α-Methyl-Tryptophan Inhibits SLC6A14 Expression and Exhibits Immunomodulatory Effects in Crohn’s Disease by Su Y, Li J, Chen Y, Bao J, Lei Z, Ma M, Zhang W, Liu Q, Xu B, Hu T, Hu Y

“…Traditional diagnostic and therapeutic methods have limitations, necessitating the exploration of more effective strategies.Methods: In this study, we employed the Gene Expression Omnibus database to identify genes that are differentially expressed in CD. …”
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From structure prediction to function: defining the domain on the African swine fever virus CD2v protein required for binding to erythrocytes by Ana Luisa Reis, Anusyah Rathakrishnan, Vlad Petrovan, Muneeb Islam, Lynnette Goatley, Katy Moffat, Mai Tuyet Vuong, Yuan Lui, Simon J. Davis, Shinji Ikemizu, Linda K. Dixon

“…These findings improve our understanding of virus–host interactions and provide a promising approach to modified live vaccine development.IMPORTANCEA better understanding of the interactions between viruses and their hosts is a crucial step in the development of strategies for controlling viral diseases, such as vaccines and antivirals. …”
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Research Status and Direction of Chronic Obstructive Pulmonary Disease Complicated with Coronary Heart Disease: A Bibliometric Analysis from 2005 to 2024 by Bian H, Zhu S, Xing W, Qi L, Xue J, Peng X, Jin Z, Zhao H

“…Through keyword clustering analysis, we categorized all keywords into three distinct groups: management strategies for COPD and CHD; diseases associated with both conditions; and epidemiological characteristics concerning their burden—current hotspots include multimorbidity factors such as hypertension and obesity alongside outcomes like diagnosis during COVID-19 pandemic implications within societal contexts are highlighted here too.Conclusion: Presently focused research on COPD coupled with CHD primarily revolves around five key areas: pathogenesis exploration, early diagnostic techniques, COVID-19 infection, dynamics intervention, methodologies, and treatment protocol development efforts. …”
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Potential diagnostic tools for intensive care unit acquired weakness: A systematic review by Chen Xin, Yubiao Gai, Lili Wei, Yanqiu Wang, Yuhong Luo, Binru Han

“…Early diagnosis of intensive care unit-acquired weakness and identification of its subcategories are essential for early implementation of targeted interventions and care strategies. Nevertheless, there remains a significant gap in the availability of widely accepted, accurate, and user-friendly diagnostic tools for intensive care unit-acquired weakness. …”
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Impact of zero-markup consumable policy and national procurement of coronary stents on hospitalization expenses: an interrupted time series analysis by Shao-long Wu, Shao-long Wu, Kun Wang, Xin Yang, Ning Liu, Ning Liu, Wen-xin Zou, Xiao-wei Li, Dan-hua Huang, Tian-hao Yu

“…Currently, research on the zero-markup consumable policy and national procurement of coronary stents for medical consumables at the hospital level lacks analysis of changes in cost structures (other expenses) and studies on hospital response strategies.ObjectiveThis study aims to examine the effects of these reforms on hospitalization expenses for patients undergoing coronary stent implantation, including the specific changes in total hospitalization expenses, the component of total expenses, and the proportion of each expense category following the implementation of the reforms.MethodsData were obtained from the case management system of Guangdong Provincial Second People’s Hospital in China. …”
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Comparison of the Impact of tNGS with mNGS on Antimicrobial Management in Patients with LRTIs: A Multicenter Retrospective Cohort Study by Li D, Li Q, Huang Z, Wu W, Fan X, Liu J, Li R, Zhang Q, Su X

