Molecular uncovering of important helminth species in wild ruminants in the Czech Republic by Lucie Škorpíková, Jaroslav Vadlejch, Jana Ilgová, Radim Plhal, Jakub Drimaj, Ondřej Mikulka, Jan Magdálek, Martin Kašný, Nikol Reslová

“…These findings are critical for planning health management and conservation strategies to mitigate the impacts of helminth infections, especially in areas affected by invasive species.…”
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Platelet-derived extracellular vesicles induced through different activation pathways drive melanoma progression by functional and transcriptional changes by Zeynep Tavukcuoglu, Umar Butt, Alessandra V. S. Faria, Johannes Oesterreicher, Wolfgang Holnthoner, Saara Laitinen, Mari Palviainen, Pia R-M Siljander

“…Inhibiting the platelet receptors that modulate the PEVs’ cancer-promoting properties may open up new strategies for identifying promising treatment targets for cancer therapy.…”
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E. Coli cytotoxic necrotizing factor-1 promotes colorectal carcinogenesis by causing oxidative stress, DNA damage and intestinal permeability alteration by Michela Tozzi, Alessia Fiore, Sara Travaglione, Francesca Marcon, Gabriella Rainaldi, Elena Angela Pia Germinario, Ilenia Laterza, Simona Donati, Daniele Macchia, Massimo Spada, Omar Leoni, Maria Cristina Quattrini, Donatella Pietraforte, Sofia Tomasoni, Filippo Torrigiani, Ranieri Verin, Paola Matarrese, Lucrezia Gambardella, Francesca Spadaro, Maria Carollo, Agostina Pietrantoni, Francesca Carlini, Concetta Panebianco, Valerio Pazienza, Filomena Colella, Donatella Lucchetti, Alessandro Sgambato, Antonella Sistigu, Federica Moschella, Marco Guidotti, Olimpia Vincentini, Zaira Maroccia, Mauro Biffoni, Roberta De Angelis, Laura Bracci, Alessia Fabbri

“…Altogether, these findings not only add new knowledge to the contribution of bacterial toxins to CRC, but also pave the way to the implementation of current screening programs and preventive strategies.…”
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Adverse events of hepatic anti-fibrotic agents in phase 3 and above clinical trials: a descriptive analysis of the WHO-VigiAccess database by Yuwei Liu, Yuwei Liu, Xu Zhao, Xu Zhao, Xinrui Wang, Xinrui Wang, Qiang Zhou, Qiang Zhou

“…This study assessed ADRs associated with anti-fibrotic agents as reported in the World Health Organization (WHO) VigiAccess database and compared the adverse reaction characteristics of these agents for optimizing therapeutic strategies.MethodsA detailed search was conducted on ClinicalTrial.gov to identify phase 3 or 4 clinical trials involving hepatic anti-fibrotic agents. …”
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Combination of clinical factors predicts successful glucocorticoid withdrawal in systemic lupus erythematosus (SLE): results from a multicentre, retrospective cohort study by Alessandra Bortoluzzi, Marcello Govoni, Dimitrios T Boumpas, Antonis Fanouriakis, Prodromos Sidiropoulos, George Bertsias, Konstantinos Parperis, Argyro Repa, Ettore Silvagni, Myrto Nikoloudaki, Nestor Avgoustidis, Sofia Pitsigavdaki, Antonio Marangoni, Irini Flouri, Spyridon Katechis

“…Objective Glucocorticoid (GC) tapering and withdrawal to reduce damage represents a key aspect of the European Alliance of Associations for Rheumatology (EULAR) SLE recommendations. However, optimal strategies for relapse-free GC cessation remain ill-defined. …”
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Mental health in public safety personnel with workplace injuries requiring surgery: a longitudinal population-wide administrative data study in Manitoba, Canada by Tracie O Afifi, Jitender Sareen, Dan Chateau, Alyson Mahar, Jordan Nantais, James Bolton, Allen Kraut, Sarvesh Logsetty, Thomas Turgeon, Brenda Comaskey, Justin Gawaziuk, Rae Spiwak, Lauren Burton, Anthony Wightman, Jai Sareen, Natalie Mota

“…PSP have a unique mental health trajectory following workplace injury that should be considered when developing rehabilitation strategies for this important population.…”
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Advances in Development of PM2.5-Exposed Animal Models and Their Application in Reproductive Toxicity Research by TIAN Fang, PAN Bin, SHI Jiayi, XU Yanyi, LI Weihua

