Clinical and genetic drivers of oligo-metastatic disease in colon cancer by Alessandro Ottaiano, Mariachiara Santorsola, Roberto Sirica, Annabella Di Mauro, Antonella Di Carlo, Monica Ianniello, Francesco Sabbatino, Rosa Castiello, Francesca Del Peschio, Marco Cascella, Francesco Perri, Maurizio Capuozzo, Nicola Martucci, Edoardo Mercadante, Valentina Borzillo, Rossella Di Franco, Francesco Izzo, Vincenza Granata, Carmine Picone, Antonella Petrillo, Massimiliano Berretta, Salvatore Stilo, Luca Tarotto, Anna Chiara Carratù, Gerardo Ferrara, Madhura Tathode, Alessia Maria Cossu, Marco Bocchetti, Michele Caraglia, Guglielmo Nasti, Giovanni Savarese

“…Conclusion: OMD, characterized by male predominance, single-site involvement, and distinct molecular features in colon cancer, suggests the need for tailored management strategies.…”
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Protein kinases MpkA and SepH transduce crosstalk between CWI and SIN pathways to activate protective hyphal septation under echinocandin cell wall stress by Alexander G. Doan, Jessica E. Schafer, Casey M. Douglas, Matthew S. Quintanilla, Meredith E. Morse, Harley Edwards, Walker D. Huso, Kelsey J. Gray, JungHun Lee, Joshua K. Dayie, Steven D. Harris, Mark R. Marten

“…This discovery of the previously unknown crosstalk between the CWI and SIN pathways not only reshapes our understanding of fungal stress responses, but also unveils a promising new target pathway for the development of novel antifungal strategies.IMPORTANCEEchinocandin-resistant species pose a major challenge in clinical mycology by rendering one of only four lines of treatment, notably one of the two that are well-tolerated, ineffective in treating systemic mycoses of these species. …”
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Association between chronic kidney disease and oxidative balance score: National Health and Nutrition Examination Survey (NHANES) 2005–2018 by Cong Liu, Jiju Yang, Hongdian Li, Yuanyuan Deng, Pengfei He, Jiao Zhang, Mianzhi Zhang, Mianzhi Zhang, Mianzhi Zhang

“…A significant interaction was found in the stratified analysis by age group (p for interaction = 0.012), suggesting that individuals older than 60 years may benefit more significantly from an increase in OBS scores compared to those aged 60 years or younger.ConclusionThis study demonstrates that higher OBS is associated with a lower risk of CKD, particularly among the elderly population, providing innovative insights and preliminary evidence for the development of preventive strategies against CKD.…”
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Social capital and physical activity: a literature review up to March 2024 by Zhendong Gao, Chen Soon Chee, Roxana Dev Omar Dev, Yutong Liu, Jianhong Gao, Rui Li, Fangyi Li, Xiaoxiao Liu, Tao Wang

“…When designing public health interventions in the future, it is crucial to tailor strategies to different populations and contexts to better leverage social capital in promoting physical activity.…”
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Altered lumbo-pelvic-hip complex muscle morphometry and contraction change in postpartum pelvic girdle pain and asymptomatic subjects: a cross-sectional study by Ziling Lin, Ziling Lin, Yanjun Hou, Xueling Chen, Yanping Liu, Yanping Liu, Xiangbin Wang, Xiangbin Wang

“…Understanding the alterations in lumbo-pelvic-hip complex muscles function associated with PGP, is crucial for tailoring effective rehabilitation strategies and promoting optimal postpartum recovery. …”
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Single-cell RNA sequencing and immune microenvironment analysis reveal PLOD2-driven malignant transformation in cervical cancer by Zhiheng Lin, Fengxin Wang, Renwu Yin, Shengnan Li, Yuquan Bai, Baofang Zhang, Chenlin Sui, Hengjie Cao, Dune Su, Lianwei Xu, Honghong Wang

“…The validation of PLOD2 as a prognostic gene highlights its therapeutic potential, underscoring the critical need for integrating immunotherapy and targeted treatment strategies to enhance diagnostic and therapeutic approaches in cervical cancer.…”
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NEAT1 regulates BMSCs aging through disruption of FGF2 nuclear transport by Zifei Wang, Wenyu Zhen, Qing Wang, Yuqiang Sun, Siyu Jin, Sensen Yu, Xing Wu, Wenhao Zhang, Yulong Zhang, Fei Xu, Rui Wang, Yuxuan Xie, Wansu Sun, Jianguang Xu, Hengguo Zhang

“…Targeting NEAT1 might offer novel therapeutic strategies to rejuvenate aged BMSCs.…”
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The steps that young people and suicide prevention professionals think the social media industry and policymakers should take to improve online safety. A nested cross-sectional stu... by Jo Robinson, Jo Robinson, Pinar Thorn, Pinar Thorn, Samuel McKay, Samuel McKay, Hannah Richards, Hannah Richards, Rikki Battersby-Coulter, Rikki Battersby-Coulter, Michelle Lamblin, Michelle Lamblin, Laura Hemming, Laura Hemming, Laura Hemming, Louise La Sala, Louise La Sala