“…Dan Li,1– 3,* Qingling Li,4,* Zhen Huang,2 Wenhao Wu,2 Xinyuan Fan,2 Jing Liu,2 Ruoran Li,2 Qi Zhang,2 Xin Su1 1Department of Respiratory and Critical Care Medicine, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, Jiangsu, 210000, People’s Republic of China; 2Department of Respiratory and Critical Care Medicine, Xuzhou Central Hospital, Xuzhou, Jiangsu, 221000, People’s Republic of China; 3Department of Respiratory and Critical Care Medicine, Jinling Hospital, Nanjing Medical University, Nanjing, 210002, People’s Republic of China; 4Department of Respiratory and Critical Care Medicine, Xuzhou First People’s Hospital, The Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xin Su, Department of Respiratory and Critical Care Medicine, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, Jiangsu, 210000, People’s Republic of China, Email suxinjs@163.com Qi Zhang, Department of Respiratory and Critical Care Medicine, Xuzhou Central Hospital, Xuzhou, Jiangsu, 221000, People’s Republic of China, Email zhangqi1107@126.comBackground: tNGS and mNGS are valuable tools for diagnosing pathogens in lower respiratory tract infections (LRTIs), which subsequently influence treatment strategies. However, the impact of tNGS and mNGS on antimicrobial stewardship in patients with LRTIs remains unclear.Methods: Patients diagnosed with LRTIs who underwent tNGS or mNGS between June 2021 and January 2024 were included. …”
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The association between stress-induced hyperglycemia ratio and cardiovascular events as well as all-cause mortality in patients with chronic kidney disease and diabetic nephropathy by Boning Cao, Zhendong Guo, Dan-Ting Li, Le-Ying Zhao, Zhen Wang, Ya-Bin Gao, Yao-Xian Wang

“…SHR may serve as a critical biomarker for prognostic assessment in these populations, enabling clinicians to identify high-risk patients and tailor personalized treatment strategies that enhance patient quality of life and mitigate mortality risk. …”
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Podstawy budowy Wspólnego Systemu Ubezpieczeń Rolnych w Unii Europejskiej by Mieczysław Łozowski, Zdzisław Obstawski

“…Chcąc odpowiednio zarządzać ryzykiem w rolnictwie należy uwzględniać dwie podstawowe strategie. Dotyczą one programów dywersyfikacji produkcji lub strategii dzielenia lub odstępowania ryzyka takich jak uczestnictwo w funduszach i ubezpieczeniach wzajemnych, ubezpieczeniach komercyjnych, kontraktach produkcyjnych, lub transakcjach terminowych. …”
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Correlation between meteorological variables, air quality, and the Coronavirus-19 pandemic events by M. Gidarjati, T. Matsumoto

“…The ongoing challenges in improving air quality persist despite the government's efforts, highlighting the need for a thorough understanding of the situation to inform effective policy interventions and strategies for reducing emissions.METHODS: The study analyzed key pollutants from five monitoring stations in Jakarta including particulate matter 2.5 from a Swiss air quality technology company. …”
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Molecular epidemiology of extended-spectrum beta-lactamases and carbapenemases-producing Shigella in Africa: a systematic review and meta-analysis by Namwin Siourimè Somda, Rabbi Nyarkoh, Abel Tankoano, Ouindgueta Juste Isidore Bonkoungou, Patience B. Tetteh-Quarcoo, Eric S. Donkor

“…Effective antimicrobial resistance (AMR) surveillance strategies are needed to improve the management and treatment of Shigella infections in Africa.…”
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The Role of Intravenous Selexipag in Managing PAH and Bridging Gaps in Oral Treatment: A Narrative Review by Goren S, Kidwai N, Aronow WS, Lanier GM

“…Furthermore, it calls for larger clinical trials to refine dosing strategies, explore long-term outcomes, and identify patient populations most likely to benefit from IV selexipag.Plain Language Summary: Pulmonary arterial hypertension (PAH) is a rare and dangerous condition that causes high blood pressure in the arteries of the lungs, leading to right heart failure and potentially death. …”
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The association of visceral and subcutaneous fat areas with phenotypic age in non-elderly adults, mediated by HOMA-IR and HDL-C by Yuanhong Liu, Min Xu, Liqing Wang, Linyun Meng, Mengran Li, Shumin Mu

