refine cost estimation methodologies and improve the efficiency and accuracy of budgeting processes.…”
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Advancing risk assessment in renewable power plant construction: an integrated DEA-SVM approach by Reza Rasinojehdehi, Seyyed Najafi

“…The construction of renewable power plants emerges as a paramount solution for achieving clean energy, a strategy successfully implemented in various countries globally, including India, China, the USA, Central Asian nations, and Africa. …”
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LiveDrive AI: A Pilot Study of a Machine Learning-Powered Diagnostic System for Real-Time, Non-Invasive Detection of Mild Cognitive Impairment by Firas Al-Hindawi, Peter Serhan, Yonas E. Geda, Francis Tsow, Teresa Wu, Erica Forzani

“…Using the LiveDrive AI system, equipped with multimodal sensing (MMS) technology and a driving performance assessment strategy, the proposed work analyzes the predictive capacity of driving patterns in indicating cognitive decline. …”
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