“…Additionally, interdisciplinary collaboration should be encouraged, involving cooperation between environmental science, toxicology, reproductive medicine, and other disciplines, to comprehensively assess the environmental health risks of PM2.5 and provide scientific support for the development of integrated prevention and control strategies. This review summarizes animal modeling methods, evaluation criteria, and their applications, providing valuable methodological references for future reproductive toxicity research on PM2.5.…”
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Magnitude, patterns, and factors associated with liver disease among clinically suspected clients in Eastern Ethiopia: hidden public health tragedy by Aliya Nuri, Sufian Jeilu, Yared Teklu, Kadir Abdu, Ahmed Muhye, Milkiyas Solomon Getachew, Imam Dagne, Muluken Yigezu, Sewmehon Amsalu Adugna, Vanisha S. Nambiar, Abdu Oumer

“…Conclusions Liver disease detection rate was found to be high and could be associated with substance use (alcohol and khat), history of hospitalization, and worm infection, which can be incorporated into the prevention strategies of liver diseases.…”
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Socially interactive industrial robots: a PAD model of flow for emotional co-regulation by Fabrizio Nunnari, Dimitra Tsovaltzi , Matteo Lavit Nicora , Matteo Lavit Nicora , Sebastian Beyrodt , Pooja Prajod , Lara Chehayeb , Ingrid Brdar , Antonella Delle Fave , Luca Negri , Elisabeth André, Patrick Gebhard , Matteo Malosio 

“…Qualitative interview analysis revealed that participants regulated negative emotions, like boredom, also without support, but some strategies could negatively impact wellbeing and productivity, which aligns with theory. …”
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Nanotechnology-based herbal medicine: Preparation, synthesis, and applications in food and medicine by Farhang H. Awlqadr, Kithar Rasheed Majeed, Ammar B. Altemimi, Arkan Mohammed Hassan, Syamand Ahmed Qadir, Mohammed N. Saeed, Aryan Mahmood Faraj, Tablo H. Salih, Alaa Jabbar Abd Al‐Manhel, Mazin A.A. Najm, Efstathia Tsakali, Jan F.M. Van Impe, Ahmed A. Abd El-Maksoud, Tarek Gamal Abedelmaksoud

“…Such advancements would modify treatment and nutritional strategies, allowing a more secure, effective, and long life.…”
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Prevalence of Salmonella and Shigella species and their multidrug resistance patterns among pediatric populations in Ethiopia: a systematic review and meta-analysis by Mihret Tilahun, Melaku Ashagrie Belete, Alemu Gedefie, Habtu Debash, Ermiyas Alemayehu, Daniel Gebretsadik Weldehana, Hussein Ebrahim, Ousman Mohammed, Bruktawit Eshetu, Saba Gebremichael Tekele, Zewudu Mulatie, Agumas Shibabaw

“…Thus, appropriate infection prevention and control strategies should be implemented and treatment should be directed based on antimicrobial stewardship protocols.…”
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Diagnostic accuracy of calculated serum osmolarity to predict dehydration in older people: adding value to pathology laboratory reports by Lee Shepstone, John F Potter, Lee Hooper, Asmaa Abdelhamid, Amy Jennings, Paul R Hunter, W Garry John, Neil P Walsh, Adam Ali, Diane K Bunn, Susan Kerry, Gregor Lindner, Carmen A Pfortmueller, Fredrik Sjöstrand, Susan J Fairweather-Tait

“…Objectives To assess which osmolarity equation best predicts directly measured serum/plasma osmolality and whether its use could add value to routine blood test results through screening for dehydration in older people.Design Diagnostic accuracy study.Participants Older people (≥65 years) in 5 cohorts: Dietary Strategies for Healthy Ageing in Europe (NU-AGE, living in the community), Dehydration Recognition In our Elders (DRIE, living in residential care), Fortes (admitted to acute medical care), Sjöstrand (emergency room) or Pfortmueller cohorts (hospitalised with liver cirrhosis).Reference standard for hydration status Directly measured serum/plasma osmolality: current dehydration (serum osmolality >300 mOsm/kg), impending/current dehydration (≥295 mOsm/kg).Index tests 39 osmolarity equations calculated using serum indices from the same blood draw as directly measured osmolality.Results Across 5 cohorts 595 older people were included, of whom 19% were dehydrated (directly measured osmolality >300 mOsm/kg). …”
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Risk factors for ocular biological parameters in Chinese preschool children: a cohort study from the Beijing whole childhood eye study by Xi Qin, Yunyun Sun, Yunyun Sun, Shana Wang, Xiaolan Xie, Lei Gao, Huijian Li, Huijian Li, Ruihua Wei, Jing Fu, Jing Fu, Bidan Zhu