“…The proportion of participants “strongly agreeing”, “somewhat agreeing”, “neither agreeing nor disagreeing”, and “somewhat disagreeing” or “strongly disagreeing” for each item were calculated; items that achieved =>80% of agreement from both panels were strongly endorsed.ResultsThere was limited consensus across the two groups regarding the utility of the safety strategies currently employed by companies. However, both groups largely agreed that self-harm and suicide-related content should be restricted. …”
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Occupational outcomes of people with multiple sclerosis: a scoping review by Guglielmo Dini, Alfredo Montecucco, Nicoletta Debarbieri, Paolo Durando, Giuliana Buresti, Benedetta Persechino, Matilde Inglese, Bruno Kusznir Vitturi, Alborz Rahmani, Elvira Sbragia, Paolo Bandiera, Michela Ponzio, Mario Alberto Battaglia, Tommaso Manacorda

“…The results were categorised into seven subtopics: ‘Changes in work and occupational status due to MS’, ‘work-related socio-economic consequences of MS’, ‘risk factors for unfavourable occupational outcomes’, ‘reported barriers to employment’, ‘reported job accommodations and vocational rehabilitation strategies’, ‘job satisfaction, stigma, and disclosing the diagnosis in the workplace’ and ‘rating clinical scales’.Conclusions There are several issues that deserve further in-depth study by the scientific community in order to improve the occupational outcomes of people with MS.…”
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Ecological impacts of single-axis photovoltaic solar energy with periodic mowing on microclimate and vegetation by Yudi Li, Yudi Li, Alona Armstrong, Alona Armstrong, Christopher Simmons, Noah Z. Krasner, Noah Z. Krasner, Rebecca R. Hernandez, Rebecca R. Hernandez, Rebecca R. Hernandez, Rebecca R. Hernandez

“…These findings suggest the consideration of micro-patch-specific maintenance strategies and nature-based solutions to control invasive, exotic plant species, conferring opportunities to enhance operational, ecological, and socioeconomic sustainability while redressing the twin crises of climate change and biodiversity loss simultaneously.…”
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To what extent is the description of streets important in estimating local air quality: a case study over Paris by A. Squarcioni, A. Squarcioni, Y. Roustan, M. Valari, Y. Kim, K. Sartelet, L. Lugon, F. Dugay, R. Voitot

“…In our study, we compare two strategies: (i) a subgrid-scale approach embedded in the chemistry–transport model (denoted Subgrid) and (ii) the street-network model MUNICH (Model of Urban Network of Intersecting Canyons and Highways). …”
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The application of a clinical-multimodal ultrasound radiomics model for predicting cervical lymph node metastasis of thyroid papillary carcinoma by Chang Liu, Chang Liu, Shangjie Yang, Shangjie Yang, Tian Xue, Qian Zhang, Qian Zhang, Yanjing Zhang, Yufang Zhao, Guolin Yin, Xiaohui Yan, Ping Liang, Liping Liu

“…Accurate preoperative identification will provide valuable reference information for the formulation of diagnostic and treatment strategies. The aim of this study was to develop and validate a clinical-multimodal ultrasound radiomics model for predicting CLNM of PTC.MethodsOne hundred sixty-four patients with PTC who underwent treatment at our hospital between March 2016 and December 2021 were included in this study. …”
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Assessing and predicting the value of ecosystem services in Sanya City, Hainan Island, China by Peihong Song, Qiu Yang, Wenyin Wu, Tianyan Su, Yamin Jiang, Jingli Lu, Zhongyi Sun, Jie Zhang, Rui Yu, Peng Wang, Lan Wu, Huai Yang, Wenjie Liu

“…Considering the LUCC characteristics and land-use strategies in Sanya, the Synthetical Protection Scenario was identified as the optimal choice to balance the red line between farmland and the ecological development of civilization. …”
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Oxaliplatin-Loaded Chitosan Nanoparticles Decorated with Cetuximab Single-Chain Variable Fragment for Human Colorectal Cancer Treatment by Khadijeh Falahzadeh, Fariba Esmaeili, Leila Nematollahi, Elham Bayat, Mehdi Khoobi, Mohammadali Mazloomi, Masumeh Jalalvand, Reza Faridi Majidi, Babak Negahdari