“…These findings provide a biological basis for future screening for accelerated ageing and appropriate intervention in high-risk populations and offer valuable insights for guiding personalized clinical interventions and health management strategies.…”
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The long-term impact of childhood sexual assault on depression and self-reported mental and physical health by Oluwasegun Akinyemi, Temitope Ogundare, Mojisola Fasokun, Fadeke Ogunyankin, Nkemdirim Ugochukwu, Walia Ajisafe, Seun Ikugbayigbe, Oluebubechukwu Eze, Kakra Hughes, Miriam Michael

“…The findings underscore the cumulative impact of multiple CSA exposures on health outcomes and emphasize the need for trauma-informed healthcare, early intervention, and public health strategies to mitigate the long-term consequences of CSA.…”
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A network analysis of depression and anxiety symptoms among Chinese elderly living alone: based on the 2017–2018 Chinese Longitudinal Healthy Longevity Survey (CLHLS) by Ze Chang, Yunfan Zhang, Xiao Liang, Yunmeng Chen, Chunyan Guo, Xiansu Chi, Liuding Wang, Xie Wang, Hong Chen, Zixuan Zhang, Longtao Liu, Lina Miao, Yunling Zhang

“…Future research should explore intervention strategies for these symptoms to improve the mental health of elderly individuals living alone.…”
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The clinical prediction model to distinguish between colonization and infection by Klebsiella pneumoniae by Xiaoyu Zhang, Xifan Zhang, Deng Zhang, Jing Xu, Jingping Zhang, Xin Zhang

“…In the future, the accuracy of infection diagnosis can be further enhanced through artificial intelligence technology to optimize treatment strategies, thereby improving patient prognosis and reducing healthcare burdens.…”
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The effects of altitude training on hormonal response in professional cyclists by Raphael Faiss, Bastien Krumm, Basile Moreillon, Lena Mettraux, Julian Wackernell, James Spragg, Martin Faulhaber

“…Overall, this study supports positive physiological adaptations in elite endurance athletes following a LHTL training camp planned according to the current state of the art knowledge collected in the past 60 years investigating hypoxic training strategies. …”
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Scaling climate information services and climate smart agriculture through bundled business models by Desire M. Kagabo, Livingstone Byandaga, Patrick Gatsinzi, Patrick Mvuyibwami, Yvonne U. Munyangeri, Nasson Ntwari, Mathieu Ouedraogo

“…Eleven CIS-CSA bundled business models with publicly available quantitative scaling readiness data (financial capacity, the number of customers, customer categories, and the number of beneficiaries) were used to quantitatively model how different CIS-CSA products and services bundling strategies, the revenue stream structure of a CIS-CSA business, and the structure of a CIS-CSA business’s stakeholder network (the diversity of its stakeholders) affect its scaling readiness. …”
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Mendelian randomization analysis of plasma proteins reveals potential novel tumor markers for gastric cancer by Wenhai Fan, Zhenjiang Wu, Shenghao Xu, Zhiheng Liu, Yiming Huang, Pan Wang

“…These results highlight the complex biological interactions between plasma proteins and tumorigenesis, providing valuable insights for preventive and therapeutic strategies in gastric malignancy management.…”
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Podstawy budowy Wspólnego Systemu Ubezpieczeń Rolnych w Unii Europejskiej by Mieczysław Łozowski, Zdzisław Obstawski

“…Chcąc odpowiednio zarządzać ryzykiem w rolnictwie należy uwzględniać dwie podstawowe strategie. Dotyczą one programów dywersyfikacji produkcji lub strategii dzielenia lub odstępowania ryzyka takich jak uczestnictwo w funduszach i ubezpieczeniach wzajemnych, ubezpieczeniach komercyjnych, kontraktach produkcyjnych, lub transakcjach terminowych. …”
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Distribution of sasX, mupA, and qacA/B genes and determination of genetic relatedness of epidemic methicillin-resistant Staphylococcus aureus strains associated with bloodstream in... by Rui Zhao, Bingyu Du, Lingling Hu, Chenxi Li, Fen Xue, Xing Wang, Changhong Jiang, Jinghua Wang, Yanfeng Zhao

“…These findings contribute to a better understanding of the genetic epidemiology of MRSA in the region, facilitating the development of effective prevention and control strategies for BSI.…”
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