“…BackgroundThe high myopia prevalence in young East Asian children necessitates early detection and prevention strategies. Axial length (AL), corneal radius of curvature (CR), and the AL to CR ratio (AL/CR) are potential myopia biomarkers. …”
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Molecular Data Confirm the Occurrence of the Allochthonous <i>Gambusia holbrooki</i> (Pisces: Poeciliidae) in Sicily and the Maltese Archipelago by Luca Vecchioni, Mirko Liuzzo, Arnold Sciberras, Jeffrey Sciberras, Justin Formosa, Alan Deidun, Gabriele Giacalone, Vincenzo Arizza, Marco Arculeo, Federico Marrone, Francesco Paolo Faraone

“…Considering the negative effects that the mosquitofish has on the native biota, it is of paramount importance to know the precise biological diversity of the native and non-native species to better implement environmental management strategies to properly preserve the already-fragile waterbodies. …”
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Genetic Polymorphisms in RNF138, ABCA1 and ESRRG-GPATCH2 Genes and their Role in Insulin Resistance Risk among Normal BMI Individuals in Indian Population: A Case-control Study by Sabitha Thummala, Sarah Fathima, Nithya Kruthi, Junaid Ahmed Khan Ghori, Katherine Saikia, Vivek Belde, Balamurali Andiyakkal Rajendran, Rahul Ranganathan

“…These findings necessitate further research into the functional significance of these associations and their potential implications for targeted interventions and preventive strategies in high-risk populations.…”
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Multicentre adaptive randomised trial of GvHD prophylaxis following unrelated donor stem cell transplantation comparing Thymoglobulin versus calcineurin inhibitor-based or sirolimu... by Simon Gates, Matthew Collin, Victoria Potter, Rebecca Bishop, Ronjon Chakraverty, Kavita Raj, Adrian Bloor, Andrea Hodgkinson, Jeff Davies, Emma Kempshall, Fiona Dignan, Ram Malladi, Siobhan Smith, Charlotte Gaskell, Gabrielle Smith

“…Many transplant protocols use alemtuzumab or anti-thymocyte globulin (ATG) in combination with a calcineurin inhibitor (CNI) and mycophenolate mofetil as GvHD prophylaxis; however, the outcomes of these treatments are complicated by high rates of infection and therefore the development of improved GvHD prophylaxis strategies represents a major unmet need.Methods and analysis The Methods of T-Cell Depletion trial is a prospective, multicentre, adaptive randomised trial in patients undergoing reduced intensity-conditioned unrelated donor allo-SCT. …”
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A digital intervention to reduce home-office workers’ sedentary behaviour: protocol for the evaluation of the Click2Move programme, a cluster randomised controlled trial by Judit Bort-Roig, Iris Parés-Salomón, Bette Loef, Cristina Vaqué-Crusellas, Alan Coffey, Arnau Gustems-Morral, Anna M. Señé-Mir, Izabela Luznik, Maja Pajek, Kieran P. Dowd, Anna Puig-Ribera, Karin I. Proper

“…The intervention group will receive the novel multicomponent Click2Move intervention (including environmental, organisational, and individual strategies) for 12 months, and the control groups will maintain their usual work practices. …”
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KEAP1 mutations as key crucial prognostic biomarkers for resistance to KRAS-G12C inhibitors by Linyan Tian, Chengming Liu, Sufei Zheng, Huiyang Shi, Fang Wei, Wenxin Jiang, Yucheng Dong, Haiyan Xu, Enzhi Yin, Nan Sun, Jie He, Yan Wang

“…The findings highlight the urgent need for alternative therapeutic approaches in KEAP1-mutant patients and emphasize the role of molecular profiling in tailored treatment strategies.…”
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Serological, phenotypic and molecular characterization of brucellosis in small ruminants in northern Algeria by Ibrahim Nabi, Rachid Achek, Rachid Achek, Abdelkadir Karim, Falk Melzer, Hanka Brangsch, Mandy C. Elschner, Heinrich Neubauer, Hosny El-Adawy, Hosny El-Adawy

“…The results of this study highlight brucellosis in small ruminants as a significant public health risk and will help to develop effective control strategies in Algeria. These findings provide specific evidence of this risk, with Brucella isolation from milk and by linking theses isolates to human cases in Algeria and abroad. …”
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cigFacies: a massive-scale benchmark dataset of seismic facies and its application by H. Gao, X. Wu, X. Sun, M. Hou, M. Hou, H. Gao, G. Wang, H. Sheng

“…Guided by the graph, we then implement the three strategies of field seismic data curation, knowledge-guided synthesization, and generative adversarial network (GAN)-based generation to construct a benchmark dataset of 8000 diverse samples for five common seismic facies. …”
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