“…Moreresearch is needed on the best strategies for improving treatment efficacy by targeting cancer cells.…”
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PrEP15-19 Choices: an implementation study protocol of HIV prevention with oral and long-acting injectable cabotegravir PrEP in real-world settings among sexual and gender minority... by Inês Dourado, Eliana Miura Zucchi, Laio Magno, Alexandre D Grangeiro, Márcia Thereza Couto, Mateus Westin, Eduardo Oliveira, Maria Mercedes Escuder, Dirceu Greco, Thais Regis Aranha Rossi, Fabiane Soares, Lorenza Dezanet, Paula Massa, Priscilla Caires, Ricardo de Paula Vasconcelos, Unaí Tupinambas, Beo Leite, Joilson Nascimento Paim, Guilherme Barreto Campos, Lucas Miranda Marques, Nathalia Suzart, Suilan Pedreira, DulceAurélia deSouza Ferraz, Dyemison Pinheiro, Eliane Sala, Raphaella Goulart, Ana Paula Silva, Erica Dumont Pena, Gabriella Jomara daSilva, Marília Greco, Matheus dePaula Alves

“…The qualitative studies will focus on investigating the processes involved in linkage and retention in care, switching between PrEP modalities and strategies of the implementation process of LAI-PrEP in the current PrEP programming and acceptability from health providers, policymakers and stakeholders’ perspectives.Ethics and dissemination The adolescent’s autonomy for consenting to their participation and understanding of PrEP will be assessed by the project team before any care is given and will be recorded in their medical record. …”
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High perioperative lactate levels as a potential predictor for severe acute kidney injury following aortic arch surgery by Dongxu Wang, Chen Yang, Han Wang, Mengmeng Ye, Chao Xue, Weiguang Wang, Bo Yu, Kai Ren, Zhenxiao Jin, Shiqiang Yu, Shiqiang Yu, Weixun Duan

“…Lacpo12h is a reliable and effective predictor of severe postoperative AKI, highlighting its clinical utility in risk stratification and management strategies.…”
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Biochemical recurrence prediction after robot-assited radical prostatectomy (BCR-PRARP) by Tanan Bejrananda, Kiyoshi Takahara, Dutsadee Sowanthip, Tomonari Motonaga, Kota Yagi, Wataru Nakamura, Masanobu Saruta, Takuhisa Nukaya, Masashi Takenaka, Kenji Zennami, Manabu Ichino, Hitomi Sasaki, Makoto Sumitomo, Ryoichi Shiroki

“…This allows for tailored follow-up strategies, optimizing resource allocation, and holds significant clinical utility, warranting broader implementation and further research.…”
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Impacts on and damage to European forests from the 2018–2022 heat and drought events by F. Knutzen, P. Averbeck, C. Barrasso, C. Barrasso, L. M. Bouwer, L. M. Bouwer, B. Gardiner, J. M. Grünzweig, S. Hänel, K. Haustein, K. Haustein, M. R. Johannessen, S. Kollet, M. M. Müller, J.-P. Pietikäinen, K. Pietras-Couffignal, K. Pietras-Couffignal, J. G. Pinto, D. Rechid, E. Rousi, A. Russo, A. Russo, L. Suarez-Gutierrez, L. Suarez-Gutierrez, S. Veit, S. Veit, J. Wendler, E. Xoplaki, D. Gliksman, D. Gliksman

“…</p> <p>Based on this assessment, we conclude that (i) European forests are highly vulnerable to drought and heat, with even resilient ecosystems at risk of severe damage; (ii) tailored strategies are essential to mitigate climate change impacts on European forests, incorporating regional differences in forest damage and resilience; and (iii) effective management requires harmonised data collection and enhanced monitoring to address future challenges comprehensively.…”
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Fluid balance and clinical outcomes in patients with aortic dissection: a retrospective case-control study based on ICU databases by Tao Chen, Peng Qiu, Yixuan Li, Xinwu Lu, Zhaoyu Wu, Zhijue Xu, Hongji Pu, Jiahao Lei, Zhuojing Zhang, Xinrui Yang, Ruihua Wang

“…A similar result was found for mean 24-hour fluid balance (OR 1.030, 95% CI (1.019, 1.042), p&lt;0.001), and the cut-off was selected to be 5.12 dL (AUC=0.778, OR 3.066, 95% CI (1.634, 5.753), p&lt;0.001).Conclusions This study stresses the importance of fluid balance in the clinical care of AD patients and provides new insights for optimising fluid management and monitoring strategies beyond the conventional focus on blood pressure and heart rate management.…”
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Long-term trends in the prevalence of cardiovascular-kidney-metabolic syndrome in South Korea, 2011–2021: a representative longitudinal serial studyResearch in context by Yesol Yim, Jae E. Lee, Yejun Son, Soeun Kim, Hojae Lee, Sooji Lee, Wonwoo Jang, Hanseul Cho, Hayeon Lee, Kyeongmin Lee, Hyesu Jo, Jaeyu Park, Jiyeon Oh, Louis Jacob, Jiseung Kang, Hyunji Sang, Sang Youl Rhee, Dong Keon Yon

“…Our findings emphasize the urgent need for tailored public health strategies targeting metabolic risk factors, particularly in vulnerable subgroups, to prevent progression to advanced CKM stages. …”
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